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Epidemiology and Histology Aspects of Breast Cancers of Women in Ivory Coast

Journal of Cancer Therapy 2012年第5期3卷 782-786页

作者： Justin N’Dah kouame Emile Troh Emmanuel Koffi Kouakou Brahima Doukouré arthur didier kouame Alain didier Abouna Benjamin Ahoua Effi Mohenou I Diomandé Department of Gynecology of the University Teaching of Cocody Abidjan Ivory Coast Department of Pathology of the University Teaching of Bouake Abidjan Ivory Coast Department of Pathology of the University Teaching of Cocody Abidjan Ivory Coast Department of Pathology of the University Teaching of Treichville Abidjan Ivory Coast

Breast cancer is a major public health problem both in developed countries, where it represents the first female cancer, and in developing countries, where its incidence is increasing. Purpose: The authors report the results of a study whose objective was to describe the epidemiological and pathological features of women’s breast cancers in Ivory Coast. Material and Methods: This is a retrospective descriptive study on breast cancer histologically confirmed and made from the records of pathology laboratories of the University Hospital in Abidjan. The study period was 24 years (1984-2007). The parameters studied were: frequency, age, risk factors, the macroscopic and histological aspects. Results: Women’s breast cancer was the second cancer among women (13.69%) after cervical cancer and represented 6.51% of cancers. The average age was 45.21 years ranging from 10 years to 85 years. Subjects from 35 to 44 years were the most affected (30.7%) and 8% of patients were under 30 years (n=61). Multiparity (53.55%) and lower socioeconomic level (79.63%) were associated. At the macroscopic level nodular aspects represented 47.62% of cases (n=301). Carcinomas were 92% (n=710) of histological types with 94.36% (n=692) of invasive carcinomas. Sarcomas (5.7%), lymphoma (2.1%) and Paget’s disease (0.3%) were also observed. With regard to prognostic, the grading of Scarff-Bloom and Richardson showed 26.75% (n=156) grade I, 60.64% (n=354) grade II and 12.52% (n=73%) grade III. Conclusion: In consideration of prognosis of advanced forms, an effort should be made for diagnosis and early treatment of women’s breast cancer in Ivory Coast.

关键词： Cancer Breast Epidemiology Pathology Ivory Coast

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Hysterectomy for Uterine Inversion: About Two Cases at University Hospital of Cocody (Abidjan—Ivory Coast)

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Open Journal of Obstetrics and Gynecology 2018年第4期8卷 368-375页

作者： Roland Adjoby Charles Kakou arthur kouame N’da kouame didier Abouna Joachim Konan Denis Effoh Christian Alla Ibrahima Balde Gynecology and Obstetrics Department University Hospital of Cocody Abidjan Ivory Coast Cote d’Ivoire Pathology Department University hospital of Cocody Abidjan Ivory Coast Cote d’Ivoire Gynecology and Obstetrics Department University Hospital Ignace Deen of Guinea Conakry Guinea

It is a rare clinical condition that may occur to two possible types: puerperal uterine inversion (IUP) and no puerperal uterine inversion (IUNP). Obstetrician will observe often only once in his professional practice. The risk of maternal mortality by hemorrhage is high. We report two cases of uterine inversion requiring a hysterectomy, including a postpartum mode and the other gynecological mode with young women. Hysterectomy remained a last resort treatment in the two types, to reduce morbidity. In the case of uterine inversion, the treatments without hysterectomy could be facilitated if the management is early and adequate. Furthermore, the support should be multidisciplinary and fast in the two types.

关键词： Uterine Inversion Delivery Hemorrhage Uterine Fibroma Hysterectomy

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Myometrium and Sigmoid Colon Metastatic Melanoma Simulating a Ewing Tumor: A Case Report

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Open Journal of Obstetrics and Gynecology 2017年第8期7卷 897-906页

作者： Adjoby Cassou Roland kouame arthur didier Alla Christian Effoh N’Drin Denis Konan Joachim Aloui Adil Andriamindimbison N. Zoly Ahounkeng Patrick Birembaut Philippe Abboud Pascal Department of Obstetrics and Gynecology University Hospital of Cocody Abidjan Cote d’Ivoire Department of Oncology Hospital Center of Soissons Soissons France Department of Gynecology Hospital Center of Soissons Soissons France Department of Pathology Hospital Center of Soissons Soissons France

Malignant melanomas or lymphoma of the skin are malignant tumors of the skin and/or the mucous membranes whose uterine metastases are rare. The secondary uterine localizations, although rare, must be evoked in front of a pelvic tumoral syndrome, or diffuse metastases and a personal past history of melanoma, even after a long time of remission. In our observation, the evolution of the tumor in the pelvis extended to the muscular structures of the uterus and the sigmoid colon of a 72 year old patient, what made it an exceptional case. The diagnosis of these secondary localizations is a diagnosis of elimination, almost always post-operative, made on the histopathological and immunocytochemical study of the surgical specimen, supported by cytogenetics, even molecular biology. The treatment is based on chemotherapy.

关键词： Melanoma Uterine Metastases Myometrium Ewing Tumor PNET

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Outcomes of Hemodialysis Patients in Public Centres in Abidjan from September 2018 to October 2021: Data from the Renal Registry of Cote d’Ivoire

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Open Journal of Nephrology 2024年第3期14卷 413-426页

作者： Sery Patrick Diopoh arthur Kanganga Serge didier Konan Kolo Claude Ouattara Marie-Dominique Kouadio Mohamed Alex Moudachirou Kouamé Hubert Yao Department of Medicine and Medical Specialties University Flix Houphout-Boigny Abidjan Cote dIvoire National Centre for Prevention and Treatment of Renal Failure Abidjan Cte dIvoire

Background: Hemodialysis is the most widely used renal replacement therapy in developing countries such as Cote d’Ivoire. Objective: To study the outcome of chronic hemodialysis patients in public centres in Abidjan using data from the Renal Registry of Cote d’Ivoire (2RCI). Method: This was a prospective analytical cohort study of End Stage Kidney Disease (ESKD) patients undergoing iterative hemodialysis in the network of public hemodialysis centres in Abidjan and who had been registered in the 2RCI register by September 2018. Results: Our study involved 363 cases out of 379 patients registered in the 2RCI registry database in 2018. The mean age of the patients was 47.3 ± 12.1 years, with a male predominance (sex ratio 1.97). In 70.24% of cases, they had no health insurance. The average duration of dialysis for our patients was 6.94 ± 4.1 years, with extremes of 2 and 28 years. This duration was less than 5 years in 44.3% of cases, between 6 and 10 years in 42.9% and more than 10 years in 12.6% of cases. The comorbidities found were hypertension in 95.6% of cases, diabetes in 7.8% and HIV in 4.6%. Anemia was found in 68% of cases and stroke in 8.6%. During the study period, 161 deaths were observed, representing a mortality rate of 44.35%. Acute lung oedema (29.8%), stroke (6.8%) and other cardiovascular diseases (19.3%) were the main causes of death. In multivariate analysis, factors such as age ≥ 65 years (HR = 3.66;CI 95% = 1.55 - 8.67;p = 0.003), “married/coupled” status (HR = 2.02;CI 95% = 1.24 - 3.31;p = 0.005) and normal weight at the start of dialysis (OR = 9.59, CI95% = 4.19 - 21.95;p = 0.001) were associated with the risk of death. Conclusion: Hemodialysis is performed in Abidjan on young patients. The mortality rate after three years of dialysis is very high. Hence the need to pursue the policy of decentralizing public centres and optimizing access to dialysis in terms of quality and quantity in order to improve patient survival.

关键词： Chronic Hemodialysis Death Renal Registry Cote d’Ivoire

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How Referred Patients Influence Cesarean Sections Rate Pattern: Analysis according to the Robson Classification

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Open Journal of Obstetrics and Gynecology 2017年第11期7卷 1132-1140页

作者： Koffi Achille Kouamé arthur didier Kakou Charles Adjoby Cassou Roland Diomande Fatoumata Alice Kimou Anicet N’Guessan Koffi Léon Pacome Obstetrics-Gynecology Department of the University Hospital Center of Cocody Abidjan Cote d’Ivoire

Objective: To improve the practice of cesarean section by analyzing the cesarean section according to Robson’s classification. Methodology: This was a cross-sectional and descriptive study carried out at the University Hospital of Cocody. It covered the Cesarean sections performed during the year 2015 and ranked according to the 10 groups of Robson. Results: The overall Cesarean section rate in 2015 was 42.8% (3100 cesarean sections for 7229 deliveries). Group 1 was the largest contributor to overall Cesarean section with a rate of 20.5% followed by Group 3 (18.6%), Group 5 (16.4%) and Group 10 (12.2%), unlike other data in the literature where groups were in descending order Groups 5, 1, 3. This difference was driven by medical evacuations and our working conditions. Conclusion: The Cesarean section rate is constantly increasing in our department. Referred patients played a huge role in the distribution of C-section along the Robson’s 10 groups classification.

关键词： Cesarean Section Robson Classification Evacuation Referred Patients

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Rupture of a Rudimentary Uterine Horn: A Case Report

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Open Journal of Obstetrics and Gynecology 2017年第7期7卷 748-752页

作者： Kouamé arthur didier Adjoby Cassou Roland Konan Joachim Effoh N’Drin Dénis Kakou Charles Diomandé Fatoumata Alice Koffi Soh Victor Kouakou Firmin Obstetrics and Gynaecology Department of the University Hospital of Cocody-Abidjan Abidjan C&ocirc te D’Ivoire

Pregnancy in an abnormal uterus is a high-risk situation in obstetrics. Uterus bicornis unicollis with a rudimentary horn is often discovered incidentally. The aim of this report is to warn obstetricians about recurrent abdominal pain in the second trimester of pregnancy without any cause identified. Pregnancy can proceed in the rudimentary horn. We presented a case of a rupture of the rudimentary horn which occurred at 25 weeks of amenorrhea in an unmarried 19-year-old primigravida. The rudimentary horn was removed after performing an emergency laparotomy for an intraperitoneal hemorrhage with signs of shock. This abnormality is often revealed by uterine rupture, which usually occurs in the second trimester of pregnancy. Conclusion: We emphasize the importance of early diagnosis of this uterine abnormality, before pregnancy if possible. Undiagnosed, this condition evolves towards uterine rupture during pregnancy and requires emergency surgery with excision of the rudimentary horn.

关键词： Uterine Rupture Abdominal Pregnancy Uterus Bicornis Rudimentary Uterine Horn

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Evolution of a Disseminated Peritoneal Leiomyomatosis: About a Case

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Open Journal of Obstetrics and Gynecology 2017年第7期7卷 742-747页

作者： Kouamé arthur didier Adjoby Cassou Roland Koffi Achille Konan K. Joachin Alla Christian Hervé Kouamé N’Da Justin I. S. Baldé Kouakou Firmin Obstetrics and Gynecology Department University Hospital of Cocody Abidjan C&ocirc te D’Ivoire Laboratory of Pathology University Hospital of Cocody Abidjan C&ocirc te d’Ivoire Obstetrics and Gynecology Department of Ignace Deen Hospital of Conakry Conakry Guinea

Disseminated peritoneal leiomyomatosis (DPL) is a benign tumor of smooth muscle tissue. It is rare and is characterized by the development of multiple peritoneal nodules simulating peritoneal carcinosis. Less than 200 cases have been reported in the literature so far. We are reporting a case of DPL detected during a Caesarean section 6 years ago in a 41-year-old female patient, G5P2. The patient underwent an elective iterative caesarean section at 38 weeks of amenorrhea for a fetus in breech presentation. During laparotomy, there was a marked regression of the peritoneal nodules varying in size from 0.1 to 0.5 cm. Histological examination showed a proliferation of smooth muscle fibers without mitosis, atypia or necrosis. DPL is a benign, confusing condition that simulates peritoneal carcinomatosis, which must be recognized as such in order to avoid a dilapidated and unnecessary surgical procedure.

关键词： Disseminated Peritoneal Leiomyomatosis Uterine Leiomyoma Caesarean Section

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Use of Ointment or Aqueous Extract of Neem(Azadirachta indica)for the Repair of Experimental Skin Lesions in Sheep

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American Journal of Plant Sciences 2020年第5期11卷 693-706页

作者： Tiago Luis Eilers Treichel Tales Dias do Prado Anaiza Simao Zucatto do Amaral Yeury de Sousa Gomes Lucas da Rocha Pinto Guilherme Toledo Martins arthur Toledo Martins didier Quevedo Cagnini Veterinary Surgery Service Faculty of Veterinary MedicineUniversity of Rio VerdeRio VerdeBrasil Clinical Laboratory Faculty of Veterinary MedicineUniversity of Rio VerdeRio VerdeBrasil Faculty of Veterinary Medicine University of Rio VerdeRio VerdeBrazil Department of Morphophysiology Institute of Biological SciencesUniversidade Federal de JataiJataiBrazil

The skin is considered the largest organ in the body and this protective barrier can be broken in some situations. The wound healing process is a complex mechanism. Based on the difficulties encountered for treatment, alternatives are sought and one of the options may be phytotherapy. Azadirachta indica, known as Nim, is perhaps one of the most widely known and used medicinal plants. This research aimed to evaluate the viability and effectiveness of therapy with Neem, in the form of ointment or aqueous leaf extract. Eighteen sheep were randomly divided into three groups and subjected to the creation of a 7 × 7 cm excision wound on the chest wall. After, treatment was started according to each group. Animals in G1 did not receive any treatment;in G2, the ointment of Neem was applied and animals in G3 were treated with the preparation of an aqueous solution of Neem leaves. Photographic images were recorded, in addition to blood collection for complete blood count and tissue biopsy. The wound area measurements showed no statistically significant difference between the groups (p > 0.05). Fibrinogen levels were not different, and there was no difference in platelet levels. In the histopathological evaluation, G2 registered a greater presence of ulceration, when compared to G3, on day 7. On day 14, G2 still had a greater amount of ulceration, differentiating from G1. G2 also registered a greater presence of crust and a higher score of granulation tissue, in the last evaluation period, compared to G3. Analyzing the results obtained in this research and taking into account the conditions in which the study was carried out, it is possible to conclude that the use of Neem was not effective in accelerating the rate of wound healing in sheep.

关键词： Phytotherapy Sheep Skin Wound

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Epidemiological and Histological Aspects of Women Genital Cancers in Cote d’Ivoire

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Open Journal of Obstetrics and Gynecology 2014年第9期4卷 516-523页

作者： Kouamé Justin N’Dah Brahima Doukoure Emile Troh N’Guessan Alphonse Aman Kouakou Emmanuel Koffi arthur didier Kouamé Ahoua Benjamin Effi Ahoua Francois de Salès D’Horpock Mohénou Isidore Jean-Marie Diomande Laboratory of Pathology University Hospital of CocodyAbidjanCôte d’Ivoire Department of Pathology Saint-Louis HospitalParisFrance Laboratory of Pathology University Hospital of BouakeBouakeCôte d’Ivoire Laboratory of Pathology University Hospital of TreichvilleAbidjanCôte d’Ivoire Department of Obstetrical Gynecology University Hospital of CocodyAbidjanCôte d’Ivoire

Genital cancers in women play an important role in cancer pathology in the developing countries. Objectives: This study aimed at clarifying the epidemiological and histopathological aspects of woman genital cancers in C?te d’Ivoire. Materials and Methods: This was a retrospective and descriptive study conducted in the anatomical pathology laboratories of the university hospitals in Abidjan. The study was carried out over a period of twenty-four years (1984-2007). The variables studied were: frequency, age, histological type and prognosis. Results: Genital cancers in women accounted for 41.28% (n = 2491) of cancer in women and 21% of cancers. The average age of patients was 46.65 years (range 2 - 88 years). The cervix (82.85%) was the main location followed by the ovary (8.6%). Histologically, carcinomas (92.93%) were the most common types of sarcomas. Cervical cancers were diagnosed at an average age of 47.36 years (range 2 to 88 years). Carcinomas were the predominant histological type (92.88%) with 57.4% (n = 450) diagnosed at pT2N0M0 stage. The average age of patients bearing ovarian cancer was 39.13 years (range 8 to 82 years).Common malignant epithelial tumours were the most common histological type (57.48%) (n = 123) followed by non-Hodgkin lymphoma (14.95%). Conclusion: Genital cancers in women are common and poorly prognosed in Cote d’Ivoire. The adoption of a policy of routine screening is needed to improve the prognosis of these tumours.

关键词： Cancer Genital Women Epidemiology-Histology-C?te d’Ivoire

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