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Science behind cisplatin-induced nephrotoxicity in humans:A clinical study

Asian pacific Journal of Tropical Biomedicine 2012年第8期2卷 640-644页

作者： arunkumar pa Viswanatha GL Radheshyam N Mukund H Belliyappa MS Department of Pharmacology PES College of Pharmacy Medical Oncology Curie Centre for OncologySt.John's Medical College Radiation Oncology Curie Centre for OncologySt.John's Medical College

Objective:To investigate the relationship between serum electrolyte changes and cisplatin induced ***:We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes,creatinine,blood urea nitrogen(BUN) and urine potassium,sodium and pH levels before and after the cisplatin *** the patients had cancer and were treated with 40-50 mg/day *** injury was assessed by measuring serum electrolytes,creatinine,BUN levels and urine potassium,sodium and pH levels. Results:The five cycles of cisplatin based chemotherapy resulted in hypomagnesia(P=0.029), hypocalcaemia(P=0.001~*),hypophosphatemia(P=0.003*),hypokalemia(P=0.001~*)and increased serum creatinine(P=0.001~*)and BUN(P=0.292~*)*** urine analysis,decrease in potassium(P=0.024~*)was found,except potassium there was no significant changes in sodium and urine pH. Conclusions:The present study demonstrates that,acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances,when no corrective measures were initiated.

关键词： Cisplatin Electrolyte imbalance Hypomagnesia Hypocalcaemia Creatinine

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Robust multifocus deep neural network for progression prediction on patient trajectory data

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International Journal of Intelligent Computing and Cybernetics 2022年第4期15卷 589-598页

作者： K.arunkumar S.Vasundra Department of CSE JNTUAAnanthapuramIndia Department of CSE JNTUACEAAnanthapuramIndia

Purpose-patient treatment trajectory data are used to predict the outcome of the treatment to particular disease that has been carried out in the *** order to determine the evolving disease on the patient and changes in the health due to treatment has not considered existing *** deep learning models to trajectory data mining can be employed to identify disease prediction with high accuracy and less computation ***/methodology/approach-Multifocus deep neural network classifiers has been utilized to detect the novel disease class and comorbidity class to the changes in the genome pattern of the patient trajectory data can be identified on the layers of the *** is employed to learn extracted feature set with activation and weight function and then merged on many aspects to classify the undetermined sequence of diseases as a new *** performance of disease progression learning progress utilizes the precision of the constituent classifiers,which usually has larger generalization benefits than those optimized ***-Deep learning architecture uses weight function,bias function on input layers and max *** of the input layer has applied to hidden layer to generate the multifocus characteristics of the disease,and multifocus characterized disease is processed in activation function using ReLu function along hyper parameter tuning which produces the effective outcome in the output layer of a fully connected *** results have proved using cross validation that proposed model outperforms methodologies in terms of computation time and ***/value-Proposed evolving classifier represented as a robust architecture on using objective function to map the data sequence into a class distribution of the evolving disease class to the patient ***,the generative output layer of the proposed model produces the progression outcome of the disease of the particular pa

关键词： patient trajectory data Deep learning representatives Disease evolution Unstructured hierarchical data Cluster reconstruction error

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Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension

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Cellular & Molecular Immunology 2021年第2期18卷 374-384页

作者： Jonathan Florentin Jingsi Zhao Yi-Yin Tai Sathish Babu Vasamsetti Scott P.O’Neil Rahul Kumar Anagha arunkumar Annie Watson John Sembrat Grant C.Bullock Linda Sanders Biruk Kassa Mauricio Rojas Brian B.Graham Stephen Y.Chan partha Dutta Center for Pulmonary Vascular Biology and Medicine Pittsburgh HeartLungBloodand Vascular Medicine InstituteDivision of CardiologyDepartment of MedicineUniversity of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Division of Pulmonary and Critical Care Medicine Zuckerberg San Francisco General Hospital and Trauma CenterUniversity of California San FranciscoBuilding 1002nd floor1001 Potrero AveSan FranciscoCAUSA Division of Pulmonary Allergy and Critical Care MedicineUniversity of PittsburghPittsburghPA15261USA Division of Hematopathology Pittsburgh HeartLungBloodand Vascular Medicine Institute University of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Department of Medicine Anschutz Medical CampusBuilding RC29th floor12700 E 19th AveAuroraCO80045USA Department of Immunology University of Pittsburgh School of MedicinePittsburghPA15213USA

Myeloid cells,such as neutrophils,are produced in the bone marrow in high quantities and are important in the pathogenesis of vascular diseases such as pulmonary hypertension(PH).Although neutrophil recruitment into sites of inflammation has been well studied,the mechanisms of neutrophil egress from the bone marrow are not well *** computational flow cytometry,we observed increased neutrophils in the lungs of patients and mice with ***,we found elevated levels of IL-6 in the blood and lungs of patients and mice with *** observed that transgenic mice overexpressing Il-6 in the lungs displayed elevated neutrophil egress from the bone marrow and exaggerated neutrophil recruitment to the lungs,resulting in exacerbated pulmonary vascular remodeling,and dysfunctional ***,we found that IL-6-induced neutrophil egress from the bone marrow was dependent on interferon regulatory factor 4(IRF-4)-mediated CX3CR1 expression in ***,Cx3cr1 genetic deficiency in hematopoietic cells in Il-6-transgenic mice significantly reduced neutrophil egress from bone marrow and decreased neutrophil counts in the lungs,thus ameliorating pulmonary remodeling and *** summary,these findings define a novel mechanism of IL-6-induced neutrophil egress from the bone marrow and reveal a new therapeutic target to curtail neutrophil-mediated inflammation in pulmonary vascular disease.

关键词： neutrophil IL-6 pulmonary hypertension CX3CR1 inflammation

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