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Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma:real-life Data on Liver Disease,Treatment and Prognosis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1106-1117页

作者： Xavier Adhoute Olivia Pietri Guillaume Pénaranda Thomas Wolf Patrick Beaurain Olivier Monnet arthur laquière Justine Bonomini Frédéric Neumann Olivier Levrel Jean-Pascal Buono Xavier Hanna Paul Castellani HervéPerrier Marc Bourliere Rodolphe Anty Department of Gastroenterology and Hepatology Hôpital Saint-JosephMarseilleFrance Department of Biostatistics AlphaBio-Biogroup LaboratoryMarseilleFrance Department of Radiology Hôpital Saint-JosephMarseilleFrance Department of Clinical research Hôpital Saint-JosephMarseilleFrance Medipath EguillesFrance Department of Hepatobiliary Surgery Hôpital Saint-JosephMarseilleFrance Department of Gastroenterology and Hepatology Hôpital Universitaire de l’ArchetNiceFrance

Background and Aims:Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)have common features and *** real-life study investigated their characteristics,treatment modalities,and ***:This retrospective comparative study was performed in 1,075 patients seen at one tertiary center between January 2008 and December *** survival(OS)was estimated by the Kaplan-Meier *** of iCCAs after histological and radiological review,and molecular profiling was ***:HCCs patients were more likely to have early-stage disease than iCCA *** patients were more likely to be female,especially those patients without cirrhosis(43%vs.17%).Cirrhosis was prominent among HCC patients(89%vs.34%),but no difference in underlying liver disease among cirrhotic patients was *** of HCC patients was 18.4(95%CI:6.4,48.3)months,that of iCCA patients was 7.0(95%CI:3.4,20.1)*** of Barcelona Clinic Liver Cancer C HCC patients was 7.8(95%CI:4.3,14.2)months,that of advanced/metastatic iCCA patients was 8.5(95%CI:5.7,12.3)*** patients treated with sorafenib,OS was longer in HCC patients who received subsequent tyrosine kinase inhibitor *** significant OS difference was found between iCCA patients with and without cirrhosis or according to histological subtype.A targetable molecular alteration was detected in 50%of the iCCA ***:In this French series,cirrhosis was common in iCCA,which showed etiological factors comparable to those of HCC,implying a distinct oncogenic *** entities had a dismal prognosis at advanced ***,systemic therapies sequencing in HCC and molecular profiling in iCCA offer new insights.

关键词： Intrahepatic cholangiocarcinoma Hepatocellular carcinoma Cirrhosis NASH Oncogenic alterations

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Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue

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World Journal of Gastroenterology 2019年第36期25卷 5530-5542页

作者： arthur laquière Arnaud Lagarde Bertrand Napoléon Raphael Bourdariat Alexandre Atkinson Gianfranco Donatelli Bernard Pol Laurence Lecomte Laurence Curel Romina Urena-Campos Thierry Helbert Vincent Valantin Francois Mithieux Jean Pascal Buono Philippe Grandval Sylviane Olschwang Department of Gastroenterology Saint Joseph Hospital Marseille 13008 France AP-HM Timone Hospital Marseille 13005 France RGDS Clairval Hospital Marseille 13009 France Aix-Marseille Univ INSERM MMG Marseille 13385 France AP-HM Conception Hospital Marseille 13385 France RGDS Jean Mermoz Hospital Lyon 69008 France RGDS Les Peupliers Hospital Paris 75013 France Department of Digestive Surgery Saint-Joseph Hospital Marseille 13008 France Department of Clinical research Saint Joseph Hospital Marseille 13008 France European Hospital Marseille 13003 France Pathological Anatomy and Cytology MEDIPATH Eguilles 13510 France

BACKGROUND DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. KRAS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanced neoplasia. Several studies recently demonstrated the ability of next-generation sequencing (NGS)analysis to detect DNA mutations in pancreatic CF, but few studies have performed a systematic comparative analysis between pancreatic CF and neoplastic surgical tissue (NT). The value of CF-NGS analysis indicators for determining surgical resection necessitates evaluation. AIM To confirm whether CF genomic profiles are a reliable malignancy predictor by comparing NGS mutational analyses of CF and NT. METHODS Patients requiring surgery for high-risk pancreatic cysts were included in a multicenter prospective pilot study. DNA from CF (collected by endoscopic ultrasound-guided fine needle aspiration (known as EUS-FNA)) and NT (collected by surgery) were analyzed by NGS. The primary objective was to compare the mutation profiles of paired DNA samples. The secondary objective was to correlate the presence of specific mutations (KRAS/GNAS, RAF/ PTPRD/CTNNB1/RNF43/POLD1/TP53) with a final cancer diagnosis. Sensitivity and specificity were also evaluated. reSULTS Between December 2016 and October 2017, 20 patients were included in this pilot study. Surgery was delayed for 3 patients. Concordant CF-NT genotypes were found in 15/17 paired DNA, with a higher proportion of mutated alleles in CF than in NT. NGS was possible for all pancreatic CF collected by EUS-FNA. In 2 cases, the presence of a KRAS/GNAS mutation was discordant between CF and NT. No mutations were found in 3 patients with NT or pancreatic cysts with high-grade dysplasia. The sensitivity and specificity of KRAS/GNAS mutations in CF to predict an appropriate indication for surgical resection were 0.78 and 0.62, respectively. The sensitivity and specificity of RAF/PTPRD/CTNNB1 /RNF43/POLD1/TP53 mutatio

关键词： Pancreatic cancer Pancreatic cystic neoplasms Pancreatic adenocarcinoma Malignancy prediction Neoplastic surgical tissue Pancreatic cystic fluid Molecular analysis Next-generation sequencing DNA mutations

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Distribution of licensed acupuncturists and educational institutions in the United States at the start of 2023,during the late stage of the COVID-19 pandemic

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Journal of Integrative Medicine 2024年第4期22卷 379-384页

作者： arthur Yin Fan De-guang He Anu Sangraula Sarah Faggert Alemi Amy Matecki American Traditional Chinese Medicine Association ViennaVA 22182USA McLean Center for Complementary and Alternative Medicine ViennaVA 22182USA New England School of Acupuncture Massachusetts College of Pharmacy and Health SciencesBostonMA 02115USA Lombardi Comprehensive Cancer Center Cancer Prevention and Control ProgramGeorgetown UniversityWashington DC 20057USA Eastern Roots Wellness PLCMcLeanVA 22101USA Sutter Health Alta Bates Summit Medical CenterOaklandCA 94609USA

This study was conducted to identify the number and density of active licensed acupuncturists(LAcs),as well as the number of accredited schools in acupuncture and Oriental medicine(AOM),as of January 1,2023,in the United States(U.S.).The number of active LAcs as of January 1,2023 was 34,524,potentially33,364 after removing license duplication in multiple states,among which the largest three states were California(with 7317 LAcs[21.19%of the total]),New York(5024[14.55%])and Florida(2644[7.66%]).The total number of LAcs decreased by 8.87%from 2018,and fell short of our projected number of LAcs in 2023 by 9037,or 20.75%.The overall LAc density in the *** as the number of LAcs per 100,000 populationDwas 10.36,less than in *** were 56 active,accredited AOM schools which offered a total of 147 programs(121 at the level necessary for licensing[entry-level],12 for an advanced practicing degree[advanced-level],and 14 for certifications).Broken down further,offerings included 50 master's degrees in acupuncture,40 master's degrees in Oriental medicine,31 entry-level doctorate degrees(10 in acupuncture and 21 in acupuncture plus Chinese herbal medicine),and 12advanced-level doctorate degrees in *** certification programs included one in East-Asian Medical Bodywork and 13 in *** these schools in 2023,institutions in the West and East Coast states comprised 67.86%(decreased from 77.42%in 2018)of the national ***,Florida and Illinois represented 39.29%.There were 48 jurisdictions with acupuncture practice laws in *** data suggests that the acupuncture profession in the *** been significantly impacted during the coronavirus disease 2019 pandemic.

关键词： Acupuncturist Acupuncture educational institution Distribution Density Oriental medicine United States

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Analysis of Gestational Diabetes Mellitus (GDM) and Its Impact on Maternal and Fetal Health: A Comprehensive Dataset Study Using Data Analytic Tool Power BI

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Journal of Data Analysis and Information Processing 2024年第2期12卷 232-247页

作者： Shahistha Jabeen Hashim arthur McAdams Department of Technology Management University of Bridgeport Bridgeport USA

Gestational Diabetes Mellitus (GDM) is a significant health concern affecting pregnant women worldwide. It is characterized by elevated blood sugar levels during pregnancy and poses risks to both maternal and fetal health. Maternal complications of GDM include an increased risk of developing type 2 diabetes later in life, as well as hypertension and preeclampsia during pregnancy. Fetal complications may include macrosomia (large birth weight), birth injuries, and an increased risk of developing metabolic disorders later in life. Understanding the demographics, risk factors, and biomarkers associated with GDM is crucial for effective management and prevention strategies. This research aims to address these aspects comprehensively through the analysis of a dataset comprising 600 pregnant women. By exploring the demographics of the dataset and employing data modeling techniques, the study seeks to identify key risk factors associated with GDM. Moreover, by analyzing various biomarkers, the research aims to gain insights into the physiological mechanisms underlying GDM and its implications for maternal and fetal health. The significance of this research lies in its potential to inform clinical practice and public health policies related to GDM. By identifying demographic patterns and risk factors, healthcare providers can better tailor screening and intervention strategies for pregnant women at risk of GDM. Additionally, insights into biomarkers associated with GDM may contribute to the development of novel diagnostic tools and therapeutic approaches. Ultimately, by enhancing our understanding of GDM, this research aims to improve maternal and fetal outcomes and reduce the burden of this condition on healthcare systems and society. However, it’s important to acknowledge the limitations of the dataset used in this study. Further research utilizing larger and more diverse datasets, perhaps employing advanced data analysis techniques such as Power BI, is warranted to corro

关键词： Gestational Diabetes Visualization Data Analytics Data Modelling Pregnancy Power BI

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Smart contract applications in the built environment: How prepared are Nigerian construction stakeholders?

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Frontiers of Engineering Management 2024年第1期11卷 50-61页

作者： Andrew EBEKOZIEN Clinton AIGBAVBOA Samuel Adeniyi ADEKUNLE Mohamad Shaharudin SAMSURIJAN John ALIU Bernard Martins arthur-AIDOO Godpower Chinyeru AMADI Department of Construction Management and Quantity Surveying University of JohannesburgJohannesburg 2006South Africa School of Social Sciences Universiti Sains MalaysiaGelugor11800 USM PenangMalaysia Department of Quantity Surveying Auchi PolytechnicAuchiNigeria Institute for resilient Infrastructure Systems College of EngineeringUniversity of GeorgiaAthensGA 30602USA Department of Building Technology Faculty of Built EnvironmentAccra Technical UniversityAccraGhana Nigerian Institute of Management Port HarcourtNigeria

Studies have demonstrated that advanced technology,such as smart contract applications,can enhance both pre-and post-contract administration within the built environment *** contract technology,exemplifying blockchain technologies,has the potential to improve transparency,trust,and the security of data transactions within this ***,there is a dearth of academic literature concerning smart contract applications within the construction industries of developing countries,with a specific focus on ***,this study seeks to explore the relevance of smart contract technology and address the challenges impeding its adoption,offering strategies to mitigate the obstacles faced by smart contract *** investigate the stakeholders,this research conducted 14 virtual interview sessions to achieve data *** interviewees encompassed project management practitioners,senior management personnel from construction companies,experts in construction dispute resolution,professionals in construction software,and representatives from government construction *** data obtained from these interviews underwent thorough analysis employing a thematic *** study duly recognizes the significance of smart contract applications within the *** the 12 identified barriers,issues such as identity theft and data leakage,communication and synchronization challenges,high computational expenses,lack of driving impetus,excessive electricity consumption,intricate implementation processes,absence of a universally applicable legal framework,and the lack of a localized legal framework were recurrent impediments affecting the adoption of smart contract applications within the *** study also delves into comprehensive measures to mitigate these *** conclusion,this study critically evaluates the relevance of smart contract applications within the built environment,with a specific focus on promoting their *** may serve

关键词： built environment industry digitalization Nigeria smart contract technological revolution

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Effects of the concentration and nature of total dissolved solids in drinking water on feed intake, nutrient digestion, energy balance,methane emission, ruminal fermentation, and blood constituents in different breeds of young goats and hair sheep

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Animal Nutrition 2024年第1期16卷 84-95页

作者： Amlan Kumar Patra Luana Paula dos Santos Ribeiro Hirut Yirga Adekayode O.Sonibare Ahmed R.Askar Ali H.Hussein Ryszard Puchala arthur Louis Goetsch American Institute for Goat research Langston University Animal and Poultry Nutrition Department Desert Research Center Agriculture Food and Natural ResourcesEastern New Mexico University

Understanding how different livestock species and breeds respond to consumption of brackish water could improve usage of this ***,Angora,Boer,and Spanish goat doelings and Dorper,Katahdin,and *** ewe lambs (6 animals per animal type[AT];initial age=296±2.1 days)consuming water with varying concentrations of minerals of a natural brackish water source (BR) and sodium chloride (NaCl;SL) were used to determine effects on water and feed intake,nutrient digestion,heat energy,methane emission,ruminal fluid conditions,and blood constituent *** were 6 simultaneous 6 (water treatments[WT])×6 (AT) Latin squares with 3-wk *** WT were fresh (FR),BR alone (100-BR),a similar total dissolved solids (TDS) concentration as 100-BR via NaCl addition to FR (100-SL),BR with concentrations of all minerals increased by approximately 50%(150-BR),a similar TDS level as 150-BR by NaCl addition to FR (150-SL),and a similar 150 TDS level achieved by addition of a 1:1 mixture of BR minerals and NaCl to 100-BR (150-BR/SL).Concentrations (mg/kg) in BR were 4928 TDS,85.9 bicarbonate,224.9 calcium,1175 chloride,60.5 magnesium,4.59 potassium,1387sodium,1962 sulfate,and 8.3 boron,and TDS in other WT were 209,5684,7508,8309,and 7319 mg/kg for FR,100-SL,150-BR,150-SL,and 150-BR/SL,*** were very few significant effects of WT or AT×WT interactions,although AT had numerous *** intake was affected by AT (P=0.02)and WT (P=0.04),with greater water intake for 150-SL than for FR,100-BR,100-SL,and *** matter intake among AT was lowest (Pred among AT (Pre similar among *** aldosterone concentration was higher (Presilient to these WT regardless of mineral source and concentrations,with TDS less than 8300 mg/kg,which did

关键词： Goats Hair sheep Nutrient utilization Ruminal fermentation Salinity Water quality

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Unveiling the secrets of diatom-mediated calcification: Implications for the biological pump

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Science China Earth Sciences 2024年第09期67卷 2895-2909页

作者： Yiwen PAN Yifan LI Chen-Tung arthur CHEN Zong-Pei JIANG Wei-Jun CAI Yunwen SHEN Zesheng DING Qixian CHEN Yanan DI Wei FAN Chenba ZHU Ying CHEN Ocean College Zhejiang University Hainan Institute of Zhejiang University Department of Oceanography Sun Yat-Sen University School of Marine Science and Policy University of Delaware Carbon Neutral Innovation research Center Xiamen University

Siliceous diatoms are one of the most prominent actors in the oceans, and they account for approximately 40% of the primary production and particulate organic carbon export flux. It is believed that changes in carbon flux caused by variations in diatom distribution can lead to significant climate shifts. Although the fundamental pathways of diatom-driven carbon sequestration have long been established, there are no reports of CaCO3precipitation induced by marine diatom species. This manuscript introduces novel details regarding the enhancement of aragonite precipitation during photosynthesis in Skeletonema costatum in both artificial and natural seawater. Through direct measurements of cell surfaces via a pH microelectrode and zeta potential analyzer, it was determined that the diatom-mediated promotion of CaCO3precipitation is achieved through the creation of specific microenvironments with concentrated [CO32–] and [Ca2+] and/or the dehydrating effect of adsorbed Ca2+.Based on this mechanism, it is highly plausible that diatom-mediated calcification could occur in the oceans, an assertion that was supported by the significant deviation of total alkalinity（TA） from the conservative TA-salinity mixing line during a Skeletonema costatum bloom in the East China Sea and other similar occurrences. The newly discovered calcification pathway establishes a link between particulate inorganic and organic carbon flux and thus helps in the reassessment of marine carbon export fluxes and CO2sequestration efficiency. This discovery may have important ramifications for assessing marine carbon cycling and predicting the potential effects of future ocean acidification.

关键词： Biological carbon pump Calcification Counter carbonate pump Diatom bloom Skeletonema costatum

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Tacrolimus-induced posterior reversible encephalopathy syndrome following liver transplantation

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World Journal of Transplantation 2024年第2期14卷 1-7页

作者： arthur Dilibe Lakshmi Subramanian Tracy-Ann Poyser Osejie Oriaifo Ryan Brady Sashwath Srikanth Olanrewaju Adabale Olayiwola Akeem Bolaji Hassam Ali Department of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine Unity Health-White County Medical CenterSearcyAR 72143United States Department of Physical Medicine and rehab ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine University of Maryland Capital Region HealthLargoMD 20774United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States

In this editorial,we talk about a compelling case focusing on posterior reversible encephalopathy syndrome(PreS)as a complication in patients undergoing liver transplantation and treated with ***(FK 506),derived from Streptomyces tsukubaensis,is a potent immunosuppressive *** inhibits Tcell transcription by binding to FK-binding protein,and is able to amplify glucocorticoid and progesterone *** effectively prevents allograft rejection in transplant patients but has adverse effects such as Tacrolimus-related *** presents with various neurological symptoms alongside elevated blood pressure,and is primarily characterized by vasogenic edema on *** computed tomography detects initial lesions,magnetic resonance imaging,especially the Fluid-Attenuated Inversion recovery sequence,is superior for diagnosing cortical and subcortical *** discussion centers on the incidence of PreS in solid organ transplant recipients,which ranges between 0.5 to 5+ACU-,with varying presentations,from seizures to visual *** case of a 66-year-old male status post liver transplantation highlights the diagnostic and management challenges associated with Tacrolimus-related *** evident in the parietal and occipital lobes,PreS underlines the need for heightened vigilance among healthcare *** editorial emphasizes the importance of early recognition,accurate diagnosis,and effective management of PreS to optimize outcomes in liver transplant *** case further explores the balance between the efficacy of immunosuppression with Tacrolimus and its potential neurological risks,underlining the necessity for careful monitoring and intervention strategies in this patient population.

关键词： Posterior reversible encephalopathy syndrome Liver transplantation Tacrolimus Immunocompromised patients Neurological complications Solid organ transplant

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Axonal Conduction Velocity: A Computer Study

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Journal of Applied Mathematics and Physics 2024年第1期12卷 60-71页

作者： arthur D. Snider Aman Chawla Salvatore D. Morgera Department of Electrical Engineering University of South Florida Tampa USA Department of Computer Science and Engineering Indian Institute of Technology New Delhi India

This paper derives rigorous statements concerning the propagation velocity of action potentials in axons. The authors use the Green’s function approach to approximate the action potential and find a relation between ... 详细信息

关键词： Neuron Axon Action Potential Conduction Velocity Internode

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Is magnesium deficiency the major cause of needle chlorosis of Pinus taeda in Brazil?

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Journal of Forestry research 2024年第2期35卷 209-221页

作者： Antônio Carlos Vargas Motta Shizuo Maeda Valdécio dos Santos dos Santos Rodrigues Tamires Maiara Ercole Stephen arthur Prior Ana Elisa Lyra Brumat Amanda Pacheco Cardoso Moura Julierme Zimmer Barbosa João Bosco Vasconcellos Gomes Department of Soil Sciences and Agriculture Engineering Federal University of ParanáR.dos Funcionários1540.CuritibaParanáCEP 80035‑050Brazil Brazilian Agricultural research Company Embrapa FlorestasEstr.da Ribeira–Br‑476Km 111–Parque Monte Castelo.ColomboParanáCEP 83411‑000Brazil United States Department of Agriculture‑Agricultural research Service USDA-ARS National Soil Dynamics Laboratory411 South Donahue DriveAuburnAL 36832USA reforestation remasa Rodovia PR 170–Km 522.BiturunaParanáCEP 84640‑000Brazil Federal Institute of Southeast of Minas Gerais R.Luz Interior360.Juiz de ForaMinas Gerais CEP 36030‑713Brazil

Needle chlorosis(NC)in Pinus taeda *** in Brazil becomes more frequent after second and third harvest rotation *** a study to identify factors contributing to yellowing needle chorosis(YNC),trees were grown in soils originating from contrasting parent materials,and soils and needles(whole,green and chlorotic portions)from 1-and 2-year-old branches and the first and second needle flush release at four sites with YNC on *** were analyzed for various elements and *** soils had very low base levels(Ca^(2+),Mg^(2+)and K^(+))and P,suggesting a possible lack of multiple *** symptoms started at needle tips,then extended toward the needle base with *** flush needles had longer portions with YNC than second flush needles *** from the lower crown also had more symptoms along their length than those higher in the *** were similar to those reported for *** chlorotic portions,Mg and Ca concentrations were well below critical values;in particular,Mg levels were only one third of the critical value of 0.3 g kg^(-1).Collectively,results suggest that Mg deficiency is the primary reason for NC of *** in various parent soils in Brazil.

关键词： Nutritional deficiency Forest management Soil depletion Pine foliar analysis Needle chlorosis

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