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Correlation of tumor-associated macrophage density and proportion of M2 subtypes with the pathological stage of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1878-1889页

作者： Fouzia Fazal Muhammad arsalan Khan Sumayya Shawana Rahma Rashid Muhammed Mubarak Department of Pathology Jinnah Medical and Dental CollegeKarachi 74800SindhPakistan Department of General Surgery Sindh Institute of Urology&Transplantation(SIUT)Karachi 74200SindhPakistan Department of Pathology Bahria University of Health SciencesKarachi 74400SindhPakistan Department of Pathology SIUTKarachi 74200SindhPakistan

BACKGROUND Colorectal cancer(CRC)is a prevalent global malignancy with complex prognostic ***-associated macrophages(TAMs)have shown paradoxical associations with CRC survival,particularly concerning the M2 *** We aimed to establish a simplified protocol for quantifying M2-like TAMs and explore their correlation with clinicopathological *** A cross-sectional study included histopathological assessment of paraffinembedded tissue blocks obtained from 43 CRC *** CD68 and CD163 immunohistochemistry,we quantified TAMs in tumor stroma and front,focusing on M2 ***,histopathological,and clinical parameters were *** TAM density was significantly higher at the tumor front,with the M2 proportion three times greater in both *** tumor front had a higher M2 proportion,which correlated significantly with advanced tumor stage(P=0.04),pathological nodal involvement(P=0.04),and lymphovascular invasion(LVI,P=0.01).However,no significant association was found between the M2 proportion in the tumor stroma and clinicopathological *** Our study introduces a simplified protocol for quantifying M2-like TAMs in CRC tissue *** demonstrated a significant correlation between an increased M2 proportion at the tumor front and advanced tumor stage,nodal involvement,and *** suggests that M2-like TAMs might serve as potential indicators of disease progression in CRC,warranting further investigation and potential clinical application.

关键词： Colorectal cancer Macrophages Tumor stroma M2 subset Tumor front Tumor stage Lymphovascular invasion Prognosis Tumor-associated macrophages Immunohistochemistry

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Molecular Characterization of <i>Echinococcus granulosus</i>in South of Iran

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Open Journal of Veterinary Medicine 2012年第4期2卷 201-206页

作者： Saeid Hosseinzadeh Mehdi Fazeli arsalan hosseini Seyed Shahram Shekarforoush Department of Basic Sciences School of Veterinary Medicine Shiraz University Shiraz Iran Department of Food Hygiene School of Veterinary Medicine Shiraz University Shiraz Iran Department of Pathobiology School of Veterinary Medicine Shiraz University Shiraz Iran

The focus of present study was to determine the epidemiological and molecular aspects of different strains of cystic echinococcosis in Fars province, Iran. Liver and lung samples from 410 sheep, 206 goats and 315 cattle were collected. In cattle, the infestation rate was 18.1% (57/315), with 11.1% hepatic cysts and 7.0% pulmonary cysts. Out of all identified cysts, 31.4% of the hepatic and 31.8% of the pulmonary cysts were found fertile. Incidence rate of hydatid cyst infection in sheep was 15.5% (64/410) with 11.9% hepatic cysts and 3.6% pulmonary cysts, of which 24.5% and 20% of hepatic and pulmonary cysts were respectively identified as fertile. The infestation rate was 16.0% (33/206) in goat, in which 10.2% and 5.8% cysts were collected from liver and lung, correspondingly. The prevalence of fertile hepatic and pulmonary cysts was recorded as 23.8% and 16.7%, respectively. Genotyping the cystic materials using PCR showed that the most prominent strains responsible for cystic echinococcosis in the Fars province are G1 and G6/7, while no evidence of E. multilocularis was recorded. This information may give us some clues to find out more about strains distribution in different regions in Iran, which may finally use to find tools in the eradication program of the disease, here and elsewhere.

关键词： Hydatid Cyst PCR Echinococcus Epidemiology

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Etiology and management of urethral calculi:A systematic review of contemporary series

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Asian Journal of Urology 2024年第1期11卷 10-18页

作者： Andrew Morton arsalan Tariq Nigel Dunglison Rachel Esler Matthew J.Roberts Faculty of Medicine The University of QueenslandBrisbaneQueenslandAustralia Department of Urology Ipswich HospitalQueenslandAustralia Department of Urology Royal Brisbane and Women's HospitalQueenslandAustralia The University of Queensland Centre for Clinical Research HerstonAustralia

Objective:To conduct a systematic literature review on urethral calculi in a contemporary cohort describing etiology,investigation,and management ***:A systematic search of MEDLINE and Cochrane Central Register of Controlled Trials(CENTRAL)databases was ***,including case reports and case series on urethral calculi published between January 2000 and December 2019,were ***-text manuscripts were reviewed for clinical parameters including symptomatology,etiology,medical history,investigations,treatment,and *** were collated and analyzed with univariate ***:Seventy-four publications met inclusion criteria,reporting on 95 *** symptoms(41.1%),pain(40.0%),and acute urinary retention(32.6%)were common presenting *** calculi were most often initially investigated using plain X-ray(63.2%),with almost all radio-opaque(98.3%).Urethral calculi were frequently associated with coexistent bladder or upper urinary tract calculi(16.8%)and underlying urethral pathology(53.7%)including diverticulum(33.7%)or stricture(13.7%).Urethral calculi were most commonly managed with external urethrolithotomy(31.6%),retrograde manipulation(22.1%),and endoscopic in situ lithotripsy(17.9%).Conclusion:This unique systematic review of urethral calculi provided a summary of clinical features and treatment trends with a suggested treatment *** in contemporary urological practice should be according to calculus size,shape,anatomical location,and presence of urethral pathology.

关键词： Urinary calculi Urethra Urethral calculi Management algorithm

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Recent Developments in Authentication Schemes Used in Machine-Type Communication Devices in Machine-to-Machine Communication: Issues and Challenges

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Computers, Materials & Continua 2024年第4期79卷 93-115页

作者： Shafi Ullah Sibghat Ullah Bazai Mohammad Imran Qazi Mudassar Ilyas Abid Mehmood Muhammad Asim Saleem Muhmmad Aasim Rafique arsalan Haider Ilyas Khan Sajid Iqbal Yonis Gulzar Kauser Hameed Department of Computer Engineering Balochistan University of Information TechnologyEngineering and Management SciencesQuetta87300Pakistan Department of Information Technology Balochistan University of Information TechnologyEngineeringand Management SciencesQuetta87300Pakistan Department of Information Systems College of Computer Sciences and Information TechnologyKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia Department of Management Information Systems College of Business AdministrationKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia Department of Software Engineering College of ComputingRiphah International UniversityFaisalabad44000Pakistan Department of Electrical Engineering Balochistan University of Information Technology Engineeringand Management SciencesQuetta87300Pakistan Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia

Machine-to-machine (M2M) communication plays a fundamental role in autonomous IoT (Internet of Things)-based infrastructure, a vital part of the fourth industrial revolution. Machine-type communication devices(MTCDs) regularly share extensive data without human intervention while making all types of decisions. Thesedecisions may involve controlling sensitive ventilation systems maintaining uniform temperature, live heartbeatmonitoring, and several different alert systems. Many of these devices simultaneously share data to form anautomated system. The data shared between machine-type communication devices (MTCDs) is prone to risk dueto limited computational power, internal memory, and energy capacity. Therefore, securing the data and devicesbecomes challenging due to factors such as dynamic operational environments, remoteness, harsh conditions,and areas where human physical access is difficult. One of the crucial parts of securing MTCDs and data isauthentication, where each devicemust be verified before data transmission. SeveralM2Mauthentication schemeshave been proposed in the literature, however, the literature lacks a comprehensive overview of current M2Mauthentication techniques and the challenges associated with them. To utilize a suitable authentication schemefor specific scenarios, it is important to understand the challenges associated with it. Therefore, this article fillsthis gap by reviewing the state-of-the-art research on authentication schemes in MTCDs specifically concerningapplication categories, security provisions, and performance efficiency.

关键词： Authentication cyber security internet of things machine-type communication devices machine-to-machine communication

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Analytical approach for predicting local scour downstream of submerged sluice gate with an apron

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International Journal of Sediment Research 2022年第4期37卷 522-537页

作者： arsalan Mostaani Amir H.Azimi Department of Civil Engineering Lakehead University

A new analytical method was evaluated for predicting scour profile downstream of a submerged sluice gate with an apron. The differential equations between bed Shear stress and Scour profile Curvature(SSC model) were utilized to predict the scour profile in both temporal and equilibrium stages. A jet momentum flux was considered as an external source of erosion on a hypothetical particle ring as the boundary between the flow and sediment bed. The scour length and sediment resistance factor were the two unknowns in the governing differential equations. Two solution strategies were introduced to provide a closed-form solution by using the prediction equations of maximum scour depth from the literature and by employing the von K arm an momentum integral equation. The first strategy was used to investigate the effect of jet angle of attack and the angle of the maximum scour slope on the prediction of scour profile. A sensitivity analysis was performed to determine an acceptable range for the maximum scour slope. The shear stress at the location of maximum scour was also estimated using the von K arm an momentum integral equation and the model was modified for erodible curved beds. The modified von K arm an equation was linked with SSC equations to predict the characteristic lengths of scour in temporal and equilibrium stages. Variations in bed shear stress at the location of maximum scour depth decreased non-linearly with time and reached the sediment critical shear stress at equilibrium. Four hydrodynamic regimes were classified to define the temporal variations of bed shear stress. The maximum error for prediction of scour profile with time occurred at the beginning of scour and the proposed model overestimated the maximum scour depth by 34.8% and underestimated the scour length by 7.6%.

关键词： Erosion Scour Turbulent wall jet Sediment transport Bed shear stress von Kármán momentum integral equation

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Performance Evaluation of MWCNTs Reinforced Cement Mortar Composites using Natural and Commercial Surfactants

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Journal of Wuhan University of Technology(Materials Science) 2022年第1期37卷 47-57页

作者： Qareeb Ullah Rao arsalan Khushnood Sajjad Ahmad Muhammad Usman Shad Muhammad Jean-Marc Tulliani School of Civil and Environmental Engineering National University of Sciences and TechnologyIslamabad-44000Pakistan Department of Structural Geotechnical and Building EngineeringPolitecnico di TorinoTurin-10129Italy Department of Civil Engineering FE&TBahauddin Zakariya UniversityMultan-56000Pakistan Department of Applied Science and Technology Politecnico di TorinoTurin-10129Italy

An efficient and promising approach for effectively dispersing multi-walled carbon nanotubes(MWCNTs)in cementitious composites has been *** naturally occurring organic extracts from species of indigenously known‘Keekar’trees scattered along tropical and sub-tropical regions;is found as an exceptional replacement to the non-natural commercial *** the initial phase of investigation,ideal surfactant’s content required for efficient dispersion of MWCNTs in solution was determined using ultra-violet *** experimental investigations were then extended to five different cement composite formulations containing 0.0,0.025,0.05,0.08 and 0.10%MWCNTs by weight of *** was observed that the natural surfactant produced efficient dispersion at much reduced cost(approx.14%)compared with the commercial *** estimated weight efficiency factor f was found 6.5 times higher for the proposed sustainable replacement to the conventional along with remarkable increase of 23%in modulus of rupture on 0.08 wt%addition of *** strength enhancement,the dispersed MWCNTs also improved the first crack and ultimate fracture toughness by 51.5%and 35.9%,*** field emission scanning electron microscopy of the cryofractured samples revealed efficient dispersion of MWCNTs in the matrix leading to the phenomenon of effective crack bridging and crack branching in the composite ***,the proposed scheme significantly reduced the early age volumetric shrinkage by 39%.

关键词： MWCNTs acacia nilotica gum keekar triton X-100 fracture crack bridging cement mortar early age micro-cracking sustainability

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Developing a new constitutive model for hot deformation behaviors of Al/Cu bimetal composites based on their components

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Transactions of Nonferrous Metals Society of China 2022年

作者： Amir arsalan SHAYANPOOR Hamid Reza REZAEI ASHTIANI School of Mechanical Engineering， Arak University of Technology

In this paper， the hot deformation behavior of Al/Cu bimetal composites was investigated using isothermal compression tests at temperatures of 400–500 ℃， strain rates of 0.001–0.1 s-1by considering the effects of volume fractions of composite components (30%-51% Al). In this regard， new proper constitutive equations were developed using Arrhenius-type and the rule of mixture (ROM) models. Experimental flow stress (FS) showed that processing parameters and volume fraction affect the flow behavior of composite as the volume fraction of copper has a more substantial impact on the flow behavior of the composite rods at elevated temperatures. The values of correlation coefficient (R) and average relative error percentage of the developed Arrhenius-type constitutive equation and ROM model were 0.9826， 0.9742， and 0.9718， and also 0.18%， 1.69%， and -0.84% for volume fractions of 51， 42， and 30% Al， respectively. The results indicate that the newly developed constitutive model can successfully predict the hot working behavior of the considered bimetal composite. Finally， the microstructure of composites was investigated under different processing conditions. The dominant mechanisms for three considered volume fractions were identified at different ranges of temperature， strain， and strain rate specified for the hot deformation of the Al/Cu composite.

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不同成分铝/铜双金属复合材料的热变形行为及其本构模型

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Transactions of Nonferrous Metals Society of China 2023年第12期33卷 3641-3660页

作者： Amir arsalan SHAYANPOOR Hamid Reza REZAEI ASHTIANI School of Mechanical Engineering Arak University of TechnologyArakIran

通过等温压缩实验,研究Al/Cu双金属复合材料在400~500℃、应变速率0.001~0.1 s^(-1)条件下的热变形行为,并考虑复合材料成分体积分数(Al含量为30%~51%)的影响。采用Arrhenius模型和混合定律(ROM)模型建立新的本构方程。流变应力(FS)实... 详细信息

通过等温压缩实验,研究Al/Cu双金属复合材料在400~500℃、应变速率0.001~0.1 s^(-1)条件下的热变形行为,并考虑复合材料成分体积分数(Al含量为30%~51%)的影响。采用Arrhenius模型和混合定律(ROM)模型建立新的本构方程。流变应力(FS)实验表明,工艺参数和体积分数对复合材料的流变行为有影响,而Cu的体积分数对复合材料的高温流变行为影响更大。对于体积分数为51%、42%和30%Al的复合材料,建立的Arrhenius型本构方程和ROM模型的相关系数(R)分别为0.9826、0.9742和0.9718,其平均相对误差分别为0.18%、1.69%和-0.84%。结果表明,新建立的本构模型能较好地预测双金属复合材料的热加工行为。最后,研究不同工艺条件下复合材料的显微组织,确定三种不同成分Al/Cu复合材料在不同温度、应变和应变速率范围内的主要热变形机制。

关键词：铝/铜双金属复合材料热变形混合定律(ROM) 本构方程力学行为显微组织

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Origin of superior low-cycle fatigue resistance of an interstitial metastable high-entropy alloy

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Journal of Materials Science & Technology 2022年第20期115卷 115-128页

作者： Seyed Amir arsalan Shams Jae Wung Bae Jae Nam Kim Hyoung Seop Kim Taekyung Lee Chong Soo Lee Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea

In this study, the deformation behaviors and related microstructural evolutions were investigated in either monotonic or cyclic deformation modes in an interstitial metastable high-entropy alloy. These investigations aimed to reveal the mechanisms underlying the superior low-cycle fatigue(LCF) life of this alloy.A thermomechanical process was applied to induce fine-grained(FG) and coarse-grained(CG) microstructures in Fe–30Mn–10Co–10Cr–0.4C(atomic percentage) alloy. Their superior combination of strength and ductility was attributed to the appearance of deformation-induced ε-martensite and the presence of carbon. The CG alloy showed a greater volume fraction of ε-martensite than the FG alloy in the monotonic deformation mode, and vice versa in the cyclic mode. Such a disparity was interpreted in light of the back-stress effect of the relaxed γ-grain boundaries in the latter mode. Meanwhile, the γ-to-ε phase transformation under cyclic loading at low strain amplitudes(0.4%) barely led to an improved fatigue life as compared with that at higher strain amplitudes(≥ 0.55%). The high reversibility of partial dislocation motions under cyclic loading and delaying the formation of dislocation cells through the martensitic transformation could explain why the alloys investigated in this study exhibited a superior LCF life compared with high-entropy alloys reported in previous studies.

关键词： High-entropy alloy Transformation-induced plasticity Monotonic deformation Cyclic deformation Low-cycle fatigue Stacking faults

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Spontaneous xenogeneic GvHD in Wilms'tumor Patient-Derived xenograft models and potential solutions

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Animal Models and Experimental Medicine 2022年第4期5卷 389-396页

作者： Seyed Mostafa Monzavi Ahad Muhammadnejad Maryam Behfar Amir arsalan Khorsand Samad Muhammadnejad Abdol-Mohammad Kajbafzadeh Department of Applied Cell Sciences School of Advanced Technologies in MedicineTehran University of Medical SciencesTehranIran Pediatric Urology and Regenerative Medicine Research Center Tehran University of Medical SciencesTehranIran Gene Therapy Research Center Digestive Diseases Research InstituteTehran University of Medical SciencesTehranIran Cancer Biology Research Center Cancer Institute of IranTehran University of Medical SciencesTehranIran PDX Platform Biomarker Evaluation and Supervision Team for Personalized MedicineMolecular Tumor BoardCancer Institute of IranTehran University of Medical SciencesTehranIran Pediatric Cell and Gene Therapy Research Center Tehran University of Medical SciencesTehranIran

Severely immunocompromised ***-PrkdcIl2rg(NOG)mice are among the ideal animal recipients for generation of human cancer *** of human solid tumors having abundant tumor-i nfiltrating lymphocytes(TILs)can induce xenogeneic graft-versus-host disease(xGvHD)following engraftment and expansion of the TILs inside the animal ***’tumor(WT)has not been recognized as a lymphocyte-predominant ***,3 consecutive generations of NOG mice bearing WT patient-derived xenografts(PDX)xenotransplanted from a single donor showed different degrees of inflammatory symptoms after transplantation before any therapeutic *** the initial generation,dermatitis,auto-amputation of digits,weight loss,lymphadenopathy,hepatitis,and interstitial pneumonitis were *** antibiotic treatment,no response was noticed,and thus the animals were prematurely euthanized(day 47 posttransplantation).Laboratory and histopathologic evaluations revealed lymphoid infiltrates positively immunostained with anti-human CD3 and CD8 antibodies in the xenografts and primary tumor,whereas no microbial infection or lymphoproliferative disorder was *** of the next generation that lived longer(91 days)developed sclerotic skin changes and more severe *** symptoms were milder in the last *** xenografts of the last 2 generations also contained TILs,and lacked lymphoproliferative *** systemic immunoinflammatory syndrome in the absence of microbial infection and posttransplant lymphoproliferative disorder was suggestive of *** there are few reports of xGvHD in severely immunodeficient mice xenotransplanted from lymphodominant tumor xenografts,this report for the first time documented serial xGvHD in consecutive passages of WT PDX-bearing models and discussed potential solutions to prevent such an undesired complication.

关键词： graft-versus-host disease patient-derived xenograft models tumor-infiltrating lymphocytes Wilms’tumor

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