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Genetic association study of P2x7 A1513C(rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1126-1134页

作者： Eyad M.A.Alshammari Raju K.Mandal Mohd Wahid Sajad A.Dar arshad jawed Mohammed Y.Areeshi Saif Khan Md.Ekhlaque Ahmed Khan Aditya K.Panda Shafiul Haque Department of Clinical Nutrition College of Applied Medical SciencesUniversity of Ha’il Research and Scientific Studies Unit College of Nursing & Allied Health SciencesJazan University The University College of Medical Sciences & GTB Hospital (University of Delhi) Centre for Life Sciences Central University of Jharkhand

Objective:To summarize the precise association between pulmonary tuberculosis(PTB) and P2x7 A1513 C gene ***:PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513 C polymorphism and PTB risk.A meta-analysis was performed for the selected case-control studies and pooled odds ratios(ORs) and 95%confidence intervals(95%CIs) were calculated for all the genetic ***:Eleven studies comprising 2 678 controls and 2 113 PTB cases were included in this *** observed overall no significant risk in all the five genetic *** stratified population by the ethnicity,Caucasian population failed to show any risk of PTB in all the genetics *** Asian ethnicity,variant allele(C vs.A:P=0.001;QR=1.375,95%CI=1.159-1.632) and heterozygous genotype(AC ***:P=0.001;OR=1.570,95%CI=1.269-1.944) demonstrated significant increased risk of ***,recessive genetic model(CC+AC ***:P=0.001;OR=1.540,95%CI= 1.255-1.890) also demonstrated increased risk of PTB in ***:Our meta-analysis did not suggest the association of P2x7 A1513 C polymorphism with PTB risk in overall or separately in Caucasian ***,it plays a significant risk factor for predisposing PTB in *** larger sample and expression studies are needed to validate this association.

关键词： Genetic model Meta-analysis Polymorphism P2x7 gene Pulmonary tuberculosis

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