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International Journal of Digital Earth 2019年第4期12卷 442-459页

作者： arzu Çöltekin Julien Biland Department of Geography University of ZurichZurichSwitzerland Department of Geography University of BernBernSwitzerland

Terrain reversal effect(TRE)causes reversed 3D shape perception in satellite images and shaded relief maps(SRMs),and introduces difficulties in identifying landforms such as valleys and *** this paper,in a controlled laboratory experiment,we compare how well 27 participants could identify valleys and ridges over 33 locations using SRMs,color satellite images and grayscale satellite *** main depth cue is shadow both in vertical-view images and ***,the presence of texture and color in images also affect 3D shape *** our participants experience the illusion strongly:with the SRMs,it is very severe(2%accuracy),with grayscale images low but considerably better than SRMs(17.6%accuracy),and slightly worse with color imagery(15.3%accuracy).These differences between SRMs and imagery suggest that the participants who are able to bypass the illusion consciously or subconsciously interpret the photographic *** support this observation further with a cue-strength ***,we provide exploratory analyses of the effects of expertise,global convexity bias,and bistable *** original empirical observations serve towards a better understanding of this visual illusion,and contribute towards nuanced and appropriate solutions to correcting for TRE differently for satellite images and SRMs.

关键词： Terrain reversal relief inversion false topographic perception phenomenon photo interpretation visual illusion user study bistable perception global convexity bias

Gestational Diabetes and Infertility

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Journal of Diabetes Mellitus 2023年第2期13卷 203-221页

作者： Guluzar arzu Turan Tuncay Delibasi Newlife Fertility Centre Toronto Canada Endocrinology Diabetes and Metabolism Joslin Diabetes Center SUNY Upstate Medical University Syracuse USA

Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications which affect the mother and offspring. In addition to adverse perinatal outcomes, it may lead to permanent health problems for the mother, such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), while increasing the risk of future obesity, CVD, T2DM and GDM in the child. Approximately 15% of women seek fertility treatment. Over the last decade, it has come to attention that patients with an infertility history are more prone to having GDM during their pregnancies, and this review examines the relationship between GDM and infertility. The elevated estrogen, progesterone, leptin, placental lactogen and growth hormone are the main reasons for increased insulin resistance during pregnancy. Despite some confounding factors in the mechanism of GDM in patients with an infertility history, infertility treatment increases the risk, according to numerous studies. The obesity epidemic and associated disorders have become a significant public health concern worldwide. Lifestyle modification for weight loss before pregnancy is encouraged, but there is no strong evidence for improvement in perinatal results. GDM, infertility and infertility treatment have a potential risk of alteration in the embryo’s environment and cause epigenetic reprogramming, which may be inherited to the next generation. The fertility treatment impacts the patient’s and offspring’s health. Patients should be informed about the risks so that they consent and get involved in the decision. Infertility treatment may be accepted as a reason for high-risk pregnancy, and patients can be screened for GDM in early pregnancy.

关键词： Gestational Diabetes Mellitus Infertility Polycystic Ovary Syndrome (PCOS) In Vitro Fertilization (IVF) Assisted Reproduction Treatment (ART)

Mathematical Modelling and 3D FEM Analysis of the Influence of Initial Stresses on the ERR in a Band Crack’s Front in the Rectangular Orthotropic Thick Plate

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Computers, Materials & Continua 2017年第3期53卷 249-270页

作者： arzu Turan Dincel Surkay DAkbarov Yildiz Technical University Department of Mathematical EngineeringDavutpasa Campus34220EsenlerIstanbul-Turkey Yildiz Technical University Faculty of Mechanical EngineeringDepartment of Mechanical EngineeringYildiz Campus34349BesiktasIstanbul-Turkey Institute of Mathematics and Mechanics of the National Academy of Science of Azerbaijan 37041BakuAzerbaijan

This paper deals with the mathematical modelling and 3D FEM study of the energy release rate(ERR)in the band crack’s front contained in the orthotropic thick rectangular plate which is stretched or compressed initially before the loading of the crack's edge *** initial stretching or compressing of the plate causes uniformly distributed normal stress to appear acting in the direction which is parallel to the plane on which the band crack is *** the appearance of the initial stress in the plate it is assumed that the crack's edge planes are loaded with additional uniformly distributed normal forces and the ERR caused with this additional loading is *** corresponding boundary value problem is formulated within the scope of the so-called 3D linearized theory of elasticity which allows the initial stress on the values of the ERR to be taken into *** results on the influence of the initial stress,anisotropy properties of the plate material,the crack’s length and its distance from the face planes of the plate on the values of the ERR,are presented and *** particular,it is established that for the relatively greater length of the crack’s band,the initial stretching of the plate causes a decrease,but the initial compression causes an increase in the values of the ERR.

关键词： Band crack energy release rate stress intensity factor initial stress orthotropic material rectangular plate 3D FEM

In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 616-624页

作者： arzu Birinci Yildirim Fatma Pehlivan Karakas arzu Ucar Turker Department of Biology Abant Izzet Baysal University

Objective: To investigate antibacterial and antitumor activities of 51 different extracts prepared with 3 types of solvents (water, ethanol and methanol) of 16 different plant species (Ajuga reptans (A. reptans) L., Phlomis pungens (P. pungens) Willd., Marrubium astracanicum (M. astracanicum) Jacq., Nepeta nuda (N. nuda) L., Stachys annua (S. annua) L., Genista lydia (G. lydia) Boiss., Nuphar lutea (N. lutea) L., Nymphaea alba (N. alba) L., Vinca minor (V. minor) L., Stellaria media (S. media) L., Capsella bursa-pastoris (C. bursa-pastoris) L., Galium spurium (G. spurium) L., Onosma heterophyllum (O. heterophyllum) Griseb., Reseda luteola (R. luteola) L., Viburnum lantana (V. lantana) L. and Mercurialis annua (M. annua) L.) grown in Turkey was conducted. Methods: Antibacterial activity was evaluated with 10 bacteria including Streptococcus pyogenes (S. pyogenes), Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), Escheria coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Salmonella typhimurium (S. typhimurium), Serratia marcescens (S. marcescens), Proteus vulgaris (P. vulgaris), Enterobacter cloacae (E. cloacea), and Klebsiella pneumoniae (K. pneumoniae) by using disc diffusion method. Antitumor activity was evaluated with Agrobacterium tumefaciens (A. tumefaciens)-induced potato disc tumor assay. Results: Best antibacterial activity was obtained with ethanolic extract of P. pungens against S. pyogenes . Ethanolic and methanolic extract of N. alba and ethanolic extract of G. lydia also showed strong antibacterial activities. Results indicated that alcoholic extracts especially ethanolic extracts exhibited strong antibacterial activity against both gram-positive and gram-negative bacteria. Best antitumor activity was obtained with methanolic extracts of N. alba and V. lantana (100% tumor inhibition). Ethanolic extract of N. alba , alcoholic extracts of N. lutea , A. reptans and V. minor flowers, methanolic extracts of G. lydia and O

关键词： Bioassays Antibacterial Antitumor Medicinal plants

Prevalence of the terrain reversal effect in satellite imagery

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International Journal of Digital Earth 2015年第8期8卷 640-655页

作者： Miguel-Angel Bernabé-Poveda arzu Çöltekin Universidad de las Fuerzas Armadas–ESPE Departamento de Ciencias de la Tierra y de la ConstrucciónSangolquíPichinchaEcuador Geographic Information Visualization and Analysis Group Department of GeographyUniversity of ZurichSwitzerland

The terrain reversal effect is a perceptual phenomenon which causes an illusion in various 3D geographic visualizations where landforms appear inverted,*** perceive valleys as ridges and vice *** that such displays are important for spatio-visual analysis,this illusion can lead to critical mistakes in interpreting the ***,it is currently undocumented how commonly this effect is *** this paper,we study the prevalence of the terrain reversal effect in satellite imagery through a two-stage online user *** experiment was conducted with the participation of a diverse and relatively large population(n=535).Participants were asked to identify landforms(valley or ridge?)or judge a 3D spatial relationship(is A higher than B?).When the images were rotated by 180°,the results were *** a control task with‘illusion-free’original images,people were successful in identifying landforms,yet a very strong illusion occurred when these images were rotated 180°.Our findings demonstrate that the illusion is acutely present;thus,we need a better understanding of the problem and its ***,the results caution us that in an interactive environment where people can rotate the display,we might be introducing a severe perceptual problem.

关键词： terrain reversal relief inversion false topographic perception phenomenon photo interpretation visual illusion user study

Solving Space-Time Fractional Differential Equations by Using Modified Simple Equation Method

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Communications in Theoretical Physics 2016年第5期65卷 563-568页

作者： Melike Kaplan arzu Akbulut Ahmet Bekir Eskisehir Osmangazi University Art-Science Faculty Department of Mathematics-Computer

In this article,we establish new and more general traveling wave solutions of space-time fractional Klein–Gordon equation with quadratic nonlinearity and the space-time fractional breaking soliton equations using the modified simple equation *** proposed method is so powerful and effective to solve nonlinear space-time fractional differential equations by with modified Riemann–Liouville derivative.

关键词：分数阶微分方程空间时间方程法二次非线性求解破裂孤子方程行波解克莱因

Toward optimizing the design of virtual environments for route learning:empirically assessing the effects of changing levels of realism on memory

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International Journal of Digital Earth 2019年第2期12卷 137-155页

作者： Ismini E.Lokka arzu Çöltekin Department of Geography University of ZurichZurichSwitzerland

Broadly,this paper is about designing memorable 3D geovisualizations for spatial knowledge acquisition during(virtual)*** is a fundamentally important task,and even though most people navigate every day,many find it difficult in unfamiliar *** people get lost in an unfamiliar environment,or are unable to remember a route that they took,they might feel anxiety,disappointment and frustration;and in real world,such incidents can be costly,and at times,***,in this paper,we study the design decisions in terms of visual realism in a city model,propose a visualization design optimized for route learning,implement and empirically evaluate this *** evaluation features a navigational route learning task,where we measure shortand long-term recall accuracy of 42 participants with varying spatial abilities and memory *** findings provide unique empirical evidence on how design choices affect memory in route learning with geovirtual environments,contributing toward empirically verified design guidelines for digital cities.

关键词： 3D representation digital city digital earth virtual reality visualization

Clinical and genetic characteristics of retinoblastoma patients in a single center with four novel RB1 variants

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1274-1279页

作者： Özge Vural Hatice Tuba Atalay Gulsum Kayhan Bercin Tarlan Merve Oral arzu Okur Faruk GüçlüPınarlı Ceyda Karadeniz Department of Pediatric Hematology and Oncology Gazi University Faculty of MedicineAnkara 06500Türkiye Department of Ophthalmology Gazi University Faculty of MedicineAnkara 06500Türkiye Department of Medical Genetics Gazi University Faculty of MedicineAnkara 06500Türkiye

AIM:To assess the clinical and genetic characteristics of children diagnosed with retinoblastoma(RB)at Gazi University Faculty of Medicine’s Department of Pediatric ***:All cases diagnosed with RB and received treatment and follow-up in the Ophthalmology and Pediatric Oncology Department,October 2016 to May 2021 were evaluated *** RB1 gene was analyzed by next-generation sequencing(NGS)technique in DNAs obtained from peripheral blood samples of the ***:This study included 53 cases with 67 RBaffected eyes during the study *** mean age was 24.6(median:18.5,range:3–151)*** were 15(22.3%)Group D eyes and 39(58.2%)Group E *** RB1 gene was sequenced by the NGS method in 19 *** RB1:NM_000321.3:c.54_76del(***19AlafsTer4)variant was detected in a 15-month-old female with bilateral *** RB1:NM_000321.3:c.1814+3A>T variant was detected in a 5.5-month-old male with bilateral *** intronic RB1:NM_000321.3:c.1332+4A>G variant was detected in patient 14,a 13-month-old male with unilateral *** RB1:NM_000321.3:c.575_576del(***192SerfsTer10)variant was found in an 18-month-old female with an allele frequency of 37%.These variants have not been reported in the literature and mutation ***:Four novel variants are described and one of them is found in two different *** data is crucial for assessing *** serves as a guide for estimating the long-term risk of secondary malignancy as well as the short-term risk of developing additional malignancies in the same eye and the other eye.

关键词： retinoblastoma RB1 novel mutations next generation sequencing

Digital earth:yesterday,today,and tomorrow

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International Journal of Digital Earth 2023年第1期16卷 1022-1072页

作者： Alessandro Annoni Stefano Nativi arzuÇöltekin Cheryl Desha Eugene Eremchenko Caroline M.Gevaert Gregory Giuliani Min Chen Luis Perez-Mora Joseph Strobl Stephanie Tumampos International Society for Digital Earth BeijingPeople’s Republic of China National Research Council RomeItaly University of Applied Sciences and Arts Northwestern Switzerland FHNW School of EngineeringInstitute of Interactive Technologies IITBrugg-WindischSwitzerland Nathan Campus Griffith UniversityCities Research InstituteBrisbaneAustralia Lomonosov Moscow State University MoscowRussia Department of Earth Observation Science University of TwenteTwenteThe Netherland Institute for Environmental Sciences/enviroSPACE University of GenevaGenevaSwitzerland Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjingPeople’s Republic of China Cities Research Institute Nathan CampusGriffith UniversityBrisbaneAustralia Department of Geoinformatics University of SalzburgSalzburgAustria Chair of Remote Sensing Technology Technical University of MunichMunichGermany Big Geospatial Data Management Technical University of MunichMunichGermany

The concept of Digital Earth(DE)was formalized by Al Gore in *** that time the technologies needed for its implementation were in an embryonic stage and the concept was quite *** then digital technologies have progressed significantly and their speed and pervasiveness have generated and are still causing the digital transformation of our *** creates new opportunities and challenges for the realization of DE.‘What is DE today?’,‘What could DE be in the future?’,and‘What is needed to make DE a reality?’.To answer these questions it is necessary to examine DE considering all the technological,scientific,social,and economic aspects,but also bearing in mind the principles that inspired its *** understanding the lessons learned from the past,it becomes possible to identify the remaining scientific and technological challenges,and the actions needed to achieve the ultimate goal of a‘Digital Earth for all’.This article reviews the evolution of the DE vision and its multiple definitions,illustrates what has been achieved so far,explains the impact of digital transformation,illustrates the new vision,and concludes with possible future scenarios and recommended actions to facilitate full DE implementation.

关键词： Digital Earth digital transformation sustainable development data governance and ethic citizen empowerment and industry engagement

Potential of fungal thermostable alpha amylase enzyme isolated from Hot springs of Central Anatolia(Turkey)in wheat bread quality

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Food Bioscience 2022年第1期45卷 214-222页

作者： arzu Unal Asiye Seis Subasi Semra Malkoc Ijlal Ocak SElif Korcan Elif Yetilmezer Seyhun Yurdugül Hülya Yaman Turgay Sanal Alaettin Keceli Igdır University Faculty of AgricultureDepartment of Agricultural BiotechnologyI˘gdırTurkey Ministry of Agriculture and Forestry Field Crops Central Research Institute Department of Quality and TechnologyAnkaraTurkey Eskisehir Technical University Faculty of EngineeringDepartment of Environmental EngineeringEskisehirTurkey Afyon Kocatepe University Faculty of EducationDepartment of Mathematics and Science EducationDivision of Science EducationAfyonTurkey Usak University Vocational School of Health ServicesMedical Laboratory Techniques ProgramUsakTurkey Ministry of Agriculture and Forestry Field Crops Central Research Institute Department of BiotechnologyAnkaraTurkey Bolu Abant Izzet Baysal University Faculty of Arts and ScienceDepartment of BiologyBoluTurkey Bolu Abant Izzet Baysal University Vocational School of the Technical Sciences of BoluFood Technology ProgramBoluTurkey Pamukkale University School of Applied SciencesDepartment of Organic Farming Business ManagementDenizliTurkey

Many industrial processes may quickly proceed with biotechnological and enzymatic *** and production facilitator properties of enzymes have provided variable advantages for ***,enzyme utilization has become inevitable for industry and supplied financial advantages in case of the high energy requirement *** the study,the amylase enzymes were isolated from thermal spring sources,and the effect on bread quality was ***,fungal amylases were isolated from thermal spring sources(29-98◦C)in various places around *** determining the functional properties of amylase enzymes,the most active enzyme was used in bread production to examine their effect on bread *** maximum alpha-amylase activity(38.6 U/mg)has been detected in Aspergillus niger G 2-1 *** compared with the commercially available one,native alpha-amylase increased the bread volume.A significant difference(p<0.01)was found in the color properties and size of the bread between microbial produced in this study and commercially produced *** ppm alpha-amylase addition showed the optimum bread properties for dough processing.

关键词： Alpha-amylase Thermal spring Quality of bread Commercial enzymes