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Analysis of diabetic foot ulcers in a tertiary care hospital-a clinico-microbiological perspective

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海南医学院学报 2010年第2期16卷 165-170,180页

作者： Shazi Shakil Shaista Alvi Mujahid Beg asad u.khan Interdisciplinary Biotechnology unit Aligarh Muslim University Aligarh Department of Medicine JN Medical University Aligarh Muslim university Aligarh

Objective:To assess potential risk factors for diabetic foot ulcers infected with multidrug-resistant-organisms(MDROs)and to investigate antibiotic susceptibility patterns and extended-spectrum-β-lactamase(ESBL)-production in bacteria isolated from these ***:Seventy-seven diabetic foot ulcer-patients were studied in a consecutive ***-four study factors were recorded for each *** were obtained by scraping the ulcer base or the deep portion of the wound edge with a sterile *** soft tissue specimens were quickly sent to the laboratory and processed for microbial ***-negative bacterial isolates were tested for ESBL production by double-disc-diffusion *** association of study variables with MDRO and non-MDRO infection status of ulcers was tested by Student's t test or Fisher's exact test using SPSS(version 11.5,Chicago).Results:An alarming number of patients were MDRO-positive(72.7%).ESBL-positive strains constituted 19.8% of total *** isolates identified as methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Staphylococcus aureus(VRSA),were 3.7%(n=8)and 0.5%(n=1)***-two study factors were found to be significantly associated with MDRO infection status of ulcers in the univariate *** logistic regressions proved that MDRO status was the only significant,independent predictor of glycemic control(Odds ratio = 4.22,Pusion:It is concluded that MDRO infected patients have poor glycemic *** and linezolid can be suggested as the drugs of choice in the described setting.

关键词：糖尿病有机体 β-内酰胺酶菌株

Swine flu pandemic:a global concern

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 81-82页

作者： asad u.khan Interdisciplinary Biotechnology unit AMU Aligarh 202002 India

Recently WHO has again declared Influenza pandemic due to the outbreak of H1N1 which has infected over 254,206 people in 80 countries,with 625 *** lab has started working on the proteome analysis of H1N1,2009 out brea... 详细信息

关键词： Influenza A Virus Swine

Multiple drug resistance and bacterial infection

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 76-82页

作者： asad u.khan Interdisciplinary Biotechnology unit Aligarh Muslim UniversityAligarh 202002India

Drug resistance is becoming a great problem in developing countries due to excessive use and misuse of antibiotics. The emergence of new pathogenic strains with resistance developed against most of the antibiotics which may cause,difficult to treat *** understand the current scenario in different mode of infection is most important for the clinicians and medical *** article summarized some common infections and antibiotic resistance pattern found among these pathogens.

关键词： Drug resistance Bacteria Infection

Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits

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Neural Regeneration Research 2022年第12期17卷 2685-2686页

作者： Mariam Masmudi-Martín Irene Navarro-Lobato Zafar u.khan Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands Laboratory of Neurobiology CIMESUniversity of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain CIBERNED Institute of Health Carlos ⅢMadridSpain

Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to use a new ***,memory deficits not only accompany normal aging but are also comorbid with many psychiatric,neurological,and neurodegenerative *** disability,autism,attention deficit disorder,learning disability,schizophrenia,and depression all have memory deficit components,as do Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and other neurodegenerative diseases(khan et al.,2014).Therefore,a large proportion of the human population is affected by this brain disorder.

关键词： Huntington remember finance

Quick screening and easy detection method of NDM-gene in clinical isolates:A need of the time

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Asian Pacific Journal of Tropical Medicine 2012年第10期5卷 839-840页

作者： asad u.khan Saeedut Z Ali Interdisciplinary Biotechnology unit Aligarh Muslim University

The emerging trend of multidrug resistance is becoming a major threat to community acquired and nosocomial infections,worldwide[1].The carbapenems are used as last-source drugs because of increasing resistance against... 详细信息

关键词： screening lactam nosocomial antibiotics isolates threat becoming emerging resist DNA

Phylogenetic Analysis of the Neuraminidase Gene Reveals that the H5N1 Strains Prevalent in Chickens During 2006 Bird Flu Outbreaks in Two Regions of Maharashtra, India Are Genetically Different

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Genomics, Proteomics & Bioinformatics 2009年第1期7卷 57-61页

作者： Mohd Danishuddin asad u. khan Interdisciplinary Biotechnology unit Aligarh Muslim University

In February 2006, two outbreaks of highly pathogenic avian influenza A virus subtype H5N1 occurred in chickens in two neighboring districts （first in Nandurbar and second in Jalgaon） of Maharashtra, India, in a span of 12 days. In the present study, the neuraminidase （NA） gene of the two Indian H5N1 isolates was taken into consideration to find if the two strains are genetically similar. Phylogenetic analysis of the NA gene showed that the H5N1 strains isolated from the two outbreaks were not originated from the same source. The first Indian isolate （Nandubar/7972/06） was clustered closest to an isolate from chicken in Vietnam in 2004, whereas the second Indian isolate （Jalgaon/8824/06） showed resemblance to strains isolated from swan in Italy and Iran in 2006. Moreover, amino acid sequence analysis showed varying hot spots for substitutions between these two Indian isolates, and three substitutions were found at functional domain sites. Secondary structure changes due to these substitutions were also reported. This study reveals that the H5N1 strains isolated from chickens during 2006 bird flu outbreaks in two neighboring districts of Maharashtra, India are genetically different.

关键词： avian influenza virus H5N1 neuraminidase phylogeny mutation

Inter-relationship of Various Results in Analysis of （14.0 MeV／u） Pb＋Pb Reaction using Mica and CN-85 Track Detectors

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Chinese Physics Letters 2005年第1期22卷 69-71页

作者： F.N.Khattak E.u.khan TabassumNasir J.J.Baluch F.u.khan u.W.C. GomalUniversityDeraIsmailKhanPakistan RadiationPhysicsDivision PINSTECHNiloreIslamabadPakistan DepartmentofPhysics GomalUniversityDeraIsmailKhanPakistan

Two detector materials mica and cellulose-nitrate(CN)-85 have been used to study (14.0MeV/u) Pb + Pb reaction. Events of different multiplicities were registered in mica and CN-85 detectors using the 2π-geometry technique of solid state nuclear track detection. After removing the target material from the detectors the damaged trails in the detectors were revealed as tracks by proper chemical etching. The irradiated area of each sample was scanned and events of different multiplicities were traced. The binary events were bifurcated into elastic and inelastic events. The elastic binary events and three prong events, observed in the reaction, have been used to search out coefficients Cμν in the presence of both the detectors, for the reaction under study. using these coefficients 3- and 4-prong events have been analysed. From the detailed analysis of the results of (14.0MeV/u) Pb+Pb reaction, obtained from mica and CN-85 track detectors we observed a great resemblance of results obtained from the two detectors. Combining the results of both the detectors, we report some important outcomes.

关键词： CN-85轨迹探测器高能物理学铅原子碰撞反应固态

Prevalence of plasmid mediated bla_(TEM-1) and bla_(CTX-M-15) type extended spectrum beta-lactamases in patients with sepsis

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 98-102页

作者： Shahzad F Haque Saeedut-Z Ali Mohammed TP asad u.khan Department of Medicine J.N.Medical CollegeAligarhIndia Interdisciplinary Biotechnology unit AMUAligarh Muslim UniversityAligarhIndia Department of Medicine J.N.Medical College.AligarhIndia

Objective:To characterize the bacterial pathogens in patients having gram negative septicaemia. Further,to evaluate the antimicrobial resistance and underlying molecular mechanisms in these ***:A total number of 70 cases of gram negative sepsis were included in this prospective,open labeled,observational *** methods for isolation and identification of bacteria were *** susceptibility and ESBL testing was performed by the standard disc diffusion *** amplification was performed to identify blaub>CTX-Mub>,blaub>SHVub>and blaub>TEMub> type *** experiments were performed to show resistant marker transfer. Results:The most prevalent isolates Escherichia coli（***） 58.6%,Klebsiella Spp.32.9%and Pseudomonas 8.6%,were resistant to most of the antimicrobials including cefazolin,ceftriaxone, cefuroxime,ampicillin and co-trimoxazole but sensitive to imipenem and *** and MBL production was seen 7.3%and 12.2%of *** isolates *** isoaltes were found to have blaub>CTX-M-15ub> and two of them also showed blaub>TEM-1ub> type ***, none of them showed blaub>SHVub>.Conjugation experiments using J-53 cells confirmed these resistant markers as plasmid ***:This work highlights the molecular epidemiology of escalating antimicrobial resistance and likely switch over of blaub>CTX-M-15ub> type extended spectrum beta-lactamases by blaub>TEMub> type ESBLs in ***,the antimicrobial resistance by horizontal gene transfer was predominant among Enterobacteraceae in the community setting.

关键词： Gram negative sepsis ESBL Antimicrobial resistance

Plasmid mediated multiple antibiotic resistance in Escherichia coli isolated from community acquired infection of urinary tract in Aligarh Hospital

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 12-15页

作者： asad u.khan Saeedut Zafar Ali Mohammed S Zaman Interdisciplinary Biotechnology unit A.M.U.Aligarh 202002India

This study was to investigate the current trends of multiple drug resistance in bacteria against antibiotics for the proper empirical *** isolates were collected from community-acquired infection of urinary tract patients in Aligarh India from March 1999 to August *** susceptibility test was performed,using the disc diffusion method followed by plasmid isolation by the method of Kado and *** experiments were performed by the method of Lederberg and *** study revealed that this infection was more common in young *** strains of *** isolated during the course of study were found to show multiple antibiotic resistance which was further characterized as plasmid-borne drug *** study shows that *** may be one of the important causative agents of urinary tract infection(uTI) in young women.

关键词： plasmid drug resistance uTI