检索结果-南通市图书馆

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

维普期刊数据库

Multiple sclerosis is at a checkpoint: advancing the program

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

维普期刊数据库

Probiotic supplementation decreases intestinal transit time: Meta-analysis of randomized controlled trials

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第29期19卷 4718-4725页

作者： Larry E Miller arthur c Ouwehand Miller Scientific consulting Inc. Arden NC 28704 United States DuPont Nutrition and Health FIN-02460 Kantvik Finland

AIM: To determine the efficacy of probiotic supplementation on intestinal transit time (ITT) and to identify factors that influence these outcomes. METHODS: A systematic review of randomized controlled trials (RcTs) of probiotic supplementation that measured ITT in adults was conducted by searching MEDLINE and EMBASE using relevant combinations. Main search limits included RcTs of probiotic supplementation in healthy or constipated adults that measured ITT. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference (SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses were conducted to examine the impact of moderator variables on ITT SMD. RESULTS: A total of 11 clinical trials with 13 treatment effects representing 464 subjects were included in this analysis. Probiotic supplementation was associated with decreased ITT in relation to controls, with an SMD of 0.40 (95%cI: 0.20-0.59, P constipation (r 2 = 39%, P = 0.01), higher mean age (r 2 = 27%, P = 0.03), and higher percentage of female subjects (r 2 = 23%, P ctive of decreased ITT with probiotics in meta-regression. Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation and in older vs younger subjects [both SMD: 0.59 (95%cI: 0.39-0.79) vs 0.17 (95%cI: -0.08-0.42), P = 0.01]. Medium to large treatment effects were identified with Bifidobacterium Lactis (B. lactis ) HN019 (SMD: 0.72, 95%cI: 0.27-1.18, P ctis DN-173 010 (SMD: 0.54, 95%cI: 0.15-0.94, P combination products yielded small treatment effects. cONcLUSION: Overall, short-term probiotic supplementation decreases ITT with consistently greater treatment effects identified in constipated or older adults and with certain probiotic strains.

关键词： constipation Gastrointestinal Intestinal transit time Meta-analysis Probiotics

The effects of human-generated sound on fish

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2009年第1期4卷 43-52页

作者： arthur N.POPPER Mardi c.HASTINGS Department of Biology University of MarylandCollege ParkUSA Applied Research Laboratory The Pennsylvania State UniversityState CollegeUSA

There is growing international concern about the effects of human-generated sound on fish and other aquatic ***,because of a striking paucity of well-designed and controlled experimental data,very little is actually known about the effects of these sounds on *** suggest that human-generated sounds,even from very high intensity sources,might have no effect in some cases or might result in effects that range from small and temporary shifts in behavior all the way to immediate *** this point,however,it is nearly impossible to ex-trapolate from results with one sound source,one fish species,or even fish of one size to other sources,species,or fish *** present paper briefly discusses the potential effects of sound on fish,describes some of the more recent well-controlled experimental studies,and points out areas for future study that will be needed before a real understanding of the effects of sound on fish can be developed.

关键词： anthropogenic sound behavior hearing noise sound.

co_(6)Se_(8)(PEt_(3))_(6) superatoms as tunable chemical dopants for two-dimensional semiconductors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj computational Materials 2018年第1期4卷 373-378页

作者： arthur c.Reber Shiv N.Khanna Department of Physics Virginia Commonwealth UniversityRichmondVA 23284USA

Electronic,optoelectronic,and other functionalities of semiconductors are controlled by the nature and density of carriers,and the location of the Fermi *** strategies to tune these parameters holds the key to precise control over semiconductors *** propose that ligand exchange on superatoms can offer a systematic strategy to vary these *** demonstrate this by considering a WSe_(2) surface doped with ligated metal chalcogenide co_(6)Se_(8)(PEt_(3))_(6) *** superatoms are characterized by valence quantum states that can readily donate multiple *** find that the WSe_(2) support binds more strongly to the co_(6)Se_(8) cluster than the PEt3 ligand,so ligand exchange between the phosphine ligand and the WSe_(2) support is energetically *** metal chalcogenide superatoms serves as a donor that may transform the WSe_(2) p-type film into an ntype *** theoretical findings complement recent experiments where WSe_(2) films with supported co_(6)Se_(8)(PEt_(3))_(6) are indeed found to undergo a change in behavior from p-to *** further show that by replacing the PEt3 ligands by cO ligands,one can control the electronic character of the surface and deposited species.

关键词： properties. semiconductors holds

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

维普期刊数据库

correcting for non-compliance when determining colonic transit time with radio-opaque markers

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第4期23卷 740-742页

作者： Alvin Ibarra Kaisa Olli arthur c Ouwehand DuPont Nutrition and Health 02460 KantvikFinland

The use of radio-opaque markers and abdominal X-ray is the standard method for determining colonic transit time(cTT). However, when there are deviations in the intake of these markers by participants in clinical trials it is desirable to improve observations by introducingcorrections, where possible. To date, there is no standard procedure to adjust for such deviations. This report proposes a series of alternatives based on possible scenarios for deviations from the intended intake of radio-opaque markers. The proposed method to correct for missed or delayed consumption of radioopaque markers can help to increase the accuracy of the cTT measurements in clinical trials.

关键词： colonic transit time Gastroenterology Gut transit time Radio-opaque marker X-ray

NumericalModeling of ElasticWave Propagation in a Fluid-Filled Borehole

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

communications in computational Physics 2008年第1期3卷 33-51页

作者： arthur c.H.cheng Joakim O.Blanch cambridge GeoSciences 14090 Southwest FreewaySuite 300Sugar LandTX 77478USA Nexus GeoSciences 14090 Southwest FreewaySuite 240Sugar LandTX 77478USA previously at SensorWise Inc.2908 RodgerdaleHoustonTX 77042USA.

We review the methods of simulating elastic wave propagation in a *** considered two different approaches: a quasi-analytic approach using theDiscreteWavenumber SummationMethod, and the purely numerical Finite DifferenceMethod. We consider the special geometry of the borehole and discuss the problem incylindrical coordinates. We point out some numerical difficulties that are particularlyunique to this problem in cylindrical coordinates.

关键词： Acoustic borehole numerical modeling.

contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第21期22卷 5122-5131页

作者： Larry E Miller Angela K Zimmermann arthur c Ouwehand Miller Scientific consulting Inc. Asheville NC 28803 United States DuPont Nutrition and Health FIN-02460 Kantvik Finland

AIM: To determine the efficacy of probiotic supplementation on intestinal transit time(ITT) in adults and to identify factors that influence these outcomes. METHODS: We conducted a systematic review of randomized controlled trials of probiotic supplementation that measured ITT in adults. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference(SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses examined the impact of moderator variables on SMD of ***: A total of 15 clinical trials with 17 treatment effects representing 675 subjects were included in this analysis. Probiotic supplementation was moderately efficacious in decreasing ITT compared to control, with an SMD of 0.38(95%cI: 0.23-0.53, P cally greater reductions in ITT with probiotics in subjects with vs without constipation(SMD: 0.57 vs 0.22, P constipation(R^2 = 38%, P centage of female subjects(R^2 = 26%, P = 0.02), and fewer probiotic strains(R^2 = 20%, P ctive of decreased ITT with probiotics in meta-regression. Medium to large treatment effects were identified with B. lactis HN019(SMD: 0.67, P ctis DN-173 010(SMD: 0.54, P c strains yielded negligible reductions in ITT relative to ***: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains.

关键词： constipation Gastrointestinal Intestinal transit time Meta-analysis Probiotics