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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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nano Research 2023年第5期16卷 7119-7133页

作者： Alexander v.Romashchenko Dmitrii v.Petrovskii Sergey Yu.Trotsky Ksenia n.Morozova nina B.Illarionova Maria v.Zhukova Elena v.Kiseleva marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

nanoparticles(nPs)can be transported via the nose-to-brain(n_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the n_(2)B transport are largely *** surveyed metal oxide/hydroxide nPs as magnetic resonance imaging(MRI)contrasts for quantitative n_(2)B *** containing divalent transition metals were the only ones capable of n_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-nPs were readily engulfed by olfactory receptor neurons(ORns)without disrupting olfactory sensing,we mapped their n_(2)B *** neurons,the Mn_(3)O_(4)-nPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** nPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-nPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the nPs was dependent on n-type Ca^(2+)channels and nMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-nP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORns,indicating a coupling of the nPs’n_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-nP n_(2)B transport odor ***,the nPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling n_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

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Attenuation correction technique for fluorescence analysis of biological tissues with significantly different optical properties

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Frontiers of Optoelectronics 2020年第4期13卷 360-370页

作者： Tatiana A.SAvELIEvA marina n.KURYAnOvA Ekaterina v.AKHLYUSTInA Kirill G.LInKOv Gennady A.MEEROvICH victor B.LOSCHEnOv Prokhorov General Physics Institute of the Russian Academy of Sciences Moscow 119991Russia national Research nuclear University MEPhl Moscow 115409Russia

During intraoperative fluorescence navigation to remove various neoplasms and during pharmacokinetic studies of photosensitizers in laboratory animals,in many cases,the ratio of photosensitizer accumulation in the tumor and normal tissue can reach>10-fold,which inevitably changes their optical *** the same time,the tumor formation process causes various metabolic and structural changes at cellular and tissue levels,which lead to changes in optical properties.A hardwaresoftware complex for the spectral-fluorescence studies of the content of fluorochromes in biological tissues with significantly different optical properties was developed,and it was tested on optical phantoms with various concentrations of photosensitizers,absorbers,and *** correct the influence of optical properties on the photosensitizer concentration analysis by fluorescence spectroscopy,we propose the spectrum-processing algorithm,which combines empirical and theory-based approaches.

关键词： fluorescence spectroscopy scattering absorption attenuation correction optical phantoms

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3-Phenyl/Pyridinyl Derivatives of <i>Trans</i>-2-(aryl/heteryl)vinyl-3<i>H</i>-quinazolin-4-ones: Synthesis and Fluorescent Properties

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International Journal of Organic Chemistry 2012年第1期2卷 56-63页

作者： Emiliya v. nosova Tatyana v. Stupina Galina n. Lipunova marina S. valova Pavel A. Slepukhin valery n. Charushin Department of Organic Chemistry Chemical Technology Institute Urals Federal University Ekaterinburg Russia Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciences Ekaterinburg Russia

novel 3-phenyl/pyridinyl-trans-2-(aryl/heteryl)vinyl-3H-quinazolin-4-ones 3a,b, 4a, 5a, 7a and their 6,7-difluoro de- rivatives 3c,d, 4b, 5b, 7b have been obtained by condensation of the correspondent 2-methylquinazolin-4-ones 1, 6 with aromatic (heterocyclic) aldehydes in the presence of ZnCl2 (AcOna) or by the reaction of 2-methyl-3,1-benzoxazin-4- ones 2 with the Shiff bases. Effects of aryl(heteryl) substituents on photophysical properties of (aryl/heteryl) quinazolinylethenes have been studied.

关键词： Styryl Benzazines Fluorinated Quinazolin-4-Ones Uv and FL Spectra X-Ray Trans-cis-Isomerisation 2-Methylquinazolinones 2-Methyl-3 1-benzoxazinones

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Assessment of Mercury in Diagnostic Biomaterials of Different Population Groups in Urban Areas of the Moscow Region

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Advances in Microbiology 2019年第7期9卷 571-580页

作者： Anatoly v. Gorbunov Sergey M. Lyapunov Irina n. Ilchenko marina v. Frontasyeva Sergey S. Pavlov Geological Institute of Russian Academy of Sciences Moscow Russian I. M. Sechenov First Moscow State Medical University (Sechenov University) Moscow Russian Frank Laboratory of neutron Physics Joint Institute for Nuclear Research Dubna Russian

The results of a survey of different population groups in urban areas of the Moscow Region (industry workers, residents of areas with increased anthropogenic load of mercury and conditionally pristine areas, cohorts of pregnant women and children) to assess the contents of mercury in samples of various diagnostic biomaterials taken during the course of research are presented. Mercury concentrations in venous and umbilical cord blood, urine, hair, and nails were determined by means of instrumental neutron activation analysis and cold vapor atomic absorption spectrometry. Peculiarities of selection, transportation, storage, and preparation for analysis of samples of hair, nails, urine and umbilical venous blood are described. The determined concentrations of mercury in the studied diagnostic biomaterials are compared with normal and thresholds values. Although increased mercury concentrations were observed in some cases, no significant exposure of mercury was evident in general in the study towns. A positive correlation between the degree of consumption of seafood during pregnancy and a high content of mercury in the analyzed diagnostic biomaterials was shown.

关键词： Mercury Hair nails Urine venous and Umbilical Cord Blood The Impact The Human

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novel method for the preparation of Cs-containing FAU（Y） catalysts for aniline methylation

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 70-76页

作者： Olga A. Ponomareva Polina A. Shaposhnik marina vo Belova Boris A. Kolozhvari Irina I. Ivanova Department of Chemistry Lomonosov Moscow State University Moscow 119991 Russia A.v. Topchiev Institute of Petrochemical Synthesis Moscow Russia

Cs-containing FAU（Y）-type zeolite catalysts were prepared by conventional and novel ion exchange procedures followed by incipient wetness impregnation with CsOH. The novel ion exchange procedure involved hydrothermal treatment of naY zeolite in aqueous solution of CsCl at 140-200 ℃ for 6-24 h. The samples were characterized by low-temperature nitrogen adsorption, X-ray fluorescence analysis, X-ray powder diffraction, scanning electron microscopy, 23na, 27Al and 133Cs magic angle spinning nuclear magnetic resonance, CO2 and nH3-Temperature programmed desorption. The results show that hydrothermal treatment at 200 ℃ allows to obtain higher degrees of ion-exchange （up to 83%） with respect to conventional method giving maximum 66%- 69%. Catalytic properties of Cs-containing FAU（Y） were studied in aniline methylation. The yield of nomethylani- line is shown to correlate with catalyst＇s basicity. The best catalyst performance was achieved over the catalyst with the highest ion-exchange degree impregnated with CsOH. The selectivity to n-methylaniline over this catalyst reached 96.4%.

关键词： FAU(Y) zeolite ion exchange with cesium aniline alkylation n-methylaniline

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Pb-Ca-Sn-Ba Grid Alloys for valve-Regulated Lead Acid Batteries

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Engineering（科研） 2013年第10期5卷 9-15页

作者： marina M. Burashnikova Irina v. Zotova Ivan A. Kazarinov Department of Physical Chemistry Saratov State University Named after N. G. Chernyshevsky Saratov Russia

The effect of barium additives on the process of anodic corrosion of lead-tin-calcium alloys in a 4.8 М sulfuric acid solution was studied. Cyclic voltammetry, impedance spectroscopy, weight loss measurements and scanning electronic microscope analysis have allowed exploring the oxidation process and characterizing the formed corrosion layer. According to our results, barium introduction into lead-tin-calcium alloys increases their hardness, reduces their electrochemical activity, and improves their corrosion stability. Reduction of the calcium content in the alloy can be compensated by adding barium. Barium dopation at lead-tin-calcium alloys decreases the resistance of the oxide layer formed on the grid surface, in a deeply discharged state, and raises its resistance during floating conditions and at a charged state of the positive electrode.

关键词： Lead-Acid Battery Lead Alloys Barium Corrosion Layer

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Fatty acids composition of erythrocytes in arterial hypertension associated with dyslipidemia

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Health 2013年第4期5卷 73-77页

作者： Tatyana P. novgorodtseva Yulia K. Karaman Tatyana A. Gvozdenko marina v. Antonyuk vera v. Knyshova vladivostok Branch of the Far Eastern Center of Physiology and Pathology of Respiration SB RAMN Institute of Medical Clima-tology and Rehabilitative Treatment Vladivostok Russia

Studied the fatty acid (FA) composition of erythrocyte membranes in patients with arterial hypertension associated with dyslipidemia. The fatty acid composition of erythrocyte membranes was studied by gaz chromatography. In all hypertensive patients are disturbed lipid FA composition of erythrocytes: increase in saturated fatty acids (15:0, 16:0), monoenic fatty acids (18:1n9, 18:1n7), polyunsaturated fatty acids (PUFA) family n6 (20:4n6), decrease in polyunsaturated fatty acids family n3:22:5n3, 22:6n3, the total value of n3 PUFA. Cells endogenous deficiency of n3 PUFA leads to the changes of the plasmatic membranes physicochemical properties, activation of eicosanoids synthesis with proinflammatory and vasoconstriction activity, the formation of the systemic inflammatory syndrome and conditions for the atherogenesis. Thus, structural and functional changes in erythrocyte membranes in hypertension developed as a part of the common systemic disorder of lipid metabolism.

关键词： Fatty Acids Arterial Hypertension Dyslipidemia

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Influence of the aspect ratio of nitrogen-doped carbon nanotubes on their piezoelectric properties

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Journal of Advanced Dielectrics 2022年第6期12卷 1-7页

作者： marina v.Il’ina Olga I.Soboleva nikolay n.Rudyk Maria R.Polyvianova Soslan A.Khubezhov Oleg I.Il’in Southern Federal University Institute of NanotechnologiesElectronics and Equipment Engineering Shevchenko St.2Taganrog347922Russia Southern Federal University Research Laboratory of Functional Nanomaterials Technology Shevchenko St.2Taganrog347922Russia

Recent studies have shown that nitrogen doping of carbon nanotubes(CnTs)can lead to the formation of piezoelectric properties in them,not characteristic of pure *** this work,nitrogen-doped CnTs were grown by plasma-enhanced chemical vapor deposition and the effect of the aspect ratio of the nanotube length to its diameter on its piezoelectric coefficient d33 was *** was observed that as the aspect ratio of the nanotube increased from 7 to 21,the value of d33 increased linearly from 7.3 to 10.7 pm/*** dependence is presumably due to an increase in curvature-induced polarization because of an increase in the curvature and the number of bamboo-like“bridges”in the nanotube cavity formed as a result of the incorporation of pyrrole-like nitrogen into the nanotube *** obtained results can be used in the development of promising elements of nanopiezotronics(nanogenerators,memory elements,and strain sensors).

关键词： Carbon nanotube nitrogen piezoelectric nanogenerator PFM

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SCREEnInG AnD MOLECULAR CHARACTERIZATIOn OF FUnGI CAPABLE OF LACCASE PRODUCTIOn FROM DIFFEREnT FOREST ECOSYSTEMS OF MICHOACAn STATE,MEXICO

SCREENING AND MOLECULAR CHARACTERIZATION OF FUNGI CAPABLE OF...

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中国菌物学会2016年学术年会

作者： Irum Mukhtar Gerardo vazquez-Marrufo Ma.Soledad vázquez-Garcidue?as marina Arredondo-Santoyo Centro Multidisciplinario de Estudios en Biotecnología CEMB Facultad de Medicina Vterinariay ZootecniaUniversidad Michoacana de San Nicolás de Hidalgo División de Estudios de Posgrado Facultad de Ciencias Médicasy Biológicas “Dr.Ignacio Chávez”Universidad Michoacana de San Nicolás de Hidalgo

The goal of this study was to isolate and molecular identification of basidiomycetes species with laccase activity from soil and vegetative mycelial aggregations in different forest *** species were isolated from soil and mycelia,using different techniques,samples collected from five different geographic regions with dominant vegetation of Pinusspp.,Abiesspp.,and Quercus spp.,in state of Michoacan,*** activity of fungal isolates was analyzed by guaiacol *** number of basidiomycetes with laccase activity were isolated from mycelialagrigations,collected from Atecuaro（pinus and oak forest）,Michoacán,*** of laccase positive fungi was carried out by sequence comparison and phylogenetic analysis of internal transcribed region（ITS1F-5.8S-ITS4B） of r DnA genes with reference taxa.A total of fourteen strains（14） with high laccase activity of basidiomycetes were identified in thirteen genera i.e.,Bjerkandera,Corticiaceae,Coriolopsis,Echinodontium,Ganoderma,Hexagonia,Irpex,Limonomyces,Psathyrella,Peniophora,Phlebiopsis,Trametes and Trichaptum.

关键词： laccase fungi basidomycetes guaiacol phylogenetic ITS region

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The Piks allele of the nLR immune receptor Pik breaks the recognition of AvrPik effectors of rice blast fungus

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Journal of Integrative Plant Biology 2023年第3期65卷 810-824页

作者： Gui Xiao Wenjuan Wang Muxing Liu Ya Li Jianbin Liu marina Franceschetti Zhaofeng Yi Xiaoyuan Zhu Zhengguang Zhang Guodong Lu Mark J.Banfield Jun Wu Bo Zhou State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterChangsha 410128China International Rice Research Institute Metro Manila 1301Philppines Guangdong Provincial Key Laboratory of High Technology for Plant Protection Plant Protection Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Department of Plant Pathology College of Plant ProtectionNanjing Agricultural Universityand Key Laboratory of Integrated Management of Crop Diseases and PestsMinistry of EducationNanjing 210095China State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Biochemistry and Metabolism John Innes CentreNorwich Research ParkNorwich NR47UHUK

Arms race co-evolution of plant–pathogen interactions evolved sophisticated recognition mechanisms between host immune receptors and pathogen effectors. Different allelic haplotypes of an immune receptor in the host mount distinct recognition against sequence or non-sequence related effectors in pathogens. We report the molecular characterization of the Piks allele of the rice immune receptor Pik against rice blast pathogen, which requires two head-to-head arrayed nucleotide-binding sites and leucine-rich repeat proteins. Like other Pik alleles, both Piks-1 and Piks-2 are necessary and sufficient for mediating resistance. However, unlike other Pik alleles, Piks does not recognize any known AvrPik variants of Magnaporthe oryzae. Sequence analysis of the genome of an avirulent isolate v86010 further revealed that its cognate avirulence(Avr) gene most likely has no significant sequence similarity to known AvrPik variants. Piks-1 and Pikm-1 have only two amino acid differences within the integrated heavy metal-associated(HMA) domain. Pikm-HMA interacts with AvrPik-A,-D, and-E in vitro and in vivo,whereas Piks-HMA does not bind any AvrPik variants. Characterization of two amino acid residues differing Piks-1 from Pikm-1 reveal that Piks-E229Q derived from the exchange of Glu229 to Gln229 in Piks-1 gains recognition specificity against AvrPik-D but not AvrPik-A or-E, indicating that Piks-E229Q partially restores the Pikm spectrum. By contrast,Piks-A261v derived from the exchange of Ala261 to val261 in Piks-1 retains Piks recognition *** conclude that Glu229 in Piks-1 is critical for Piks breaking the canonical Pik/AvrPik recognition pattern. Intriguingly, binding activity and ectopic cell death induction is maintained between Piks-A261v and AvrPik-D, implying that positive outcomes from ectopic assays might be insufficient to deduce its immune activity against the relevant effectors in rice and rice blast interaction.

关键词： AvrPik co-evolution nBS-LRR Piks recognition

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