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Ultrasound guided percutaneous cholecystostomy in high-risk patients for surgical intervention

World Journal of Gastroenterology 2006年第44期12卷 7179-7182页

作者： Huseyin Bakkaloglu Hakan Yanar Recep Guloglu Korhan Taviloglu Fatih Tunca Murat Aksoy Cemalettin Ertekin arzu Poyanli Istanbul University Istanbul Faculty of Medicine Trauma and Emergency Surgery Service Capa-Istanbul Turkey Istanbul University Istanbul Faculty of Medicine Department of Radiology Capa-Istanbul Turkey

AIM: To assess the efficacy and safety of ultrasound guided percutaneous cholecystostomy (PC) in the treatment of acute cholecystitis in a well-defined high risk patients under general anesthesia. METHODS: The data of 27 consecutive patients who underwent percutaneous transhepatic cholecystostomy for the management of acute cholecystitis from January 1999 to June 2003 was retrospectively evaluated. All of the patients had both clinical and sonographic signs of acute cholecystitis and had comorbid diseases. RESULTS: Ultrasound revealed gallbladder stones in 25 patients and acalculous cholecystitis in two patients. Cholecystostomy catheters were removed 14-32 d (mean 23 d) after the procedure in cases where complete regression of all symptoms was achieved. There were statistically significant reductions in leukocytosis, (13.7 × 103 ± 1.3 × 103 μg/L vs 13 × 103 ± 1 × 103 μg/L, P < 0.05 for 24 h after PC; 13.7 × 103 ± 1.3 × 103 μg/L vs 8.3 × 103 ± 1.2 × 103 μg/L, P < 0.0001 for 72 h after PC), C -reactive protein (51.2 ± 18.5 mg/L vs 27.3 ± 10.4 mg/L, P < 0.05 for 24 h after PC; 51.2 ± 18.5 mg/L vs 5.4 ± 1.5 mg/L, P < 0.0001 for 72 h after PC), and fever (38 ± 0.35℃ vs 37.3 ± 0.32℃, P < 0.05 for 24 h after PC; 38 ± 0.35℃ vs 36.9 ± 0.15℃, P < 0.0001 for 72 h after PC). Sphincterotomy and stone extraction was performed successfully with endoscopic retrograde cholangio-pancreatography (ERCP) in three patients. After cholecystostomy, 5 (18%) patients underwent delayed cholecystectomy without any complications. Three out of 22 patients were admitted with recurrent acute cholecystitis during the follow-up and recoveredwith medical treatment. Catheter dislodgement occurred in three patients spontaneously, and two of them were managed by reinsertion of the catheter. CONCLUSION: As an alternative to surgery, percutan- eous cholecystostomy seems to be a safe method in critically ill patients with acute cholecystitis and can be performed with low mortality and morbidity. Delayed c

关键词：经皮胆囊造口术胆囊炎超声波检查中年

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Investigation of genome instability in patients with non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2013年第32期19卷 5295-5301页

作者： Ahmet Karaman Hamiyet Donmez-Altuntas Nazmiye Bitgen Zuhal Hamurcu arzu Oguz Cigdem Karakukcu Department of Gastroenterology Kayseri Education and Research Hospital Department of Medical Biology Medical SchoolErciyes University Department of Medical Oncology Kayseri Education and Research Hospital Department of Clinical Biochemistry Kayseri Education and Research Hospital

AIM:To evaluate the occurrence of micronucleus(MN),nucleoplasmic bridges(NPBs)and nuclear buds(NBUDs)in the mitogen-stimulated lymphocytes of patients with non-alcoholic steatohepatitis(NASH).METHODS:The study was performed in 25(9 females,16 males)patients newly diagnosed with NASH,and 25healthy subjects of similar ages and genders were used as a control *** of the controls was known to be receiving any drugs for medical or other reasons or using *** was further excluded by abdominal ultrasound imaging in the control *** numbers of MN,NPBs and NBUDs scored in binucleated(BN)cells were obtained from the mitogen-stimulated lymphocytes of patients and control *** comparisons of the numbers of BN cells with MN,NPBs and NBUDs and ages between the patients with NASH and control subjects were ***:The mean ages of the patients and the control group were 41.92±13.33 and 41.80±13.09 years(P>0.05),*** values of the mean body mass index(BMI),HOMA-IR,hemoglobin,creatinin,aspartate aminotransferase,alanine aminotransferase,triglyceride,high density lipoprotein,and low density lipoprotein were 31.19±4.62 kg/m2vs 25.07±4.14 kg/m2,6.71±4.68 vs 1.40±0.53,14.73±1.49 g/dL vs 14.64±1.30 g/dL,0.74±0.15 mg/dL vs 0.80±0.13 mg/dL,56.08±29.11 U/L vs 16.88±3.33 U/L,92.2±41.43U/L vs 15.88±5.88 U/L,219.21±141.68 mg/dL vs102.56±57.98 mg/dL,16.37±9.65 mg/dL vs 48.72±15.31 mg/dL,and 136.75±30.14 mg/dL vs 114.63±34.13 mg/dL in the patients and control groups,*** total numbers and frequencies of BN cells with MN,NPBs and NBUDs,which were scored using the CBMN cytome assay on PHA-stimulated lymphocytes,were evaluated in the patients with NASH and control *** found significantly higher numbers of MN,NPBs and NBUDs in the BN cells of patients with NASH than in those of the control subjects(21.60±9.32vs 6.88±3.91;29.28±13.31 vs 7.84±3.96;15.60±5.55 vs 4.20±1.63,respectively,P<0.0001).CONCLUSION:The increased

关键词： Non-alcoholic steatohepatitis Micronucleus Nucleoplasmic bridges Nuclear buds

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Synthesis of Polyacethylenes and Polysaccharides by Mushroom Ganoderma Lucidum (Curtis) P. Karst and Pleurotus Ostreatus (Jacq.) P. Kumm

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Advances in Bioscience and Biotechnology 2019年第8期10卷 226-232页

作者： Konul Farukh Bahshaliyeva Nizami Rza Namazov arzu Rasul Hasanova Sevinch Chamaladdin Garayeva Sevil Ehtibar Nagiyeva Institute of Microbiology National Academy of Sciences of Azerbaijan Baku Azerbaijan Institute of Fruit and Tea-Making of the Ministry of Agriculture of the Republic of Azerbaijan Kuba Azerbaijan Sumkayit State University Sumkayit Azerbayijan

The purpose of the present work was to study the biosynthesis of various compounds of basidial xylotrophic mushroom Ganoderma lucidum and Pleurotus ostreatus, which were taken to the pure culture from the fruit body of the mushroom living on hornbeam and beech. Shown, that mushroom can synthesize various substances, which composed includes fractions differing in functionality. Among the found fractions, one relates to the polyacetylene (PA), which are characterized by a high degree of unsaturation, contain many double and triple bonds, and are well absorbed in the ultraviolet range.

关键词： Fungi Biosynthesis Subfractions Polyacethylenes Polysaccharides Structure Chromatographic Condition

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Current state and clinical outcome in Turkish patients with hepatocellular carcinoma

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World Journal of Hepatology 2018年第1期10卷 51-61页

作者： Omer Ekinci Bulent Baran Asli Cifcibasi Ormeci Ozlem Mutluay Soyer Suut Gokturk Sami Evirgen arzu Poyanli Mine Gulluoglu Filiz Akyuz Cetin Karaca Kadir Demir Fatih Besisik Sabahattin Kaymakoglu Department of Gastroenterohepatology Istanbul Faculty of Medicine Istanbul University Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Department of Gastroenterology Ko? University Hospital Department of Radiology Istanbul Faculty of Medicine Istanbul University Department of Pathology Istanbul Faculty of Medicine Istanbul University

AIM To investigate clinical, etiological, and prognostic features in patients with hepatocellular *** Patients with hepatocellular carcinoma who were followed-up from 2001 to 2011 were included in the study. The diagnosis was established by histopathological and/or radiological criteria. We retrospectively reviewed clinical and laboratory data, etiology of primary liver disease, imaging characteristics and treatments. ChildPugh and Barcelona Clinic Liver Cancer stage was determined at initial diagnosis. Kaplan-Meier survival analysis was done to find out treatment effect on survival. Risk factors for vascular invasion and overall survival were investigated by multivariate Cox regression analyses. RESULTS Five hundred and forty-five patients with hepatocellular carcinoma were included in the study. Viral hepatitis was prevalent and 68 patients either had normal liver or were non-cirrhotic. Overall median survival was 16(13-19) mo. Presence of extrahepatic metastasis was associated with larger tumor size(OR = 3.19, 95%CI: 1.14-10.6). Independent predictor variables of vascular invasion were AFP(OR = 2.95, 95%CI: 1.38-6.31), total tumor diameter(OR = 3.14, 95%CI: 1.01-9.77), and hepatitis B infection( OR = 5.37, 95 % CI : 1.23-23.39). Liver functional reserve, tumor size/extension, AFP level and primary treatment modality were independent predictors of overall survival. Transarterial chemoembolization(HR = 0.38, 95%CI: 0.28-0.51) and radioembolization(HR = 0.36, 95%CI: 0.18-0.74) provided a comparable survival benefit in the real life setting. Surgical treatments as resection and transplantation were found to be associated with the best survival compared with loco-regional treatments(log-rank, P < 0.001).CONCLUSION Baseline liver function, oncologic features including AFP level and primary treatment modality determines overall survival in patients with hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Cirrhosis Alfafetoprotein Prognosis Treatment Survival

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鞣制工艺产生的铬革屑中铬的浸析作用及其稳定性的研究

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北京皮革（中外鞋讯）（下） 2009年第8期 98-101页

作者： Mehmet Erdem[土耳其] arzu Ozverdi[土耳其] 王睿（编译）不详四川大学制革清洁技术国家工程实验室成都610065

铬革屑（CS）是制革工业中附带的一种固体残渣，本研究考察铬革屑（CS）中铬的浸析作用和潜在污染。通常铬革屑含有2.27％的铬．对CS应用热稳定方式实验铬固定。为达到该目的，首先我们研究液／固比率，接触时间，pH值和逐级提取对铬革... 详细信息

铬革屑（CS）是制革工业中附带的一种固体残渣，本研究考察铬革屑（CS）中铬的浸析作用和潜在污染。通常铬革屑含有2.27％的铬．对CS应用热稳定方式实验铬固定。为达到该目的，首先我们研究液／固比率，接触时间，pH值和逐级提取对铬革屑中铬浸析作用的影响。可以确定的是由铬革屑附带的铬对环境是一种有毒材料。在250℃～500℃下对CS应用热稳定程序进行铬固定。CO2空气下当加热铬革屑温度达到350℃时，CS中的铬可以有效的稳定，对从稳定实验的得到的样品进行浸析实验，将其结果与铬革屑的样品对比。同时，通过样品的TCLP实验确定污染潜在性，铬革屑的排放情况以及它的稳定产物。当所有样品在350℃以上热稳定时测试液中的铬浓度低于USEPA常规限量值5毫克／升时．从铬革屑中浸出的铬浓度是USEPA常规限量值的30倍以上。

关键词：铬热稳定制革废弃物铬革屑皮革工艺

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Treatment of Massive Low-Grade Chondrosarcoma of Nasal Septum with Helical Tomotherapy: A Case Report

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第4期5卷 263-269页

作者： Hamit Basaran Timur Koca Sibel Karaca Ozlem Eser K&iota l&iota nc Fikriye Gul Karauc Okan Ö zdemir Ozan Kuduban arzu Tatar Sare Ş ipal Department of Radiation Oncology Regional Training and Research Hospital Erzurum Turkey Department of Otorhinolaryngology Regional Training and Research Hospital Erzurum Turkey Department of Otorhinolaryngology Ataturk University Faculty of Medicine Erzurum Turkey Department of Pathology Ataturk University Faculty of Medicine Erzurum Turkey

Chondrosarcomas are malignant bone tumors which develop as a cartilaginous differentiation of primary mesenchymal cells and the second most frequently seen malignant tumor of the bone after osteosarcoma. These malignancies are slowly growing non-epithelial tumors with unknown etiology and most frequently seen during the 4 decades of life. They are frequently localized on pelvis, ribs and long bones. Nasal septum CSs are very rarely seen malignancies. They originate from septal mucosa or cartilage and it is difficult to make a diagnosis unless they reach a certain size. A few cases of CSs with nasal septum have been reported in the literature. In cases of CSs, surgery is the gold standard treatment modality;however in surgically unresectable cases or close to margins, radiotherapy plays a significant role in primary and adjuvant treatment. Based on the position of the tumor in head and neck and extremely closeness of the tumor to vital organs as optic nerve, chiasm and brain, image guided-intensity modulated radiation therapy (IG-IMRT) becomes very effective and reliable modalities and may be a favorable treatment alternative.

关键词： Chondrosarcoma Image Guided Intensity Modulated Radiation Therapy

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Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2007年第6期13卷 837-844页

作者： Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak Uludag University Medical School Department of Internal Medicine Bursa Turkey Uludag University Medical School Department of Gastroenterology Bursa Turkey Uludag University Medical School Department of Biochemistry Bursa Turkey Uludag University Medical School Department of Statistics Bursa Turkey Uludag University Medical School Department of Pathology Bursa Turkey

AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology.

关键词：单纯肝脂肪变性非酒精性脂肪肝鉴别可溶性细胞角蛋白18 M30抗原 M65抗原

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Drug delivery interfaces:A way to optimize inhalation therapy in spontaneously breathing children

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World Journal of Clinical Pediatrics 2016年第3期5卷 281-287页

作者： arzu Ari Department of Respiratory Therapy Georgia State University

There are several different types of drug delivery interfaces available on the *** the right interface for aerosol drug delivery to children is essential for effective inhalation ***,clinicians usually focus on selecting the right drug-device combination and often overlook the importance of interface selection that lead to suboptimal drug delivery and therapeutic response in neonates and ***,it is necessary to critically assess each interface and understand its advantage and disadvantages in aerosol drug delivery to this patient *** purpose of this paper is to provide a critical assessment of drug delivery interfaces used for the treatment of children with pulmonary diseases by emphasizing advantages and problems associated with their use during inhalation therapy.

关键词： Aerosols Inhalation therapy Children Masks Mouthpiece High flow nasal cannula Blow-by Hood Spacer/valved holding chamber

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Geographic information science in the era of geospatial big data: A cyberspace perspective

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The Innovation 2022年第5期3卷 21-22页

作者： Xintao Liu Min Chen Christophe Claramunt Michael Batty Mei-Po Kwan Ahmad MSenousi Tao Cheng Josef Strobl arzu Cöltekin John Wilson Temenoujka Bandrova Milan Konecny Paul MTorrens Fengyuan Zhang Li He Jinfeng Wang Carlo Ratti Olaf Kolditz Alexander Klippel Songnian Li Hui Lin Guonian Lu Department of Land Surveying and Geo-Informatics Hong Kong Polytechnic UniversityHong Kong SARKowloonChina Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China The French Naval Academy Research Institute 29240 Lanveoc-PoulmicFrance The Bartlett Centre for Advanced Spatial Analysis(CASA) University College London(UCL)WC1E 6BT LondonUK Institute of Space and Earth Information Science The Chinese University of Hong KongHong Kong SARShatin 999077China Department of Civil Engineering Cairo University12613 CairoEgypt SpaceTimeLab Department of CivilEnvironmental and Geomatic EngineeringUniversity College London(UCL)WC1E 6BT LondonUK Department of Geoinformatics University of Salzburg5020 SalzburgAustria Institute of Interactive Technologies(IIT) University of Applied Sciences and Arts Northwestern Switzerland FHNW5210 WindischSwitzerland Spatial Sciences Institute University of Southern CaliforniaLos AngelesCA 90007USA Laboratory on Cartography Department of Photogrammetry and CartographyUniversity of ArchitectureCivil Engineering and Geodesy1164 SofiaBulgaria Laboratory on Geoinformatics and Cartography Department of GeographyMasaryk University61137 BrnoCeskáRepublika Computer Science and Engineering Tandon School&Center for Urban Science+ProgressNew York UniversityNew YorkNY 10012USA School of Humanities and Social Science Xi’an Jiaotong UniversityXi’an 710049China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Department of Urban Studies and Planning Massachusetts Institute of TechnologyCambridgeMA 02139USA Centre for Environmental Research Helmholtz Centre for Environmental Research-UFZ04318 LeipzigGermany Laboratory of Geo-information Science and Remote Sensing Wageningen University&ResearchWageningen 6708the Netherlands Department of Civil Engineering Toronto Metropolitan UniversityTorontoON M5B 2K3Canada School of Geography and Env

The advent of information and communication technology and the Internet of Things have led our society toward a digital *** proliferation of personal computers,smartphones,intelligent autonomous sensors,and pervasive network interactions with individuals have gradually shifted human activities from offline to online and from in person to *** transformation has brought a series of challenges in a variety of fields,such as the dilemma of placelessness,some aspects of timelessness(no time relevance),and the changing relevance of distance in the field of geographic information science(GIScience).In the last two decades,“cyber thinking”in GIScience has received significant attention from different *** instance,human activities in“cyberspace”need to be reconsidered when coupled with the geographic space to observe the first law of geography.

关键词： computer cyber instance

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Implementation of lung ultrasound in the triage of pregnant women during the SARS-CoV-2 pandemics

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Artificial Intelligence in Medical Imaging 2021年第3期2卷 56-63页

作者： arzu Bilge Tekin Murat Yassa Department of Obstetrics and Gynecology Sancaktepe Sehit Prof.Dr.Ilhan Varank Training and Research HospitalIstanbul 34785SancaktepeTurkey

Lung ultrasound(US)has been shown that it is able to detect interstitial lung disease,subpleural consolidations and acute respiratory distress syndrome in clinical and physical studies that assess its role in upper respiratory *** is used worldwide in the coronavirus disease 2019(COVID-19)outbreak and the effectiveness has been assessed in several *** diagnosis of COVID-19 is essential in deciding for patient isolation,clinical care and reducing *** the lung and pleura by ultrasound is efficient,cost-effective,and safe and it is recognized as rapid,repeatable,and *** are already using the US and are quite proficient in doing *** the pandemic,performing lung US(LUS)right after the fetal assessment until reverse transcription polymerase chain reaction results are obtained,particularly in settings that have a centralized testing center,was found feasible for the prediction of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** use of LUS is efficient in the triage and monitoring of pregnant *** dealing with pregnant women should consider LUS as the first-line diagnostic tool in pregnant women during the SARS-CoV-2 pandemic.

关键词： COVID-19 pandemics Lung Ultrasound imaging Pregnancy SARS-CoV-2 Triage

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