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The Profile of Glycated Hemoglobin in Non-Diabetic Pregnant Women with Preeclampsia: A Case-Control Study in Kinshasa, the Democratic Republic of Congo

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Open Journal of Obstetrics and Gynecology 2020年第3期10卷 365-389页

作者： Guelord Mukiapini Luzolo Dophie Tshibuela Beya Daddy Kabamba Numbi Passy Kimena Nyota Placide Cyanga Ngandu Blaise Sumbu Matondo Manzambi Aliocha Nkodila Natuhoyila Mamy Ngole Zita Gustave Ilunga Ntita Mireille Nganga Nkanga Jérémie Muwonga Masidi Donatien Kayembe Nzongola-Nkasu Dieudonné Sengeyi Mushengezi arsene mputu lobota Baudouin Buassa-Bu-Tsumbu Cathy Ali Risasi Fons Verdonck Bernard Spitz Jean Pierre Elongi Moyene Département de Biologie Médicale Service de Biologie Clinique Cliniques Universitaires de Kinshasa Kinshasa Congo Département de Médecine interne Cliniques Universitaires de Kinshasa Kinshasa Congo Département de Gynécologie-Obstétrique Cliniques Universitaires de Kinshasa Kinshasa Congo Département de Biologie Clinique Hopital Général de Référence de Kinshasa Kinshasa Congo Department of Physiology KU Leuven Belgium Department of Gynecology-Obstetrics KU Leuven Belgium Département de Gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa Congo

Background: A disturbed glucose metabolism is quite common during pregnancy. It is due to the diabetogenic potential of pregnancy and responsible for many obstetric complications. The glycated hemoglobin is one of the markers used to depict these disorders. Higher concentrations of this marker would be associated with unfavorable results of pregnancy. Objective: To describe the profile of HbA1c in non-diabetic preeclamptic pregnant women and to establish the association between the values of this marker and the maternal and fetal complications. Materials and Method: This is a case-control study of 142 pregnant women in their second and third trimester. They were followed in the maternity hospitals of University Clinics and the General Reference Hospital in Kinshasa, Democratic Republic of Congo between May and October 2019. The sampling of preeclamptic pregnant women was exhaustive. Controls were healthy pregnant women carrying pregnancies of the same type and of the same gestational age as the cases. Ultimately, 71 were preeclamptic and 71 healthy (controls). HbA1c was determined by immunoturbidimetry. Results: A total of 142 pregnant women took part in this study consisting of 71 preeclamptic women (cases) and 71 healthy pregnant women (controls). The average age of these pregnant women was 28.8 ± 6.8 (28.2 ± 6.8 years vs 29.5 ± 6.8 years p = 0.559), with an average parity of 2.3 ± 1.5 (2.2 ± 1.7 vs 2.4 ± 1.2, p = 0.005). The majority were carriers of monofoetal pregnancy. Higher HbA1c values were observed in the preeclamptic pregnant women compared to the controls (5.7 ± 1.3% vs 4.8 ± 0.7%, p 0.001). The proportion of pregnant women with pathological HbA1c values (>5.6%) was also higher in the group of preeclamptic pregnant women (46.5% vs 9.9%, p Conclusion: This study established that 46.5% of non-diabetic pregnant women with preeclampsia have high HbA1c values, which moreover are associated with preeclampsia and its complications. Systematic screening is essen

关键词： HbA1c Preeclampsia Prognosis Congo

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Knowledge, Attitudes and Practices of Congolese Women in Kinshasa on Breast Cancer

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1207-1222页

作者： Pierre Joseph Ingala Amasa Ernest Ombha Loshima Arsène mputu lobota Guy Lambert Monzango Sibo Malka Salamo Azama Gracia Tambola Wasinga Dieudonné Omatuku Tshofu Fidèle Djamba Okitokonda Department of Obstetrics and Gynecology University Clinics of Kinshasa Kinshasa DR Congo Public Hospital Group of the South of the Oise Senlis France National Border Hygiene Program of Kinshasa Kinshasa DR Congo

Context: Breast cancer is a high-mortality disease. Early detection has considerably reduced mortality in developed countries. Objectives: To assess the knowledge, attitudes and practices of Congolese women in Kinshasa on breast cancer, their levels and to identify factors associated with insufficient knowledge, negative attitudes and non-beneficial practices. Material and Methods: This was a descriptive cross-sectional study with analytical aims, carried out from June 1 to September 30, 2023, in Kinshasa. It involved 1170 female respondents, aged 18 to 65, who agreed to take part in the survey. Data were collected using a pre-established questionnaire. Data analysis was performed using SPSS software version 20.0. The study variables were socio-demographics, morbid history, knowledge, attitudes and practices of respondents regarding breast cancer. Statistical measures and tests used were Mean ± standard deviation, median, proportions, logistic regression Backward stepwise and p Results: 60% had insufficient knowledge, 75% had negative attitudes and 80% had non-beneficial practices. The risk factors common to insufficient knowledge, negative attitudes and non-beneficial practices towards breast cancer were low level of education, membership of revivalist or Muslim churches, and primiparity. Conclusion: 60% of Congolese women in Kinshasa have insufficient knowledge about breast cancer, 75% have negative attitudes and 80% have non-beneficial practices, with a positive association between insufficient knowledge and negative attitudes on the one hand, and insufficient knowledge and non-beneficial practices on the other. In this context, increasing the population’s literacy and access to information are essential.

关键词： Knowledge Attitudes Practices Breast Cancer Congolese Woman in Kinshasa

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Diagnosis Delay and Assessment of the Quality of Life of Patients with Endometriosis Using the Endometriosis Health Profile 5 Questionnaire in a Sub-Saharan Population

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Open Journal of Obstetrics and Gynecology 2023年第5期13卷 907-917页

作者： Monzango Sibo Mboloko Esimo mputu lobota Itewa Monka Kitenge Kia Kayembe Tambola Grace Samba Kevine Maesheka Patrick Ntanga Kabuya Amba Naomie Maxime Fastrez Buka Ikoko Ndjukendi Ally Sangana Georges Barhayiga Berthe Mbanzulu Pita Longo Mbenza Clément Ferrier Emile Darai Department of Gynecology and Obstetrics University Clinics of Kinshasa Faculty of Medicine Kisangani Democratic Republic of the Congo Department of Gynecology Service of Laparoscopic Surgery Onyx Medical Center Kisangani Democratic Republic of the Con-go 3Department of Gynecology and Obstetrics Erasme Endometriosis Clinic Free University of Brussels Brussels Kingdom of Belgium Department of Psychiatry Neuro-Psychopathological Center of Kinshasa Faculty of Medicine Kinshasa Democratic Republic of the Congo Department of Surgery Department of Laparoscopic Visceral Surgery HJ Hospital Kinshasa Democratic Republic of the Congo Department of Anesthesia and Resuscitation University Clinics of Kinshasa Faculty of Medicine Kinshasa Democratic Republic of the Congo Department of Internal Medicine University Clinics of Kinshasa Faculty of Medicine Kinshasa Democratic Republic of the Congo Department of Gynecology and Obstetrics Tenon Hospital Sorbonne University Paris France

Context: Endometriosis is a pathology that directly affects the daily lives of women with frequent impairment of their quality of life. In our environment, medical, socio-cultural, financial factors and factors related to the organization of the health care system greatly delay its diagnosis. The objectives of the present study were to determine the diagnosis delay and to assess the quality of life before surgery of women with endometriosis using the specific Endometriosis Health Profile 5 (EHP-5) questionnaire. Methods: We carried out a descriptive, observational, retrospective study in 8 medical centers in the City of Kinshasa, from January 2019 to October 2022. A total of 80 women with endometriosis confirmed by laparoscopy (16 diagnostic and 64 operative laparoscopies) and histopathology were interviewed. We used the revised American Society for Reproductive Medicine (rASMR) classification, the Endometriosis Fertility Index (EFI) score was calculated for infertile women and the EHP-5 questionnaire to assess quality of life. Our data was entered and analyzed using Statistical Analysis Software 16.1 (STATA 16.1). Results: Diagnosis delay of endometriosis was on average 12 ± 4.3 years. The overall mean EHP-5 score of all patients showed a severe deterioration in quality of life (604 ± 235). A negative relationship was observed between the age of the patient, the diagnostic delay, and the alteration of the quality of life in patients over 36 years old and those with about 11 years of diagnostic delay presenting the slight alteration. Patients with a high social level had very severe quality impairment. Women on hormonal treatment, those with a history of pregnancy, childbirth, miscarriage and abortion had a slight and significant deterioration in quality of life (p 0.05). Conclusion: Despite some limitations, our preliminary study highlights that in sub-Saharan Africa, the diagnosis of endometriosis is delayed and associated with a severe alteration in quality of li

关键词： Diagnosis Delay EHP-5 Endometriosis Quality of Life Sub-Saharan

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Serum Vitamin E Reference Intervals in a Black Congolese Population of Kinshasa

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Open Journal of Obstetrics and Gynecology 2023年第4期13卷 737-744页

作者： Monzango Sibo Mboloko Esimo mputu lobota Mbemba Fundu Nganga Mireille Itewa Monka Mayoka Mamoi Ntanga Kabuya Amba Naomie Lezaka Ensemeya Bola Jonita Maxime Fastrez Lebwaze Bienvenu Balthazar Phoba Destin Mbongi Tshilolo Léon Kahindo P. Muyalalo Mbanzulu Pita Emile Darai Department of Gynecology and Obstetrics Faculty of Medicine University Clinics of Kinshasa Kinshasa Democratic Republic of the Congo Department of Gynecology Service of Laparoscopic Surgery Onyx Medical Center Kinshasa Democratic Republic of the Congo Department of Biology Faculty of Science University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Medical Biology Faculty of Medicine University Clinics of Kinshasa Kinshasa Democratic Republic of the Congo Department of Gynecology and Obstetrics Erasme Endometriosis Clinic Free University of Brussels Brussels Kingdom of Bel-gium Department of Histopathology Faculty of Medicine University Clinics of Kinshasa Kinshasa Democratic Republic of the Congo Institute of Biomedical Research (IRB) Health Training and Support Center (CEFA) Monkole Kinshasa Democratic Republic of the Congo Department of Gynecology and Obstetrics Tenon Hospital Sorbonne University Paris French Republic

Context: Vitamin E is a powerful antioxidant and plays an important role in human reproduction. However, micronutrient deficiency is a major public health problem, particularly in developing countries. This study aimed to establish reference intervals (RIs) for vitamin E in black Congolese people of childbearing age using an ELISA method to provide a reference for clinically assessing vitamin E status. Methods: A total of 127 healthy people between the ages of 20 and 42 who underwent check-ups were randomly selected for the study. ELISA method measured the level of vitamin E. The effect of gender on vitamin E level was assessed, and RI was established using a parametric approach. Results: Women showed significantly higher levels of vitamin E than men (p = 0.01). The RI of vitamin E in people of childbearing age was 3.71 to 13.72, 4.52 to 14.64, and 4.17 to 13.52 mg/L, respectively, for the whole population, women and men. Conclusion: Using an ELISA method, this study established RI for vitamin E in the black Congolese population of childbearing age. We also found that women had significantly higher vitamin E levels than men. The results could provide a scientific basis for interpreting vitamin status in people of childbearing age in our setting.

关键词： ELISA Reference Interval People of Childbearing Age Vitamin E

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Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo

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Open Journal of Obstetrics and Gynecology 2019年第11期9卷 1492-1509页

作者： Daddy Kabamba Numbi Dophie Tshibuela Beya Guelord Mukiapini Luzolo Passy Kimena Nyota Placide Cyanga Ngandu Mamy Ngole Zita Gustave Ilunga Ntita Donatien Kayembe Nzongola-Nkasu Jérémie Muwonga Masidi Mireille Nganga Nkanga Justin Mboloko Esimo Arsène mputu lobota Jean Bosco Kasiam Onkin Baudouin Buassa-bu-Tsumbu Cathy Ali Risasi Fons Verdonck Bernard Spitz Jean Pierre Elongi Moyene Département de Biologie Médicale Service de Biologie Clinique Cliniques Universitaires de Kinshasa Kinshasa DR Congo Département de Gynécologie-Obstétrique Cliniques Universitaires de Kinshasa Kinshasa DR Congo Département de Médecine Interne Service d’Endocrinologie et Diabétologie Cliniques Universitaires de Kinshasa Kinshasa DR Congo Département de Biologie Clinique Hopital Général de Référence de Kinshasa Kinshasa DR Congo Department of Physiology KU Leuven Leuven Belgium Department of Gynecology-Obstetrics KU Leuven Leuven Belgium Département de Gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa DR Congo

Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related to the metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of hyperglycemia that may be associated with this syndrome and to understand her pathophysiology. Aims: The purposes of this study are to determine the profile of HbA1c in Congolese women with PCOS, to determine the frequency of states of hyperglycemia and to assess the impact of this marker on clinical signs on this syndrome. Material and methods: This is a case-control study of 130 Congolese subfertile women;65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of childbearing age. All these women were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA medical centers in Kinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as also the cases of anemia. HbA1c was assayed via the immunoturbidimetric method and the results interpreted according to the ADA recommendations with a pathological cut-off point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/dl (11.5 ± 1.1 g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568). The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group compared to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P 0.001). The multivariate analysis showed a strong correlation between elevated HbA1c levels and PCOS (OR 14.79 (CI 5.43 - 40.32), P 0.001). In the PCOS group, higher HbA1c values were significantly correlated with a higher socio-economic status (OR 3.38 (1.67 - 8.47), P = 0.018) and with obesity (OR 3.48 IC (1.31 - 7.13) P = 0.029). A perfect, positive and significant linear correlation was found between HbA1c and fasting blood glucose (r = 0.807). 60% of women in the PCOS group had pathological values of H

关键词： PCOS HbA1c Subfertility Congolese Women

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