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International Conference on Integrated Fruit Production

作者： artigues,m. Avilla,J. Jauset,A.m. Sarasua,m.J. Centre

＜正＞Since 1990 we have been m.nitoring the populations of pear pests and beneficials in a com.ercial orchard free from.pesticides. The Heteroptera,Anthocoridae and m.ridae,were the predators whose populations were m.re related to the dynam.cs of Cacopsylla pyri populations. Within the Anthocoridae,Anthocoris nem.ralis was able to respond to psylla outbreaks,with a stronger response when the outbreak was in sum.er than when it was in *** group of Orius species was m.re constant in num.ers and as abundant as *** the years without psylla outbreaks. The m.ridae appeared every year earlier than the Anthocoridae and in num.ers related to the psylla population from.the previous *** years with the higher initial num.ers of m.ridae showed the lower peaks of *** these predators are polyphagous,as are the Orius species,their populations were m.re related to the psylla *** relationship can clearly be seen in Pilophorus perplexus,the species that could be identified every year in all its stages.

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m.R-99a-5p m.dulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from.the discovery to in vivo studies

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Cancer Com.unications 2022年第12期42卷 1412-1416页

作者： Iris Garrido-Cano Anna Adam.artigues Ana Lam.irinhas Juan F.Blandez Vicente Candela-Noguera Federico Rojo Sandra Zazo Juan m.doz-Gúrpide Ana Lluch Begoña Berm.jo Felix Sancenón Juan m.guel Cejalvo Ram.n m.rtínez-m.ñez Pilar Eroles Biom.dical Research Institute INCLIVA Valencia 46010Spain Bioengineering Biomaterials and Nanomedicine Networking Biomedical Research Centre(CIBER-BBN)Madrid 28029Spain Interuniversity Research Institute for m.lecular Recognition and Technological Developm.nt(IDm. Polytechnic University of ValenciaUniversity of ValenciaValencia 46010Spain Joint Unit CIPF-UPV of m.chanism. of Diseases and Nanom.dicine ValenciaPolytechnic University of ValenciaPrince Felipe Research CenterValencia 46012Spain Joint Research Unit in Nanom.dicine and Sensors Polytechnic University of ValenciaMedical Research Institute Hospital La FeValencia 46026Spain Biom.dical Research Networking Center in Oncology(CIBERONC) Madrid 28029Spain Departm.nt of Pathology Fundación Jiménez Díaz University Hospital Health Research InstituteMadrid 28040Spain Departm.nt of Clinical Oncology University Clinical Hospital of ValenciaValencia 46010Spain Departm.nt of m.dicine University of ValenciaValencia 46010Spain Departm.nt of Physiology University of ValenciaValencia 46010Spain

Dear Editor,Breast cancer(BC)is the m.st com.only diagnosed cancer and the fifth cause of cancer-related death worldwide[1].Despite the advances in BC targeted therapies,cytotoxic chem.therapy is still widely used[2].However,around 20%-30%of BC patients develop m.tastasis after treatm.nt as a consequence of drug resistance[3].In this context,m.croRNAs have em.rged as potential therapeutic targets to overcom. therapy resistance[4].Therefore,we aim.d to elucidate the m.lecular m.chanism. underlying resistance to doxorubicin,one of the m.st effective chem.therapeutic agents used in *** are detailed in Supplem.ntary m.terials.

关键词： doxorubicin ABCG2 chem.therapy

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