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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey arvind k.singh Chandel Rupa Sanyal Amarnath Mishra Devendra k.mar Pandey Valentina De Falco Arun Upadhyay Ramesh kandimalla Anupama Chaudhary Jaspreet kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,k-51,UPSIDA Industrial Area,kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Diagenesis,facies and palaeocurrent analysis of Upper Rewa Sandstone around Sagar,Central India

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Journal of Palaeogeography 2023年第4期12卷 546-563页

作者： Gaurav k.singh Ashish k.Rai arvind k.singh Department of Applied Geology Dr.Harisingh Gour VishwavidyalayaSagar 470003Madhya PradeshIndia Geological Survey of India ShillongIndia

The stratigraphic surface represented by a major contact between the Archean Bundelkhand Granite and the extensive Proterozoic Vindhyan sediments is a regional basement cover *** crystalline—sedimentary interface reflects an intense weathering of continental crust during marine *** time-transgressive sand deposition events ***,Rewa and Bhander are mainly witnessed during the entire Vindhyan ***,the Upper Rewa Sandstone comprises one of these events in the Vindhyan *** progress has been made in interpreting these sandstones as a function of entirely marine process to a combination of tidal—fluvio—eolian *** the results have so far been attained on the basis of sedimentary facies,provenance,palaeocurrent analysis,and some of petrography.A distinct differentiation between marine and fluvial components of the Upper Rewa Sandstone still remains ***,we use diagenesis as a parameter for the first time along with facies and palaeocurrent analysis to acquire a clear comprehension of marine-and fluvial-dominated *** present study spans 27 square kilometer area covering 15 stratigraphic sections with a collection of 571directional data from the facies specific sedimentary structures,and 28 samples obtained for the thin section *** lower unit of the Upper Rewa Sandstone shows facies association typical of tidal environment,along with polymodal *** rocks are well sorted and dominantly lithified by authigenic *** development of a complex of syntaxial,passive pore fills,and grain replacive cements reflect normally pressured nature of the lower unit *** upper unit of the Upper Rewa Sandstone however,reveals a facies pattern resembling fluvial processes and unimodal palaeocurrent *** exhibit poor sorting,siliceous,and ferruginous matrix,and development of intense ***,pressure solution is a dominant mode of l

关键词： Palaeocurrent Diagenesis Facies Upper Rewa Sandstone Vindhyan Basin

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Prediction of Alzheimer’s Using Random Forest with Radiomic Features

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Computer Systems Science & Engineering 2023年第4期45卷 513-530页

作者： Anuj singh Raman k.mar arvind k.mar Tiwari kNIT Sultanpur Sultanpur228118India

Alzheimer’s disease is a non-reversible,non-curable,and progressive neurological disorder that induces the shrinkage and death of a specific neuronal population associated with memory formation and *** is a frequently occurring mental illness that occurs in about 60%–80%of cases of *** is usually observed between people in the age group of 60 years and *** upon the severity of symptoms the patients can be categorized in Cognitive Normal(CN),Mild Cognitive Impairment(MCI)and Alzheimer’s Disease(AD).Alzheimer’s disease is the last phase of the disease where the brain is severely damaged,and the patients are not able to live on their *** is an approach to extracting a huge number of features from medical images with the help of data characterization ***,105 number of radiomic features are extracted and used to predict the alzhimer’*** paper uses Support Vector Machine,k-Nearest Neighbour,Gaussian Naïve Bayes,eXtreme Gradient Boosting(XGBoost)and Random Forest to predict Alzheimer’s *** proposed random forest-based approach with the Radiomic features achieved an accuracy of 85%.This proposed approach also achieved 88%accuracy,88%recall,88%precision and 87%F1-score for AD ***,it achieved 72%accuracy,73%recall,72%precisionand 71%F1-score for AD *** and it achieved 69%accuracy,69%recall,68%precision and 69%F1-score for MCI *** comparative analysis shows that the proposed approach performs better than others approaches.

关键词： Alzheimer’s disease radiomic features cognitive normal support vector machine mild cognitive impairment extreme gradient boosting random forest

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Geochemistry and hydrocarbon source rock potential of shales from the Palaeo-Mesoproterozoic Vindhyan Supergroup, central India

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能源地球科学(英文) 2023年第3期4卷 276-295页

作者： arvind k.mar singh Partha Pratim Chakraborty Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow226007India Department of Geology University of DelhiNew Delhi110007India Hiroshima Institute of Plate Convergence Region Research Hiroshima UniversityHigashi-Hiroshima7398526Japan

With increase in shale gas exploration, inorganic and organic geochemical investigations of shale have become extremely important. Here, we explore the six argillaceous (shale) intervals (Arangi, koldaha, Rampur, Bijaygarh, Rewa and Sirbu shale) from Son valley sector, Vindhyan Basin with an aim to understand provenance conditions, palaeoclimate, tectonic setting and hydrocarbon generation potential. Whole rock geochemistry indicates Vindhyan sediments derived from felsic source(s) except for Sirbu shale that indicates additional influx of mafic rocks with differentiated felsic source. A comparative study of Vindhyan shale rare earth elements (REEs) points to Mahakoshals and Chhotanagpur gneissic complex (CGC) as probable sediment provenance for Vindhyan sediments. CIA analysis, after necessary corrections for k-metasomatism, suggests evolution in weathering and palaeoclimate indicating a transformation from moderate weathering conditions with warm and humid climate during lower Vindhyan deposition to intense weathering conditions with hot and humid climate during upper Vindhyan deposition. Trace (La/Y vs. Sc/Cr) and REE analysis indicates passive margin setting for Vindhyan sediments whereas a wide range spanning passive to active continental margin setting is also inferred using (Th-Sc-Zr/10) and (Th–La-Sc) ternary diagrams. However, these tectonic discriminant diagrams lack in explaining rift- or sag-related origin of any intracratonic basin such as the Vindhyan Basin. The total organic carbon (TOC) content in Vindhyan shales ranges from 0.29% to 8.44%. The thermally liberated hydrocarbon (S1) values range from 0.01 to 0.18 mg HC/g rock (milligram hydrocarbon per gram of rock sample), whereas hydrocarbon from cracking of the kerogen (S2) shows values ranging from 0.04 to 0.47 mg HC/g rock. Based on modified Van krevelen correlation (HI vs. Tmax) diagram, organic matter from Arangi and Bijaygarh shales is characterized as thermally mature, Type III kerogen of gas

关键词： Shale geocheristry Provenance Organic matter Hydrocarbon potential VIndhyan basin

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Intensification of photocatalytic decomposition of water by ultrasound

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Journal of Energy Chemistry 2018年第4期27卷 1183-1188页

作者： arvind singh A.S.k.Sinha Department of Chemical Engineering and Technology Indian Institute of Technology (Banaras Hindu University)

Photocatalysis of water with and without ultrasound was studied using rGO supported CdS catalyst utilizing visible light. A higher hydrogen production was observed when ultrasound was used. This is attributed to a faster removal of bubbles of hydrogen from the surface of photocatalyst due to the mechanical energy associated with ultrasound overcoming surface tension. It has been further reported that the rate of hydrogen production decreased with time due to reversible deactivation of catalyst. This has been attributed to decrease in rate of hydrogen desorption with time.

关键词： Hydrogen Photocatalysis Ultrasound kinetics

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Evidence that cultural food practices of Adi women in Arunachal Pradesh,India,improve social-ecological resilience:insights for Sustainable Development Goals

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Ecological Processes 2020年第1期9卷 327-345页

作者： Ranjay k.singh arvind k.mar Anshuman singh Poonam singhal College of Horticulture and Forestry Central Agricultural UniversityPasighatArunachal Pradesh 791102India ICAR-Central Soil Salinity Research Institute KarnalHaryana 132001India University of Hyderabad HyderabadTelanganaIndia

Introduction:Sustainable use of biocultural diversity can help achieve Sustainable Development Goals(SDGs)in many *** tribal communities of bio-culturally rich Northeastern India rely heavily on local food resources and knowledge for livelihood *** this study with Adi women of East Siang district,Arunachal Pradesh,India,we aimed to understand(i)access and use patterns for biocultural plants and animal species from diverse ecosystems and(ii)species diversity and conservation strategies deployed by *** employed a novel participatory approach called“recipe contest”to mobilize Adi women from 15 randomly selected remote and transitional *** collected through interviews,focus group discussions and transect walks from 75 women,were analyzed using qualitative and quantitative ***:We found that traditional local food was linked intricately with women’s knowledge,access patterns,and socio-cultural *** an end-user perspective,remote Adi villages had more widespread use of plant species(14 as food;34 as food-cum-ethnomedicine and 13 as income-generating species)and animal(17)as food in remote than in transitional ***,there were significant differences(pknowledge and institutions and varying with social systems,to conserve their key local *** correlations(r=0.63 to 0.92)were seen between conservation and use of food and animal *** knowledge on these aspects was linked intricately to the socio-cultural milieu and is transmitted inter-generationa

关键词： Adi women Arunachal Pradesh Conservation Diverse ecosystems SDGs Traditional food species

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Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics

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Genes & Diseases 2023年第4期10卷 1367-1401页

作者： Uttpal Anand Abhijit Dey arvind k.singh Chandel Rupa Sanyal Amarnath Mishra Devendra k.mar Pandey Valentina De Falco Arun Upadhyay Ramesh kandimalla Anupama Chaudhary Jaspreet kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu José M.Pérez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affiliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples Federico IINaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarh AjmerRajasthan 305817India CSIR-Indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(IIIT-D)Okhla Industrial EstatePhase IIINew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologíaIPNA-CSICSan Cristóbal de La Laguna 38206TenerifeSpain

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every *** the new understanding of the molecular mechanism(s)of disease progression,our knowledge about the disease is snowballing,leading to the evolution of many new therapeutic regimes and their successive *** the past few decades,various combinations of therapies have been pro-posed and are presently employed in the treatment of diverse *** drug therapy,immunotherapy,and personalized medicines are now largely being employed,which were not common a few years *** field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies,extending patients’disease-free survival *** growing evidence shows that a systematic and targeted approach could be the future of cancer medicine,chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological ***-apeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific *** present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals;it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.

关键词： Antimicrobial peptides Cancer therapies Clinical trials Combination therapy Immunotherapy Patient survival Personalized medicine Targeted drug delivery

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Genealogy and phylogeography of Cyprinid fish Labeo rohita （Hamilton, 1822） inferred from ATPase 6 and 8 mitochondrial DNA gene analysis

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Current Zoology 2014年第4期60卷 460-471页

作者： Rupesh k. LUHARIYA kuldeep k. LAL Rajeev k. singh Vindhya MOHINDRA Arti GUPTA Prachi MASIH arvind k. DWIVEDI Rakhi DAS U. k. CHAUHAN J. k. JENA National Bureau ofFish Genetic Resources (ICAR) Lucknow- 226 002 UP India School of Environmental Sciences APS University Rewa- 486 003 MP India

ATPase 6/8 gene (842 bp) of mitochondrial DNA was sequenced inLabeo rohitasamples (n= 253) collected from nine rivers belonging to four river basins; Indus, Ganges, Brahmaputra and Mahanadi. Analysis revealed 44 haplotypes with high haplotype diversity (Hd) 0.694 and low nucleotide diversity (π) 0.001. The within population variation was larger (83.44%) than among population differences (16.56%). The mean FSTvalue (0.166;Pk presented a single clade for wildL. rohitapopulation, from different rivers. Negative values for Fu’s index (FS), mismatch distribution analysis indicated period of expansion inL. rohitapopulation. The time after recent expansion was estimated for each population, between 0.042 to 0.167 mya. The pattern of Isolation by Distance (IBD) was not significant (r= -0.113,Pkm) was seen. The analysis of data demonstrated that ATPase6/8 gene polymorphism is a potential marker to understand genetic population structure of wildL. rohitaexisting in different rivers. The study identified population substructure in wildL. rohitawith common ancestral origin [Current Zoology60 (4): 460–471, 2014].

关键词：线粒体DNA 系统地理学基因分析 ATP酶野鲮鲤科鱼类南亚家谱

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A Comprehensive Transcriptome Assembly of Pigeonpea （Cajanus cajan L.） using Sanger and Second-Generation Sequencing Platforms

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Molecular Plant 2012年第5期5卷 1020-1028页

作者： Himabindu kudapa arvind k. Bharti Steven B. Cannon Andrew D. Farmer Benjamin Mulaosmanovi Robin kramer Abhishek Bohra Nathan T. Weeks John A. Crow Reetu Tuteja Trushar Shah Sutapa Dutta Deepak k. Gupta Archana singh kishor Gaikwad Tilak R. Sharma Gregory D. May Nagendra k. singh Rajeev k. Varshney International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Patancheru 502324 india National Center for Genome Resources (NCGR) Santa Fe NM 87505 USA United States Department of Agriculture-Agricultural Research Service (USDA-ARS) Corn Insects and Crop Genetics Research Unit Ames IA USA National Research Centre on Plant Biotechnology (NRCPB) Indian Agricultural Research Institute New Delhi 110 012 India Department of Agronomy Iowa State University Amens IA USA CGIAR Generation Challenge Programme (GCP) c/o ClMMYT 06600 Mexico DF Mexico

A comprehensive transcriptome assembly for pigeonpea has been developed by analyzing 128.9 million short Illumina GA IIx single end reads, 2.19 million single end FLX/454 reads, and 18 353 Sanger expressed sequenced tags from more than 16 genotypes. The resultant transcriptome assembly, referred to as CcTA v2, comprised 21 434 transcript as- sembly contigs （TACs） with an N50 of 1510 bp, the largest one being -8 kb. Of the 21 434 TACs, 16 622 （77.5%） could be mapped on to the soybean genome build 1.0.9 under fairly stringent alignment parameters. Based on knowledge of intron junctions, 10 009 primer pairs were designed from 5033 TACs for amplifying intron spanning regions （ISRs）. By using in silico mapping of BAC-end-derived SSR loci of pigeonpea on the soybean genome as a reference, putative mapping posi- tions at the chromosome level were predicted for 6284 ISR markers, covering all 11 pigeonpea chromosomes. A subset of 128 ISR markers were analyzed on a set of eight genotypes. While 116 markers were validated, 70 markers showed one to three alleles, with an average of 0.16 polymorphism information content （PIC） value. In summary, the CcTA v2 transcript assembly and ISR markers will serve as a useful resource to accelerate genetic research and breeding applications in pigeonpea.

关键词： Cajanus cajan (L.) second-generation sequencing transcriptome assembly intron spanning region (ISR)markers.

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ZnO/eosin-Y混合薄膜的生长机理和形态(英文)

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物理化学学报 2012年第1期28卷 251-256页

作者： marí Bernabé singh krishan-Chander MOLLAR Miguel MOYA Mónica RANA Ravi Departament de Física Aplicada-IDF Universitat Politècnica de ValènciaCamí de Vera s/n46022ValènciaSpain Department of Chemistry Maharshi Dayanand University

Thin hybrid films of ZnO/eosin-Y were prepared by electrodeposition at-0.8 and-0.9 V in aqueous and non-aqueous baths at temperatures ranging from 40 to 90 ℃ with dye concentrations of 100 and 400 μmol·*** films were characterized by X-ray diffraction (XRD),scanning electron microscopy (SEM),energy-dispersive X-ray analysis (EDX),and absorption *** films prepared in a non-aqueous bath were non-porous and did not adsorb dye molecules on their ***,the films grown in aqueous media were porous in nature and adsorbed dye during the deposition of *** growth of the film along the (002) face was observed,and the highest crystallinity was achieved when the film was deposited at 60 ℃.The maximum absorption was achieved for the films grown at 60 to 70 ℃,a deposition potential of-0.9 V,and a dye concentration of 100 μmol·L-1.

关键词：摘要编辑部编辑工作读者

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