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Drosophila seizure disorders： genetic suppression of seizure susceptibility

Frontiers in Biology 2016年第2期11卷 96-108页

作者： arunesh saras Laura E. Simon Harlan J. Brawer Richard E. Price Mark A. Tanouye Division of Organismal Biology Department of Environmental Science Policy and Management University of California Berkeley CA 94720 USA Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA Helen Wills Neuroscience Institute University of California Berkeley CA 94720 USA

Various Drosophila models of human disease have recently received increased interest. The main goal is to uncover the fundamental biological basis for human pathology taking advantage of the power of Drosophila genetics. This review examines a set of Drosophila seizure-sensitive mutations that model human seizure disorders, especially epilepsy. Also described is a novel set of mutations that act as seizure-suppressors that ameliorate epilepsy phenotypes in double mutant combinations.

关键词： Drosophila epilepsy seizure disorders sodium channel seizttre-suppressor genes

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E-Learning during COVID-19 Outbreak: Cloud Computing Adoption in Indian Public Universities

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Computers, Materials & Continua 2021年第3期66卷 2471-2492页

作者： Amit Kumar Bhardwaj Lalit Garg arunesh Garg Yuvraj Gajpal L.M.Thapar School of Management Thapar Institute of Engineering&TechnologyDera BassiPunjabIndia Faculty of Information&Communication Technology University of MaltaMsidaMSD2080Malta Supply Chain Management Asper School of BusinessUniversity of ManitobaWinnipegCanada

In the COVID-19 pandemic situation,the need to adopt cloud computing(CC)applications by education institutions,in general,and higher education(HE)institutions,in particular,has especially increased to engage students in an online mode and remotely carrying out *** adoption of CC across various sectors,including HE,has been picking momentum in the developing countries in the last few *** the Indian context,the CC adaptation in the HE sector(HES)remains a less thoroughly explored sector,and no comprehensive study is reported in the ***,the aim of the present study is to overcome this research vacuum and examine the factors that impact the CC adoption(CCA)by HE institutions(HEIs)in *** scope of the study is limited to public universities(PUs)in *** are,in total,465 Indian PUs and among these 304 PUs,(i.e.,65%PUs)are surveyed using questionnaire-based *** study has put forth a novel integrated technology adoption framework consisting of the Technology Acceptance Model(TAM),Technology-Organization-Environment(TOE),and Diffusion of Innovation(DOI)in the context of the *** integrated TAM-TOE-DOI framework is utilized in the study to analyze eleven hypotheses concerning factors of CCA that have been tested using structural equation modelling(SEM)and confirmatory factor analysis(CFA).The findings reveal that competitive advantage(CA),technology compatibility(TC),technology readiness(TR),senior leadership support,security concerns,government support,and vendor support are the significant contributing factors of CCA by Indian *** study contends that whereas the rest of the factors positively affect the PUs’intention towards CCA,security concerns are a significant reason for the reluctance of these universities against adopting *** findings demonstrated the application of an integrated TAM-TOE-DOI framework to assess determining factors of CCA in Indian ***,the study has given useful insights into the suc

关键词： Cloud computing higher education institutions public universities adoption techniques TAM TOE DOI structural equation modeling(SEM)

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Long-range current-induced spin accumulation in chiral crystals

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npj Computational Materials 2022年第1期8卷 2315-2321页

作者： arunesh Roy Frank T.Cerasoli Anooja Jayaraj Karma Tenzin Marco Buongiorno Nardelli Jagoda Sławińska Zernike Institute for Advanced Materials University of GroningenNijenborgh 49747AGGroningenThe Netherlands Department of Physics University of North TexasDentonTX76203USA Department of Physical Science Sherubtse CollegeRoyal University of Bhutan42007KanglungTrashigangBhutan The Santa Fe Institute Santa FeNM87501USA

Chiral materials,similarly to human hands,have distinguishable right-handed and left-handed enantiomers which may behave differently in response to external ***,we use for the first time an approach based on the density functional theory(DFT)+PAOFLOW calculations to quantitatively estimate the so-called collinear Rashba–Edelstein effect(REE)that generates spin accumulation parallel to charge current and can manifest as chirality-dependent charge-to-spin conversion in chiral ***,we reveal that the spin accumulation induced in the bulk by an electric current is intrinsically protected by the quasi-persistent spin helix arising from the crystal symmetries present in chiral systems with the Weyl spin–orbit *** contrast to conventional REE,spin transport can be preserved over large distances,in agreement with the recent observations for some chiral *** allows,for example,the generation of spin currents from spin accumulation,opening novel routes for the design of solid-state spintronics devices.

关键词： materials protected handed

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