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Neurological manifestations of hepatitis E virus infection:An overview

World Journal of Gastroenterology 2021年第18期27卷 2090-2104页

作者： Ashish Kumar Jha Gaurav Kumar Vishwa Mohan Dayal Abhay Ranjan arya suchismita Department of Gastroenterology Indira Gandhi Institute of Medical SciencesPatna 800014India Department of Neurology Indira Gandhi Institute of Medical SciencesPatna 800014India Department of Pediatric Hepatology Institute of Liver and Biliary SciencesBasant Kunj 110070New DelhiIndia

Hepatitis E virus(HEV)is an important cause of repeated waterborne outbreaks of acute ***,several extrahepatic manifestations(EHMs)have been described in patients with HEV *** these,neurological disorders are the most common EHM associated with *** involvement of both the peripheral nervous system and central nervous system can occur together or in *** can present with normal liver function tests,which can often be misleading for *** is a paucity of data on HEV-related neurological manifestations;and these data are mostly described as case reports and case *** this review,we analyzed data of 163 reported cases of HEV-related neurological *** mechanisms of pathogenesis,clinico-demographic profile,and outcomes of the HEV-related neurological disorders are described in this *** root and plexus disorder were found to be the most commonly reported disease,followed by meningoencephalitis.

关键词： Hepatitis E virus Acute hepatitis E Extrahepatic manifestations Neurological manifestations Neuralgic amyotrophy Guillain-Barrésyndrome

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Torsion of spleen and portal hypertension: Pathophysiology and clinical implications

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World Journal of Hepatology 2021年第7期13卷 774-780页

作者： Ashish Kumar Jha Sameer Bhagwat Vishwa Mohan Dayal arya suchismita Department of Gastroenterology Indira Gandhi Institute of Medical SciencesPatna 800014India Department of Paediatric Hepatology Institute of Liver and Biliary SciencesDelhi 110070India

The displacement of spleen from its normal location to other places is known as wandering spleen(WS)and is a rare *** repeated torsion of WS is due to the presence of long pedicle and absence/laxity of anchoring ligaments.A WS is an extremely rare cause of left-sided portal hypertension(PHT)and severe gastric variceal ***-sided PHT usually occurs as a result of splenic vein occlusion caused by splenic torsion,extrinsic compression of the splenic pedicle by enlarged spleen,and splenic vein *** is a paucity of data on WSrelated PHT,and these data are mostly in the form of case *** this review,we have analyzed the data of 20 reported cases of WS-related *** mechanisms of pathogenesis,clinico-demographic profile,and clinical implications are described in this *** majority of patients were diagnosed in the second to third decade of life(mean age:26 years),with a strong female preponderance(M:F=1:9).Eleven of the 20 WS patients with left-sided PHT presented with abdominal pain and *** 6 of the 11 patients,varices were detected incidentally on preoperative imaging studies or discovered ***,pre-operative search for varices is required in patients with splenic torsion.

关键词： Wandering spleen Splenic torsion Left-sided portal hypertension Gastric variceal bleeding Splenectomy

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Spectrum of gastrointestinal involvement in Stevens-Johnson syndrome

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World Journal of Gastrointestinal Endoscopy 2019年第2期11卷 115-123页

作者： Ashish Kumar Jha arya suchismita Rajeev Kumar Jha Vikas Kumar Raj Department of Gastroenterology Indira Gandhi Institute of Medical Science Department of Pediatrics Indira Gandhi Institute of Medical Science VMMC and Safdarjung Hospital Health Center National Institute of TechnologyPatna

Stevens-Johnson syndrome(SJS) or toxic epidermal necrolysis(TEN) is a severe adverse drug reaction associated with involvement of skin and mucosal membranes, and carries significant risk of mortality and morbidity. Mucus membrane lesions usually involve the oral cavity, lips, bulbar conjunctiva and the anogenitalia. The oral/anal mucosa and liver are commonly involved in SJS or TEN. However, intestinal involvement is distinctly rare. We herein review the current literature regarding the gastrointestinal involvement in SJS or TEN. This review focuses mainly on the small bowel and colonic involvement in patients with SJS or TEN.

关键词： Stevens-Johnson syndrome Toxic epidermal necrolysis Lyell’s syndrome Gastrointestinal involvement Colon Ileum

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