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The transcontinental variability of nonalcoholic fatty liver disease

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Hepatoma Research 2020年第10期6卷 75-87页

作者： Claudia P.Oliveira Angelo Paredes Mohammed Siddiqui Lawrence Serfaty Abhijit Chowdhury jose Tadeu Stefano Denise Siqueira Vanni Sherry Boyett arun j.sanyal Department of Gastroenterology Faculdade de Medicina da Universidade de São PauloSão PauloSP 01000-000Brazil Laboratório de Gastroenterologia Clínica e Experimental(LIM-07)do Departamento de Gastroenterologia e Hepatologia do Hospital das Clínicas HCFMUSP da Faculdade de Medicina da Universidade de São Paulo São PauloSP 01000-000Brazil Internal Medicine Gastroenterology and Hepatology ServicesBrooke Army Medical CenterSan AntonioTX 78234USA Div.of Gastroenterology Hepatology and NutritionDept.of Internal MedicineVirginia Commonwealth University School of MedicineRichmondVA 23298-0341USA Viral and Metabolic Liver Unit Department of HepatologySaint-Antoine Hospital75012 ParisParis Department of Hepatology School of Digestive and Liver DiseaseInstitute of Post Graduate Medical Education&ResearchKolkata 700020India Disease Biology John C Martin Centre for Liver Research and Innovations SonarpurKolkata 7000150India

Aim:To compare the phenotype of lean versus overweight(OW)and obese(OB)subjects with non-alcoholic fatty liver disease(NAFLD)across multiple ***:A retrospective study of histologically defined subjects from a single center each in France(Fr),Brazil(Br),India(In)and United States(US)was ***:A total of 70 lean[body mass index(BMI)jects(Fr:Br:In:US:16:19:22:13)with NAFLD were compared to 136 OW(BMI>25 kg/m2,BMIjects(BMI>29 kg/m2)(n=81:11:22:103).Lean French subjects had the lowest incidence of type 2 diabetes while those from Brazil(Pjects had similar low-density lipoprotein-cholesterol,but higher high-density lipoprotein-cholesterol compared to obese subjects in all *** both lean and obese subjects,there were both insulin-sensitive and insulin-resistant *** French subjects were most insulin-sensitive while those from Brazil were mostly *** each weight category,subjects from India were more insulin-sensitive than those from other *** activity increased from lean to overweight to obese in France but was similar across weight categories in other ***:The phenotype of NAFLD in lean subjects varies by *** obese subjects with NAFLD are *** hypothesize that genetics and region-specific disease modifiers account for these differences.

关键词： Non-alcoholic fatty liver disease phenotype epidemiology demographics

Foregut bypass *** bariatric procedures for nonalcoholic fatty liver disease:a meta-analysis of 3,355 individuals

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 658-670,I0001-I0003页

作者： Wen Hui Lim Snow Yunni Lin Cheng Han Ng Darren jun Hao Tan jieling Xiao jie Ning Yong Phoebe Wen Lin Tay Nicholas Syn Yip Han Chin Kai En Chan Chin Meng Khoo Nicholas Chew Roger S.Y.Foo Asim Shabbir Eunice X.Tan Daniel Q.Huang Mazen Noureddin arun j.sanyal Mohammad Shadab Siddiqui Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Division of Endocrinology Department of MedicineNational University HospitalSingaporeSingapore Department of Cardiology National University Heart CentreNational University HospitalSingaporeSingapore Division of General Surgery(Upper Gastrointestinal Surgery) Department of SurgeryNational University HospitalSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehensive Transplant CenterCedars-Sinai Medical CentreLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background:Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease(NAFLD).However,there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters,especially for histological ***,this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic,biochemical,and histological parameters for patients with ***:Medline and Embase were searched for articles relating to bariatric procedures and *** meta-analysis was conducted to compare efficacy of bariatric procedures ***-procedure with subgroup analysis to further compare restrictive against foregut bypass ***:Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures(n=1,460)and foregut bypass(n=1,895)were *** foregut bypass(P<0.01)and restrictive procedures(P=0.03)significantly increased odds of fibrosis *** to restrictive procedures,foregut bypass resulted in a borderline non-significant decrease in fibrosis score(P=0.06)and significantly lower steatosis score(P<0.001).For metabolic parameters,foregut bypass significantly lowered body mass index(P=0.003)and low-density lipoprotein(P=0.008)compared to restrictive *** significant differences were observed between both procedures for aspartate aminotransferase(P=0.17)and alkaline phosphatase(P=0.61).However,foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures(P=0.01)while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass(P=0.02).Conclusions:The significant histological and metabolic advantages and comparable improvements in biochemical outcomes support the choice of foregut bypass over restrictive bariatric procedures in NAFLD management.

关键词： Bariatric surgery non-alcoholic fatty liver disease(NAFLD) obesity fibrosis endoscopy

肝硬化胃食管静脉曲张与曲张破裂出血的治疗和预防

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影像诊断与介入放射学 2010年第5期19卷 299-307页

作者： Guadalupe Garcia-Tsao arun j.sanyal Norman D.Grace William Carey 范文哲陈斌向贤宏黄勇慧杨建勇 the Practice Guidelines Committee of the American Association for the Study of Liver Diseases the Practice Parameters Committee of the American College of Gastroenterology 中山大学附属第一医院介入放射科广州510080

这份指南已经被美围肝病学会和美国胃食管医师协会所认可，体现了两个协会对胃底食管静脉曲张与曲张破裂出血的治疗和预防的观点：

关键词：胃食管静脉曲张破裂出血预防治疗肝硬化胃底食管静脉曲张医师协会肝病学会

Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals

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World journal of Gastroenterology 2018年第11期24卷 1269-1277页

作者： Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu arun j.sanyal Edward A Mena Fatty Liver Program Cedars-Sinai Medical CenterLos AngelesCA 90048United States Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States California Liver Research Institute PasadenaCA 91105United States Comprehensive Transplant Center Department of SurgeryCedars-Sinai Medical CenterLos AngelesCA 90048United States Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineSchool of MedicineVirginia Commonwealth UniversityRichmondVA 23298United States

AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting *** Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study *** stiffness/fibrosis was measured before and 47 wk after treatment *** with genotype 3 and patients with cirrhosis were *** One hundred and one patients were included in the ***-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced *** with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < ***,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients *** patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced *** term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR.

关键词： Nonalcoholic fatty liver disease Hepatitis C Fibrosis Steatosis Sustained virological response Direct-acting antivirals

Biosynthesis of gold nanoparticles using aqueous extract of Ricinus cummunis leaves to augment catalytic degradation of organic dyes and study of its antifungal and antibacterial activities

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Particuology 2024年第4期87卷 87-98页

作者： Mrinalini Parmar Mallika sanyal Department of Chemistry Gujarat UniversityAhmedabadGujarat 380009India St.Xaviers College NavrangpuraAhmedabadGujarat 380009India

In this study,biosynthesis of gold nanoparticles(Au NPs)using aqueous extract of fresh leaves of Ricinus cummunis plant is reported without the use of any synthetic chemical in the reaction *** prepared NPs are mostly spherical in shape with some particles having triangular or hexagonal *** average size of the particles as calculated using TEM data is 18 *** biosynthesised Au NPs were studied for their application in remediation of Congo Red,Methylene Blue,Reactive Red 120 and Rhodamine B dyes present in industrial *** degradation of dyes was confirmed spectropho-tometrically using UV-Vis *** Red 120 and Congo red dyes were most effec-tively reduced with 88%*** Au NPs were further studied for their potential as an effective antifungal agent against fungal strains namely Candida albicans and Aspergillus fumigatus and antibac-terial properties against Bacillus subtilis(Gram+ve)and Pseudomonas aeruginosa(Gram-ve)bacterial *** MIC values being 7.8 and 15.6(μg/mL)for Bacillus subtilis and Pseudomonas aeruginosa respectively.

关键词： Gold nanoparticles Photocatalysts Dye degradation Antifungal studies Antibacterial studies

Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases

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Acta Pharmaceutica Sinica B 2021年第10期11卷 2995-3014页

作者： arun Upadhyay Department of Biochemistry Central University of Rajasthan 305817India

Cells have different sets of molecules for performing an array of physiological *** acids have stored and carried the information throughout evolution,whereas proteins have been attributed to performing most of the cellular *** perform these functions,proteins need to have a unique conformation and a definite *** attributes are achieved by a highly coordinated protein quality control(PQC)system comprising chaperones to fold the proteins in a proper threedimensional structure,ubiquitin-proteasome system for selective degradation of proteins,and autophagy for bulk clearance of cell *** kinds of stresses and perturbations may lead to the weakening of these protective cellular machinery,leading to the unfolding and aggregation of cellular proteins and the occurrence of numerous pathological ***,modulating the expression and functional efficiency of molecular chaperones,E3 ubiquitin ligases,and autophagic proteins may diminish cellular proteotoxic load and mitigate various pathological *** medicine and small molecule-based therapies have been well-documented for their effectiveness in modulating these pathways and reestablishing the lost proteostasis inside the cells to combat disease *** present article summarizes various similar reports and highlights the importance of the molecules obtained from natural sources in disease therapeutics.

关键词： Proteostasis Proteinopathies Chaperones Ubiquitin proteasome system Autophagy Cancer Neurodegeneration Ageing Natural molecules Drug discovery

The energetic relationship among geoeffective solar flares, associated CMEs and SEPs

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Research in Astronomy and Astrophysics 2013年第8期13卷 978-990页

作者： Nipa j Bhatt Rajmal jain arun Kumar Awasthi Physics Dept C. U. Shah Science College Physical Research Laboratory (Dept. of Space Govt. of India)

Major solar eruptions （flares, coronal mass ejections （CMEs） and solar energetic particles （SEPs）） strongly influence geospace and space weather. Currently, the mechanism of their influence on space weather is not well understood and requires a detailed study of the energetic relationship among these eruptive phenomena. From this perspective, we investigate 30 flares （observed by RHESSI）, followed by weak to strong geomagnetic storms. Spectral analysis of these flares suggests a new power-law relationship （r - 0.79） between the hard X-ray （HXR） spectral index （before flarepeak） and linear speed of the associated CME observed by LASCO/SOHO. For 12 flares which were followed by SEP enhancement near Earth, HXR and SEP spectral analysis reveals a new scaling law （r - 0.9） between the hardest X-ray flare spectrum and the hardest SEP spectrum. Furthermore, a strong correlation is obtained between the linear speed of the CME and the hardest spectrum of the corresponding SEP event （r - 0.96）. We propose that the potentially geoeffective flare and associated CME and SEP are well-connected through a possible feedback mechanism, and should be regarded within the framework of a solar eruption. Owing to their space weather effects, these new results will help improve our current understanding of the Sun-Earth relationship, which is a major goal of research programs in heliophysics.

关键词： Sun coronal mass ejections (CMEs) - Sun flares - Sun particle emission - Sun solar-terrestrial relations - Sun X-rays

Comparative cytotoxicity of nanoparticles and ions to Escherichia coli in binary mixtures

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journal of Environmental Sciences 2017年第5期29卷 11-19页

作者： Swati Srivastaua arun Kumar Department of Civil Engineering Indian Institute of Technology Delhi New Delhi 110016 India

The objective of this study was to understand toxicity of mixture of nanoparticles （NPs）（ZnO and TiO2） and their ions to Escherichia coll. Results indicated the decrease in percentage growth of E. coli with the increase in concentration of NPs both in single and mixture setups. Even a small concentration of I mg/L was observed to be significantly toxic to E. coli in binary mixture setup （exposure concentration： 1 mg/L ZnO and 1 mg/L TiO2; 21.15% decrease in plate count concentration with respect to control）. Exposure ofE. coli to mixture of NPs at 1000 mg/L （i.e., 1000 mg/L ZnO and 1000 mg/L TiO2） resulted in 99.63% decrease in plate count concentration with respect to control. Toxic effects of ions to E. coli were found to be lesser than their corresponding NPs. The percentage growth reduction was found to be 36% for binary mixture of zinc and titanium ions at the highest concentration （i.e., 803.0 mg/L Zn and 593.3 mg/L Ti where ion concentrations are equal to the Zn ions present in 1000 mg/L ZnO NP solution and Ti＋4 ions present in 1000 mg/L TiO2 NP solution）. Nature of mixture toxicity of the two NPs to E. coli was found to be antagonistic. The alkaline phosphatase （Alp） assay indicated that the maximum damage was observed when E. coli was exposed to 1000 mg/L of mixture of NPs. This study tries to fill the knowledge gap on information of toxicity of mixture of NPs to bacteria which has not been reported earlier.

关键词： E. coli Zinc oxide nanoparticles Titanium dioxide nanoparticles Mixture toxicity Alkaline phosphatase assay

Shock wave mitigation using zig-zag structures and cylindrical obstructions

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Defence Technology（防务技术） 2021年第6期17卷 1840-1851页

作者： arun Kumar R Vaibhav Pathak Department of Mechanical Engineering Indian Institute of Technology Jodhpur(IITJ)JodhpurRajasthan342037India

The present study focuses on the mitigation of shock wave using novel geometric passages in the flow *** strategy is to produce multiple shock reflections and diffractions in the passage with minimum flow obstruction,which in turn is expected to reduce the shock wave strength at the target *** the present study the interaction of a plane shock front(generated from a shock tube)with various geometric designs such as,1)zig-zag geometric passage,2)staggered cylindrical obstructions and 3)zigzag passage with cylindrical obstructions have been investigated using computational *** is seen from the numerical simulation that,among the various designs,the maximum shock attenuation is produced by the zig-zag passage with cylindrical obstructions which is then followed by zig-zag passage and staggered cylindrical obstructions.A comprehensive investigation on the shock wave reflection and diffraction phenomena happening in the proposed complex passages have also been carried *** the new zig-zag design,the initial shock wave undergoes shock wave reflection and diffraction process which swaps alternatively as the shock front moves from one turn to the other *** cyclic shock reflection and diffraction process helps in diffusing the shock wave energy with practically no obstruction to the flow *** is found that by combining the shock attenuation ability of zig-zag passage(using shock reflection and diffraction)with the shock attenuation ability of cylindrical blocks(by flow obstruction),a drastic attenuation in shock strength can be achieved with moderate level of flow blocking.

关键词： Blast wave mitigation Blockage ratio Geometric obstructions Shock wave reflection and diffraction Zig-zag structure