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Biomedical studies on lipid peroxidation and erythrocyte fragility during the process of aging

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 6-7页

作者： arun Kumar Department of Biochemistry International Medical School Management and Science UniversityMSU Holdings Sdn.Bhd.University DriveOff Persiaran OlahragaSection 1340100 Shah AlamSelangor Darul EhsanMalaysia

Objective:To investigate oxidative stress,hemoglobin percentage and erythrocyte osmotic fragility in various aging ***:A total of 200 healthy volunteers of hoth genders between age group 20-65 years were selected by random *** of hemoglobin percentage was done employing modified cyanide method of Dacie and *** erythrocyte lysis was observed in hypotonic solution of buffered saline at varying concentrations and optical density was measured at 540 *** extent of lipid peroxidation in form of malondialdehyde was measured by thiobarbituric acid ***:The study found a significant decrease in hemoglobin percentage,increase in erythrocyte osmotic fragility and increased lipid peroxidation in form of malondialdehyde with increasing ***:Supplementation of antioxidants may prevent the oxidative injury in elderly group of subjects.

关键词： Lipid peroxidation Hemoglobin Erythrocyte osmotic fragility Aging

MODELING AND ANALYSIS OF SALT TRANSPORT IN THE SINGLE CYLINDRICAL ROOT WITH FINITE LENGTH

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International Journal of Biomathematics 2013年第6期6卷 53-61页

作者： arun KUMAR BEENA SHARMA ASHU RANI Department of Mathematics Government College Kota (Raj.) India Department of Pure and Applied Chemistry University of Kota Kota (Raj.) India

A mathematical model for salt transport by a cylindrical root in an infinite extent of soil is derived and solved analytically by asymptotic matching of the inner and outer solutions. By asymptotic analysis it is shown that the salt solution uptake by a single cylindrical root in the absence of competition does not influence the overall salt concentration in the soil even when the soil moisture concentration is less than full saturation.

关键词： Uptake parameter asymptotic matching van Genuchten formula relative solute concentration.

Hierarchical Stream Clustering Based NEWS Summarization System

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Computers, Materials & Continua 2022年第1期70卷 1263-1280页

作者： M.arun Manicka Raja S.Swamynathan Department of Computer Science and Engineering RMKCollege of Engineering and TechnologyChennai602106India Department of Information Science and Technology College of Engineering GuindyAnna UniversityChennai600025India

News feed is one of the potential information providing sources which give updates on various topics of different *** updates on various topics need to be collected since the domain specific interested users are in need of important updates in their domains with organized data from various *** this paper,the news summarization system is proposed for the news data streams from RSS feeds and Google *** news stream analysis requires live content,the news data are continuously collected for our *** contributions of thiswork involve domain corpus based news collection,news content extraction,hierarchical clustering of the news and summarization of *** of the existing news summarization systems lack in providing dynamic content with domain wise *** is alleviated in our proposed systemby tagging the news feed with domain corpuses and organizing the news streams with the hierarchical structure with topic wise ***,the news streams are summarized for the users with a novel summarization *** proposed summarization system generates topic wise summaries effectively for the user and no system in the literature has handled the news summarization by collecting the data dynamically and organizing the content *** proposed system is compared with existing systems and achieves better results in generating news *** Online news content editors are highly benefitted by this system for instantly getting the news summaries of their domain interest.

关键词： News feed content similarity parallel crawler collaborative filtering hierarchical clustering news summarization

Effects of Tillage Practices and Land Use Management on Soil Aggregates and Soil Organic Carbon in the North Appalachian Region,USA

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Pedosphere 2017年第1期27卷 172-176页

作者： arun Jyoti NATH Rattan LAL Carbon Management and Sequestration Center Ohio State University Department of Ecology and Environmental Science Assam University

Promoting soil carbon sequestration in agricultural land is one of the viable strategies to decelerate the observed climate changes. However, soil physical disturbances have aggravated the soil degradation process by accelerating erosion. Thus, reducing the magnitude and intensity of soil physical disturbance through appropriate farming/agricultural systems is essential to management of soil carbon sink capacity of agricultural lands. Four sites of different land use types/tillage practices, i） no-till （NT） corn （Zea mays L.）（NTC）, ii） conventional till （CT） corn （CTC）, iii） pastureland （PL）, and iv） native forest （NF）, were selected at the North Appalachian Experimental Watershed Station, Ohio, USA to assess the impact of NT farming on soil aggregate indices including water-stable aggregation, mean weight diameter （MWD） and geometric mean diameter （GMD）, and soil organic carbon and total nitrogen contents. The NTC plots received cow manure additions （about 15 t ha-1） every other year. The CTC plots involved disking and chisel ploughing and liquid fertilizer application （110 L ha-l）. The results showed that both water-stable aggregation and MWD were greater in soil for NTC than for CTC. In the 0-10 cm soil layer, the 〉 4.75-mm size fraction dominated NTC and was 46% more than that for CTC, whereas the 〈 0.25-mm size fraction was 380% more for CTC than for NTC. The values of both MWD and GMD in soil for NTC （2.17 mm and 1.19 mm, respectively） were higher than those for CTC （1.47 and 0.72 mm, respectively） in the 0-10 cm soil layer. Macroaggregates contained 6%-42% and 13%-43% higher organic carbon and total nitrogen contents, respectively, than microaggregates in soil for all sites. Macroaggregates in soil for NTC contained 40% more organic carbon and total nitrogen over microaggregates in soil for CTC. Therefore, a higher proportion of microaggregates with lower organic carbon contents created a carbon-depleted environment for CTC. In contrast, soil for NTC had mor

关键词： aggregate stability macroaggregates microaggregates no-till water-stable aggregation

Estimation of lung cancer burden in Australia,the Philippines,and Singapore:an evaluation of disability adjusted life years

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Cancer Biology & Medicine 2017年第1期14卷 74-82页

作者： Suman Morampudi Neha Das arun Gowda Anand Patil Phamax Analytic Resources Pvt.Ltd. Bengaluru 560095India

Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and ***: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for ***: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these ***: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.

关键词： Lung cancer DALY YLD YLL burden of disease DALY rate discount rate

Emerging therapies in gastrointestinal cancers

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World Journal of Gastroenterology 2006年第46期12卷 7440-7450页

作者： Jyoti Nautiyal arun K Rishi Adhip PN Majumdar Karmanos Cancer Institute Detroit MI 48201United States Karmanos Cancer Institute Veterans Affairs Medical Center Departments of Internal Medicineand Wayne State University Detroit MI 48201 United States

Members of the receptor tyrosine kinase family, that include EGFR, ErbB-2/HER-2, ErbB-3/HER-3 and ErbB-4/ HER-4, are frequently implicated in experimental models of epithelial cell neoplasia as well as in human cancers. Therefore, interference with the activation of these growth factor receptors represents a promising strategy for de- velopment of novel and selective anticancer therapies. Indeed, a number of inhibitors that target either EGFR or HER-2, with the exception of a few that target both; have been developed for treatment of epithelial cancers. Since most solid tumors express different ErbB receptors and/or their ligands, identification of inhibitor(s), targeting multiple EGFR family members may provide a therapeutic benefit to a broader patient population. Here we describe the significance of an ErbB family of receptors in epithelial cancers, and summarize different available therapeutics targeting these receptors. It also emphasizes the need to develop pan-ErbB inhibitors and discusses EGF-Receptor Related Protein, a recently isolated negative regulator of EGFR as a potential pan-ErbB therapeutic for a wide vari- ety of epithelial cancers.

关键词： Gastrointestinal cancers Carcinogenesis Targeted therapies Pan-ErbB family EGF-Receptor Related Protein

Simulations of Eurasian Winter Temperature Trends in Coupled and Uncoupled CFSv2

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Advances in Atmospheric Sciences 2018年第1期35卷 14-26页

作者： Thomas W.COLLOW Wanqiu WANG arun KUMAR INNOVIM LLC NOAA/NCEP Climate Prediction Center College Park

Conflicting results have been presented regarding the link between Arctic sea-ice loss and midlatitude cooling, particularly over Eurasia. This study analyzes uncoupled(atmosphere-only) and coupled(ocean–atmosphere) simulations by the Climate Forecast System, version 2(CFSv2), to examine this linkage during the Northern Hemisphere winter, focusing on the simulation of the observed surface cooling trend over Eurasia during the last three decades. The uncoupled simulations are Atmospheric Model Intercomparison Project(AMIP) runs forced with mean seasonal cycles of sea surface temperature(SST)and sea ice, using combinations of SST and sea ice from different time periods to assess the role that each plays individually,and to assess the role of atmospheric internal variability. Coupled runs are used to further investigate the role of internal variability via the analysis of initialized predictions and the evolution of the forecast with lead *** AMIP simulations show a mean warming response over Eurasia due to SST changes, but little response to changes in sea ice. Individual runs simulate cooler periods over Eurasia, and this is shown to be concurrent with a stronger Siberian high and warming over Greenland. No substantial differences in the variability of Eurasian surface temperatures are found between the different model configurations. In the coupled runs, the region of significant warming over Eurasia is small at short leads, but increases at longer leads. It is concluded that, although the models have some capability in highlighting the temperature variability over Eurasia, the observed cooling may still be a consequence of internal variability.

关键词： Eurasian winter climate sea-ice loss SST increase CFSv2

Culm characteristics and volume-weight relationship of a forest bamboo(Melocanna baccifera(Roxb.) Kurz) from northeast India

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Journal of Forestry Research 2015年第4期26卷 841-849页

作者： Pator Singnar arun Jyoti Nath Ashesh Kumar Das Department of Ecology and Environmental Science Assam University

Culm characteristics of Melocanna baccifera, locally ＇muli＇, culms at five different culm ages of 11 girth classes （5-6 to 15-16 cm） were studied from Cachar Dis- trict of southern Assam, northeast India. We recorded internode length, internode diameter, number of internodes per culm, total culm height, total culm green weight and total culm volume of all five culm age classes. Data were gathered on 165 culms, each culm age class containing 33 culms with 3 culms per girth class. Culm height ranged from 3.2 to 15.3 m with highest mean of 9.15 m （in threeyear old culms） and maximum culm height was recorded in four-year old culms. Highest mean and maximum internode length （27.45 and 54.2 cm, respectively）, internode diameter （3.12 and 4.75 cm, respectively） and total culm green weight （5.42 and 12.87 kg/culm, respectively） were recorded in three-year old culms and lowest in current-year culms. Best fitted regression models for all parameters were developed. Significant linear relationships between culm green weight and culm solid volume were documented for all five culm age classes. Their corresponding best-fit regression models were also developed.

关键词： Regression model - Volume equation Ageclass Girth class Yield determination

Functional relationship between p53 and RUNX proteins

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Journal of Molecular Cell Biology 2019年第3期11卷 224-230页

作者： Suk-Chul Bae arun Mouli Kolinjivadi Yoshiaki Ito Department of Biochemistry School of Medicineand Institute for Tumour ResearchChungbuk National UniversityCheongju 28644South Korea Cancer Science Institute of Singapore National University of SingaporeSingapore 117599Singapore

RUNX genes belong to a three-membered family of transcription factors,which are well established as master regulators of *** them,aberrations in RUNX3 expression are frequently observed in human malignancies primarily due to epigenetic silencing,which is often *** the G1 phase of the cell cycle,RUNX3 regulates the restriction(R)-point,a mechanism that decides cell cycle *** at the R-point or loss of RUNX3 results in premature entry into S phase,leading to a proliferative *** of Runxl and Runx2 induce immortalization of mouse embryo *** a consequence,RUNX loss induces pre-cancerous lesions independent of oncogene activation.p53 is the most extensively studied tumour suppressor.p53 plays an important role to prevent tumour progression but not tumour ***,upon oncogene activation,early inactivation of RUNX genes and subsequent mutation of p53 appear to result in tumour initiation and ***,transcription-independent DNA repairing roles of RUNX3 and p53 are *** evolutionarily old genes,it appears that the primordial function of p53 is to protect genome integrity,a function that likely extends to the RUNX gene as *** this review,we examine the mechanism and sequence of actions of these tumour suppressors in detail.

关键词： RUNX tumour suppressor p53