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Factors Associated with Antigen HBs Seroconversion among Blood Donors in Ouagadougou from 2008 to 2017

Advances in Infectious Diseases 2021年第3期11卷 278-289页

作者： Abdoul-Guaniyi Sawadogo T. Isidore Traore Salam Sawadogo Kompingnin Nebie Lucien Désiré Dahourou Juste Some Hervé Kpoda Ahmed Kabore Dahourou Honorine arzouma paul yooda Bia Emile Drabo Jean-Etienne Koanda Alain Konseybo Eléonore Kafando Nicolas Meda Léon Blaise Savadogo Centre National de Transfusion Sanguine (CNTS) Ouagadougou Burkina Faso ONG Terre des hommes Lausanne Ouagadougou Burkina Faso Centre MURAZ Bobo-Dioulasso Burkina Faso Université Nazi BONI Bobo-Dioulasso Burkina Faso Université Joseph KI-ZERBO Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Université Norbert ZONGO Koudougou Burkina Faso

Introduction: The risk of transmission of pathogens such as hepatitis B virus threatens the safety of transfused patients especially in high endemic areas. The aim of this study was to determine the incidence and factors associated with hepatitis B virus surface antigen (HBsAg) seroconversion in blood donors at the Regional Blood Transfusion Centre of Ouagadougou. Methods: A retrospective cohort study of voluntary non-remunerated blood donors (VNRBD), was conducted from 2008 to 2017. Data on HBsAg seroconversion were collected. The Kaplan-Meier method and the Log-Rank test were used to estimate the survival curves. Cox’s regression identified the factors associated with this seroconversion. Results: Of 23,494 donors, 559 had HBsAg seroconversion. The number of donor years was 58,637.50 and the HBV incidence rate was 9.53 per 1000 donor years. The median seroconversion time was 75.73 months with extremes of 2.7 months and 107.12 months. The risk of seroconversion was 1.30 times higher among donors aged 21 to 24 years old (p = 0.007) and 2.49 times higher among those over 24 years old (p Conclusion: The incidence of HBsAg remains high among blood donors, which could have a negative impact on transfusion safety. The age of the blood donor was significantly associated to AgHBs seroconversion.

关键词： Time to Onset Viral Hepatitis B Blood Donors Seroconversion

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Evaluation of Two Serological Screening Kits for Hepatitis C Virus Infection at the Regional Blood Transfusion Center of Ouagadougou, Burkina Faso

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Advances in Infectious Diseases 2020年第4期10卷 216-227页

作者： arzouma paul yooda Koumpingnin Nebie Juliette Tranchot-Diallo Salam Sawadogo Moutanou Modeste Judes Zeye Abdoul-Guaniyi Sawadogo Abdou Azaque Zoure Dinanibè Kambire Serge Sawadogo Seimbou Zalla Yetema Dieudonné Yonli Abibou Simpore Sibiri Nana Ashmed Chèickh Bachirou Nana Anita Pierrette Siritie Fiffou Yougbare Sonia Ba-Nébhane Sontie Alain Konseybo Jean Etienne Koanda Oury Sanou Jacques Simpore National Blood Transfusion Center (NBTC) Ouagadougou Burkina Faso Laboratory of Molecular Biology and Genetics (LABIOGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso Training and Research Unit/Science and Technology (TRU/ST) Nazi-BONI University Bobo-Dioulasso Burkina Faso Research Institute in Health Sciences (IRSS/CNRST) Ouagadougou Burkina Faso

Introduction: In Burkina Faso, screening for hepatitis C virus in blood donations is made using sensitive ELISA (Enzyme Linked Immuno Sorbent Assay) type kits. However, no confirmation of the positive results obtained with these kits is made before their notification to the blood donors due to the high costs of the confirmation kits of immunoblots type. Objective: Evaluate two rapid kits against one immunoblot kit in order to determine the most efficiency which will be proposed as an alternative for the confirmation of ELISA tests in the socio-economic context of Burkina Faso. Material and Methods: The study was carried out using a panel of 72 sera, of which 22 were positive for anti-HCV antibodies and 50 were negative. The sera were tested using the Monolisa® HCV Ag-Ab ULTRA kit and confirmed with the DECISCAN HCV Plus kit. The panel was then tested with the SD BIOLINE HCV kit and the HCV TRI-DOT kit and the results obtained were evaluated against those of the DECISCAN HCV Plus kit used as “gold standard”. Results: Compared to the DECISCAN HCV Plus kit, the HCV TRI-DOT kit exhibited a sensitivity and specificity of 100% and the SD BIOLINE HCV kit a sensitivity of 86.36% and a specificity of 100%. Conclusion: Based on the results recorded by the HCV TRI-DOT kit, it would be best suited to the sero-epidemiological context of blood donors from the National Blood Transfusion Center and could be proposed as an alternative for confirmation of ELISA tests.

关键词： HCV Sensitivity Specificity Burkina Faso

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