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Mate assessment behavior is correlated to learning ability in female threespine sticklebacks

current Zoology 2019年第3期65卷 295-304页

作者： Taylor L.RYSTROM Theo c.M.BAKKER Ingolf P.RIcK Department of Behavioural Biology University of Munster Badestrasse 13 Munster 48149 Germany Institute for Evolutionary Biology and Ecology University of Bonn An der Immenburg 153121 Bonn Germany

In many species, males signal quality with elaborate traits, but females often show inter-individual variation in pref ere nee for these traits. choosi ng a mate requires multiple cog nitive steps;therefore, cog nitive style (how an in dividual processes information) likely in fluences the perception of sexual signals and ability to choose a high-quality mate. An important component of cognitive style is flexibility;cognitively flexible individuals are more perceptive to shifts in cues. We hypothesized that cognitively flexible individuals would acquire more information about potential mates, better discern between two quality-signaling traits, and thus be more discriminatory. Here, we show that mate assessment is correlated to other cognitive traits. Although we did not detect an effect of cogn itive style on mate pref ere nee or discriminatio n, we found that female threespi ne sticklebacks Gasterosteus aculeatus that spent more time assessing potential mates (more responsive) in a dichotomous mate choice task reached both the initial and reversal learning criterion in a spatial learning task with fewer errors. However, these highly responsive females made more consecutive mistakes immediately at the beginning of the reversal phase, suggest!ng that they did not quickly adapt to the en vironmental cha nge but in stead rapidly formed strict routi nes duri ng the learning task that were eventually reversible after repeated errors. Furthermore, we found evidenee for condition-dependent mate pref ere nee, with larger females preferring the high-quality male. These are among the first results that illustrate how cog nitive traits might in flue nee mate choice, which has implicati ons for the st re ngth and di recti on of sexual selection.

关键词： cognition cognitive flexibility choosiness computer animation mate choice sexual selection

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撞车模拟的不稳定性分析(英文)

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工程数学学报 2002年第2期19卷 47-51,56页

作者：梅立泉 Thole c A. Fraunhofer-Institute of Algorithms and Scientific computing D53754 St.Augustin Germany

众所周知 ,在并行机器上多次执行同一应用会产生不同的撞击数值模拟结果。为了研究这一问题 ,我们开发了一个工具 ,它可从PAM cRASH读取多个结果文件 ,计算各种统计量并可利用可视化工具产生这些量的输出以用于分析。

关键词：数值模拟软件稳定性分析撞车模拟并行机器撞击

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Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis

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World Journal of Gastroenterology 2014年第28期20卷 9458-9467页

作者： Bruno césar da Silva Andre castro Lyra Raquel Rocha Genoile Oliveira Santana Post-graduate Program in Medicine and Health Federal University of Bahia Gastroenterology Department of the University Hospital Professor Edgard Santos Federal University of Bahia Gastro-Hepatology Service of Hospital S?o Rafael Department of Sciences of Nutrition School of NutritionFederal University of Bahia

Ulcerative colitis(Uc)is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and *** hallmark clinical symptom of Uc is bloody *** clinical course is marked by exacerbations and remissions,which may occur spontaneously or in response to treatment changes or intercurrent *** is most commonly diagnosed in late adolescence or early adulthood,but it can occur at any *** incidence of Uc has increased worldwide over recent decades,especially in developing *** contrast,during this period,therapeutic advances have improved the life expectancy of patients,and there has been a decrease in the mortality rate over *** is important to emphasize that there is considerable variability in the phenotypic presentation of *** this context,certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor *** this group of patients,better clinical surveillance and more intensive therapy may change the natural course of the *** aim of this article was to review the epidemiology and demographic characteristics of Uc and the factors that may be associated with its clinical prognosis.

关键词： Ulcerative colitis Incidence Prevalence Risk factors Predictive factors

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Hairless canary seeds (Phalaris canariensis L.) as a potential source of antioxidant, antihypertensive, antidiabetic, and antiobesity biopeptides

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Food Production, Processing and Nutrition 2021年第1期3卷 80-91页

作者： U.c.Urbizo-Reyes J.E.Aguilar-Toalá A.M.Liceaga Protein chemistry and Bioactive Peptides Laboratory Department of Food SciencePurdue University745 Agriculture Mall DriveWest LafayetteIN 47907USA

Rising consumer concerns with synthetic drugs to treat non-communicable diseases(NcDs)have promoted a shift towards using natural biological active constituents that offer similar health *** canary seed(Phalaris canariensis L)is an emerging crop traditionally used in Mexico to treat *** liberated during simulated digestion of canary seed protein are believed to be responsible for their biological activity;however,no studies have shown the effect of controlled protein hydrolysis using commercial proteases on canary seed protein’s biological ***,this study aimed to explore the in vitro antihypertensive,antidiabetic,and anti-obesity activity of canary seed peptides derived from proteolysis with Alcalase®.Protein fractions were primarily composed of prolamins(54.07±1.8%),glutelins(32.19±3.18%),globulins(5.97±0.52%)and albumins(5.97±0.52%).Thections showed the highest inhibition capacity(pconverting enzyme(Ic50=0.028–0.032 mg/mL)lipase(Ic50=2.15–2.27 mg/mL),α-glucosidase(Ic50=0.82–1.15 mg/mL),and dipeptidyl-peptidase-IV(Ic50=1.27–1.60 mg/mL).Additionally,these peptide fractions showed high antioxidant activity against DPPH(134.22–150.66μmol TE/mg)and ABTS(520.92–813.33μmol TE/mg).These results provide an insight into the potential development of functional foods using commercial enzymatic hydrolysis of canary seed proteins for treating hypertension,type-2 diabetes,and obesity.

关键词： canary seeds Bioactive peptides Anti-obesity activity Antihypertensive activity Antidiabetic activity

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Methionine adenosyltransferases in liver cancer

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World Journal of Gastroenterology 2019年第31期25卷 4300-4319页

作者： Ben Murray Lucia Barbier-Torres Wei Fan JoséM Mato Shelly c Lu Division of Digestive and Liver diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCA 90048United States cIc bioGUNE Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(Ciberehd)TechnologyPark of BizkaiaDerio 48160BizkaiaSpain

Methionine adenosyltransferases(MATs)are essential enzymes for life as they produce S-adenosylmethionine(SAMe),the biological methyl donor required for a plethora of reactions within the *** systems express two genes,MAT1A and MAT2A,which encode for MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,respectively.A third gene MAT2B,encodes a regulatory subunit known as MATβwhich controls the activity of MATα***1A,which is mainly expressed in hepatocytes,maintains the differentiated state of these cells,whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver(e.g.,hepatic stellate and Kupffer cells).The biosynthesis of SAMe is impaired in patients with chronic liver disease and liver cancer due to decreased expression and inactivation of MATα1.A switch from MAT1A to MAT2A/MAT2B occurs in multiple liver diseases and during liver growth and dedifferentiation,but this change in the expression pattern of MATs results in reduced hepatic SAMe *** of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular carcinoma(Hcc)to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver *** increasing volume of work indicates that MATs have SAMe-independent functions,distinct interactomes and multiple subcellular *** we aim to provide an overview of MAT biology including genes,isoenzymes and their regulation to provide the context for understanding consequences of their *** will highlight recent breakthroughs in the field and underscore the importance of MAT’s in liver tumorigenesis as well as their potential as targets for cancer therapy.

关键词： Methionine adenosyltransferases S-adenosylmethionine Liver cancer Hepatocellular carcinoma cholangiocarcinoma Biomarkers Therapeutic targets

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comparison and evaluation of network clustering algorithms applied to genetic interaction networks

Comparison and evaluation of network clustering algorithms a...

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第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Lin Hou Lin Wang arthur Berg Minping Qian Yunping Zhu Fangting Li 邓明华 LMAM School of Mathematical SciencesPeking University center for Theoretical Biology Peking University State Key Laboratory of Proteomics Beijing Proteome Research CenterBeijing Institute of Radiation Medicine center for Statistical Genetics Pennsylvania State UniversityHersheyPennsylvaniaUSA School of Physics Peking University center for Statistical Science Peking University

The goal of network clustering algorithms is to detect dense clusters in a network, which provides a first step towards the understanding of large scale biological *** numerous recent advances in biotechnologies,large-scale genetic interactions are widely available,but there is a limited understanding of which clustering algorithms may be most *** order to address this problem,we conducted a systematic study to compare and evaluate six clustering algorithms in analyzing genetic interaction networks,and investigated influencing factors in choosing *** algorithms considered in this comparison include hierarchical clustering,topological overlap matrix,bi-clustering,Markov clustering, Bayesian discriminant analysis based community detection,and variational Bayes approach to *** experimentally identified and synthetically constructed networks were used in this *** accuracy of the algorithms is measured by the Jaccard index in comparing predicted gene modules with benchmark gene *** results suggest that the choice differs according to the network topology and evaluation *** clustering showed to be best at predicting protein complexes;Bayesian discriminant analysis based community detection proved best under epistatic miniarray profile(EMAP) datasets;the variational Bayes approach to modularity was noticeably better than the other algorithms in the genome-scale networks.

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Secure smart contract-based digital twins for the Internet of Things

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Blockchain(Research and Applications) 2024年第1期5卷 39-49页

作者： Iakovos Pittaras Nikos Fotiou christos Karapapas Vasilios A.Siris George c.Polyzos Mobile Multimedia Laboratory Department of InformaticsSchool of Information Sciences and TechnologyAthens University of Economics and BusinessAthens10434Greece School of Data Science The Chinese University of Hong KongShenzhen518172China

The proliferation of Internet of Things(IoT)devices that operate unattended providing a multitude of important and often sensitive services highlights the need for seamless interoperability and increased *** argue that digital twins of IoT devices,with the right design,can enhance the security,reliability,auditability,and interoperability of IoT *** salient features of digital twins have made them key elements for the IoT and Industry *** this paper,we leverage advances in W3c’s Web of Things(WoT)standards and distributed ledger technologies(DLTs)to present a novel design of the smart contract-based digital twins with enhanced security,transparency,interoperability,and *** provide two different variations of that general design using two different blockchains(one public and one private,permissioned blockchain),and we present design ***,we introduce an architecture for accessing and controlling IoT devices securely and reliably,providing full auditability,while at the same time using the proposed digital twins as an indirection mechanism(proxy).The proposed architecture leverages the blockchain to offer notable properties,namely,decentralization,immutability,auditability,non-repudiation,availability,and ***,it introduces mass actuation,easier management of IoT devices,and enhanced security to the IoT gateways,enables new business models,and makes consumer devices(vendor-)agnostic.

关键词： Digital twins Internet of Things Web of Things Distributed ledger technologies Hyperledger Fabric Ethereum

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Variation of basic density,calorific value and volumetric shrinkage within tree height and tree age of Ugandan grown Eucalyptus grandis wood

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Journal of Forestry Research 2021年第2期32卷 503-512页

作者： Owen Emmanuel Sseremba P.Mugabi A.Y.Banana B.c.Wessels M.Plessis Department of Forestry Biodiversity and TourismMakerere UniversityKampalaUganda Department of Forestry and Wood Science Stellenbosch UniversityStellenboschSouth Africa

Insufficient knowledge on Ugandan grown Eucalyptus grandis *** ex Maiden wood properties,high demand,and processing challenges led to a study into its physical *** obtained the variation of basic density(BD),calorific value(cV)and volumetric shrinkage(VS)within tree height and tree-age of ***,and its appropriate use based on these *** with good boles were harvested from Kabarole District in western Uganda to produce specimens as prescribed by British Standards and ASTM standard wood testing *** data reviews and statistical analysis using ANOVA,Tukey’s test and multivariate analysis were done to obtain property estimates and their variation within trees and amongst tree *** mean BD of *** is 413.6,380.5,471.0,and 501.1 kg m^(−3)at 3,6,9,and 12 years,respectively,showing significant increase with tree age(p=0.003).The pattern of BD with tree height showed a reduction with tree height although with higher values in the middle portion of the *** cV increases(p=0.014)with tree age and reduces with tree height with values of 14,560.32,15,447.3,16,079.11,and 16,932.6 kJ kg^(−1)at 3,6,9,and 12 years,*** percentage VS was 11.02,9.84,12.31,and 14.45 for 3-,6-,9-,and 12-year-old trees,respectively,and it did not vary significantly(p=0.088)with tree *** on these property values,*** wood could be used for scaffolding,light constructions and fuel wood *** seasoning needs to be longer with well monitored drying schedules to reduce seasoning defects caused by the high *** studies on strength properties,seasoning schedules,panel products properties and tree-age chemical variations would improve the knowledge about its wood quality and would enhance its efficient utilization.

关键词： Eucalyptus grandis Age calorificvalue Basic density Volumetric shrinkage Wood

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恐惧之谷

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作者： (英)亚瑟·柯南·道尔(arthur conan Doyle)

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大学生留美直通车

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作者： Student services L.L.c.

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