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Biomedical studies on lipid peroxidation and erythrocyte fragility during the process of aging

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 6-7页

作者： arun Kumar Department of Biochemistry International Medical School Management and Science UniversityMSU Holdings Sdn.Bhd.University DriveOff Persiaran OlahragaSection 1340100 Shah AlamSelangor Darul EhsanMalaysia

Objective:To investigate oxidative stress,hemoglobin percentage and erythrocyte osmotic fragility in various aging ***:A total of 200 healthy volunteers of hoth genders between age group 20-65 years were selected by random *** of hemoglobin percentage was done employing modified cyanide method of Dacie and *** erythrocyte lysis was observed in hypotonic solution of buffered saline at varying concentrations and optical density was measured at 540 *** extent of lipid peroxidation in form of malondialdehyde was measured by thiobarbituric acid ***:The study found a significant decrease in hemoglobin percentage,increase in erythrocyte osmotic fragility and increased lipid peroxidation in form of malondialdehyde with increasing ***:Supplementation of antioxidants may prevent the oxidative injury in elderly group of subjects.

关键词： Lipid peroxidation Hemoglobin Erythrocyte osmotic fragility Aging

Estimation of lung cancer burden in Australia,the Philippines,and Singapore:an evaluation of disability adjusted life years

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Cancer Biology & Medicine 2017年第1期14卷 74-82页

作者： Suman Morampudi Neha Das arun Gowda Anand Patil Phamax Analytic Resources Pvt.Ltd. Bengaluru 560095India

Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and ***: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for ***: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these ***: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.

关键词： Lung cancer DALY YLD YLL burden of disease DALY rate discount rate

Simulations of Eurasian Winter Temperature Trends in Coupled and Uncoupled CFSv2

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Advances in Atmospheric Sciences 2018年第1期35卷 14-26页

作者： Thomas W.COLLOW Wanqiu WANG arun KUMAR INNOVIM LLC NOAA/NCEP Climate Prediction Center College Park

Conflicting results have been presented regarding the link between Arctic sea-ice loss and midlatitude cooling, particularly over Eurasia. This study analyzes uncoupled(atmosphere-only) and coupled(ocean–atmosphere) simulations by the Climate Forecast System, version 2(CFSv2), to examine this linkage during the Northern Hemisphere winter, focusing on the simulation of the observed surface cooling trend over Eurasia during the last three decades. The uncoupled simulations are Atmospheric Model Intercomparison Project(AMIP) runs forced with mean seasonal cycles of sea surface temperature(SST)and sea ice, using combinations of SST and sea ice from different time periods to assess the role that each plays individually,and to assess the role of atmospheric internal variability. Coupled runs are used to further investigate the role of internal variability via the analysis of initialized predictions and the evolution of the forecast with lead *** AMIP simulations show a mean warming response over Eurasia due to SST changes, but little response to changes in sea ice. Individual runs simulate cooler periods over Eurasia, and this is shown to be concurrent with a stronger Siberian high and warming over Greenland. No substantial differences in the variability of Eurasian surface temperatures are found between the different model configurations. In the coupled runs, the region of significant warming over Eurasia is small at short leads, but increases at longer leads. It is concluded that, although the models have some capability in highlighting the temperature variability over Eurasia, the observed cooling may still be a consequence of internal variability.

关键词： Eurasian winter climate sea-ice loss SST increase CFSv2

Culm characteristics and volume-weight relationship of a forest bamboo(Melocanna baccifera(Roxb.) Kurz) from northeast India

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Journal of Forestry Research 2015年第4期26卷 841-849页

作者： Pator Singnar arun Jyoti Nath Ashesh Kumar Das Department of Ecology and Environmental Science Assam University

Culm characteristics of Melocanna baccifera, locally ＇muli＇, culms at five different culm ages of 11 girth classes （5-6 to 15-16 cm） were studied from Cachar Dis- trict of southern Assam, northeast India. We recorded internode length, internode diameter, number of internodes per culm, total culm height, total culm green weight and total culm volume of all five culm age classes. Data were gathered on 165 culms, each culm age class containing 33 culms with 3 culms per girth class. Culm height ranged from 3.2 to 15.3 m with highest mean of 9.15 m （in threeyear old culms） and maximum culm height was recorded in four-year old culms. Highest mean and maximum internode length （27.45 and 54.2 cm, respectively）, internode diameter （3.12 and 4.75 cm, respectively） and total culm green weight （5.42 and 12.87 kg/culm, respectively） were recorded in three-year old culms and lowest in current-year culms. Best fitted regression models for all parameters were developed. Significant linear relationships between culm green weight and culm solid volume were documented for all five culm age classes. Their corresponding best-fit regression models were also developed.

关键词： Regression model - Volume equation Ageclass Girth class Yield determination

Reproductive biology of Cornus capitata Wall. ex Roxb.: a native species in East Asia

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Journal of Forestry Research 2019年第6期30卷 2039-2050页

作者： Vinod Prasad Khanduri arun Sukumaran Chandra Mohan Sharma College of Forestry VCSG Uttarakhand University of Horticulture and Forestry

The reproductive biology of Cornus capitata was studied in detail from June 2014 to October 2015 in Tehri Garhwal, Uttarakhand, western Himalaya, India and elucidated floral morphology, confirming autogamy, geitonogamy, and xenogamy. A new inflorescence ball formed each year with developing fruits that were initiated the previous year; thus reproduction is a continuous cycle. The total pollen production within a tree ranged between 4.0 × 10~7 and 9.3 × 10~7. Anthesis peaked between 08:00 and 10:00. There was significant effect of micro-environmental condition on anthesis(F = 243.8, p = 3.01). A significant positive relationship between the number of lateral shoots and total inflorescence showed that the inflorescence production in C. capitate depends largely on the number of lateral shoots. Time and concentration of various solutions significantly affected pollen germination(time: F = 5.39, p = 0.002; concentration: F = 1.40,p = 0.234). Anthophora bees and thrips were observed as the main pollinators. There was a significant difference in seed set between natural and obligate self-pollination(t = 11.84, p = 1.99). Significant effect was also observed on fruit size(t = 8.88, p = 2.09) between open and shaded conditions. SEM micrographs of pollen grains showed that the shape of dehydrated pollen grains differed greatly due to variations in the rate of dehydration among pollen grains within the anther. Seed germination was observed only in quality seed derived from open pollination, supporting xenogamy in C. capitata. Findings of the present study will be of immense value in formulating effective conservation measures for the species in wild habitats.

关键词： Floral development Pollen production Pollination Pollinators Reproductive success SEM analysis

Functional relationship between p53 and RUNX proteins

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Journal of Molecular Cell Biology 2019年第3期11卷 224-230页

作者： Suk-Chul Bae arun Mouli Kolinjivadi Yoshiaki Ito Department of Biochemistry School of Medicineand Institute for Tumour ResearchChungbuk National UniversityCheongju 28644South Korea Cancer Science Institute of Singapore National University of SingaporeSingapore 117599Singapore

RUNX genes belong to a three-membered family of transcription factors,which are well established as master regulators of *** them,aberrations in RUNX3 expression are frequently observed in human malignancies primarily due to epigenetic silencing,which is often *** the G1 phase of the cell cycle,RUNX3 regulates the restriction(R)-point,a mechanism that decides cell cycle *** at the R-point or loss of RUNX3 results in premature entry into S phase,leading to a proliferative *** of Runxl and Runx2 induce immortalization of mouse embryo *** a consequence,RUNX loss induces pre-cancerous lesions independent of oncogene activation.p53 is the most extensively studied tumour suppressor.p53 plays an important role to prevent tumour progression but not tumour ***,upon oncogene activation,early inactivation of RUNX genes and subsequent mutation of p53 appear to result in tumour initiation and ***,transcription-independent DNA repairing roles of RUNX3 and p53 are *** evolutionarily old genes,it appears that the primordial function of p53 is to protect genome integrity,a function that likely extends to the RUNX gene as *** this review,we examine the mechanism and sequence of actions of these tumour suppressors in detail.

关键词： RUNX tumour suppressor p53

Gender plasticity uncovers multiple sexual morphs in natural populations of Cedrus deodara (Roxb.) G. Don

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Ecological Processes 2021年第1期10卷 459-469页

作者： Vinod Prasad Khanduri arun Sukumaran Chandra Mohan Sharma Department of Forestry College of ForestryVCSG Uttarakhand University of Horticulture and ForestryRanichauriTehri GarhwalUttarakhand 249199India Present Address:State Farming Corporation of Kerala Chithalvetty EstateKalanjoor KollamKeralaIndia.

Background:The expression of gender in gymnosperms is challenging because the extent of variability in gender segregations in tree crowns and selection pressure of nature can modify the gender through ***:An in-depth investigation on spatial segregation of genders in tree crowns and sex expression of a total of 500 trees in five different natural populations of Cedrus deodara was carried out and verified the occurrence of subdioecious(co-existence of male,female,and monoecious)genders in ***:Five different sexual morphs were apparent among the 500 selected individuals as(1)pure male(M):bearing only male strobili in the whole crown with 22.2%;(2)pure female(F):bearing only female strobili in the whole crown with 12.4%;(3)mixed-monoecious(MM):bearing both male and female strobili with 13.6%;(4)predominantly female(PF)with 25.6%;and(5)predominantly male(PM)with 26.2%.The occurrence of multiple sexual morphs resulted from the complex selection pressure,which increased the stability of the *** segregation of genders in crown layers deemed to increase the fitness that may be a mechanism for accelerating *** results of the study suggest that the subdioecious gender expression in *** is evolved through the monoecy–paradioecy *** production of male strobili revealed non-significant effect of tree sizes whereas a significant effect was observed for the production of female *** study established that the total pollen and seed outputs in *** changed frequently according to gender ***:The size of the tree,resource availability,sex allocation,plant architecture,gender segregation in crowns,and habitat conditions are the prominent causes for gender plasticity.

关键词： Gender Sex expression Gender segregation Strobili Pre-fertilisation Monoecy Dioecy

Spectrum handoff scheme with multiple attributes decision making for optimal network selection in cognitive radio networks

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Digital Communications and Networks 2017年第3期3卷 164-175页

作者： Krishan Kumar arun Prakash Rajeev Tripathi Department oJ:Electronics and Communication Engineering Motilal Nehru National Institute of Technology Allahabad 211004 India Electronics and Communication Engineering Department National Institute of Technology Hamirpur 177005 India Director Motilal Nehru National Institute of Technology Allahabad 211004 India

It is envisaged that in future Cognitive Radio （CR） networks deployment, multiple radio access networks may coexist. The networks may have different characteristics in terms of multiple attributes. CRs will have choices of selecting the optimal network out of the available networks. Optimal network selection is a challenging task that can be performed by spectrum handoff with Multiple Attribute Decision Making （MADM）. The spectrum handoff decision with MADM provides wider and optimal choice with quality of service. This motivates the development of a spectrum handoff scheme with MADM methods such as simple additive weighting, a technique for order preference by similarity to the ideal solution, a grey relational analysis and a cost function based method, which is the objective of this study. The CR preferences are based on voice, video and data services, called triple play services. The numerical results show that all MADM methods are effective for selecting the optimal network for spectrum handoff with a reduced complexity for the spectrum handoff decision. The paper shows that the proposed spectrum handoff scheme can be effectively implemented to select the optimal network according to triple play services in CR networks.

关键词： Spectrum handoff Cognitive radio SAW TOPSIS GRA Cost function

Pollinator-mediated self-pollination and reproductive assurance in an isolated tree of Magnolia grandiflora L.

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Ecological Processes 2020年第1期9卷 517-525页

作者： arun Sukumaran Vinod Prasad Khanduri Chandra Mohan Sharma College of Forestry VCSG Uttarakhand University of Horticulture and ForestryRanichauriTehri GarhwalUttarakhand 249199India

Background:The ability to produce seeds when pollinators or potential mates are scarce is one of the principal advantages of self-pollination in flowering ***,the role of pollinators mediating self-pollination to ensure seed set when pollen or potential mates are limited has received less *** study examined the reproductive consequences and involvement of pollinators in assuring seed set in an isolated tree of Magnolia grandiflora,a predominantly outcrossing ***:We tested various aspects of reproduction such as flower density,floral rewards,stigma receptivity,pollinator abundance and behaviour,fruit set and seed set,in two successive reproductive years(2015-2016).Results:Flowers of *** possess a suite of traits facilitating pollinator-mediated self-pollination(PMS),although the chances of autonomous self-pollination are reduced due to herkogamy,spatial separation of anther and *** mean pollen production/flower was 5,152,289±285,094 with a pollen-to-ovule ratio of 39430±*** found a significant positive correlation between number of visits and seed production for bees(r=0.5099,p=0.0007)and beetles(r=0.7159,p=0.00001),indicating these are effective at *** was a significant negative correlation for thrips(r=-0.3206,p=0.044)and no correlation for flies or *** percent fruit set was 100%and the seed set per ovule ranged between 19 and 20%.Conclusions:PMS will guarantee reproductive assurance and mitigate the effect of reduced mates or pollen limitation which is expected to increase the fecundity and establishment of individual trees in geographically isolated locations.

关键词： Pollinator-mediated self-pollination Magnolia grandiflora Autonomous self-pollination Pollinator behaviour Reproductive assurance