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Metabolic disease and the liver: A review

World Journal of Hepatology 2024年第1期16卷 33-40页

作者： Márcia vargas Sheila de Castro Cardoso Toniasso Patricia G Riedel Camila Pereira Baldin Francielle Lopes dos Reis Robson Martins Pereira Maria Carlota Borba Brum Dvora Joveleviths Mario Reis Alvares-da-Silva Program of Graduate Science in Gastroenterology and Hepatology Federal University of Rio Grande do SulPorto Alegre 90040-060Rio Grande do SulBrazil School of Medicine Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Program of Graduate Science in Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90410000Brazil Medicine Faculty Federal University of Rio Grande do Sul Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Division of Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90035007Brazil

Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common liver disease worldwide,with an estimated prevalence of 31%in Latin *** presence of metabolic comorbidities coexisting with liver disease varies substantially among *** is acknowledged that obesity is boosting the type 2 diabetes mellitus“epidemic,”and both conditions are significant contributors to the increasing number of patients with *** steatohepatitis represents a condition of chronic liver inflammation and is considered the most severe form of *** diagnosis is based on the presence of steatosis,noninvasive scores and altered liver *** scores of liver fibrosis,such as serum biomarkers,which should be used in primary care to rule out advanced fibrosis,are simple,inexpensive,and widely ***,guidelines from international hepatology societies recommend using noninvasive strategies to simplify case finding and management of high-risk patients with MASLD in clinical ***,there is no definite pharmacological treatment for the *** public health policies to treat patients with risk factors for MASLD prevention is essential.

关键词： Nonalcoholic fatty liver disease Primary care Metabolic risk Liver Metabolism

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Root Sprouts of Domesticated Phaseolus coccineus L. Overwinter Plants and the Environment at Its Collection Sites

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Open Journal of Ecology 2024年第5期14卷 508-521页

作者： Ma. Luisa Patricia vargas-Vázquez Jorge Alberto Acosta-Gallegos Fabián Islas-Gutiérrez Enrique Buendía-Rodríguez Campo Experimental Valle de Mé xico Instituto Nacional de Investigaciones Forestales Agr&#237colas y Pecuarias Texcoco Mexico Campo Experimental Bají o Instituto Nacional de Investigaciones Forestales Agr&#237colas y Pecuarias Guanajuato M&#233xico

Buds emerge from the roots of domesticated runner bean plants (Phaseolus coccineus L.) as sprouts and give the crop its persistence. This particularity of the species seems to be associated with the environment where the species was cultivated during long time. Data on regrowth traits were recorded on 70 accessions of domesticated P. coccineus after overwintering at a site in the central highlands of Mexico. The characteristics recorded included fresh weight of vegetative regrowth, root length, root crown diameter, and diameter of the main root. Most accessions that sprout the following spring, after the grain harvest of the previous year, come from temperate and semi-cold sites with cambisol and andosol soils in mixed Quercus pine forest and high mountain fir trees. Those that do not sprout are from sites of semiarid temperate climate, haplic phaeozem soil in shrub grasslands with deciduous broadleaved trees, and semiwarm subhumid climate, eutrophic regosol soil in deciduous broadleaved forest. Two types of roots were differentiated: branched and thickened taproots, also associated with a different climate, and the type of soil of the collection sites.

关键词： P. coccineus Distribution Vegetation-Environment Interactions Drought-Alternative Species Root-Regrowth

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Cost-Effectiveness Analysis of Renalof® versus Extracorporeal Shockwave Lithotripsy (ESWL) for the Treatment of Kidney Stones ≤ 1 cm in Nicaragua

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Health 2024年第7期16卷 674-687页

作者： Mélida M. Aguilar Chamorro Sergio vargas Collado Leslie Pérez Ruíz David Márquez Soriano Jorge Luis Soriano García Clínica Senior Managua Nicaragua Centro de Inmunología Molecular Havana Cuba Catalysis S.L. Madrid Spain

Objectives: To assess the efficiency in terms of cost-effectiveness (CE) of oral Renalof® treatment versus extracorporeal shockwave lithotripsy (ESWL) in the treatment of kidney stones ≤ 1 cm in Nicaragua. Methods: A cost-effectiveness economic evaluation was carried out based on the results obtained in the randomised, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the incremental cost-effectiveness ratio (ICER) were calculated. Economic data were obtained from the Economics Department of Clínica Senior in Managua, Nicaragua. The monetary cost was expressed in US dollars (USD). Results: Treatment with Renalof® yielded a CE of $1,323.08/% remission, while ESWL was $9,498.54/% remission. The ICER shows that, in order to achieve a high percentage of kidney stone remission with ESWL, an extra $4,734.70 per patient must be invested. Conclusions: The use of Renalof® is shown to be a more cost-effective option than ESWL. It is recommended for the treatment of kidney stones ≤ 1 cm in size.

关键词： Economic Evaluation Pharmacoeconomics Renalof® Extracorporeal Shockwave Lithotripsy Kidney Stones

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New Rotative Radiofrequency Technology: A Multicenter Retrospective Study on Efficacy and Safety

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 69-83页

作者： José Antonio Ferrández Martínez Gregorio Viera Mármol Fabrizio Vignoli Joanet Perera Agustin Blanch Mara Suárez Alicia Robledo Jorge Reyna vargas Lamas Sinclair Barcelona Spain Studio Vignoli Bologna Italy Clinica Perla Medic Alicante Spain Dr. Agustin Blanch Clinica Barcelona Spain Intek Medical Technology S.L.U. Barcelona Spain

Background: Non-ablative radiofrequency (RF) technology is widely used for the treatment of signs of aging, skin laxity, localized fat and cellulite. However, many RF devices suffer from technical limitations that make the results highly dependent on the user’s experience or clinical limitations that compromise safety, efficacy and comfort. Objective: To evaluate the efficacy and safety of a novel semi-automatic non-ablative RF device for skin tightening, body shaping and cellulite reduction. Materials and methods: A retrospective multicenter study was performed using a novel rotative RF device with temperature and impedance control (Sculpt&Shape®, Sinclair, Spain). 58 subjects underwent a minimum of 4 treatments every 1-2 weeks. A total of 120 treatments (56.7% body and 43.3% facial) and 1034 sessions were performed. Efficacy was evaluated by 3 researchers using the Global Aesthetic Improvement Scale (GAIS) and anthropometric measurements were collected. Subject and practitioner satisfaction were recorded. Safety was evaluated by analyzing the perception of pain during the treatment and the side and adverse effects immediately after treatment and over the next 48 hours. Results: Between 25% and 50% improvement was achieved according to the GAIS. Statistically significant (p < 0.01) abdominal fold reduction of 5.1 mm and circumference reduction of 32.0 mm, 16.4 mm and 13.9 mm were recorded for the abdomen, legs and arms, respectively. 77.5% of subjects and 94.9% of practitioners were either satisfied or very satisfied. Minor adverse effects were found in 0.97% of the sessions. Conclusion: This novel semi-automatic rotative RF device has been found to provide treatments that are effective, safe and comfortable for both practitioners and subjects. .

关键词： Rotative Radiofrequency RF Cellulite Skin Tightening Body Shaping

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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Experimental investigations of a full model with adaptive elasto-flexible membrane wings

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Chinese Journal of Aeronautics 2021年第7期34卷 211-218页

作者： Jonathan PFLU ger Christian BREITSAMTER Chair of Aerodynamics and Fluid Mechanics Technical University of MunichGarching 85748Germany

The morphing wing concept aims to constantly adapt the aerodynamics to different flight *** wing is able to adapt to different flight conditions by an adjustable Aspect Ratio(AR)and sweep.A high AR configuration provides high aerodynamic efficiency,while a low AR configuration,with highly swept wings offers a good ***,the flexible membrane allows the wing surface to stretch and contract in-plane as well as the airfoil to adapt to different aerodynamic *** the context of this work,the aerodynamic characteristics of a full model with form-adaptive elasto-flexible membrane wings are investigated *** focus is on the high-lift regime and on the analysis of the aerodynamic coefficients as well as their ***,the lateral aerodynamic derivatives at asymmetric wing positions are of interest.

关键词： Experimental aerodynamics Flexible wing surface Force and moment measurements Morphing wing Particle image velocimetry

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Emerging melt quality control solution technologies for aluminium melt

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China Foundry 2009年第4期6卷 358-365页

作者： arturo Pascual Foseco Foundry(China)Co. Ltd.2002 Leishing International Plaza1319 Yan'an RoadShanghaiChinaJr

The newly developed ＂MTS 1500＂ Melt Treatment System is performing the specifically required melt treatment operations like degassing, cleaning, modification and/or grain refinement by an automated process in one step and at the same location. This linked process is saving time, energy and metal losses allowing - by automated dosage of the melt treatment agents - the production of a consistent melt quality batch after batch. By linking the MTS Metal Treatment System with sensors operating on-line in the melt, i.e., with a hydrogen sensor ＂Alspek H＂, a fully automated control of parts of the process chain like degassing is possible. This technology does guarantee a pre-specified and documented melt quality in each melt treatment batch. Furthermore, to ensure that castings are consistent and predictable there is a growing realization that cdtical parameters such as metal cleanliness must be measured prior to casting. There exists accepted methods for measuring the cleanliness of an aluminum melt but these can be both slow and costly. A simple, rapid and meaningful method of measuring and bench marking the cleanliness of an aluminum melt has been developed to offer the foundry a practical method of measuring melt cleanliness. This paper shows the structure and performance of the integrated MTS melt treatment process and documents achieved melt quality standards after degassing, cleaning, modification and grain refinement operations under real foundry conditions. It also provides an insight on a melt cleanliness measuring device ＂Alspek MQ＂ to provide foundry men better tools in meeting the increasing quality and tighter specification demand from the industry.

关键词： melt quality aluminum casting melt treatment cleanliness measuring

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Automatic route planning for GPS art generation

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Computational Visual Media 2019年第3期5卷 303-310页

作者： Andre Waschk Jens Krüger University of Duisburg-Essen

In this paper, we present a novel approach to automated route generation of global positioning system(GPS) artwork. The term GPS artwork describes the generation of drawings by leaving virtual traces on digital maps. Until now, the creation of these images has required a manual planning phase in which an artist designs the route by hand. Once the route for this artwork has been planned, GPS devices have been used to track the movement. Using our solution, the lengthy planning phase can be significantly shortened,thereby opening art creation to a broader public.

关键词： GPS art walking routing shape detection navigation

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Introduction of Dr. Andrew V Schally

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Asian Journal of Andrology 2015年第6期17卷 923-924页

作者： arturo Mendoza-Valdes UROLOGO Hospital Medica Sur Puente dePiedra 150 T2-625 Col. Toriello Guerra Tlalpan14050Mexico DF.

Ifirst met Dr. Andrew V Schally （PhD, MDhc （Multi）, DSc, Distinguished Medical Research Scientist, U.S. Department of Veterans Affairs Professor of Pathology and Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA） many years ago, probably around the beginning of the 1990＇s in one of his visits to Mexico City （Figure 1）. He has many friends in my country since some of the investigations that led to the development of the LHRH agonists were made in a couple of Mexican hospitals in collaboration with some outstanding Mexican physicians that I will mention later. In that time, I was the head of the Department of Urology of the Mexican National Cancer Institute and our Director, Dr. Jaime de la Garza, invited him for a meeting. I was surprised by his humbleness, intelligence and easy going personality, in spite of being a Nobel Prize scientist.

关键词： Introduction Andrew Schally

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Usability perceptions and beliefs about smart thermostats by chi-square test, signal detection theory, and fuzzy detection theory in regions of Mexico

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Frontiers in Energy 2019年第3期13卷 522-538页

作者： Pedro PONCE Therese PEFFER arturo MOLINA Tecnologico de Monterrey calle del puente 222 MexicoMexico CityNon-US/Non-Canadian 64849Mexico California Institute for Energy and Environment University of California BerkeleyBerkeleyCA 94720USA

It is well known that smart thermostats (STs) have become key devices in the implementation of smart homes;thus, they are considered as primary elements for the control of electrical energy consumption in households. Moreover, energy consumption is drastically affected when the end users select unsuitable STs or when they do not use the STs correctly. Furthermore, in future, Mexico will face serious electrical energy challenges that can be considerably resolved if the end users operate the STs in a correct manner. Hence, it is important to carry out an in-depth study and analysis on thermostats, by focusing on social aspects that influence the technological use and performance of the thermostats. This paper proposes the use of a signal detection theory (SDT), fuzzy detection theory (FDT), and chi-square (CS) test in order to understand the perceptions and beliefs of end users about the use of STs in Mexico. This paper extensively shows the perceptions and beliefs about the selected thermostats in Mexico. Besides, it presents an in-depth discussion on the cognitive perceptions and beliefs of end users. Moreover, it shows why the expectations of the end users about STs are not met. It also promotes the technological and social development of STs such that they are relatively more accepted in complex electrical grids such as smart grids.

关键词： thermostats perceptions beliefs signal detection theory (SDT) fuzzy signal detection theory (FSDT) chi-square (CS) test

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