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Foregut bypass *** bariatric procedures for nonalcoholic fatty liver disease:a meta-analysis of 3,355 individuals

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 658-670,I0001-I0003页

作者： Wen Hui Lim Snow Yunni Lin Cheng Han Ng Darren jun Hao Tan jieling Xiao jie Ning Yong Phoebe Wen Lin Tay Nicholas Syn Yip Han Chin Kai En Chan Chin Meng Khoo Nicholas Chew Roger S.Y.Foo Asim Shabbir Eunice X.Tan Daniel Q.Huang Mazen Noureddin arun j.sanyal Mohammad Shadab Siddiqui Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Division of Endocrinology Department of MedicineNational University HospitalSingaporeSingapore Department of Cardiology National University Heart CentreNational University HospitalSingaporeSingapore Division of General Surgery(Upper Gastrointestinal Surgery) Department of SurgeryNational University HospitalSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehensive Transplant CenterCedars-Sinai Medical CentreLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background:Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease(NAFLD).However,there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters,especially for histological ***,this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic,biochemical,and histological parameters for patients with ***:Medline and Embase were searched for articles relating to bariatric procedures and *** meta-analysis was conducted to compare efficacy of bariatric procedures ***-procedure with subgroup analysis to further compare restrictive against foregut bypass ***:Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures(n=1,460)and foregut bypass(n=1,895)were *** foregut bypass(P<0.01)and restrictive procedures(P=0.03)significantly increased odds of fibrosis *** to restrictive procedures,foregut bypass resulted in a borderline non-significant decrease in fibrosis score(P=0.06)and significantly lower steatosis score(P<0.001).For metabolic parameters,foregut bypass significantly lowered body mass index(P=0.003)and low-density lipoprotein(P=0.008)compared to restrictive *** significant differences were observed between both procedures for aspartate aminotransferase(P=0.17)and alkaline phosphatase(P=0.61).However,foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures(P=0.01)while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass(P=0.02).Conclusions:The significant histological and metabolic advantages and comparable improvements in biochemical outcomes support the choice of foregut bypass over restrictive bariatric procedures in NAFLD management.

关键词： Bariatric surgery non-alcoholic fatty liver disease(NAFLD) obesity fibrosis endoscopy

The transcontinental variability of nonalcoholic fatty liver disease

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Hepatoma Research 2020年第10期6卷 75-87页

作者： Claudia P.Oliveira Angelo Paredes Mohammed Siddiqui Lawrence Serfaty Abhijit Chowdhury jose Tadeu Stefano Denise Siqueira Vanni Sherry Boyett arun j.sanyal Department of Gastroenterology Faculdade de Medicina da Universidade de São PauloSão PauloSP 01000-000Brazil Laboratório de Gastroenterologia Clínica e Experimental(LIM-07)do Departamento de Gastroenterologia e Hepatologia do Hospital das Clínicas HCFMUSP da Faculdade de Medicina da Universidade de São Paulo São PauloSP 01000-000Brazil Internal Medicine Gastroenterology and Hepatology ServicesBrooke Army Medical CenterSan AntonioTX 78234USA Div.of Gastroenterology Hepatology and NutritionDept.of Internal MedicineVirginia Commonwealth University School of MedicineRichmondVA 23298-0341USA Viral and Metabolic Liver Unit Department of HepatologySaint-Antoine Hospital75012 ParisParis Department of Hepatology School of Digestive and Liver DiseaseInstitute of Post Graduate Medical Education&ResearchKolkata 700020India Disease Biology John C Martin Centre for Liver Research and Innovations SonarpurKolkata 7000150India

Aim:To compare the phenotype of lean versus overweight(OW)and obese(OB)subjects with non-alcoholic fatty liver disease(NAFLD)across multiple ***:A retrospective study of histologically defined subjects from a single center each in France(Fr),Brazil(Br),India(In)and United States(US)was ***:A total of 70 lean[body mass index(BMI)jects(Fr:Br:In:US:16:19:22:13)with NAFLD were compared to 136 OW(BMI>25 kg/m2,BMIjects(BMI>29 kg/m2)(n=81:11:22:103).Lean French subjects had the lowest incidence of type 2 diabetes while those from Brazil(Pjects had similar low-density lipoprotein-cholesterol,but higher high-density lipoprotein-cholesterol compared to obese subjects in all *** both lean and obese subjects,there were both insulin-sensitive and insulin-resistant *** French subjects were most insulin-sensitive while those from Brazil were mostly *** each weight category,subjects from India were more insulin-sensitive than those from other *** activity increased from lean to overweight to obese in France but was similar across weight categories in other ***:The phenotype of NAFLD in lean subjects varies by *** obese subjects with NAFLD are *** hypothesize that genetics and region-specific disease modifiers account for these differences.

关键词： Non-alcoholic fatty liver disease phenotype epidemiology demographics

肝硬化胃食管静脉曲张与曲张破裂出血的治疗和预防

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影像诊断与介入放射学 2010年第5期19卷 299-307页

作者： Guadalupe Garcia-Tsao arun j.sanyal Norman D.Grace William Carey 范文哲陈斌向贤宏黄勇慧杨建勇 the Practice Guidelines Committee of the American Association for the Study of Liver Diseases the Practice Parameters Committee of the American College of Gastroenterology 中山大学附属第一医院介入放射科广州510080

这份指南已经被美围肝病学会和美国胃食管医师协会所认可，体现了两个协会对胃底食管静脉曲张与曲张破裂出血的治疗和预防的观点：

关键词：胃食管静脉曲张破裂出血预防治疗肝硬化胃底食管静脉曲张医师协会肝病学会

Bilateral nephrolithiasis and upper tract transitional cell carcinoma in horseshoe kidney

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Current Urology 2024年第3期18卷 247-249页

作者： jacob M.Gaines Eric j.Macdonald arun Rai David Hoenig Arthur Smith Zeph Okeke Tareq Aro The Smith Institute for Urology Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellLake SuccessNYUSA

Nephroureterectomy is currently the criterion-standard treatment for high-grade upper tract urothelial carcinoma(UTUC).Current guidelines and expert opinions propose some exceptions to this approach based on patient characteristics,disease status,and function of the contralateral *** present a rare case of a patient with horseshoe kidney,bilateral large nephrolithiasis,high-grade UTUC in one moiety,and relative parenchymal thinning of the contralateral *** patient was treated with a percutaneous,minimally invasive,nephron sparing *** patient also had intracollecting system instillations of gemcitabine and *** invasive percutaneous resection of high-grade UTUC is a safe procedure in select *** guidelines may not apply to all patients;unique scenarios with UTUC may require personalized decision-making and treatment at specialized centers.

关键词： Upper tract urothelial cancer Percutaneous resection Horseshoe kidney Nephrolithiasis

Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco arun Upadhyay Ramesh Kandimalla Anupama Chaudhary jaspreet Kaur Dhanjal Saikat Dewanjee jayalakshmi Vallamkondu jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael j.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven P.Hooker Humberto Parada jr. john Bellettiere arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology Mortality

Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals

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World journal of Gastroenterology 2018年第11期24卷 1269-1277页

作者： Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu arun j.sanyal Edward A Mena Fatty Liver Program Cedars-Sinai Medical CenterLos AngelesCA 90048United States Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States California Liver Research Institute PasadenaCA 91105United States Comprehensive Transplant Center Department of SurgeryCedars-Sinai Medical CenterLos AngelesCA 90048United States Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineSchool of MedicineVirginia Commonwealth UniversityRichmondVA 23298United States

AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting *** Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study *** stiffness/fibrosis was measured before and 47 wk after treatment *** with genotype 3 and patients with cirrhosis were *** One hundred and one patients were included in the ***-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced *** with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < ***,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients *** patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced *** term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR.

关键词： Nonalcoholic fatty liver disease Hepatitis C Fibrosis Steatosis Sustained virological response Direct-acting antivirals

The energetic relationship among geoeffective solar flares, associated CMEs and SEPs

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Research in Astronomy and Astrophysics 2013年第8期13卷 978-990页

作者： Nipa j Bhatt Rajmal jain arun Kumar Awasthi Physics Dept C. U. Shah Science College Physical Research Laboratory (Dept. of Space Govt. of India)

Major solar eruptions （flares, coronal mass ejections （CMEs） and solar energetic particles （SEPs）） strongly influence geospace and space weather. Currently, the mechanism of their influence on space weather is not well understood and requires a detailed study of the energetic relationship among these eruptive phenomena. From this perspective, we investigate 30 flares （observed by RHESSI）, followed by weak to strong geomagnetic storms. Spectral analysis of these flares suggests a new power-law relationship （r - 0.79） between the hard X-ray （HXR） spectral index （before flarepeak） and linear speed of the associated CME observed by LASCO/SOHO. For 12 flares which were followed by SEP enhancement near Earth, HXR and SEP spectral analysis reveals a new scaling law （r - 0.9） between the hardest X-ray flare spectrum and the hardest SEP spectrum. Furthermore, a strong correlation is obtained between the linear speed of the CME and the hardest spectrum of the corresponding SEP event （r - 0.96）. We propose that the potentially geoeffective flare and associated CME and SEP are well-connected through a possible feedback mechanism, and should be regarded within the framework of a solar eruption. Owing to their space weather effects, these new results will help improve our current understanding of the Sun-Earth relationship, which is a major goal of research programs in heliophysics.

关键词： Sun coronal mass ejections (CMEs) - Sun flares - Sun particle emission - Sun solar-terrestrial relations - Sun X-rays

Investigations on the nonlinear optical properties of glycinium oxalate single crystals

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Optoelectronics Letters 2011年第2期7卷 136-138页

作者： arun. K. j S. jayalekshmi Division for Research in Advanced Materials Department of Physics Cochin University of Science and Technology

Single crystals of glycinium oxalate (GLO) are grown by solution growth technique. The Z scan technique is used to elucidate the third order nonlinearity in the material. The results indicate that the compound exhibits reverse saturable absorption (RSA) and self-defocusing performance. The second harmonic generation (SHG) efficiency of the crystal evaluated by Kurtz and Perry technique is compared with that of the standard KDP crystal. Attempt is made to correlate the SHG efficiency with the crystalline perfection in the material.

关键词：非线性光学性能单晶生长技术草酸三阶非线性光学特性 KDP晶体二次谐波产生倍频效率反饱和吸收