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Rib Osteosynthesis for Sub-Acute Management of a Flail Chest in a Tertiary Centre in a Low-Middle Income Country of Sub-Saharan Africa: Case Report at Douala Laquintinie Hospital

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Open Journal of Thoracic Surgery 2024年第1期14卷 1-16页

作者： Fabrice Stéphane Arroye Betou Nyankoue Mebouinz Ferdinand Guy Aristide Bang Kobe Folkabo Zephany Banga Nkomo Douglas Moussa Seck Diop Abdoul Lahad Mbeng Marcella Derboise Christelle Biyouma Noel Essomba Souleyman Diatta Handy Eone Daniel arthur Essomba Hassan Ndiaye Maurice Aurelien Sosso Department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon Department of Surgery and Affiliated Disciplines Douala Laquintinie Hospital Douala Cameroon Department of Surgery and Specialties Yaoundé General Hospital Yaoundé Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service de Chirurgie Thoracique et Cardiovasculaire Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR des Sciences de la Santé Ziguinchor Sénégal

Background: Costal fracture surgical is still a debate, therefore we shall select between early and delay surgical management. Case Report: We are reporting two cases of post road traffic clash delay ribs fractures osteosynthesis involving a 63-year-old man with multistage fractures on the left and pulmonary pinning of one of the costal arches, complicated by a homolateral haemothorax and a 41-year-old man with a bilateral flail chest. Conclusion: The simple postoperative course and the immediate postoperative improvement in the patient’s clinical respiratory condition enabled us to discuss the time frame for management, in this case the indication for early or later surgery.

关键词： Flail Chest Fixation Plate Rib Fracture Osteosynthesis

Multiplex Rapid Test with Acceptable Diagnosis Performance as a Solution to Increase Diagnosis of Hepatitis B and C Viruses in Pregnant Women in an Area of High Prevalence of Both Hepatitis Viruses Associated with HIV

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Open Journal of Medical Microbiology 2024年第1期14卷 50-65页

作者： Catherine Boni-Cisse Nina Esther Onstira Ngoyi Hermione Dahlia Mossoro-Kpinde Noella Packo Rabi Senekian Hermann Ndoidet Koutou Coretha Bokia-Baguida Christelle Luce Bobossi-Gadia arthur Simplice Sombot-Ndicky Daniel Yvon Gonessa Freddy Samuel Ngbonga Konzapa Voulou Christian Diamant Mossoro-Kpinde Alassane OUATTARA National Center of Medical Oncology and Radiotherapy Abidjan Ivory Cost Department of Microbiology UFR of Medical Sciences University of Cocody Abidjan Ivory Cost Laboratory of Bacteriology-Virology of Teaching Hospital Center of Brazzaville Brazzaville Republic of Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Republic of Congo Department of Labor Medicine Service of HIV and STDs Control in the Workplace Bangui Central African Republic (CAR) Faculty of Health Sciences University of Bangui Bangui Central African Republic National Reference Center of Sexually Transmitted Diseases and Antiretroviral Therapy Bangui Central African Republic National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Medicine Department District Hospital of Alindao Alindao Ouaka Prefecture Central African Republic Doctoral School of Sciences and Technology University of Bangui Bangui Central African Republic Coordination of Specialized Study of Clinical Biology University of Bangui Bangui Central African Republic Doctors without Borders Hospital Sica BanguiCRA Laboratory of Medical Analysis of Teaching Hospital Center Mother Elisabeth DOMITIEN of Bimbo Bimbo Central African Republic

Background and Objective: HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of HIV, HCV and HBV co-infections in pregnant women at Bangui Community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. HIV, HCV antibodies and HBV antigens were detected using Exacto Triplex? HIV/HCV/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of HIV and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of HIV, HBV, and HCV viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for HIV-HBV, 10.2% for HIV-HCV, 14.7% for HBV-HCV and 6.5% for HIV-HBV-HCV. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 FCFA (60 Euros) by ELISA compared to 10,000 FCFA (15.00 Euros) with Exacto Triplex? HIV/HCV/AgHBs (BioSynex, Strasbourg, France). Conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.

关键词： HIV-HCV-HBV Co-Infection Multiplex Immunochromatographic Rapid Test Central Africa Serology Test Cost Diagnostic Accessibility

Recurrences for Callan's Generalization of Narayana Polynomials

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Journal of Systems Science & Complexity 2022年第4期35卷 1573-1585页

作者： CHEN Xi YANG arthur Li Bo ZHAO James Jing Yu School of Mathematical Sciences Dalian University of TechnologyDalian116024China Center for Combinatorics LPMCNankai UniversityTianjin300071China School of Mathematics Tianjin UniversityTianjin300350China

By using Chen,Hou and Mu’s extended Zeilberger algorithm,the authors obtain two recurrence relations for Callan’s generalization of Narayana *** on these recurrence relations,the authors further prove the real-roote... 详细信息

关键词： Asymptotic normality Callan’s Narayana polynomials central limit theorem local limit theorem real zeros

Resolving the age-related decline in central nervous system myelin turnover and drug discovery for oligodendroglial rejuvenation

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Neural Regeneration Research 2022年第12期17卷 2677-2678页

作者： Andrea Domenico Rivera arthur Morgan Butt Kasum Azim Institute of Biomedical and Biomolecular Sciences School of Pharmacy and Biomedical ScienceUniversity of PortsmouthPortsmouthUK Section of Human Anatomy Department of NeuroscienceUniversity of PaduaPaduaItaly Department of Neurology Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany

Myel i n genes are amongst the most dysregulated genes in the aged brain:Just over half of the weight of an entire adult human brain is attributed to myelin,which wraps around neuronal axons and is essential for superfast axonal conduction and neuronal *** the central nervous system,it is the function of specialized cells called oligodendrocytes(OLs)to make myelin,which is made up of lipids and *** are generated throughout life by a significant population of oligodendrocyte progenitor cells(OPCs)that are responsible for the lifelong generation of OLs and myelin,essential for learning,as well as repair following pathological insults(*** demyelinating diseases that include multiple sclerosis)(Simons and Nave,2015;Philips and Rothstein,2017).Changes in myelin content in the human brain over the lifespan of individuals have been well documented,as well as evidence of myelin loss in rodent models using classical histological approaches(Bartzokis et al.,2012;Soreq et al.,2017).

关键词： myelin system specialized

Next generation drug connectivity mapping for acquiring therapeutic agents to differentially regulate myelination

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Neural Regeneration Research 2023年第4期18卷 797-798页

作者： Kasum Azim Andrea Domenico Rivera arthur Morgan Butt Department of Neurology Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Institute of Biomedical and Biomolecular Sciences School of Pharmacy and Biomedical ScienceUniversity of PortsmouthSt Michael’s BuildingWhite Swan RoadPortsmouthUK Section of Human Anatomy Department of NeuroscienceUniversity of PaduaPaduaItaly

The need for new therapeutic approaches:Conventional drug discovery is a lengthy and expensive process,taking decades and billions of dollars to get a drug from bench to *** of the costs incurred are at the pre-clinical stages,between drug design and synthesis to delineating the cellular“Mechanisms of Action”(MoA).Notably,there is a very high risk of failure,and only a very small proportion of therapeutic agents reach later-phase clinical ***,drug repositioning has become a valuable strategy aimed at fast-tracking treatments into clinical use and improving the chances of therapeutic success.A novel addition to this approach is connectivity mapping,which defines cell-specific transcriptional responses to small molecules in disease-dependent *** commentary outlines how some of the latest innovations in connectivity mapping can be exploited for drug repurposing.

关键词： connectivity dollar therapeutic

Modified Appleby:experience improves short-term results,but is it enough?

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 740-742页

作者： arthur Marichez Laurence Chiche Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation Haut Levêque HospitalBordeaux University HospitalPessacFrance INSERM U1312-Team 3“Liver Cancers and Tumoral Invasion”-Bordeaux Institute of Oncology University of BordeauxTalenceFrance

The aim of this retrospective study(1)from one of the largest European centres of pancreatic surgery was to report the surgical and oncological results of a series of 71 distal pancreatectomies with monobloc resection of the celiac trunk(DP-CAR or modified Appleby)performed for locally advanced pancreatic cancer,over almost 20 years and comparing two periods:before 2013(n=16)and after 2014(n=55).

关键词： Modified Appleby pancreatectomy vascular resection pancreatic adenocarcinoma

Comment on:“Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant:the OCS Liver PROTECT randomized clinical trial”

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 267-269页

作者： arthur Marichez Jean-Philippe Adam Department of Hepato-Bilio-Pancreatic Surgery and Liver Transplantation Haut Lévêque HospitalCHU de BordeauxFrance

We read with great interest the paper by Markmann et ***“Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant:The OCS Liver PROTECT randomized clinical trial”(1).In this multicenter randomized clinical trial,the authors compared posttransplant outcomes for recipients who received donation after brainstem death(DBD)or donation after circulatory death(DCD)livers preserved using ischemic cold storage(ICS)or a portable normothermic machine perfusion(NMP)[Organ Care System(OCS)Liver].The primary endpoint was the incidence of early allograft dysfunction(EAD)as defined by Olthoff et ***(2).The trial was methodologically designed to test both non-inferiority on the primary endpoint,and superiority if non-inferiority was *** study was conducted from 2016 to 2019 at 20 US liver transplant programs.

关键词： Impact portable Liver

Microtextures on quartz grains from the Gulf of Mexico and the Mexican Pacific coastal sediments:Implications for sedimentary processes and depositional environment

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Journal of Palaeogeography 2022年第2期11卷 256-274页

作者： Jayagopal Madhavaraju John SArmstrong-Altrin Kandasamy Selvaraj Rathinam arthur James Estaci on Regional Del Noroeste Instituto de GeologíaUniversidad Nacional Aut onoma de MexicoHermosilloSonora 83000Mexico Universidad Nacional Aut onoma de Mexico Instituto de Ciencias Del Mary LimnologíaUnidad de Procesos Oce anicosy CosterosCiudad UniversitariaCiudad de Mexico 04510Mexico Department of Geological Oceanography and State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen UniversityXiamenChina Department of Marine Science Bharathidasan UniversityTiruchirapalli620024Tamil NaduIndia

Microtexture analyes on quartz from coastal sediments of the Gulf of Mexico and the Mexican Pacific Coast reveal 35 and 30 types of microtextures,respectively,which were grouped into mechanical,mechanical/chemical and chemical categories based on their mode of *** of chemical origin are rarer in the El Carrizal than in the Manzanillo beach sediments of the Mexican Pacific *** of mechanical origin like straight and curved scratches,pits,broken edges,and V-shaped marks indicate high energy,fluvial to marine depositional *** scarcity to absence of chemical features suggest that the energy level was higher at the Mexican Pacific coast than on the Gulf of Mexico coast.V-shaped marks are common in the Gulf of Mexico sediments,whereas they are abundant in the quartz grains from the Mexican Pacific *** frequency and density of V-shaped marks are produced by exceedingly high wave velocity during storm events or *** of V-shaped marks with fresh surfaces of quartz grains from the Mexican Pacific coast indicate an extremely high-energy impact *** quartz grains from the El Carrizal beach of the Mexican Pacific coast have abundant closely spaced Vshaped marks with fewer fresh *** high frequency of V-shaped marks is mainly linked to grain-tograin collision,typically associated with high-energy sub-aqueous conditions with a large volume of sedimentary particles in the water column that are produced during a tsunami or storm *** contrast,many quartz grains from the Gulf of Mexico have large fresh surfaces with moderate percentages of V-shaped marks that might have been produced by high-energy waves with low sediment concentrations during storm events.

关键词： Microtextures Quartz grains V-shaped marks Tsunami and storm events Sedimentary processes

Acupuncture Legislation in Virginia,United States:A Personal Experience and Beyond

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Chinese Medicine and Culture 2022年第4期5卷 248-252页

作者： arthur Yin Fan American TCM Association ViennaVA 22182USA McLean Center for Complementary and Alternative Medicine PLCViennaVA 22182USA

Virginia was once considered as one of three states in the United States that was particularly resistant to acupuncture and its legislation,due to the historically strong conservative force in *** this article,the author aims to review and discuss the history and the current situation of acupuncture legislation in Virginia,and provides some insights for the related legislations in other states and at federal *** study was based on author’s personal experience and an interview with *** Herdrich,former president of the Acupuncture Society of Virginia,who made the biggest contribution to this *** by the Acupuncture Society of Virginia,and supported by the School Tai Sophia Institute,Virginia acupuncture legislation began in 1988 and the law was implemented in *** is the 27th state in the United States to legalize acupuncture practice,and it has been 28 years since *** author’s insights are:the first important factor is dedications as the persistent efforts in legislation usually take many years to *** second factor is the strategy,that is,legislation through the executive or administrative system is probably a much easier route or shortcut.

关键词： Acupuncture Legislation Traditional Chinese medicine Virginia