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Significant association of a single nucleotide polymorphism in the upstream region of FGFR1OP2/wit3.0 gene with residual ridge resorption of mandible in Saudis

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BIOCELL 2020年第1期44卷 55-62页

作者： Sahar alZAIN Hana al SHEIKH arwa al thomali Fatimah al-MUKAYNIZI Noha alMOBEREK Sahar A.alMalKI Narasimha Reddy PARINE Arjumand WARSY Department of Prosthetic Dental Sciences College of DentistryKing Saud UniversityRiyadhSaudi Arabia Central Laboratory&Prince Naif Health Research Center Center for Science and Medical Studies for GirlsKing Saud UniversityRiyadhSaudi Arabia Genome Research Chair Department of BiochemistryCollege of ScienceKing Saud UniversityRiyadhSaudi Arabia

Residual ridge resorption(RRR)is the decrease in the jaw structure that follows tooth *** is a multifactorial disorder,but reports on the associated genetic factors are scarce,particularly amongst the *** study aimed to investigate the role of single nucleotide polymorphisms(SNPs)in fibroblast growth factor receptor 1 oncogene partner 2(FGFR1OP2)in RRR development in *** study included 192 individuals(RRR=96;controls=96)attending outpatient clinics at the College of Dentistry,King Saud *** and clinical data were collected,the digital panoramic dental radiograph was obtained,and mandibular residual ridge height was *** was extracted from saliva and genotyping was conducted on“Sequenom MassARRAY iPLEX”.Genotype and allele frequencies of three SNPs were calculated and *** age at first diagnosis and bone height were compared in the three genotypes of each *** age of the patients,age at first edentulism,and bone height ranged 21-80 years,12-70 years,and 13-34.6 mm,*** three genotypes of the studied SNPs(rs2279351,rs78054962 and rs2306852)were *** rs2279351 associated significantly with RRR,and the mutant C allele was highly *** association was observed for the other two *** genotypes of all SNPs had an influence on age at first edentulism and bone height,but the results were not statistically *** FGFR1OP2 plays a role in the process of rapid wound healing in the oral cavity,it may be playing a role in the development of RRR by influencing the rate of resorption of the *** rs2279351 may alter its expression and hence RRR *** study is limited due to small a sample size,and further large-scale studies are required to confirm this association and to consider rs2279351 as a possible marker of RRR development.

关键词： Bone resorption FGFR1OP2/wit3.0 gene Residual ridge resorption Single nucleotide polymorphisms

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Comparison of Self-Perception of Esthetics and Orthodontic Treatment Needs among Dental and Non-Dental Students with Assessment by Orthodontist

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Open Journal of Stomatology 2023年第2期13卷 89-96页

作者： Yousef al-thomali Department of Preventive Dental Sciences (Orthodontic Division) Faculty of Dentistry Taif University Taif Saudi Arabia

Objectives: The present study was conducted to compare the self-perception of esthetics and wish for seeking orthodontic treatment among dental and non-dental students. The realistic orthodontic treatment needs were confirmed by expert orthodontist. Methods: A cross-sectional study was conducted among 255 male students (Dental—75, Medical—93 and Pharmacy—87 students). The questionnaire included 20 items covering dental esthetics self-perception (10 questions), self-confidence and psychological impact (5 questions), and the need for seeking orthodontic treatment (5 questions) on a five-point Likert scale. The realistic orthodontic treatment needs were confirmed by photographs using aesthetic component of IOTN and clinical examination for the participants and analysis of jaw models using Dental aesthetic index (DAI). Kruskal-Wallis ANOVA was used to check the significant difference between groups. Results: The overall average esthetic self-perception score for total sample was 3.83. The overall average psychological impact score for the whole sample was 2.67. The total percentage of participants who either agree or strongly agree with the question related to their perception of need for seeking orthodontic treatment was 70%. According to the assessment of orthodontic needs using AC-IOTN, 19.8% required definitive treatment. According to the assessment of orthodontic treatment needs based on DAI, 20.3% and 9.9% needed highly desirable (DAI 31 - 35) and definite need of treatment (DAI ≥ 36) respectively. Conclusion: It can be concluded that there was no difference between the esthetic perception of dental and non-dental students. The self-perception for seeking orthodontic treatment was over-reported by participants compared to real requirement as assessed by orthodontic specialist. Dental esthetics has no psychological impact on academic performance and self-confidence as perceived by study participants.

关键词： Self-Perception Orthodontic Treatment Needs Orthodontist Opinion Esthetics

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