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Computers, Materials & Continua 2021年第2期66卷 1613-1629页

作者： G.arun Sampaul Thomas Y.Harold Robinson E.Golden julie Vimal Shanmuganathan Seungmin Rho Yunyoung Nam CSE Department J.B.Institute of Engineering and TechnologyHyderabad500075India School of Information Technology and Engineering Vellore Institute of TechnologyVellore632014India Department of Computer Science and Engineering Anna University Regional CampusTirunelveli627007India Department of Information Technology National Engineering CollegeKovilpatti628503India Department of Software Sejong University209 Neungdong-roGwangjin-guSeoul05006Korea Department of Computer Science and Engineering Soonchunhyang UniversityAsan31538Korea

Retinopathy is a human eye disease that causes changes in retinal blood vessels that leads to bleed,leak fluid and vision *** of retinopathy are blurred vision,changes in color perception,red spots,and eye pain and it cannot be detected with a naked *** this paper,a new methodology based on Convolutional Neural Networks(CNN)is developed and proposed to intelligent retinopathy prediction and give a decision about the presence of retinopathy with automatic diabetic retinopathy screening with accurate *** CNN model is trained by different images of eyes that have retinopathy and those which do not have *** fully connected layers perform the classification process of the images from the dataset with the pooling layers minimize the coherence among the adjacent *** feature loss factor increases the label value to identify the patterns with the kernel-based *** performance of the proposed model is compared with the related methods of DREAM,KNN,GD-CNN and *** results show that the proposed CNN performs better.

关键词： Convolutional neural networks dental diagnosis image recognition diabetic retinopathy detection

Climate change in the Hindu Kush Himalaya

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Advances in Climate Change Research 2017年第3期8卷 137-140页

作者： REN Guo-Yu arun Bhakta SHRESTHA Laboratory for Climate Studies National Climate Center China Meteorological Administration Beijing 100081 China Department of Atmospheric Science School of Environmental Science China University of Geosciences Wuhan 430074 China International Centre for Integrated Mountain Development Kathmandu 3226 Nepal

The Hindu Kush Himalaya is the highest mountainous andplateau system in the world, sitting on most of the world'shighest peaks over 8000 m in height (Fig. 1). This regionencompasses an area of more than 4.3 million km2 and is characterized by a diversity of physiographic landscapes, climate types and bio-systems, the largest cryosphere in the world beyond the two poles, and being the source of a number of highly important large rivers including the Brahmaputra, Ganges, Indus, Mekong, Yangtze, and Yellow Rivers. The HKH is populated by about 210 million people and an additional 1.3 billion people live in downstream basins of the ten large rivers originating from this region.

关键词： The Hindu Kush Himalaya Yellow Rivers

Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells

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journal of Pharmaceutical Analysis 2021年第6期11卷 799-807页

作者： Ebony Nottingham Elizabeth Mazzio Sunil Kumar Surapaneni Shallu Kutlehria Arindam Mondal Ramesh Badisa Stephen Safe arun K.Rishi Mandip Singh Department of Pharmaceutics College of Pharmacy and Pharmaceutical SciencesFlorida A&M UniversityTallahasseeFL32307USA Department of Veterinary Physiology and Pharmacology College of Veterinary MedicineTexas A&M UniversityCollege StationTX77843USA john D.Dingell VA medical Center and Department of Oncology Wayne State UniversityDetroitMI48201USA

Non-small cell lung cancer(NSCLC)is often characterized by an underlying mutation in the epidermal growth factor receptor(EGFR),contributing to aggressive metastatic *** 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate(CDODA-Me),a glycyrrhetinic acid derivative,reportedly improves the therapeutic response to erlotinib(ERL),an EGFR tyrosine kinase *** the present study,we performed a series of studies to demonstrate the efficacy of CDODA-Me(2μM)in sensitizing HCC827 R(ERL-resistant)cells to ***,we first established the selectivity of ERL-induced drug resistance in the HCC827 R cells,which was sensitized when ERL was combined with CDODA-Me(2μM),shifting the IC50 from 23.48μM to 5.46μ***,whole transcriptomic microarray expression data demonstrated that the combination of ERL+CDODA-Me elicited 210 downregulated genes(0.44%of the whole transcriptome(WT))and 174 upregulated genes(0.36%of the WT),of which approximately 80%were unique to the ERL+CDODA-Me *** effects centered on losses to cell cycle progression transcripts,a reduction of minichromosome maintenance complex components(MCM2-7),all key components of the Cdc45·MCM2-7 GINS(CMG)complex,and replicative helicases;these effects were tantamount to the upregulation of processes associated with the nuclear factor erythroid 2 like 2 translational response to oxidative stress,including sulfiredoxin 1,heme oxygenase 1,and stress-induced growth inhibitor ***,these findings indicate that the synergistic therapeutic effects of ERL+CDODA-Me on resistant NSCLC cells are mediated via the inhibition of mitosis and induction of oxidative stress.

关键词： Transcriptomic analysis Combination therapy Drug resistance Erlotinib Epidermal growth factor receptor

Advancements in nanotechnology for the delivery of phytochemicals

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journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： Divya Chauhan Pavan K.Yadav Nazneen Sultana arun Agarwal Saurabh Verma Manish K.Chourasia jiaur R.Gayen Division of Pharmaceutics and Pharmacokinetics Central Drug Research InstituteCouncil of Scientific and Industrial ResearchLucknow 226031Uttar PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Phytochemical Bioavailability Drug delivery system Phytosome Plant extracts

BeaLib: A Beacon Enabled Smart Library System

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Wireless Sensor Network 2017年第8期9卷 302-310页

作者： Monica Laxman Uttarwar arun kumar Peter H. j. Chong Department of Electrical and Electronic Engineering Auckland University of Technology Auckland New Zealand School of Electrical and Computer Engineering National University of Singapore Singapore City Singapore

Nowadays, Global Positioning Systems (GPS) receivers are used for outdoor navigation, which are the part of recent smartphones and tablet devices. However, GPS is not suitable for indoor navigations due to its signal limitations which are blocked by ceiling and walls. Indoor navigation can be achieved through a mobile phone using a recent technology that utilizes Bluetooth, namely beacons. Beacons are small transmitters, run on Bluetooth Low Energy (BLE) technology, used as a point of reference for mobile devices and they can detect a Bluetooth enabled device once it enters its transmission range. In this paper, we present BeaLib: a beacon assisted indoor navigation technique for smart libraries. The proposed indoor navigation technique can also be used for other applications such as offices, retails, airports, hospitality, and education. For experimentation, beacons are placed in a library and a Bluetooth enabled smartphone is used to install a digital library application (App) which communicates with the beacons. The result shows that when the smartphone comes in the range of a beacon, it shows the information related to the book on the smartphone screen.

关键词： Bluetooth Low Energy Beacons Proximity Sensor Indoor Navigation Global Positioning System

QUARTIC CONVEX TYPE PIECEWISE POLYNOMIAL

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Analysis in Theory and Applications 2012年第2期28卷 172-179页

作者： Manprit Kaur arun Kumar R. D. University

In the present paper we consider quartic piecewise polynomial for approximation to the function f E C2[0, 1]. A convex type condition has been imposed in the partition so that the matrix involved for the computation of pp functions is of lower band. This reduces the computation for constructions of the pp functions for the approximation.

关键词： piecewise polynomial interpolation deficient splines

Mixed epithelial and stromal tumour with extension to vesicoureteric junction

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Asian journal of Urology 2019年第3期6卷 302-304页

作者： arun Ramdas Menon T.P.Rajeev Nivedita Suresh Suraj Hegde Department of Urology K.S.Hegde Medical AcademyMangaloreIndia Department of Pathology K.S.Hegde Medical AcademyMangaloreIndia

Mixed epithelial and stromal tumour(MEST)is an uncommon renal tumour with a tendency to protrude into the collecting *** present a 50-year-old woman with a renal tumour extending up to the vesicoureteric junction(VUj)who was suspected to have an upper tract transitional cell carcinoma for which a nephroureterectomy was *** examination revealed a MEST arising from the kidney and extending up to the *** the best of our knowledge,this is the first report of a renal MEST with extension to the VUj.

关键词： Mixed epithelial and stromal tumour Renal cell carcinoma Renal tumour Upper tract transitional cell carcinoma Vesicoureteric junction

Chatbots:a critical look into the future of the academia

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International journal of Agricultural and Biological Engineering 2024年第2期17卷 287-288页

作者： Samuel Ariyo Okaiyeto arun S.Mujumdar Parag Prakash Sutar Wei Liu junwen Bai Hongwei Xiao College of Engineering China Agricultural UniversityBeijing 100083China Department of Bioresource Engineering McGill UniversitySte.Anne de BellevueQuebecCanada Department of Food Process Engineering National Institute of Technology RourkelaRourkela 769008India School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China

Like every other societal domain,science faces yet another reckoning caused by a bot called ChatGPT(Chat Generative Pre-Trained Transformer).ChatGPT was introduced in November 2022 to produce messages that seem like they were written by humans and are *** the release of the latest version of ChatGPT called GPT-4,and other similar models such as Google Bard,Chatsonic,Collosal Chat,these chatbots combine several(about 175 billion)neural networks pre-trained on large Language Models(LLMs),allowing them to respond to user promptings just like ***-4 for example can admit its mistakes and confront false assumptions thanks to the dialogue style,which also enables it to write essays and to keep track of the context of a discussion while it is ***,users may be deceived by the human-like text structure of the AI models to believe that it came from a human origin[1].These chatbot models could be better,even though they generate text with a high level of ***,they produce inappropriate or wrong responses,resulting in faulty inferences or ethical *** article will discuss some fundamental strengths and weaknesses of this Artificial intelligence(AI)system concerning scientific research.

关键词： ChatGPT AI generative models academia ethical and moral restraints

Determination of cilostazol and its active metabolite 3,4-dehydro cilostazol from small plasma volume by UPLC-MS/MS

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journal of Pharmaceutical Analysis 2015年第1期5卷 1-11页

作者： Nejal M.Bhatt Vijay D.Chavada Daxesh P.Patel Primal Sharma Mallika sanyal Pranav S.Shrivastav Department of Chemistry School of SciencesGujarat UniversityNavrangpuraAhmedabad 380009GujaratIndia Department of Chemistry St.Xavier's CollegeNavrangpuraAhmedabad 380009GujaratIndia

A simple,rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry（UPLC-MS/MS） method has been developed for the simultaneous determination of cilostazol and its pharmacologically active metabolite 3,4-dehydro cilostazol in human plasma using deuterated analogs as internal standards（ISs）.Plasma samples were prepared using solid phase extraction and chromatographic separation was performed on UPLC BEH C18（50 mm × 2.1 mm.1.7 μm） *** method was established over a concentration range of 0.5-1000 ng/mL for cilostazol and 0.5-500 ng/mL for 3.4-dehydro ***- and inter-batch precision（%CV） and accuracy for the analytes were found within 0.93-1.88 and 98.8-101.7% for cilostazol and 0.91-2.79 and 98.0-102.7% for the metabolite *** assay recovery was within 95-97% for both the analytes and internal *** method was successfully applied to support a bioequivalence study of 100 mg cilostazol in30 healthy subjects.

关键词： Cilostazol 3 4-dehydro cilostazol UPLC-MS/MS Sensitive High throughput

Estimation of lung cancer burden in Australia,the Philippines,and Singapore:an evaluation of disability adjusted life years

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Cancer Biology & Medicine 2017年第1期14卷 74-82页

作者： Suman Morampudi Neha Das arun Gowda Anand Patil Phamax Analytic Resources Pvt.Ltd. Bengaluru 560095India

Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and ***: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for ***: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these ***: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.

关键词： Lung cancer DALY YLD YLL burden of disease DALY rate discount rate