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The Effects of Omega-3 Fatty Acids Supplementation in Bronchial Asthma

Journal of Biosciences and Medicines 2023年第4期11卷 208-219页

作者： Uttam kumar Barua Pranab Karmaker arup kumar saha Md. Merazul Mostofa Dilip kumar Ghosh Kamal Krishna Biswas Department of Respiratory Medicine Shaheed Suhrawardy Medical College Hospital Dhaka Bangladesh Bangladesh Reference Institute for Chemical Measurements (BRiCM) Dhaka Bangladesh Department of Dental Public Health City Dental College and Hospital Dhaka Bangladesh Department of Genetic Engineering and Biotechnology University of Rajshahi Rajshahi Bangladesh Department of Gastroenterology Shaheed Suhrawardy Medical College Hospital Dhaka Bangladesh Department of Biochemistry and Molecular Biology University of Rajshahi Rajshahi Bangladesh

Bronchial asthma is a chronic inflammatory disease. Allergies are intensely related to bronchial asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Treatment can vary from inhalers to oral medications to drugs delivered in a nebulizer or breathing machine. Besides, dietary involvement was a significant tool to reduce the severity of many chronic inflammatory diseases including asthma. Randomly assigned, double blind, and placebo controlled 290 adults with mild to moderately persistent bronchial asthma concluded in this study, were subjected to alternating phases of supplementation with omega-3 fatty acids, vitamin C and Zn either singly or in combination. Subjective symptom improvement, pulmonary function, and biochemical tests were carried out at the beginning of the study and at the end of each therapeutic phase. The study findings showed that nearly half of the cases were in age between 18 years to 40 years followed by 29.6 of the cases that fall in age range between 40 years and 60 years. It was clear that all the four supplements (ogema-3 fatty acids, vitamin C and Zn, and combination) contributed more than placebo in reducing the severity of bronchial asthma. However, omega 3 fatty acids and combined supplement significantly contributed in symptomatic improvement (p < 0.05). There was a significant improvement of pulmonary function and sputum inflammatory markers with diet supplementation (p < 0.05). So, the subjects with mild and moderately persistent bronchial asthma may get benefit from their dietary supplementation with omega 3 fatty acids, Zinc and vitamin C. It is evident from this study that omega 3 fatty acids and combined supplementation significantly improved the severity of bronchial asthma.

关键词： Bronchial Asthma FEV1 FVC Omega 3 Fatty Acids

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Management of Sepsis in Intensive Care Units in Rajshahi Medical College, Bangladesh

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Advances in Infectious Diseases 2020年第1期10卷 11-25页

作者： Abu Hena Mostafa Kamal Pranab Karmaker Wahida Khatun arup kumar saha Md. Latifur Rahman Parvez Hassan ICU Rajshahi Medical College Hospital Rajshahi Bangladesh Institute of Biological Sciences University of Rajshahi Rajshahi Bangladesh City Dental College Dhaka Bangladesh Islami Bank Medical College and Hospital Rajshahi Bangladesh

Background: Sepsis was a life-threatening situation affecting roughly 27 million individuals globally every year. Devoid of proper management, sepsis could develop to austere sepsis and septic shock that reason certain eight million expiries every year. Initial identification and analysis of contaminations and quick introductions of antimicrobial management had long been predictable as essential principles of treatment. Methods: All patients were evaluated thoroughly by history, clinical and laboratory findings. Serum lactate levels were collected at 0 hr and 24 hrs of the total admission in the ICU. Blood culture and sensitivity was performed prior to antibiotic administration in this study. Results: In this research, total sample was 1367 patients. Among these sepsis patients were 305 (nearly 22%). These 305 studied sepsis cases, majority 128 (42%) of the patients were within the age group of 41 - 65 years, followed by 18 - 30 years consisting of 116 (38%) and the least number of sepsis patients were in the age group of >65 years (20%). This study found that 129 (42.3%) out of 305 blood samples screened from assumed sepsis infection were affirmative for the presence of sepsis causing pathogens. Among the 129 culture positive samples, majority of the isolated micro-organisms were gram negative bacteria 58% (75), followed by gram positive bacteria 38% (49), and 3.8% (5) were the fungi Candida albicans. Conclusion: At present, mortality & morbidity of sepsis subject was too big due to late identification, wrong & inadequate management of sepsis in the ward and also in the intensive care unit of Bangladesh.

关键词： Sepsis ICU SIRS Empirical Antibiotic

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A Hybrid Moth Flame Optimization Algorithm for Global Optimization

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Journal of Bionic Engineering 2022年第5期19卷 1522-1543页

作者： Saroj kumar Sahoo Apu kumar saha Department of Mathematics National Institute of TechnologyAgartalaTripura 799046India

The Moth Flame Optimization(MFO)algorithm shows decent performance results compared to other meta-heuristic algorithms for tackling non-linear constrained global optimization ***,it still suffers from obtaining quality solution and slow convergence *** the other hand,the Butterfly Optimization Algorithm(BOA)is a comparatively new algorithm which is gaining its popularity due to its simplicity,but it also suffers from poor exploitation *** this study,a novel hybrid algorithm,h-MFOBOA,is introduced,which integrates BOA with the MFO algorithm to overcome the shortcomings of both the algorithms and at the same time inherit their *** performance evaluation,the proposed h-MFOBOA algorithm is applied on 23 classical benchmark functions with varied *** tested results of the proposed algorithm are compared with some well-known traditional meta-heuristic algorithms as well as MFO *** rank test and Wilcoxon signed rank test are employed to measure the performance of the newly introduced algorithm *** computational complexity has been ***,the proposed algorithm has been applied to solve one constrained and one unconstrained real-life problems to examine its problem-solving capability of both type of *** comparison results of benchmark functions,statistical analysis,real-world problems confirm that the proposed h-MFOBOA algorithm provides superior results compared to the other conventional optimization algorithms.

关键词： Moth fame optimization algorithm Butterfly optimization algorithm Bio-inspired Benchmark functions Friedman rank test

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Polynomial friction pendulum isolators(PFPIs)for seismic performance control of benchmark highway bridge

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Earthquake Engineering and Engineering Vibration 2017年第4期16卷 827-840页

作者： Arijit saha Pumachandra saha Sanjaya kumar Patro School of Civil Engineering KIlT UniversityBhubaneswarOdishaIndia

The seismic response of a benchmark highway bridge isolated with passive polynomial friction pendulum isolators （PFPIs） is investigated and subjected to six bidirectional ground motion records. The benchmark study is based on a lumped mass finite-element model of the 91/5 highway overcrossing located in Southern California. The PFPI system possesses two important parameters; one is horizontal flexibility and the other is energy absorbing capacity through friction. The evaluation criteria of the benchmark bridge arc analyzed considering two parameters, time period of the isolator and coefficient of friction of the isolation surface. The results of the numerical study are compared with those obtained from the traditional friction pendulum system （FPS）. Dual design performance of the PFPI system suppressed the displacement and acceleration response of the benchmark highway bridge. The dual design hysteresis loop of the PFPI system is the main advantage over the linear hysteresis loop of the FPS. The numerical result indicates that the seismic performance of the PFPI system is better than that of the traditional FPS isolated system. Further, it is observed that variations of the isolation time period and coefficient of friction of the FPS and PFPI systems have a significant effect on the peak responses of the benchmark highway bridge.

关键词： benchmark highway bridge seismic isolation FPS PFPI evaluation criteria

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A Novel Variant of Moth Flame Optimizer for Higher Dimensional Optimization Problems

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Journal of Bionic Engineering 2023年第5期20卷 2389-2415页

作者： Saroj kumar Sahoo Sushmita Sharma Apu kumar saha Department of Mathematics National Institute of Technology AgartalaJiraniaTripura799046India

Moth Flame Optimization(MFO)is a nature-inspired optimization algorithm,based on the principle of navigation technique of moth toward *** to less parameter and easy implementation,MFO is used in various field to solve optimization ***,for the complex higher dimensional problems,MFO is unable to make a good trade-off between global and local *** overcome these drawbacks of MFO,in this work,an enhanced MFO,namely WF-MFO,is introduced to solve higher dimensional optimization *** a more optimal balance between global and local search,the original MFO’s exploration ability is improved by an exploration operator,namely,Weibull flight *** addition,the local optimal solutions have been avoided and the convergence speed has been increased using a Fibonacci search process-based technique that improves the quality of the solutions ***-nine benchmark functions of varying complexity with 1000 and 2000 dimensions have been utilized to verify the projected *** popular algorithms and MFO versions have been compared to the achieved *** addition,the robustness of the proposed WF-MFO method has been evaluated using the Friedman rank test,the Wilcoxon rank test,and convergence *** to other methods,the proposed WF-MFO algorithm provides higher quality solutions and converges more quickly,as shown by the ***,the proposed WF-MFO has been used to the solution of two engineering design issues,with striking *** improved performance of the proposed WF-MFO algorithm for addressing larger dimensional optimization problems is guaranteed by analyses of numerical data,statistical tests,and convergence performance.

关键词： Moth Flame Optimization(MFO)algorithm Bio-inspired algorithm Fibonacci search method Weibull distribution Higher dimensional functions

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Fast Identification of Symmetrical or Asymmetrical Faults During Power Swings with Dual Use Line Relays

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CSEE Journal of Power and Energy Systems 2020年第1期6卷 184-192页

作者： Soumesh Chatterjee Biman kumar saha Roy National Institute of Technology Agartala AgartalaTripura-799046India National Institute of Technology Durgapur DurgapurWest Bengal-713209India

Increasing power demand,penetration of renew-ables,and limitations of necessary grid expansion are proffering new challenges to existing power system protection and control ***,with the advancement in intelligent elec-tronic devices and relaying technology,fast,accurate and reliable protection schemes can be developed for smart power *** this paper,a new protection scheme based on admittance and power change has been proposed with dual-use line relays to detect symmetrical/asymmetrical faults in power systems.A large number of fault environments have been simulated by varying fault distances from relay location,fault resistance,and power angle in single machine infinite bus and WSCC 9-bus *** crucial decisive fault scenarios *** in/far end faults,faults in series compensated line,faults during asymmetrical swings,switching ON/OFF large loads,single and multi-modal swings have also been verified for the proposed *** this paper,for the first time,detection of faults during power swings have been examined and verified in the presence of wind *** simulation results show the proficiency of the proposed algorithm for detecting faults in the presence or absence of power swings.

关键词： Dual use line relays(DULR) power swing power system protection synchrophasor measurements

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Colorectal cancer cell dormancy:An insight into pathways

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World Journal of Gastroenterology 2024年第33期30卷 3810-3817页

作者： Anil kumar Lekha saha Department of Pharmacology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Cancer cell dormancy(CCD)in colorectal cancer(CRC)poses a significant challenge to effective *** CRC,CCD contributes to tumour recurrence,drug resistance,and amplifying the disease's *** molecular mechanisms governing CCD and strategies for eliminating dormant cancer cells remain largely ***,understanding the molecular mechanisms governing dormancy is crucial for improving patient outcomes and developing targeted *** editorial highlights the complex interplay of signalling pathways and factors involved in colorectal CCD,emphasizing the roles of Hippo/YAP,pluripotent transcription factors such as NANOG,HIF-1αsignalling,and Notch signalling ***,ERK/p38α/β/MAPK pathways,AKT signalling pathway,and Extracellular Matrix Metalloproteinase Inducer,along with some potential less explored pathways such as STAT/p53 switch and canonical and non-canonical Wnt and SMAD signalling,are also involved in promoting colorectal *** their clinical significance,these findings may offer the potential for identifying key dormancy regulator pathways,improving treatment strategies,surmounting drug resistance,and advancing personalized medicine ***,insights into dormancy mechanisms could lead to the development of predictive biomarkers for identifying patients at risk of recurrence and the tailoring of targeted therapies based on individual dormancy *** is essential to conduct further research into these pathways and their modulation to fully comprehend CRC dormancy mechanisms and enhance patient outcomes.

关键词： Colorectal cancer Colorectal cancer cell dormancy Cancer cell dormancy Pathways in colorectal cancer dormancy

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Reliability of IEC 61850 based substation communication network architecture considering quality of repairs and common cause failures

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Protection and Control of Modern Power Systems 2022年第1期7卷 174-188页

作者： Vonani Clive Mathebula Akshay kumar saha School of Engineering Discipline of ElectricalElectronics and Computer EngineeringUniversity of KwaZulu-NatalDurbanSouth Africa

Mission-critical IEC 61850 system architectures are designed to tolerate hardware failures to achieve the highest reliability ***,multi-channel systems are used in such systems within industrial facilities to isolate machinery when there are process ***,multi-channel systems introduce Common Cause Failure(CCF)since the subsystems can rarely be *** paper integrates CCF into the Markov reliability model to enhance the model flexibility to investigate synchronous generator intra-bay SCN architecture reliability performance considering the quality of repairs and *** Markov process enables integration of the impact of CCF factors on system *** case study results indicate that CCF,coupled with imperfect repairs,significantly reduce system reliability *** sensitivity is observed at low levels of CCF,whereas the highest level of impact occurs when the system diagnostic coverage is 99%based on ISO 13849-1,and reduces as the diagnostic coverage level ***,it is concluded that the severity of CCF depends more on system diagnostic coverage level than the repair efficiency,although both factors impact the system overall ***,CCF should be con-sidered in determining the reliability performance of mission-critical communication networks in power distribution centres.

关键词： IEC 61850 Substation communication network(SCN) Reliability Common cause failure(CCF) Diagnostic coverage Repair efficiency Sensitivity Elasticity Markov Matrix calculus

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Influence of land cover features on avian community and potential conservation priority areas for biodiversity at a Ramsar site in India

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Ecological Processes 2022年第1期11卷 345-359页

作者： Souvik Barik Goutam kumar saha Subhendu Mazumdar Department of Zoology University of Calcutta35Ballygunge Circular RoadKolkata 700019India Department of Zoology Shibpur Dinobundhoo Institution(College)ShibpurHowrahIndia

Background:Wetlands provide diverse ecological services to sustain rich biodiversity,but they are recklessly exploited around the *** Kolkata Wetlands(EKW;Ramsar site No.1208,~125 km^(2))was once very rich in faunal diversity that declined over the years due to various anthropogenic *** such scenarios,effective management plans need to contemplate local and landscape level initiatives and prioritize areas for *** the foraging guild structure and spatial patterns of relationship between bird and its environment provides important insight of ecological processes of ***,we carried out extensive surveys in 142 point count stations to explore the diversity and foraging guild structure of birds in *** addressed two important questions that how bird diversity varied from the outer periphery of the city towards the wetlands and how bird diversity is influenced by land cover features at local and landscape level in wetland *** goal of this study was to prepare a spatial map of avian diversity and to find the conservation priority areas for birds in this internationally recognized wetland ***:We recorded 94 species of birds and the Shannon diversity index values ranged between 1.249 and *** found that the avian diversity increased with increasing distance from city *** and insectivores were the dominant foraging guilds,followed by carnivores,granivores,frugivores and *** Linear Models revealed that bird communities were positively influenced by areas of wetlands,dikes and banks,agricultural field and emergent vegetation,and negatively influenced by built-up *** the projected spatial map of species diversity,74.15 km^(2)area has high ***,we identified 12.82 km^(2) of top 10%conservation priority ***:Low bird diversity near city periphery is related to habitat degradation due to anthropogenic *** of omnivores and insectivores

关键词： Bird diversity Spatial mapping FRAGSTATS ZONATION Wetland management East Kolkata Wetlands

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mLBOA:A Modified Butterfly Optimization Algorithm with Lagrange Interpolation for Global Optimization

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Journal of Bionic Engineering 2022年第4期19卷 1161-1176页

作者： Sushmita Sharma Sanjoy Chakraborty Apu kumar saha Sukanta Nama Saroj kumar Sahoo Department of Mathematics National Institute of Technology AgartalaAgartalaTripura 799046India Department of Computer Science and Engineering Iswar Chandra Vidyasagar CollegeBeloniaTripura 799155India Department of Computer Science and Engineering National Institute of Technology AgartalaAgartalaTripura 799046India Department of Applied Mathematics Maharaja Bir Bikram UniversityAgartalaTripura 799004India

Though the Butterfly Bptimization Algorithm(BOA)has already proved its effectiveness as a robust optimization algorithm,it has certain ***,a new variant of BOA,namely mLBOA,is proposed here to improve its *** proposed algorithm employs a self-adaptive parameter setting,Lagrange interpolation formula,and a new local search strategy embedded with Levy flight search to enhance its searching ability to make a better trade-off between exploration and ***,the fragrance generation scheme of BOA is modified,which leads for exploring the domain effectively for better *** evaluate the performance,it has been applied to solve the IEEE CEC 2017 benchmark *** results have been compared to that of six state-of-the-art algorithms and five BOA ***,various statistical tests,such as the Friedman rank test,Wilcoxon rank test,convergence analysis,and complexity analysis,have been conducted to justify the rank,significance,and complexity of the proposed ***,the mLBOA has been applied to solve three real-world engineering design *** all the analyses,it has been found that the proposed mLBOA is a competitive algorithm compared to other popular state-of-the-art algorithms and BOA variants.

关键词： Butterfly optimization algorithm Lagrange interpolation Levy flight search IEEE CEC 2017 functions Engineering design problems

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