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Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in mexico

World Journal of Gastroenterology 2015年第41期21卷 11552-11566页

作者： Omar Ramos-Lopez Erika martinez-Lopez Sonia Roman Nora A Fierro arturo Panduro Department of molecular Biology in medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" Guadalajara Jalisco Mexico and Health Sciences Center University of Guadalajara

Liver cirrhosis(LC) is a chronic illness caused by inflammatory responses and progressive fibrosis. Globally, the most common causes of chronic liver disease include persistent alcohol abuse, followed by viral hepatitis infections and nonalcoholic fatty liver disease. However, regardless of the etiological factors, the susceptibility and degree of liver damage may be influenced by genetic polymorphisms that are associated with distinct ethnic and cultural backgrounds. Consequently, metabolic genes are influenced by variable environmental lifestyle factors, such as diet, physical inactivity, and emotional stress, which are associated with regional differences among populations. This Topic Highlight will focus on the genetic and environmental factors that may influence the metabolism of alcohol and nutrients in the setting of distinct etiologies of liver disease. The interaction between genes and environment in the current-day admixed population, mestizo and Native mexican, will be described. Additionally, genes involved in immune regulation, insulin sensitivity, oxidative stress and extracellular matrix deposition may modulate the degree of severity. In conclusion, LC is a complex disease. The onset, progression, and clinical outcome of LC among the mexican population are influenced by specific genetic and environmental factors. Among these are an admixed genome with a heterogenic distribution of European, Amerindian and African ancestry; a high score of alcohol consumption; viral infections; a hepatopathogenic diet; and a high prevalence of obesity. The variance in risk factors among populations suggests that intervention strategies directed towards the prevention and management of LC should be tailored according to such population-based features.

关键词： Genomic medicine Polymorphisms Viral hepatitis Obe

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A mean Curvature Regularized Based model for Demodulating Phase maps from Fringe Patterns

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Communications in Computational Physics 2018年第6期24卷 27-43页

作者： Carlos Brito-Loeza Ricardo Legarda-Saenz arturo Espinosa-Romero Anabel martin-Gonzalez CLIR at Facultad de matematicas Universidad Autonoma de YucatanMexico

We introduce a variationalmethod for demodulating phasemaps fromfringe *** newmethod is based on themean curvature of the level sets of the phase surface that is used for *** performance of the method is illustrated w... 详细信息

关键词： Fringe analysis interferometry high-order regularization variational models

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Patch isolation and shape predict plant functional diversity in a naturally fragmented forest

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Journal of Plant Ecology 2018年第1期11卷 136-146页

作者： Amaranta Arellano-Rivas J.arturo De-Nova miguel A.munguía-Rosas Instituto de Investigación de Zonas Desérticas Universidad Autónoma de San Luís PotosíSan Luis Potosí78377México Laboratorio de Ecología Terrestre Departamento de Ecología HumanaCentro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV)Mérida 97310México Facultad de Agronomía Universidad Autónoma de San Luís PotosíSan Luis Potosí78321México

Aims It is known that taxonomic diversity can be predicted by the spatial configuration of the habitat,in particular by its area and degree of ***,taxonomic diversity is a poor predictor of ecosystem *** functional diversity is strongly linked to the func-tionality and stability of ecosystems,little is known about how changes in the spatial configuration of the habitat affect functional *** this study,we evaluated whether the spatial configuration of forest patches predicts the functional diversity of plants in a fragmented *** Five functional leaf traits(leaf dry matter content,leaf punch force,specific leaf area,leaf size and leaf thickness)were measured for 23 dominant plant species in 20 forest patches in a naturally fragmented forest on the yucatan ***-weighted multivariate and individual trait metrics of functional diversity were calculated and cor-related with size,degree of isolation and the shape of forest *** Findings Patch shape was negatively correlated with multivariate and individ-ual trait(leaf dry matter content and leaf size)metrics of functional *** isolation measures were also negatively correlated with individual trait(leaf dry matter content,leaf punch force and leaf size)metrics of functional *** other words,greater patch shape irregularity and isolation degree impoverish plant func-tional *** is the first report of the negative effects of patch shape irregularity and isolation on the functional diversity of plant communities in a forest that has been fragmented for a long time.

关键词： forest fragmentation functional diversity habitat spatial configuration petenes yucatan

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A New model to Evaluate the Economic Effects of Floods and Its Application to China

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Fudan Journal of the Humanities and Social Sciences 2016年第4期9卷 627-641页

作者： mario arturo Ruiz Estrad Ibrahim.ndoma Donghyun Park Faculty of Economics and Administration (FEA) University of Malaya 50603 Kuala LumpurMalaysia Principal Economist Asian Development Bank (ADB) 6 ADB Avenue1550 Mandaluyong City Metro Manila Philippines

We set forth the macroeconomics evaluation of floods （mEF） model, a new model to assess and evaluate the impact of floods on GNP growth. This model points to a new, more concrete approach to measure the economic impact of floods. Up to now, the measurement has been subject to a great deal of uncertainty. The main contribution of the model is to significantly reduce this uncertainty by mea- suring the impact with four well-defined, economically intuitive indicators. To illuminate and demonstrate its promise, we employ the model to evaluate and analyze the impact of two major floods on the economy of the People＇s Republic of China. Our mEF-model analysis indicates that the floods of Zhangshu and Jiangxi in 2010 caused greater economic damage than the floods of Central South China in 1931. Going forward, mEF-model simulations are a valuable tool for estimating the effect of potential future floods in the PRC and elsewhere.

关键词： Floods Economic impact Economic evaluation mEF-model China

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Alcoholism and liver disease in mexico:Genetic and environmental factors

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World Journal of Gastroenterology 2013年第44期19卷 7972-7982页

作者： Sonia Roman Eloy Alfonso Zepeda-Carrillo Laura Eugenia moreno-Luna arturo Panduro Department of molecular Biology in medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" and Health Sciences Center University of GuadalajaraGuadalajara Jalisco 44280 Mexico Universidad Autónoma de Nayarit and Hospital Civil Tepic "Antonio González Guevara" Tepic Nayarit 63000 Mexico

Alcoholism and cirrhosis,which are two of the most serious health problems worldwide,have a broad spectrum of clinical *** diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each *** contrast to other regions around the world,mexicans present the highest drinking score and a high mortality rate for alcoholic liver disease with an intermediate category level of per capita alcohol *** has a unique history of alcohol consumption that is linked to profound anthropological and social *** mexican population has an admixture genome inherited from different races,Caucasian,Amerindian and African,with a heterogeneous distribution within the ***,genes related to alcohol addiction,such as dopamine receptor D2 in the brain,or liver alcoholmetabolizing enzymes,such as alcohol dehydrogenase classⅠpolypeptide B,cytochrome P450 2E1 and aldehyde dehydrogenase class 2,may vary from one individual to ***,they may be inherited as risk or non-risk haplogroups that confer susceptibility or resistance either to alcohol addiction or abusive alcohol consumption and possibly liver ***,in this era of genomics,personalized medicine will benefit patients if it is directed according to individual or population-based *** association studies will be required to establish novel strategies for the prevention,care and treatment of liver disease in mexico and worldwide.

关键词： Alcohol Genes Alcoholism Alcohol dependence Alcohol addiction Alcohol abuse Alcoholic liver cirrhosis Anthropology

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Novel electrode structure in a DBD reactor applied to the degradation of phenol in aqueous solution

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Plasma Science and Technology 2017年第7期19卷 71-84页

作者： Antonio mERCADO-CABRERA Rosendo PE?A-EGUILUZ Régulo LóPEZ-CALLEJAS Bethsabet JARAmILLO-SIERRA Raúl VALENCIA-ALVARADO Benjamín RODRíGUEZ-méNDEZ arturo E mU?OZ-CASTRO Instituto Nacional de Investigaciones Nucleares Plasma Physics Laboratory Tecnológico de Estudios Superiores de Tianguistenco

Phenol degradation experimental results are presented in a similar wastewater aqueous solution using a non-thermal plasma reactor in a coaxial dielectric barrier discharge. The novelty of the work is that one of the electrodes of the reactor has the shape of a hollow screw which shows an enhanced efficiency compared with a traditional smooth structure. The experimentation was carried out with gas mixtures of 90% Ar-10% O2, 80% At-20% 02 and 0% Ar-100% 02. After one hour of treatment the removal efficiency was 76%, 92%, and 97%, respectively, assessed with a gas chromatographic mass spectrometry technique. For both reactors used, the ozone concentration was measured. The screw electrode required less energy, for all gas mixtures, than the smooth electrode, to maintain the same ozone concentration. On the other hand, it was also observed that in both electrodes the electrical conductivity of the solution changed slightly from ,-0.0115 S m^-1 up to -0.0430 S m^-1 after one hour of treatment. The advantages of using the hollow screw electrode structure compared with the smooth electrode were：（1） lower typical power consumption, （2） the generation of a uniform plasma throughout the reactor benefiting the phenol degradation, （3） a relatively lower temperature of the aqueous solution during the process, and （4） the plasma generation length is larger.

关键词： DBD gas discharges removal organic compounds discharge in liquids

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micro- and nanoporous materials capable of absorbing solvents and oils reversibly： the state of the art

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Petroleum Science 2017年第1期14卷 84-104页

作者： Javier S. acevedo Cortez Boris I. Kharisov Thelma E. Serrano Quezada Tomas C. Hernandez Garcia Facultad de Ciencias Qufmicas Universidad Autonoma de Nuevo Leon Ave. Universidad s/n66455 San Nicolas de los Garza NL Mexico

Treatment of petroleum spills and organic solvent pollution in general is an important issue; several techniques are under development to remove oil from water. The use of absorbents is one of the most common techniques to tackle this problem. These absorbents can be classified based on their characteristics of recyclability into irreversible and reversible ones. In this review, we discuss the application of several materials as oil absorbents, according to their classification and characteristics such as hydrophobicity, surface area and oil absorption capacity. Also, the fabrication methods for some materials are presented and analyzed.

关键词： Oil spills - Composites Reversibility Aerogels - Natural absorbents micro- and nanoporousmaterials

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Biodiversity studies of myxomycetes in madagascar

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Fungal Diversity 2013年第2期59卷 55-83页

作者： Diana Wrigley de Basanta Carlos Lado arturo Estrada-Torres Steven L.Stephenson Real Jardín Botánico CSICPlaza de Murillo228014 MadridSpain Centro de Investigación en Ciencias Biológicas Universidad Autónoma de TlaxcalaApartado Postal 183Tlaxcala 90000 TlaxcalaMexico Department of Biological Sciences University of ArkansasFayettevilleAR 72701USA

The results of the first comprehensive study of myxomycetes from the island of madagascar,a world biodiversity hotspot,are reported in this *** island is of continental origin,the fourth largest in the world,and has been geographically isolated for more than 160 million years,since its separation from *** isolation,size and topography of madagascar have triggered the development of a great variety of different habitats and favoured multiple evolutionary pathways,resulting in many animals and plants that exist nowhere else on *** for the biodiversity survey of the central and southern parts of the island took place in may 2009,to coincide with the end of the rainy *** moist forest,sclerophyll forest and dry forest were selected for sampling in Ranomafana,Andringitra,Andohahela and L’Isalo National *** unique vegetation was sampled in the spiny dry forest and succulent scrub with plants from the genera Alluaudia,Euphorbia,Kalanchoe and *** survey produced 124 species from 22 different genera in more than 750 myxomycete *** this paper one species,Perichaena madagascariensis,is described as new to science,21 species are new records for Africa,and 106 are reported for the first time from *** unusual collections included Physarum lakhanpalii that appeared on Ravenala madagascariensis,Fuligo intermedia and Licea nannengae found on Adansonia grandidieri,Perichaena pulcherrima,Physarum dictyosporum,and *** on Euphorbia and Licea rufocuprea on *** scope,methods and results of this survey are included in this paper,and comments are made on the ecology,distribution and substrate association of the myxomycetes of these areas of ***,micrographs and SEm images of interesting species are *** results indicate that the island of madagascar has a unique assemblage of species of myxomycetes,different from neighbouring islands and from similar but distant envi

关键词： Amoebozoa Biogeography Endemism myxogastria SEm Spiny forest

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Zeolite-templated carbons as effective sorbents to remove methylsiloxanes and derivatives:A computational screening

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Green Energy & Environment 2021年第6期6卷 884-892页

作者： Shiru Lin Kaitlyn A.Jacoby Jinxing Gu Dariana R.Vega-Santander arturo J.Hernaandez-maldonado Zhongfang Chen Department of Chemistry University of Puerto RicoRío PiedrasSan JuanPR 00931USA Department of Chemistry&Biochemistry Elizabethtown CollegeElizabethtownPA 17022USA Department of Chemical Engineering University of Puerto RicoMayaguez CampusMayaguezPR 00681USA

Though widely used in our daily lives,volatile methylsiloxanes and derivatives are emerging contaminants and becoming a high-priority environment and public health *** effective sorbent materials can remove siloxanes in a cost-effective ***,by means of Grand Canonical monte Carlo(GCmC)simulations,we evaluated the potentials of the recently proposed 68 stable zeolite-templated carbons(ZTCs)(PNAS 2018,115,E8116-E8124)for the removal of four linear methylsiloxanes and derivatives as well as two cyclic methylsiloxanes by the calculated average loading and average adsorption energy *** ZTCs,namely ISV,FAU1,FAU3,and H8326836,were identified with the top 50%adsorption performance toward all the six targeted contaminants,which outperform activated *** first principles computations revealed that steric hindrance,electrostatic interactions(further enhanced by charge transfer),and CH-p interactions account for the outstanding adsorption performance of these *** work provides a quick procedure to computationally screen promising ZTCs for siloxane removal,and help guide future experimental and theoretical investigations.

关键词： Zeolite-templated carbons Contaminants of emerging concern methylsiloxanes GCmC simulations Density functional theory calculations

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