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Modified malleable prosthesis with a fixed mesh:case series for the Ghattas technique

Asian Journal of Andrology 2022年第2期24卷 167-170页

作者： Osama Ghattas Mohamed Fahmy Doheim Hossam Kotb arthur l burnett Dar-elzokora Center of Andrology Alexandria 21500Egypt Alexandria Faculty of Medicine Alexandria UniversityAlexandria 21131Egypt Department of Urology Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Penile prosthetic implantation represents a cornerstone for patients with organic erectile dysfunction(ED)that is refractory,unsatisfactory,or contra-indicated for other approved medical or mechanical *** this study,we introduce the“Ghattas technique,”wherein we constructed a polypropylene mesh sheath that surrounds and is fixed to a 13-mm malleable prosthesis cylinder,which can increase the cylinder diameter for cases that need a larger *** patients underwent preoperative evaluation and completed the five-item International Index of Erectile Function questionnaire(IIEF-5).Postoperative outcomes were evaluated by IIEF-5 and Erectile Dysfunction Inventory of Treatment Satisfaction(EDITS)questionnaires at final *** mean age of the 23 included patients was 57.9(standard deviation[s.d.]:11.4)years and the mean duration of ED was 8.5(s.d.:7.9)*** improvement was determined by comparing mean preoperative and postoperative IIEF-5 scores(8.3[s.d.:3.9]vs 24.6[s.d.:0.6],Plarger than 13 *** studies are needed to confirm these results.

关键词： erectile dysfunction mesh penile prosthesis surgical technique

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Postphalloplasty urinary function test:an observational study of novel outcome instrument to capture urinary dysfunction and quality of life after phalloplasty

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Asian Journal of Andrology 2022年第6期24卷 570-574页

作者： James l liu lauren Eisenbeis Stephanie Preston arthur l burnett Heather N DiCarlo Devin Coon The James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins University School of MedicineBaltimoreMD 21287USA Department of Plastic and Reconstructive Surgery Johns Hopkins School of MedicineBaltimoreMD 21287USA Johns Hopkins Center for Transgender Health Johns Hopkins MedicineBaltimoreMD 21287USA Department of Surgery University of Texas SouthwesternDallasTX 75370USA

Due to growing social acceptance,there has been an increasing number of gender-affirmation surgeries performed in North *** research in this patient population focuses on surgical outcomes and advancing ***,little work has been done to study functional *** better evaluate urinary dysfunction in the postphalloplasty trans men patient population,our group developed a novel patient-reported outcome instrument-the postphalloplasty urinary function test(PP UFT)and protocol to measure postvoid urethral volume(PVUR),and we present our preliminary *** conducted a cross-sectional pilot study in a cohort of 15 adult trans men who had undergone phalloplasty with urethral lengthening surgery between 2018 and *** had stable urinary function via the neophallus at the time of *** filled out the PP UFT and were asked to record their PVUR as per our *** average PP UFT score was 8.9 out of 40 and the average quality-of-life(QOl)score was *** dribbling constituted the major complaint and on average comprised 63.2%of the reported PP UFT *** average PVUR was 2.2 ml(range:0.5-5.6 ml).There was a positive correlation between higher PP UFT and worse-reported quality of life(Ple urology have limitations for accurately capturing urinary dysfunction in this specific patient *** combination of PP UFT and PVUR measurement offers potential for quantifying urinary function and quality of life in patients who undergo *** studies will validate these instruments.

关键词： gender affirmation gender surgery phalloplasty postvoid urethral residual urethral lengthening urinary dysfunction

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NADPH oxidase： recent evidence for its role in erectile dysfunction

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Asian Journal of Andrology 2008年第1期10卷 6-13页

作者： liming Jin arthur l.burnett Department of Urology The James Buchanan Brady Urological Institute Johns Hopkins Medical Institutions Baltimore MD 21287 USA

Important roles for reactive oxygen species （ROS） in physiology and pathophysiology have been increasingly recognized. Under normal conditions, ROS serve as signaling molecules in the regulation of cellular functions. However, enhanced ROS production as a result of the activation of nicotinamide adenine dinucleotide phosphate （NADPH） oxidase contributes significantly to the pathogeneses of vascular diseases. Although it has become evident that increased ROS is associated with erectile dysfunction （ED）, the sources of ROS in the penis remain largely unknown. In recent years, emergent evidence suggests the possible role of NADPH oxidase in inducing ED. In this review, we examine the relationship between ROS and ED in different disease models and discuss the current evidence basis for NADPH oxidase-derive＇d ROS in ED.

关键词： reactive oxygen species erectile function superoxide penis nitric oxide

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阴茎癌改良临床病理肿瘤分期预后意义分析

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癌症 2019年第6期38卷 261-271页

作者： Zai-Shang li Antonio Augusto Ornellas Christian Schwentner Xiang li Alcides Chaux Georges Netto arthur l.burnett Yong Tang Jiun Hung Geng Kai Yao Xiao-Feng Chen Bin Wang Hong liao Nan liu Peng Chen Yong-Hong lei Qi-Wu Mi Hui-lan Rao Ying-Ming Xiao Qi-lin Wang Zi-Ke Qin Zhuo-Wei liu Yong-Hong li Zi-Jun Zou Jun-Hang luo Hui li Hui Han Fang-Jian Zhou 深圳市人民医院泌尿外科暨南大学第二临床学院广东深圳518060 Department of Urology Johns Hopkins UniversityBaltimoreMD 21218USA 广西医科大学附属肿瘤医院泌尿外科广西南宁530021 高雄医科大学附属医院泌尿外科台湾高雄807 郴州市第一人民医院泌尿外科湖南郴州423000 广州医科大学肿瘤中心泌尿外科广东广州510000 四川省肿瘤医院泌尿外科四川成都610041 重庆市肿瘤医院&肿瘤研究所&癌症中心泌尿肿瘤外科重庆400040 新疆医科大学附属肿瘤医院泌尿外科新疆乌鲁木齐830011 云南省肿瘤医院昆明医科大学第三附属医院泌尿外科云南昆明650118 东莞市人民医院泌尿外科广东东莞523059 中山大学肿瘤防治中心华南肿瘤学国家重点实验室肿瘤医学协同创新中心广东广州 510060 中山大学肿瘤防治中心病理科广东广州510060 中山大学附属第一医院泌尿外科广东广州510000 香港中文大学病理学系香港999077 中山大学肿瘤防治中心泌尿外科广东广州510060 Department of Urology Brazilian National Institute of Cancer and Hospital Mario KroeffRio de Janeiro 20230-130Brazil Section of Urology National Institute of CancerRio de Janeiro Brazil Department of Urology Diakonie Klinikum StuttgartGermany 四川大学华西医院泌尿外科四川成都610041 Department of Scientific Research Norte University1001-1925 AsuncionParaguay Department of Pathology Johns Hopkins UniversityBaltimoreMD21218USA

背景与目的第8版美国癌症联合会-TNM(American Joint Committee on Cancer tumor–node–metastasis,AJCC-TNM)分期基于的是一些回顾性单中心研究。本研究旨在分析分期的预后价值,并探讨加入脉管癌栓的改良的临床病理肿瘤分期能否提高... 详细信息

背景与目的第8版美国癌症联合会-TNM(American Joint Committee on Cancer tumor–node–metastasis,AJCC-TNM)分期基于的是一些回顾性单中心研究。本研究旨在分析分期的预后价值,并探讨加入脉管癌栓的改良的临床病理肿瘤分期能否提高对T2–3期阴茎癌患者预后预测的准确性。方法根据第8版AJCC-TNM分期对2000年至2015年在中国和巴西2个中心接受治疗的411例患者所组成的训练队列进行分期。采用C-indexes一致性系数进行预测模型的评估,Bbootstrap再抽样法(1000次)进行模型验证。采用来自4个大洲15个中心接受治疗的436例患者的数据进行外部验证。结果根据第8版AJCC-TNM分期的T2和T3期患者有存活率重叠(P=0.587)。脉管癌栓是转移和生存的重要预后因素(均P l,CSS)有显著影响(风险比=1.587,95%置信区间=1.253–2.011;P=0.001)。发生脉管癌栓的T2和T3期患者的CSS显著短于无脉管癌栓的患者(P <0.001)。因此,我们提出一种改良的临床病理分期,将第8版AJCC-TNM分期的T2和T3期细分为如下2个新类别:T2期肿瘤侵犯尿道海绵体和/或阴茎海绵体和/或尿道且无淋巴管侵犯;T3期肿瘤侵犯尿道海绵体和/或阴茎海绵体和/或尿道并有淋巴管侵犯。加入脉管癌栓的改良的分期显示出预后分层改善,各组间CSS差异显著(均P <0.005),患者预后预测的准确性高于第8版AJCC-TNM分期(C-index,0.739 vs. 0.696)。以上结果在外部验证队列中得到了确认。结论 T2–3期阴茎癌是异质性的,加入脉管癌栓的改良临床病理分期比第8版AJCC-TNM分期对阴茎癌患者的预后预测能力更强。

关键词：阴茎肿瘤淋巴结转移分期淋巴结清扫预后

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4D imaging of void nucleation,growth,and coalescence from large and small inclusions in steel under tensile deformation

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Journal of Materials Science & Technology 2022年第28期123卷 168-176页

作者： Yi Guo Timothy l.burnett Samuel A.McDonald Michael Daly Andrew H.Sherry Philip J.Withers Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Henry Royce Institute Department of MaterialsUniversity of ManchesterM139PLUK European Synchrotron Radiation Facility(ESRF) 6 rue J Horowitz38000 GrenobleFrance National Nuclear laboratory Chadwick HouseBirchwood ParkWarringtonWA36AEUK

Samples of SA508 grade 3 nuclear pressure vessel ferritic steel were subjected to tensile straining whilst being simultaneously imaged in 3D in real time using high resolution,high frame rate time-lapse synchrotron computed tomography(CT).This enabled direct observation of void development from nucleation,through growth to coalescence and final failure validating many inferences made post-mortem or by theoretical models,as well as raising new *** sparse,large inclusions were found to nucleate voids at essentially zero plastic strain(consistent with zero interfacial strength);these became increasingly elongated with *** contrast,a high density of small spherical voids were found to nucleate from the sub-micron cementite particles at larger strains(>200%)only in the centre of the necked(high triaxiality)*** interfacial strength approaching 2100 MPa was inferred and soon after their nucleation,these small voids coalesce to form internal microcracks that lead to the final failure of the *** surprisingly,under these conditions of generally low triaxial constraint the large voids are simply cut across and appear to play no significant role in determining the final *** implications of these results are discussed in terms of ductile fracture behaviour and the Gurson model for ductile fracture.

关键词： Void growth Ductile fracture Synchrotron X-ray tomography 4D imaging Bainitic steel

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