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Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal gautam Jain Anshuman Elhence arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat Kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

Fragment emission and critical behavior in light and heavy charged systems

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Chinese Physics C 2021年第1期45卷 215-225页

作者： Samiksha Sood Rohit Kumar arun Sharma Sakshi gautam Rajeev K.Puri Department of Physics Panjab UniversityChandigarh 160014India Department of Physics G.D.College.BillawarJammu 185204India

We study the emission of fragments in central collisions of light and heavily charged systems of^4+Ar+^45 Sc and^s4Kr+^197 Au,respectively,using the Quantum Molecular Dynamics(QMD)model as the primary *** fragments are identified using an energy based clusterization algorithm,i.e.,the Simulated Annealing Clusterization Algorithm(SACA).The charge distributions of intermediate mass fragments[3≤Zf≤12]are fitted with power-law(∝Zf^-τ)and exp on ential(∝e^-λZf)fits in order to extract the parametersτandλ,whose minimum values are also sometimes linked with the onset of fragmentation or the critical point for a liquid-gas phase *** parameters such as the normalized second moment,,average size of the second largest cluster,phase separation parameter(Sp),bimodal parameter(P),information entropy(H),and Zipfs law are also analyzed to find the exact energy of the onset of *** detailed analysis predicts that an energy point exists between 20-23.1 MeV/nucleon,which is very close to the experimentally observed value of 23.9 MeV/nucleon for the^40Ar+^45Sc *** also find that the critical energy deduced using Zipfs law is higher than those predicted from other critical ***,no minimum is found for t values of the highly charged system of^84Kr+^197Au,in agreement with experimental findings and various theoretical *** observe that the QMD+SACA model calculations are in agreement with the experimental *** agreement supports our results regarding the energy point of the liquid-gas phase transition and the onset of fragmentation.

关键词： heavy-ion collisions transport model clusterization algorithm Monte-Carlo technique li・quid-gas phase transition

Big Data Analytics Using Swarm-Based Long Short-Term Memory for Temperature Forecasting

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Computers, Materials & Continua 2022年第5期71卷 2347-2361页

作者： Malini M.Patil P.M.Rekha arun Solanki Anand Nayyar Basit Qureshi JSS Academy of Technical Education Bengaluru560060India gautam Buddha University Greater Noida201312India Graduate School Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam College of Computer&Info Sc Prince Sultan UniversitySaudi Arabia

In the past few decades,climatic changes led by environmental pollution,the emittance of greenhouse gases,and the emergence of brown energy utilization have led to global *** warming increases the Earth’s temperature,thereby causing severe effects on human and environmental conditions and threatening the livelihoods of millions of *** warming issues are the increase in global temperatures that lead to heat strokes and high-temperature-related diseases during the summer,causing the untimely death of thousands of *** forecast weather conditions,researchers have utilized machine learning algorithms,such as autoregressive integrated moving average,ensemble learning,and long short-term memory *** techniques have been widely used for the prediction of *** this paper,we present a swarm-based approach called Cauchy particle swarm optimization(CPSO)to find the hyperparameters of the long shortterm memory(LSTM)*** hyperparameters were determined by minimizing the LSTM validationmean square error *** optimized hyperparameters of the LSTM were used to forecast the temperature of Chennai *** proposed CPSO-LSTM model was tested on the openly available 25-year Chennai temperature *** experimental evaluation on MATLABR2020a analyzed the root mean square error rate and mean absolute error to evaluate the forecasted *** proposed CPSO-LSTM outperforms the traditional LSTM algorithm by reducing its computational time to 25 min under 200 epochs and 150 hidden neurons during *** proposed hyperparameter-based LSTM can predict the temperature accurately by having a root mean square error(RMSE)value of 0.250 compared with the traditional LSTM of 0.35 RMSE.

关键词： Climatic change big data temperature forecasting swarm intelligence deep learning

Wheat Stripe Rust Virulence and Varietal Resistance in the Foot Hill Himalayas of Nepal

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Journal of Agricultural Science and Technology(B) 2015年第7期5卷 477-485页

作者： Sarala Sharma Etienne Duveiller Chandra Bahadur Karki Dhruba Bahadur Thapa Ram Chandra Sharma arun Kumar Joshi Plant Pathology Division Nepal Agricultural Research Council Lalitpur 44700 Nepal CIMMYT Global Wheat Program Apdo Postal 6-641 Mexico 06600 DF Mexico Agriculture Botany Division Nepal Agricultural Research Council Lalitpur 44700 Nepal ICARDA Central Asia and the Caucasus Regional Program Tashkent 10000 Uzbekistan CIMMYT South Asia Regional Office Kathmandu 44600 Nepal

Stripe rust, caused by Puccinia striiformis f. sp. tritici （Pst） is an important disease of wheat （Triticum aestivum） in Nepal, which is a part of the Himalayas stretching over the North of Nepal, India, Pakistan, Bhutan and beyond. Wheat production plays a crucial role in food security of the marginal hill farmers of Nepal. Frequent epidemics of the rust have caused huge loss in farmer＇s field. Periodic monitoring during 1980-2008 showed that changes in virulence occurred during this period. The objective of this study was to evaluate Pst resistance and its effective genes in wheat genotypes. For this, trap nurseries, wheat stripe rust differentials, commercial cultivars and advanced breeding lines were tested under artificial epiphytotic and natural hot spots conditions during 2005 to 2010. Four genes （Yr5, Yr10, Yr15 and YrSp） consistently showed resistance to the prevailing races. The gene Yr9 and Yr27 in combinations with Yrl8 were found effective. Other lines with combination of minor genes were also found effective. The genotypes Amadina, Kukuna, Tukuru, Kakatsi and Buck Buck widely used in breeding program were resistant. The cultivation of varieties WK1204, gautam, Gaura and Dhaulagiri have ensured genetic diversity for the rust resistance and slowed down frequent occurrence of epidemics. The findings of these studies could help in developing effective varietal resistance program in the sub-continent.

关键词： Puccinia striiformis resistance virulence stripe rust Triticum aestivum wheat.

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喜马拉雅中部榴辉岩相变质作用的条件和时代

喜马拉雅中部榴辉岩相变质作用的条件和时代