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Colon Adenocarcinoma in a Retrograde Intussusception: A Case Report and Literature Review

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Lyapunov stability of competitive cells dynamics in tumor mechanobiology

Open Journal of Gastroenterology（肠胃病学期刊） 2024年第5期 153页

作者： Carlos Hernández Brito Pedro Arredondo Ruiz Brenda Paola Sáenz dávila arsenio torres d.lgad. Luis Eduardo Méndez Turrubiates Luis Ángel Amezcua Toledo Omar Josué Herrera López

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Acta Mechanica Sinica 2021年第2期37卷 244-263页

作者： Angelo Rosario Carotenuto arsenio Cutolo Stefania Palumbo Massimiliano Fraldi department of Structures for Engineering and Architecture University of Napoli Federico IINapoliItaly

Poromechanics plays a key role in modelling hard and soft tissue behaviours,by providing a thermodynamic framework in which chemo-mechanical mutual interactions among fluid and solid constituents can be consistently rooted,at different scale *** this context,how different biological species(including cells,extra-cellular components and chemical metabolites)interplay within complex environments is studied for characterizing the mechanobiology of tumor growth,governed by intra-tumoral residual stresses that initiate mechanotransductive processes deregulating normal tissue homeostasis and leading to tissue *** the coupling between tumor poroelasticity and interspecific competitive dynamics has recently highlighted how microscopic cells and environment interactions influence growth-associated stresses and tumor pathophysiology,the nonlinear interlacing among biochemical factors and mechanics somehow hindered the possibility of gaining qualitative insights into cells *** by this,in the present work we recover the linear poroelasticity in order to benefit of a reduced complexity,so first deriving the well-known Lyapunov stability criterion from the thermodynamic dissipation principle and then analysing the stability of the mechanical competition among cells fighting for common space and resources during cancer growth and *** the end,the linear poroelastic model enriched by interspecific dynamics is also exploited to show how growth anisotropy can alter the stress field in spherical tumor masses,by thus indirectly affecting cell mechano-sensing.

关键词： Tumor growth Poroelasticity Cells competition Volterra-Lotka dynamics Stability

Celeboxib-mediated neuroprotection in focal cerebral ischemia: an interplay between unfolded protein response and inflammation

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Neural Regeneration Research 2022年第2期17卷 302-303页

作者： Maria Santos-Galdiano diego Perez-Rodriguez arsenio Fernandez-Lopez Area de Biologia Celular Instituto de BiomedicinaCampus de Vegazana s/nUniversidad de LeonLeonSpain Neural Therapies SL Campus de Vegazana s/nLeónSpain department of Clinical and Movement Neurosciences UCL Queen Square Institute of NeurologyLondonUK

Ischemic stroke results from the temporary or permanent lack of blood supply in the brain due to the occlusion of a brain blood vessel. Around 85% of patients with cerebrovascular accidents suffer from ischemic strokes.

关键词： inflammation cerebral ischemia

PANoptosis:new insights in regulated cell death in ischemia/reperfusion models

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Neural Regeneration Research 2023年第2期18卷 342-343页

作者： Paloma González-Rodríguez arsenio Fernández-López Área de Biología Celular Instituto de BiomedicinaUniversidad de LeónSpain

See related article,pp 357-363The first study describing the cell death and destruction of tissues,organs,and organ systems as programmed events during the development of multicellular organisms was performed by JW Saunders Jr in *** term apoptosis was introduced by Kerr,Wyllie,and Currie in 1972 to describe a programmed phenomenon opposite to mitosis in the regulation of animal cell ***,a description of ectodermal cell lineages as programmed cell death in the worm Caenorhabditis elegans was publishedby JE Sulston and HR Horvitz in 1976.

关键词： organs insight opposite

Combining anti-inflammatory and unfolding protein responses to fight stroke

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Neural Regeneration Research 2019年第3期14卷 450-451页

作者： Berta Anuncibay-Soto Enrique Font-Belmonte arsenio Fernández-López área de Biología Celular Instituto de Biomedicina Universidad de León Neural Therapies SL Edificio Institutos de Investigación Campus de Vegazana

This perspective shows an attempt to obtain synergy effects to fight ischemic stroke by combining agents acting on two different homeostatic mechanisms:inflammation and unfolded protein response (Anuncibay-Soto et al.,2018).different pharmacological approaches have been assayed to alleviate cerebrovascular accident (stroke), which represents one of the most devastating diseases in the elderly.

关键词： Combining anti-inflammatory

Necroptosis in global cerebral ischemia: a role for endoplasmic reticulum stress

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Neural Regeneration Research 2020年第3期15卷 455-456页

作者： Enrique Font-Belmonte Paloma González-Rodríguez arsenio Fernández-López Area de Biologia Celular Instituto de BiomedicinaUniversidad de LeonLeonSpain Neural Therapies SL Edificio Institutos de InvestigacionCampus de VegazanaLeonSpain

Necroptosis has been reported in the last years as a type of regulated cell death that can be ignited by a number of specific death receptors,such as FAS,tumor necrosis factor receptor 1(TNFR1),or pathogen recognition *** cell death subroutine is involved in the response to stress and in homeostatic functions,such as the maintenance of adult T-cell balance(Galluzzi et al.,2018).dead receptor activation leads to the recruitment of protein complexes that act as nodes of signaling that can elicit different pathways driving to death or survival,depending on the cell conditions.

关键词： death cerebral ischemia

Neuroprotection by salubrinal treatment in global cerebral ischemia

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Neural Regeneration Research 2016年第11期11卷 1744-1745页

作者： Berta Anuncibay-Soto María Santos-Galdiano arsenio Fernández-López Area de Biologia Celular Instituto de BiomedicinaUniversidad de León

Most common cerebrovascular accidents （CVAs） result from the occlusion of a blood vessel and are called ischemic stroke. The interruption of the blood flow reduces the oxygen and glucose levels in the neural pareuchyma, which in turn decreases the energy of the cells and compromises their homeostasis. This condition has to be reverted for cell survival. One of the homeostatic processes impaired by cerebral ischemia is protein folding in the endoplasmic reticulum （ER） lumen where unfolded proteins are accumulated （degracia and Monti, 2004）. This situation, known as ER stress, elicits the so called unfolded protein response （UPR）,

关键词： Neuroprotection by salubrinal treatment in global cerebral ischemia MCAO BBB

A role for lipids as agents to alleviate stroke damage： the neuroprotective effect of 2-hydroxy arachidonic acid

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Neural Regeneration Research 2017年第8期12卷 1273-1275页

作者： Irene F.Ugidos diego Pérez-Rodríguez arsenio Fernández-López Area de Biologia Celular Instituto de Biomedicina Universidad deLeon Leon Spain

Cerebrovascular accident（CVA）or stroke is one of the world＇s leading causes of death and permanent *** high social and medical costs associated with this pathology mean there is an urgent need to find effective ***... 详细信息

关键词： the neuroprotective effect of 2-hydroxy arachidonic acid FFA OAA A role for lipids as agents to alleviate stroke damage MCAO

Using organotypic hippocampal slice cultures to gain insight into mechanisms responsible for the neuroprotective effects of meloxicam: a role for gamma aminobutyric and endoplasmic reticulum stress

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Neural Regeneration Research 2019年第1期14卷 65-66页

作者： Elisa Landucci Irene L.Llorente Berta Anuncibay-Soto domenico E.Pellegrini-Giampietro arsenio Fernández-López Sezione di Farmacologia Clinica e Oncologia Dipartimento di Scienze della SaluteUniversità di Firenze department of Neurology David Geffen School of Medicine University of California área de Biología Celular Instituto de BiomedicinaUniversidad de León Neural Therapies SL Edificio Institutos de Investigación

This perspective aims to put into context the recent article by Landucci et al.(2018)on mechanisms involved in the neuroprotective effects of meloxicam on an organotypic hippocampal slice cultures(OHSCs)*** vitro cell cultures are the main method for studying large quantities of homogeneous cells in an isolated ***,the use of primary dissociated neuron,astrocyte,oligodendrocyte,microglia,or endothelial cell cultures has become a standard

关键词： gamma 文化海马机制应力蜂窝环境学习胃