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丹参对外周血中性粒细胞和单核细胞的调整作用

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广西医科大学学报 1997年第3期14卷 9-11页

作者：王潮临 arsalan kharazmi Viggo Faber 广西医科大学病理生理学教研室丹麦哥本哈根大学医院临床微生物部

研究丹参对外周血中性粒细胞和单核细胞的化学趋化和超氧化物产物的影响。结果表明：丹参能明显增加两种细胞的超氧化物的产生；并对两种细胞的化学趋化有明显的抑制作用，丹参能调整中性粒细胞的氧化过程（呼吸爆发），参与化学趋化作... 详细信息

研究丹参对外周血中性粒细胞和单核细胞的化学趋化和超氧化物产物的影响。结果表明：丹参能明显增加两种细胞的超氧化物的产生；并对两种细胞的化学趋化有明显的抑制作用，丹参能调整中性粒细胞的氧化过程（呼吸爆发），参与化学趋化作用、炎症过程和增强中性粒细胞的杀菌能力。

关键词：丹参化学趋化超氧化物中性粒细胞单核细胞

一种新的黄芩类黄酮3',5,6',7-四羟基-2',8-二甲氧基黄酮的体外免疫药理作用

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广西医科大学学报 2000年第3期17卷 353-355页

作者：贺海平秦箐陈明 arsalan kharazmi Soren Brogger Christensen 广西肿瘤防治研究所南宁530021 广西医科大学南宁530021 丹麦国家医院临床微生物学研究室哥本哈根22200

目的 :对新发现的一种黄芩类黄酮 ,3',5 ,6 ',7-四羟基 - 2 ',8-二甲氧基黄酮 ( TDF)的免疫药理作用进行研究。方法 :检测 TDF对人多形核细胞 ( PMN)、单个核细胞 ( MNC)化学发光反应、化学趋向性和 PHA诱导淋巴细胞增殖的影响。结果 :... 详细信息

目的 :对新发现的一种黄芩类黄酮 ,3',5 ,6 ',7-四羟基 - 2 ',8-二甲氧基黄酮 ( TDF)的免疫药理作用进行研究。方法 :检测 TDF对人多形核细胞 ( PMN)、单个核细胞 ( MNC)化学发光反应、化学趋向性和 PHA诱导淋巴细胞增殖的影响。结果 :TDF本身不能激活 PMN和 MNC的氧呼吸爆发 ,TDF对 PMN和 MNC无毒性作用 ;当 TDF与 PMN或 MNC预先孵育后 ,明显的抑制 f ML P或 OZ激活 PMN以及 f ML P激活 MNC的氧呼吸爆发 ,抑制的强度与孵育的剂量成正比关系 ;对PMN的抑制能力大于 MNC。 TDF本身对 PMN和 MNC没有明显的化学趋化作用 ,但经与 TDF预先与细胞孵育后的 PMN或 MNC对 ZAS的化学趋向性明显增强 ,对 f ML P的化学趋向性作用不明显 ;TDF浓度在 ( 1.2 5× 10 - 4～ 5× 10 - 4 ) mol/ L 时 ,显著地抑制 PHA诱导的淋巴细胞增殖 ,抑制率达 31%～ 10 0 %。结论

关键词：黄芩类黄酮 TDF 免疫药理化学发光

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板蓝根低极性流分的分离及其免疫活性

中国临床药学杂志 2001年第1期10卷 29-31页

作者：秦箐贺海平 Soren Brogger Christensen Hasse Bonde Rasmussen arsalan kharazmi 陈鸣广西医科大学化学教研室南宁530021 广西肿瘤研究所生化室丹麦皇家药学院药物化学系丹麦国家大学医学院微生物部

目的 :进行板蓝根低极性流分及其亚流分的分离 ,并研究其免疫活性。方法 :用快速低压干柱柱层析从板蓝根中分离出一个低极性流分及其一组亚流分 ;用化学发光法检测其对人多形核细胞化学发光的影响。结果 :板蓝根低极性流分具有双向免疫... 详细信息

目的 :进行板蓝根低极性流分及其亚流分的分离 ,并研究其免疫活性。方法 :用快速低压干柱柱层析从板蓝根中分离出一个低极性流分及其一组亚流分 ;用化学发光法检测其对人多形核细胞化学发光的影响。结果 :板蓝根低极性流分具有双向免疫活性 ,在低浓度时具有激活作用 ,在高浓度时具有抑制作用 ;而亚流分的免疫活性并未因其纯度的提高而相应提高。结论 :板蓝根低极性流分及其亚流分含有抗炎成分。

关键词：板蓝根快速低压干柱柱层析人多形核细胞化学发光

中药板蓝根中蓝色流分的分离及其对体外人多形核细胞化学发光的影响

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广西医科大学学报 2001年第2期18卷 196-197页

作者：秦箐贺海平 Soren Brogger Christensen Hasse Bonde Rasmussen arsalan kharazmi 陈鸣广西医科大学化学教研室南宁530021 广西肿瘤研究所生化室丹麦皇家药学院药物化学系丹麦国家大学医院微生物部

目的 :研究从十字花科植物菘蓝 (Isatis tinctoria L)的根中分离出一个蓝色的流分对体外人多形核细胞 (PMN)化学发光 (CL)的影响。方法 :板蓝根蓝色流分的提取用快速低压干柱柱层析法完成 ,用化学发光法检测其对人多形核细胞(PMN)化学发... 详细信息

目的 :研究从十字花科植物菘蓝 (Isatis tinctoria L)的根中分离出一个蓝色的流分对体外人多形核细胞 (PMN)化学发光 (CL)的影响。方法 :板蓝根蓝色流分的提取用快速低压干柱柱层析法完成 ,用化学发光法检测其对人多形核细胞(PMN)化学发光 (CL)的影响。结果 :发现其具有很高的双向活性 ,因浓度的不同 ,既具有激活作用 ,又具有抑制作用。结论

关键词：板蓝根快速低压干柱柱层析人多形核细胞(PMN) 化学发光(CL)

晚发性结直肠癌患者亲属的结肠镜筛查时间间隔:一项全国性匹配队列研究

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Science Bulletin 2024年第6期69卷 732-736页

作者：梁群风 Kristina Sundquist Jan Sundquist Hermann Brenner Elham kharazmi Mahdi Fallah Division of Preventive Oncology National Center for Tumor DiseasesGerman Cancer Research CenterHeidelberg 69120Germany Medical Faculty Heidelberg Heidelberg UniversityHeidelberg 69120Germany Center for Primary Health Care Research Lund UniversityMalmö20213Sweden Department of Family Medicine and Community Health Department of Population Health Science and PolicyIcahn School of Medicine at Mount SinaiNew YorkNY10029USA Center for Community-based Healthcare Research and Education Department of Functional PathologySchool of MedicineShimane UniversityIzumo 693-8501Japan Division of Clinical Epidemiology and Aging Research German Cancer Research CenterHeidelberg 69120Germany German Cancer Consortium German Cancer Research CenterHeidelberg 69120Germany Institute of Primary Health Care University of BernBern 3012Switzerland

Colorectal cancer(CRC)is a major global cancer burden,ranking third in terms of incidence,but second in terms of mortality[1].Early detection of CRC through screening combined with subsequent removal of polyps remains a predominant strategy for CRC *** history is a known risk factor for CRC[2-4].However,only a few screening guidelines provide recommendations for individuals with familial CRC risk[5].

关键词：队列研究时间间隔晚发性

Thermal Characteristics of PVA-PANI-ZnS Nanocomposite Film Synthesized by Gamma Irradiation Method

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Chinese Physics Letters 2018年第11期35卷 83-85页

作者： Afarin Bahrami Kasra Behzad Nastaran Faraji Alireza kharazmi Department of Physics Islamshahr Branch Islamic Azad University Department of Physics Shahr-e-Qods Branch Islamic Azad University School of Materials Science and Engineering UNSW Australia School of Chemistry University of New South Wales

Gamma irradiation is employed for in situ preparation of PVA-PANI-ZnS nanocomposite. The irradiation dose is varied from 10 to 40 kGy at 10 kGy intervals. The XRD result confirms the formation of crystalline phases corresponding to ZnS nanoparticles, PVA and PANI. Field emission scanning electron microscopy shows the formation of agglomerated PANI along the PVA backbone, within which the ZnS nanoparticles are ***-visible spectroscopy is conducted to measure the transmittance spectra of samples revealing the electronic absorption characteristics of ZnS and PANI nanoparticles. Photo-acoustic（PA） setup is installed to investigate the thermal properties of samples. The PA spectroscopy indicates a high value of thermal diffusivity for samples due to the presence of ZnS and PANI nanoparticles. Moreover, at higher doses, the more polymerization and formation of PANI and ZnS nanoparticles result in enhancement of thermal diffusivity.

关键词： ZnS XRD Thermal Characteristics of PVA-PANI-ZnS Nanocomposite Film Synthesized by Gamma Irradiation Method PVA

A New Generalized Weibull Model:Classical and Bayesian Estimation

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Computer Systems Science & Engineering 2021年第7期38卷 79-92页

作者： Mi Zichuan Saddam Hussain Zubair Ahmad Omid kharazmi Zahra Almaspoor School of Statistics Shanxi University of Finance and EconomicsTaiyuanChina Department of Statistics Yazd UniversityYazdIran Department of Statistics Faculty of SciencesVali-e-Asr University of RafsanjanRafsanjanIran

Statistical distributions play a prominent role in applied sciences,particularly in biomedical *** medical data sets are generally skewed to the right,and skewed distributions can be used quite effectively to model such kind of data *** the present study,therefore,we propose a new family of distributions suitable for modeling right-skewed medical data *** proposed family may be called a new generalized-X family.A special sub-model of the proposed family called a new generalized-Weibull distribution is discussed in *** maximum likelihood estimators of the model parameters are obtained.A brief Monte Carlo simulation study is conducted to evaluate the performance of these ***,the proposed model is applied to the remission times of the stomach cancer patient’s *** comparison of the goodness of fit results of the proposed model is made with the other competing models such as Weibull,Kumaraswamy Weibull,and exponentiated Weibull *** analytical measures such as Akaike information criterion,Bayesian information criterion,Anderson Darling statistic,and Kolmogorov-Smirnov test statistic are considered to show which distribution provides the best fit to *** on these measures,it is showed that the proposed distribution is a reasonable candidate for modeling data in medical sciences and other related fields.

关键词： Weibull distribution stomach cancer hazard function statistical modeling akaike information criterion

Optical Properties of CdS/PVA Nanocomposite Films Synthesized using the Gamma-Irradiation-Induced Method

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Chinese Physics Letters 2013年第5期30卷 160-164页

作者： Alireza kharazmi Elias Saion Nastaran Faraji Nayereh Soltani Arash Dehzangi Physics Department Faculty of ScienceUniversity Putra MalaysiaSerdang 43400Malaysia Institute of Microengineering and Nanoelectronics Universiti Kebangsaan MalaysiaBangi 43600Malaysia

Monodispersed spherical CdS nanoparticles embedded into polyvinyl alcohol (PVA) films are synthesized by using an in-situ gamma-irradiation-induced method. The formation mechanism of CdS nanoparticles capped by two united cells of PVA is purposed by means of surrounding the CdS nanoparticles with OH bonds of the PVA chain. CdS nanoparticles are found to possess an unusual orthorhombic structure in monoclinic crystalline PVA. The polymer matrix affords protection from agglomeration and controls the particle size. It is found that the distribution of the prepared nanoparticles increases and a narrower size distribution is observed when the gamma radiation is varied from 10 to 50 kGy. While the average size of the nanoparticles is found to be less affected by the variation of the gamma radiation doses. The size range of the synthesized nanoparticles is 14±1 nm. The optical absorption spectra of synthesized CdS nanoparticles in a polymer matrix reveal the blue shift in the band gap energy with respect to CdS bulk materials owing to quantum confinement effect. The photoluminescence study of nanocomposite films shows the green emission arising from the crystalline defects.

关键词： nanoparticles composite crystalline

Fractional Buffer Layers:Absorbing Boundary Conditions for Wave Propagation

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Communications in Computational Physics 2022年第2期31卷 331-369页

作者： Min Cai Ehsan kharazmi Changpin Li George Em Karniadakis Department of Mathematics Shanghai University99 Shangda RoadShanghai 200444P.R.China Division of AppliedMathematics Brown University170 Hope StProvidenceRI 02906USA School of Engineering Brown University184 Hope StProvidenceRI 02912USA

We develop fractional buffer layers(FBLs)to absorb propagating waves without reflection in bounded *** formulation is based on variable-order spatial fractional *** select a proper variable-order function so that dissipation is induced to absorb the coming waves in the buffer layers attached to the *** particular,we first design proper FBLs for the one-dimensional one-way and two-waywave ***,we extend our formulation to two-dimensional problems,wherewe introduce a consistent variable-order fractionalwave *** each case,we obtain the fully discretized equations by employing a spectral collocation method in space and Crank-Nicolson or Adams-Bashforth method in *** compare our results with a finely tuned perfectly matched layer(PML)method and show that the proposed FBL is able to suppress reflected waves including corner reflections in a two-dimensional rectangular *** also demonstrate that our formulation is more robust and uses less number of equations.

关键词： Variable-order fractional derivatives FBL wave equation