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World Journal of Clinical Cases 2024年第14期12卷 2420-2425页

作者： Shinya Mikami Sae Kimura Yoshitsugu Tsukamoto Masaki Hiwatari Yasuhito Hisatsune asako Fukuoka Tsunehisa Matsushita Takeharu Enomoto Takehito Otsubo Department of Gastrointestinal and General Surgery St.Marianna University School of MedicineKanagawa 216-8511Japan

BACKGROUND A Bochdalek hernia(BH)is a congenital diaphragmatic hernia that often develops in the neonatal *** typically occurs on the left side of the diaphragm.A right-sided BH in an adult is *** SUMMARY A 45-year-old man was referred to our hospital because of an abnormal shadow seen on chest radiography during a medical check-up.A chest radiograph showed elevation of the right *** tomography showed prolapse of multiple intraabdominal organs into the right thoracic cavity,corresponding to a right-sided *** herniated contents included the stomach,transverse colon,and left lobe of the *** left lobe of the liver was enlarged,particularly the medial *** surgery was ***,the left lobe of the liver was completely trapped in the thoracic ***,thoracoscopic manipulation had to be performed to return the liver to the abdominal *** hernia was repaired with interrupted nonabsorbable sutures and reinforced with *** Combined laparoscopic and thoracoscopic surgery was successfully performed for right-sided BH with massive liver prolapse and abnormal liver morphology.

关键词： Bochdalek hernia Right-sided Adult Laparoscopic and thoracoscopic repair Liver prolapse Abnormal liver morphology Case report

Epidemiology and Management of Drug-induced Liver Injury: Importance of the Updated RUCAM

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1239-1245页

作者： Takashi Kobayashi Michihiro Iwaki asako Nogami Masato Yoneda Department of Gastroenterology and Hepatology Yokohama City University Graduate School of MedicineYokohamaJapan

Drug-induced liver injury(DILI)is a major cause of acute liver injury,liver failure,and liver transplantation *** recent years,immune checkpoint inhibitors have become widely *** has led to an increase in DILI,for which pathophysiology and management methods differ significantly from the *** the number of cases of acute liver injury and liver transplantation due to DILI is expected to increase,information about a DILI is becoming more *** is classified into two types according to its etiology:intrinsic DILI,in which the drug or its metabolites cause liver damage that is dose-dependent and predictable;and idiosyncratic DILI,in which liver damage is also dose-independent but *** addition,depending on the course of the disease,chronic DILI or drug-induced autoimmune hepatitis may be *** number of DILI cases caused by antimicrobial agents is decreasing,whereas that caused by drugs for malignant tumors and health foods is *** Roussel Uclaf Causality Assessment Method is widely used to assess causality in *** injury is a type of immune-related adverse *** pattern of hepatic injury in immune-related adverse events is mostly hepatocellular,but mixed type and bile stasis have also been *** cholangitis caused by immune checkpoint inhibitors has also been reported as a unique type of *** mainly comprises withdrawal of immune checkpoint inhibitors and steroid administration;however,mycophenolate mofetil may be considered if the disease is refractory to steroids.

关键词： Drug-induced liver injury Immune-related adverse events Immune checkpoint inhibitor Updated RUCAM

Using eye drops in compliance may improve the symptoms and quality of life in patients with seasonal allergic conjunctivitis: analysis of a two-season web survey

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 988-991页

作者： asako Kodama Dogru Murat Hiroshi Fujishima Kazumi Fukagawa Department of Ophthalmology Eiju General HospitalTokyo 110-8645Japan Department of Ophthalmology Tsurumi University School of Dental MedicineKanagawa 230-0063Japan Ryogoku Eye Clinic Tokyo 130-0062Japan

Dear Editor,Allergic conjunctivitis is the most common ocular surface allergic disease, affecting more than 30% of the population[1-2]. In the immediate phase of the allergic reactions(type Ⅰ) in patients with seasonal allergic conjunctivitis(SAC), the binding of antigen with the reaginic antibody leads to the formation and release of chemical mediators, such as histamines, in the local anaphylactic reaction[3].

关键词： allergic patients seasonal

Pan-peroxisome proliferator-activated receptor agonist lanifibranor as a dominant candidate pharmacological therapy for nonalcoholic fatty liver disease

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 433-435页

作者： Masato Yoneda Takashi Kobayashi Nogami asako Michihiro Iwaki Satoru Saito Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University HospitalKanazawa-kuYokohamaJapan

As obesity incidence increases worldwide,nonalcoholic fatty liver disease(NAFLD)has become the most common form of liver disease,with a reported global prevalence of 25.2%(1).Nonalcoholic steatohepatitis(NASH)is a severe form of ***,the precise natural history of NAFLD/NASH remains *** is rapidly becoming the leading cause of end-stage liver disorders and liver transplants and is associated with increased cardiovascular disease risk(2).As a result,it poses critical health issues globally from both medical and socioeconomic perspectives.

关键词： NAFLD liver cardiovascular

Tropifexor,a selective non-acid farnesoid X receptor agonist,improved nonalcoholic steatohepatitis in a phase 2 trial,but several issues remain to be resolved

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 759-762页

作者： Masato Yoneda Takashi Kobayashi Naohiro Wada Tomohiro Otani asako Nogami Michihiro Iwaki Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University HospitalYokohamaJapan

As obesity continues to escalate worldwide,nonalcoholic fatty liver disease(NAFLD)has emerged as the most prevalent form of liver disease,with a reported global prevalence of 30.1%(1).The prevalence of NAFLD,which was around 25%in the 1990s,has been increasing year by year in recent years and has exceeded 35%in the past few years(1).The spectrum of disease includes nonalcoholic fatty liver(NAFL),characterized by macrovesicular hepatic steatosis that may be accompanied by mild inflammation,and nonalcoholic steatohepatitis(NASH),which is additionally characterized by the presence of inflammation and cellular injury(2).

关键词： Nonalcoholic fatty liver disease(NAFLD) obesity nonalcoholic steatohepatitis(NASH) tropifexor selective non-acid farnesoid X receptor agonists(selective non-acid FXR agonists)

Near-Infrared Imaging Using a High-Speed Monitoring Near Infrared Hyperspectral Camera(Compovision)

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光谱学与光谱分析 2015年第4期35卷 865-869页

作者： Daitaro Ishikawa asako Motomura Yoko Igarashi Yukihiro Ozaki Graduate School of Agricultural Science Tohoku University 1-1 Amamiya Tsutsumidori Aobaku Sendai 981-8555 Japan Sumitomo Electric Industries Ltd. 1 Taya Sakae Yokohama Kanagawa 244-8588 Japan School of Science and Technology Kwansei Gakuin University 2-1 Gakuen Sanda Hyogo 669-1337 Japan

This review paper reports near-infrared(NIR)imaging studies using a newly-developed NIR camera,*** can measure a significantly wide area of 150mm×250mm at high speed of between 2and *** enables a wide spectral region measurement in the 1 000~2 350nm range at 6nm *** investigated the potential of Compovision in the applications to industrial problems such as the evaluation of pharmaceutical tablets and *** studies have demonstrated that NIR imaging based on Compovision can solve several issues such as long acquisition times and relatively low sensitivity of *** imaging with Compovision is strongly expected to be applied not only to pharmaceutical tablet monitoring and polymer characterization but also to various applications such as those to food products,biomedical substances and organic and inorganic materials.

关键词： Near infrared spectroscopy Imaging Hyperspectral camera

Dynamic Force Reduction and Heat Transfer Improvement for Horizontal Tubes in Large-Particle Gas-Fluidized Beds

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Journal of Thermal Science 2008年第1期17卷 77-83页

作者： Yusumi Nagahashi John R.Grace Kok-Seng Lim Yutaka asako Dept.Mech.Eng. Kochi National College of Technol.KochiJAPAN Professor Dept.Chem.Biological Eng. The University of British ColumbiaVancouverCANADA CSIRO Minerals VictoriaAUSTRALIA Dept.Mech.Eng. Tokyo Metropolitan UniversityTokyoJAPAN

力量和热转移上的试管银行配置的效果为二维、三维的煤气的使流体化的床被调查。有效动态力量和热转移系数为几种试管银行配置被测量，并且平均力量比为一个单个试管小，这被发现。热转移系数能被提供足够的空间让粒子在试管银行的双方... 详细信息

力量和热转移上的试管银行配置的效果为二维、三维的煤气的使流体化的床被调查。有效动态力量和热转移系数为几种试管银行配置被测量，并且平均力量比为一个单个试管小，这被发现。热转移系数能被提供足够的空间让粒子在试管银行的双方附近下降增加。结果为优化试管银行的配置当由于动态力量减少试管侵蚀时，完成高热转移系数提供有用指南。

关键词：流化床热传输管状器具环流量

Diagnosed corrected transposition of great arteries after cesarean section:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9821-9827页

作者： Naoki Ichii Toshiyuki Kakinuma Atsushi Fujikawa Morihiko Takeda Tomoyuki Ohta Masataka Kagimoto Ayaka Kaneko Ryo Izumi Kaoru Kakinuma Koyomi Saito asako Maeyama Kaoru Yanagida Nobuhiro Takeshima Michitaka Ohwada Department of Obstetrics and Gynecology International University of Health and Welfare HospitalTochigi 329-2763Japan Department of Cardiovascular Medicine International University of Health and Welfare HospitalTochigi 329-2763Japan Department of Radiology International University of Health and Welfare HospitalTochigi 329-2763Japan

BACKGROUND Corrected transposition of the great arteries(cTGA) is a cardiac malformation in which the ventricular and arterial-ventricular positions in the heart are doubly *** general,this defect puts a load on the systemic circulation and causes heart failure,resulting in a poor *** article reports a case of cTGA detected in a patient with post-caesarean pregnancy who had undergone elective caesarean section and was experiencing an episode of acute heart *** SUMMARY This was the case of a 36-year-old gravida 3 para 1 *** problems were noted in the puerperal course following the previous *** current pregnancy was also *** elective caesarean section was performed and the patient was discharged from the hospital 7 d after the *** postoperative day 18,the patient became aware of breathing difficulty and presented at a nearby clinic,where she was referred to our institution after bilateral pleural effusions were *** was then diagnosed with acute heart failure after noting the presence of a prominent pedal oedema and SpO_(2) 91%(supine position and room air);the patient was promptly hospitalised for close examination and *** chest computed tomography revealed the presence of cTGA,no other cardiac malformations were *** to improvements in both the pedal oedema and pleural effusions,the patient was discharged on day *** Close examination should be performed on the premise of congenital cardiac malformation when heart failure symptoms are noted during perinatal control.

关键词： Corrected transposition of the great arteries Pregnancy Puerperal period Tricuspid insufficiency Case report

Optical recordings reveal the differential distribution of glutamatergic transmission in the cochlear and vestibular nuclei in the newborn mouse brainstem

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Journal of Otology 2009年第2期4卷 106-114页

作者： Doi Tadashi Kaneko Toshihiko Matsumoto Ayumi asako Mikiya Yamashita Toshio Department of Otolaryngology Kansai Medical University

Objective Using optical imaging in brainstem slices, we studied evoked responses in the mouse cochlear (CN) and vestibular (VN) nuclei. Methods The use of optical imaging allowed us to visualize the spatiotemporal patterns of excitatory propagation in the CN and VN. Optical recordings can differentiate excitatory propagation in the ventral CN(VCN) from that in the dorsal CN(DCN). Furthermore, we assessed the relative distribution of NMDA and non-NMDA receptors in these regions using the glutamate antagonists APV (NMDA receptor antagonist) and CNQX (non-NMDA receptor antagonist) in mouse brainstem slices during postnatal days 1 to 3. Results The average sensitivity to APV was 99.1% in the VCN, 76.0% in the DCN and 64.9% in the VN. The average sensitivity to CNQX was 0.9% in the VCN, 24.0% in the DCN and 35.1% in the VN. These results indicate that the effect of APV dominated in the VCN, while both APV and CNQX were effective antagonists in the DCN and VN. In the VN, the distribution of APV-and CNQX-sensitive cells was almost completely uniform. However, in the DCN the distribution of APV-and CNQX-sensitive cells was highly complex. The area that was more sensitive to CNQX was located in the superficial layer of the DCN while the area with a higher sensitivity to APV was located progressively in the deep layer. Conclusion This optical recording data suggests that there is a differential distribution of NMDA and non-NMDA receptor mediated neurotransmission in the VCN, DCN and VN.

关键词： voltage-sensitive dye NMDA non-NMDA photo diode array

The Effects of a Hyaluronan Lotion with a Molecular Weight of around 50 - 110 kDa on the Aged Atrophic Skin

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第3期4卷 150-155页

作者： asako Ito Ookuma Hospital Nagoya Japan

Background: Hyaluronic acids act upon keratinocytes via CD44 receptors and regulate proliferation and differentiation. Some cosmetic hyaluronan lotions manufactured based upon the fact are nowadays available. Aims: To evaluate a cosmetic hyaluronan lotion (Dr. Fukaya’s skin repair lotion or Hyaluprotect) from the viewpoint of anti-aging effects and to consider its mechanism. Patients/Methods: In ten healthy volunteers at the age over 60, immunohistochemical research of the biopsied skin was performed before and after the application of the hyaluronan lotion for two weeks. Results: Expression of PCNA in the lower epidermis increased in 8 of 10 subjects. Filaggrin expression of the upper epidermis increased in 6 subjects. 11βHSD1 decreased in 5 subjects and 11βHSD2 increased in 5 subjects. Conclusions: The proliferative and differentiative effects of the hyaluronan lotion upon keratinocytes were confirmed immunohistologically. There is a possibility that hyaluronic acids work through the regulation of corticosteroids by 11βHSD1 and 11βHSD2.

关键词： Hyaluronic Acid Anti-Aging PCNA Filaggrin 11βHSD1 11βHSD2 Atrophic Skin