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Exophiala dermatitidis

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World Journal of Clinical Cases 2021年第27期9卷 7963-7972页

作者： Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako ito Toshihiko Yoshizawa Suguru asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Department of Geriatric Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan

Exophiala is a genus comprising several species of opportunistic black yeasts,which belongs to *** is a rare cause of fungal ***,infections are often chronic and recalcitrant,and while the number of cases is steadily increasing in both immunocompromised and immunocompetent people,detailed knowledge remains scarce regarding infection mechanisms,virulence factors,specific predisposing factors,risk factors,and host *** most common manifestations of Exophiala infection are skin infections,and the most frequent type of deep infection is pulmonary infection due to *** invasive disease ranges from cutaneous or subcutaneous infection to systemic dissemination to internal *** final identification of the causative organism should be achieved through a combination of several methods,including the newly introduced diagnostic analysis,matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry,together with sequencing of the ribosomal ribonucleic acid internal transcribed spacer region of the fungi,and histological and culture *** treatment,because anti-infective agents and natural compounds exhibited poor antibiofilm activity,few treatments have ultimately been found to be effective for specific antifungal therapy,so the optimal antifungal therapy and duration of therapy for these infections remain ***,most forms of disease caused by Exophiala dermatitidis require aggressive combination therapies:Both surgical intervention and aggressive antifungal therapy with novel compounds and azoles are necessary for effective treatment.

关键词： Exophiala dermatitidis Black yeast Immunocompromised host Matrixassisted laser desorption/ionization-time-of-flight mass spectrometry Ribosomal ribonucleic acid Antifungal drugs

Angiotensin receptor blocker neprilysin inhibitors

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World Journal of Cardiology 2021年第8期13卷 325-339页

作者： Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako ito Toshihiko Yoshizawa Suguru asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Geriatric Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531ToyamaJapan

Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,*** is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public *** the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of *** receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for ***/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital *** inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/*** the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic *** the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models.

关键词： Angiotensin receptor blocker and neprilysin inhibitor Chronic heart failure Renin-angiotensin-aldosterone-system Sympathetic nervous system Natriuretic peptide Sacubitril/valsartan

Diffuse large B cell lymphoma originating from the maxillary sinus with skin metastases:A case report and review of literature

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World Journal of Clinical Cases 2021年第23期9卷 6886-6899页

作者： Daisuke Usuda Toshihide Izumida Nao Terada Ryusho Sangen Toshihiro Higashikawa Sayumi Sekiguchi Risa Tanaka Makoto Suzuki Yuta Hotchi Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako ito Suguru asako Yoshie Takagi Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Yuji Kasamaki Department of General Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-0035Tokyo-toJapan Kanazawa Medical University Himi Municipal Hospital Himi-shi 935-8531Toyama-kenJapan

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is the most common type of malignant lymphoma(ML),accounting for 30%-40%of cases of non-Hodgkin’s lymphoma(NHL)in *** paranasal sinus lymphoma is a rare presentation of extranodal NHL that accounts for only 0.17%of all *** from the maxillary sinus(MS)is a particularly rare presentation,and is thus often difficult to *** have reported the first known case of DLBCL originating from the MS with rapidly occurrent multiple skin *** SUMMARY An 81-year-old Japanese man visited our hospital due to continuous pain for 12 d in the left maxillary nerve *** medical history included splenectomy due to a traffic injury,an old right cerebral infarction from when he was 74-years-old,hypertension,and type 2 diabetes mellitus.A plain head computed tomography(CT)scan revealed a 3 cm×3.1 cm×3 cm sized left *** day 25,left diplopia and ptosis occurred,and a follow-up CT on day 31 revealed the growth of the left MS *** on an MS biopsy on day 50,we established a definitive diagnosis of DLBCL,non-germinal center B-cell-like originating from the left *** patient was admitted on day 62 due to rapid deterioration of his condition,and a plain CT scan revealed the further growth of the left MS mass,as well as multiple systemic metastasis,including of the skin.A skin biopsy on day 70 was found to be the same as that of the left MS *** notified the patient and his family of the disease,and they opted for palliative care,considering on his condition and *** patient died on day *** This case suggests the need for careful,detailed examination,and for careful follow-up,when encountering patients presenting with a mass.

关键词： Diffuse large B cell lymphoma Non-germinal center B-cell-like lymphoma Malignant lymphoma Maxillary sinus Skin metastasis Case report

High doses of dextromethorphan induced shock and convulsions in a 19-year-old female:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3870-3876页

作者： Shintaro Shimozawa Daisuke Usuda Toru Sasaki Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako ito Suguru asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-city 177-8521TokyoJapan Clinical Training Center Juntendo University Nerima HospitalNerima-city 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo-city 113-8421TokyoJapan

BACKGROUND Dextromethorphan is a prevalent antitussive agent that can be easily obtained as an over-the-counter *** has been a growing number of reported cases of toxicity in recent ***,there are numerous instances of mild symptoms,with only a limited number of reports of severe cases necessitating intensive *** presented the case of a female who ingested 111 tablets of dextromethorphan,leading to shock and convulsions and requiring intensive care that ultimately saved her *** SUMMARY A 19-year-old female was admitted to our hospital via ambulance,having overdosed on 111 tablets of dextromethorphan(15 mg)obtained through an online importer in a suicide *** patient had a history of drug abuse and multiple self-inflicted *** the time of admission,she exhibited symptoms of shock and altered ***,upon arrival at the hospital,the patient experienced recurrent generalized clonic convulsions and status epilepticus,necessitating tracheal *** convulsions were determined to have been caused by decreased cerebral perfusion pressure secondary to shock,and noradrenaline was administered as a *** lavage and activated charcoal were also administered after *** systemic management in the intensive care unit,the patient’s condition stabilized,and the need for vasopressors *** patient regained consciousness and was *** patient was subsequently transferred to a psychiatric facility,as suicidal ideation *** We report the first case of shock caused by an overdose of dextromethorphan.

关键词： Dextromethorphan Drug overdose Shock Symptom Treatment Case report

Integrated genome-wide differentiation and association analyses identify causal genes underlying breeding-selected grain quality traits in japonica rice

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Molecular Plant 2023年第9期16卷 1460-1477页

作者： Hideki Yoshida Satoshi Okada Fanmiao Wang Shohei Shiota Masaki Mori Mayuko Kawamura Xue Zhao Yiqiao Wang Naho Nishigaki asako Kobayashi Kotaro Miura Shinya Yoshida Masaru Ikegami Akitoshi ito Lin-Tzu Huang Yue-le Caroline Hsing Yoshiyuki Yamagata Yoichi Morinaka Masanori Yamasaki Toshihisa Kotake Eiji Yamamoto Jian Sun Ko Hirano Makoto Matsuoka Institute of Fermentation Sciences Fukushima UniversityFukushima 960-1248Japan Bioscience and Biotechnology Center Nagoya UniversityNagoyaAichi 464-8601Japan Food Resources Education and Research Center Graduate School of Agricultural ScienceKobe UniversityUzuranoKasaiHyogo 675-2103Japan Research Center of Genetic Resources NARO2-1-1 KannondaiTsukubaIbaraki 305-8602Japan Rice Research Institute Shenyang Agricultural UniversityShenyangChina Division of Life Science Graduate School of Science and EngineeringSaitama University255 Shimo-okuboSakura-kuSaitamaJapan Fukui Agricultural Experiment Station Fukui 918-8215Japan Department of Bioscience and Biotechnology Fukui Prefectural UniversityFukui 910-1195Japan Hyogo Prefectural Research Center for Agriculture Forestry and FisheriesKasaiHyogo 679-0198Japan Research Insttute for Food and Agriculture Ryukoku UniversityOotsuShiga 520-2194Japan Food Research Centre Aichi Centre for Industry and Science Technology2-1-1 Shimpukuji-choNagoyaAichi 451-0083Japan institute of Plant and Microbial Biology Academia SinicaTaipeiTaiwanChina Department of Agronomy National Taiwan UniversityTaipeiTaiwanChina lant Breeding Laboratory Facultyf gricultureKyushu University744MoookaNishikuFukukaJapan Graduate School of Agiculture Meji University1-1-1 Higashi-MitaTama-kuKawasakiKanagawa 214571Japa Crop Science Laboratory Faculty of AgricultureNigata UniversityIkarashiNishi-kuNigata 950-2181Japan

Improving grain quality is a primary objective in contemporary rice *** modern rice breeding has developed two different types of rice,eating and sake-brewing rice,with different grain characteristics,indicating the selection of variant gene alleles during the breeding *** the critical importance of promptly and efficiently identifying genes selected in past breeding for future molecular breeding,we conducted genome scans for divergence,genome-wide association studies,and map-based ***,we successfully identified two genes,OsMnS and OsWOX9D,both contributing to rice grain *** encodes a mannan synthase that increases the white core frequency in the endosperm,a desirable trait for sake brewing but decreases the grain appearance ***9D encodes a grass-specific homeobox-containing transcription factor,which enhances grain width for better sake ***,haplotype analysis revealed that their defective alleles were selected in East Asia,but not Europe,during modern *** addition,our analyses indicate that a reduction in grain mannan content during African rice domestication may also be caused a defective OsMnS allele due to breeding *** study not only reveals the delicate balance between grain appearance quality and nutrition in rice but also provides a new strategy for isolating causal genes underlying complex traits,based on the concept of“breeding-assisted genomics”in plants.

关键词： rice grain quality sake brewing mannan genomic analysis