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Are claudin-5 tight-junction proteins in the blood-brain barrier porous?

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Neural Regeneration Research 2020年第10期15卷 1838-1839页

作者： David Fisher shireen Mentor Department of Medical Biosciences University of the Western CapeBellvilleCape TownSouth Africa School of Health Professions University of MissouriColumbiaMOUSA

The capillaries of the brain are particularly special,as they are not simply conduits for blood,but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic *** endothelial cells(BECs)express a plethora of ion channels on its luminal and abluminal surfaces,namely:potassium(K^+)channels(i.e.,Kir2 and Kv1),chloride(Cl^)/bicarbonate(HCO3^–)channels,as well as a number of ion-solute exchangers(Redzic et al.,2011).

关键词： porous potassium solute

Antioxidant-induced reductive stress has untoward consequences on the brain microvasculature

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Neural Regeneration Research 2017年第5期12卷 743-744页

作者： David Fisher shireen Mentor Neurobiology Group Department of Medical Biosciences Faculty of Natural Sciences University of the Western Cape Bellville Cape Town South Africa School of Health Professions University of Missouri Columbia MO USA

All cells in the body metabolize oxygen in a series of reactions in the mitochondria to generate energy.A by-product of these reactions is the production of highly reactive oxygen radicals which have the potential to cause irreparable damage to cellular components,and have been linked to mutagenic and neurotoxicity of the nervous *** normal conditions,innate molecular systems,glutathione,superoxide dismutases,

关键词： cell AO Antioxidant-induced reductive stress has untoward consequences on the brain microvasculature BBB OS

Systematic review and meta-analysis of augmented reality in medicine, retail, and games

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Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 227-246页

作者： Pranav Parekh shireen Patel Nivedita Patel Manan Shah Department of Computer Engineering Nirma UniversityAhmedabadGujarat 382481India Department of Chemical Engineering School of TechnologyPandit Deendayal Petroleum UniversityGandhinagarGujaratIndia

This paper presents a detailed review of the applications of augmented reality(AR)in three important fields where AR use is currently *** objective of this study is to highlight how AR improves and enhances the user experience in entertainment,medicine,and *** authors briefly introduce the topic of AR and discuss its differences from virtual *** also explain the software and hardware technologies required for implementing an AR system and the different types of displays required for enhancing the user *** growth of AR in markets is also briefly *** the three sections of the paper,the applications of AR are *** use of AR in multiplayer gaming,computer games,broadcasting,and multimedia videos,as an aspect of entertainment and gaming is *** in medicine involves the use of AR in medical healing,medical training,medical teaching,surgery,and post-medical *** in retail was discussed in terms of its uses in advertisement,marketing,fashion retail,and online *** authors concluded the paper by detailing the future use of AR and its advantages and disadvantages in the current scenario.

关键词： Augmented reality Software Medicine Gaming

Internationalization of Higher Education:A South African Perspective

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Frontiers of Education in China 2015年第1期10卷 91-109页

作者： Ihron RENSBURG shireen MOTALA Solomon Arulraj DAVID University of Johannesburg JohannesburgSouth Africa Faculty of Education The British University in DubaiDubaiUnited Arab Emirates

The evolution of South African universities continues to be shaped by both apartheid and more recent post-apartheid *** the South African university system is mainly an elite,low participation and high attrition system,offering a medium quality ***,there is uneven attention to the opportunities that internationalization might bring to South *** paper explores South Africa’s position in a global,African and regional perspective,and looks at post-apartheid trends in the internationalization of higher ***,it provides an analysis,looking forward,of the essential conditions for more beneficial *** will include addressing“brain drain”and“brain gain,”global dialogue and mutual learning,and collaborative partnerships,marked by a common commitment to sound academic values,scientific integrity,ethics and social responsibility.

关键词： internationa lization higher education South African perspectives

A machine learning enabled hybrid optimization framework for efficient coarse-graining of a model polymer

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npj Computational Materials 2022年第1期8卷 2128-2138页

作者： Zakiya shireen Hansani Weeratunge Adrian Menzel Andrew W.Phillips Ronald G.Larson Kate Smith-Miles Elnaz Hajizadeh Department of Mechanical Engineering Faculty of Engineering and Information TechnologyThe University of MelbourneMelbourneAustralia Platforms Division Defence Science and Technology GroupMelbourneAustralia Department of Chemical Engineering University of MichiganAnn ArborMIUSA School of Mathematics and Statistics The University of MelbourneMelbourneAustralia

This work presents a framework governing the development of an efficient,accurate,and transferable coarse-grained(CG)model of a polyether *** framework combines bottom-up and top-down approaches of coarse-grained model parameters by integrating machine learning(ML)with optimization *** the bottom-up approach,bonded interactions of the CG model are optimized using deep neural networks(DNN),where atomistic bonded distributions are *** the top-down approach,optimization of nonbonded parameters is accomplished by reproducing the temperature-dependent experimental *** demonstrate that developed framework addresses the thermodynamic consistency and transferability issues associated with the classical coarse-graining *** efficiency and transferability of the CG model is demonstrated through accurate predictions of chain statistics,the limiting behavior of the glass transition temperature,diffusion,and stress relaxation,where none were included in the parametrization *** accuracy of the predicted properties are evaluated in context of molecular theories and available experimental data.

关键词： optimization grain integrating

The 100 top-cited articles on childhood obesity: a bibliometric analysis

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Global Health Journal 2022年第3期6卷 136-148页

作者： Joseph Kawuki Taha Hussein Musa Upama Ghimire Nathan Obore shireen Salome Papabathini Centre for Health Behaviours Research Jockey Club School of Public Health and Primary CareFaculty of MedicineThe Chinese University of Hong KongHong Kong999077China Ministry of Education Key Laboratory of Environmental Medicine EngineeringSchool of Public HealthSoutheast UniversityNanjingJiangsu 210096China Biomedical Research Institute Darfur CollegeNyalaSouth Darfur 63313Sudan

Background:Childhood obesity(CHO)is a serious global health challenge affecting both developed and developing *** feats attained in addressing this global health challenge can be reflected through the top-cited *** study’s aim was to analyze the features of the 100 top-cited articles concerning ***:We used a bibliometric analysis,and searched for relevant articles from the Web of Science(December 1,2021),using an appropriate keyword search-strategy((child OR childhood OR children OR adolescent)AND(obese OR obesity OR overweight)).The retrieved documents were analysed based on the citation number,publication year,authorship,institution,journal and *** analyses were performed mainly by the Bibliometrix application(using R-studio cloud)and ***:The 100 top-cited articles were published between 1976 and 2018,their citations ranged from 365 to 10789,with a mean citation of 1146.2 and 31 studies had more than 1000 *** articles were published in 31 journals,with the“Pediatrics”journal having the most publications(n=18).The studies were from 12 countries,with the most-productive being the USA(n=68),followed by the United Kingdom(n=12)and France(n=3).The leading institution was the University of Bristol(n=8),while Dietz WH(n=12),and Flegal KM(n=8)were the most productive *** most common research fields covered by these articles were;“General Internal Medicine”(n=34),“Pediatrics”(n=29),and“Nutrition Dietetics”(n=18).The study noted significant correlations between the total article citation and the number of authors(R=0.203),countries involved(R=0.407),institutions(R=0.407),and the publication year(R=0.847),all with P<***:Through these top-cited articles,this analysis provides discernment into the historical advancements,including the prime roles performed by various stakeholders in addressing the issue of ***,Asian countries’contribution is not adequately reflected in these articles,and thus

关键词： Childhood obesity Bibliometric analysis 100 top-cited Citation classics

Database Commons:A Catalog of Worldwide Biological Databases

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1054-1058页

作者： Lina Ma Dong Zou Lin Liu Huma shireen Amir AAbbasi Alex Bateman Jingfa Xiao Wenming Zhao Yiming Bao Zhang Zhang National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Center for Bioinformatics Programme of Comparative and Evolutionary GenomicsFaculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan European Molecular Biology Laboratory European Bioinformatics Institute(EMBL-EBI)HinxtonCambridge CB101SDUnited Kingdom

Biological databases serve as a global fundamental infrastructure for the worldwide scientific community,which dramatically aid the transformation of big data into knowledge discovery and drive significant innovations in a wide range of research *** the rapid data production,biological databases continue to increase in size and *** build a catalog of worldwide biological databases,we curate a total of 5825 biological databases from 8931 publications,which are geographically distributed in 72 countries/regions and developed by 1975 institutions(as of September 20,2022).We further devise a z-index,a novel index to characterize the scientific impact of a database,and rank all these biological databases as well as their hosting institutions and countries in terms of citation and ***,we present a series of statistics and trends of worldwide biological databases,yielding a global perspective to better understand their status and impact for life and health *** up-to-date catalog of worldwide biological databases,as well as their curated meta-information and derived statistics,is publicly available at Database Commons(https://***/databasecommons/).

关键词： Biological database Catalog Database Commons Citation z-index

Efficacy and biosafety assessment of neuropeptide CAPA analogues against the peach-potato aphid (Myzus persicae)

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Insect Science 2022年第2期29卷 521-530页

作者： Yan Shi Ronald J.Nachman Shun-Hua Gui Niels Piot Krzysztof Kaczmarek Janusz Zabrocki Julian A.T.Dow shireen-A.Davies Guy Smagghe College of Plant Health and Medicine Qingdao Agricultural UniversityQingdaoShandongChina Laboratory of Agrozoology Department of Plants and CropsFaculty of Bioscience EngineeringGhent UniversityGhentBelgium U.S.Department of Agriculture Insect Neuropeptide LaboratoryInsect Control and Cotton Disease Research UnitSouthern Plains Agricultural Research CenterCollege StationAustinTexasUSA Institute of Entomology Guizhou UniversityGuiyangGuizhouChina Institute of Organic Chemistry Lodz University of TechnologyLodz90-924 Poland College of Medical Veterinary and Life SciencesInstitute of MolecularCell and Systems BiologyUniversity of GlasgowGlasgowUK

Insect CAPA neuropeptidesare considered to affect water and ion balance by mediating the physiological metabolism activities of the Malpighian *** previous studies,the CAPA-PK analogue 1895(2Abf-Suc-FGPRLamide)was reported to decrease aphid fitness when administered through microinjection or via topical ***,a further statistically significant decrease in the fitness of aphids and an increased mortality could not be established with pairwise combinations of 1895 with other CAPA *** this study,we assessed the topical application of new combinations of 1895 with five CAPA-PVK analogues on the fitness of *** found that 1895 and CAPA-PVK analogue 2315(ASG-[β3L]-VAFPRVamide)was statistically the most effective combination to control the peach potato aphid Myzus persicae nymphs via topical application,leading to 72%***,the combination(1895+2315)was evaluated against a selection of beneficial insects,that is,a pollinator(Bombus terrestris)and three natural enemies(Chrysoperla carnea,Nasonia vitripennis,and Adalia bipunctata).We found no significant influence on food intake,weight increase,and survival for the pollinator and the three representative natural *** results could facilitate to further establish and generate CAPA analogues as alternatives to broad spectrum and less friendly insecticides.

关键词： biosafety assessment insecticidal agents Myzus persicae neuropeptide CAP2b analogues

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冠心病合并糖尿病的危险因素的回顾性研究

冠心病合并糖尿病的危险因素的回顾性研究

作者： Papabathini shireen Salome 东南大学

学位级别：硕士

背景:与非糖尿病患者相比,糖尿病患者死于心脏病的风险增加了2-4倍。目前冠心病合并糖尿病的风险日益增加,成为全球性的健康问题。YKL-40作为一种新的炎症生物标志物,在炎症和慢性疾病中被发现有较高的水平,是可用于检测疾病与预测预后... 详细信息

背景:与非糖尿病患者相比,糖尿病患者死于心脏病的风险增加了2-4倍。目前冠心病合并糖尿病的风险日益增加,成为全球性的健康问题。YKL-40作为一种新的炎症生物标志物,在炎症和慢性疾病中被发现有较高的水平,是可用于检测疾病与预测预后的生物标志物。本研究旨在探讨冠心病合并糖尿病的主要危险因素,并评价冠心病合并糖尿病患者血清YKL-40水平。方法:在本次病例对照研究中,我们收集了2011年9月至2018年12月之间在中大医院招募的3284名研究对象,分别为诊断为非CAD、CAD以及糖尿病合并CAD的住院患者。采用SPSS 22.0进行数据分析。通过卡方检验(分类变量)和t检验(连续变量)比较病例组和对照组在基线时的平均差异。采用logistic回归分析探讨糖尿病合并CAD发生的危险因素。在meta分析中,利用谷歌scholar,PubMed,Scopus等数据库系统检索文献,并且只提取了英文的相关文章。使用STATA12.0进行统计分析,计算计量资料的标准差(SMD)及其对应的95%置信区间。使用Cochran Q检验和I统计量测试异质性,I>30%,P<0.05判断为有异质性,使用随机效应模型合并效应,否则,使用固定效应模型,使用Egger’s test进行发表偏倚的检验。使用meta回归分析影响因素。结果:本研究共纳入3284例住院患者,其中766例为非冠心病,1726例为冠心病,792例为冠心病合并糖尿病。年龄、BMI、TG、TC、LDL-C、HDL-C、WBC、吸烟、HBP、肌酐与冠心病的发生有显著相关性(P<0.001)。BMI(P=0.003)、WBC(P<0.001)、RBC(P=0.009)、肌酐(P=0.05)和HBP(P<0.001)与CAD合并DM显著相关。Logistic回归显示,HBP患者发生CAD(OR=2.017,95%CI=1.318-3.088)和CAD合并DM(OR=2.845,95%CI=1.714-4.724)的风险是非HBP者的2倍以上。其他风险因素,例如TC,TG,饮酒与单纯CAD和CAD合并DM也有显著的关联;多因素分析表明,白细胞,BMI和HBP与单纯CAD和CAD合并DM的发生风险有显著关联(P<0.001)。在meta分析中,共纳入了25项研究,1400名CAD患者和1685名CAD对照,790名DM和699名DM对照进行了统计分析,结果表明,CAD患者的血清YKL-40水平显著高于对照组(SMD=1.76,95%CI=0.96-2.57)和DM患者的血清YKL-40水平显著高于对照组(SMD=1.87,95%CI=0.44-3.31)。结论:本研究发现了CAD合并DM的主要危险因素包括BMI、HBP和白细胞计数增加。早期识别各种危险因素有助于早期筛查,及早治疗、降低不良预后的风险。同时meta分析提示,升高的血清YKL-40水平可用作早期识别CAD和DM的诊断工具。

关键词：冠心病糖尿病危险因素 Meta分析 YKL-40