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Amniotic membrane covering for facial nerve repair

Neural Regeneration Research 2013年第11期8卷 975-982页

作者： Murat Karaman arzu tuncel Shahrouz Sheidaei Mehmet Güney ■enol Murat Hakan Karabulut Ildem Deveci Nihan Karaman Department of Otorhinolaryngology ümraniye State Hospital for Research and Training Department of Otorhinolaryngology Haydarpa a Numune State Hospital for Research and Training Department of Neurology GATA Haydarpa a State Hospital for Research and Training Department of Dentistry Turkish Military Services

Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anastomosis was performed. Amniotic membranes were covered on the anastomosis sites in four rats. Electromyography results showed that, at the end of the 3rd and 8th weeks after amniotic membrane covering, the latency values of the facial nerves covered by amniotic membranes were significantly shortened and the amplitude values were significantly increased. Compared with simple facial nerve anastomosis, after histopathological examination, facial nerve anastomosed with amniotic membrane showed better continuity, milder inflammatory reactions, and more satisfactory nerve conduction. These findings suggest that amniotic membrane covering has great potential in facial nerve repair.

关键词： neural regeneration peripheral nerve injury tissue engineering amniotic membrane facial nerveinjury electromyography nerve anastomosis latency amplitude neuroregeneration

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