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关于大麻素-1受体阻断剂利莫那班对超重或肥胖患者体重和心脏代谢危险因素影响的随机对照试验:RIO-北美研究

世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 6-7页

作者： Pi-Sunyer F.X. aronne l.j. Heshmati H.M. 任付先 Obesity Research Center St. Luke's- Roosevelt Hospital WH1020 1111 Amsterdam Ave New York NY 10025 United States Dr.

Context: Rimonabant, a selective cannabinoid- 1 receptor blocker, may reduce body weight and improve cardiometabolic risk factors in patients who are overweight or obese. Objective: To compare the efficacy and safety of rimonabant with placebo each in conjunction with diet and exercise for sustained changes in weight and cardiometabolic risk factors over 2 years. Design, Setting, and Participants: Randomized, double- blind, placebo- controlled trial of 3045 obese(body mass index ≥ 30) or overweight(body mass index >27 and treated or untreated hypertension or dyslipidemia) adult patients at 64 US and 8 Canadian clinical research centers from August 2001 to April 2004. Intervention: After a 4- week single- blind placebo plus diet(600 kcal/d deficit) run- in period, patients were randomized to receive placebo, 5 mg/d of rimonabant, or 20 mg/d of rimonabant for 1 year. Rimonabant- treated patients were rerandomized to receive placebo or continued to receive the same rimonabant dose while the placebo group continued to receive placebo during year 2. Main Outcome Measures: Body weight change over year 1 and prevention of weight regain during year 2. Additional efficacy measures included changes in waist circumference, plasma lipid levels, and other cardiometabolic risk factors. Results: At year 1, the completion rate was 309(51% ) patients in the placebo group, 620(51% ) patients in the 5 mg of rimonabant group, and 673(55% ) patients in the 20 mg of rimonabant group. Compared with the placebo group, the 20 mg of rimonabant group produced greater mean(SEM) reductions in weight(- 6.3 [0.2] kg vs - 1.6[0.2] kg; Plevel of triglycerides(percentage change,- 5.3[1.2] vs 7.9 [2.0]; Plevel of high- density lipoprotein cholesterol(percentage change, 12.6 [0.5] vs 5.4 [0.7]; Placebo group during y

关键词：随机对照试验肥胖患者受体阻断剂危险因素心脏代谢大麻素体重超重北美限制饮食

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.j.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Fish embryo and juvenile size under hypoxia in the mouth- brooding African cichlid Pseudocrenilabrus multicolor

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Current Zoology 2012年第3期58卷 401-412页

作者： E.E. REARDON l.j. CHAPMAN Department of Biology McGill University 1205 Dr. Penfield Ave Montreal Quebec H3A 1B 1 Canada Wildlife Conservation Society 2300 Southern Boulevard Bronx NY 10460 USA

We used a field survey and a laboratory rearing experiment to （a） examine response （size and survival） to life-long hypoxia in offspring of the African maternal mouth-brooding cichlid Pseudocrenilabrus multicolor victoriae （Seegers） and （b） explore the degree to which developmental response can be environmentaUy-induced. Embryo size metrics were quantified in 9 field populations across a range of dissolved oxygen （DO） concentrations. In the laboratory, first generation （F1） broods of low-DO origin were reared under high or low DO. Brooding period was quantified for the mothers; and egg size, egg metabolic rate and juvenile size-at-release were quantified in their （F2） offspring. The F2 offspring were split and grown for 3 months post-release under high or low DO, and juvenile size and survival were quantified. In the field survey, across stages, embryos from low-DO field populations were shorter and weighed less than embryos from high-DO populations. In the laboratory experi- ment, F2 eggs and juveniles-at-release from mother＇s mouth did not differ in mass, length, survival regardless of development DO environment. However, juveniles diverged in size after leaving mother＇s mouth, exhibiting smaller size when grown under low DO. Size differences in embryo size across field populations and divergence in embryo size after release from the mother＇s mouth support predictions for smaller body size under hypoxia. There was no evidence for negative effects on survival of juveniles after 3 months. Brooding period was 16% shorter in females reared under low DO suggesting that hypoxia may accelerate embryo de- velopment. This work provides insights into how bearer fishes respond to hypoxic stress relative to fishes with no post-spawning parental care; a shorter brooding interval and smaller body size may provide an optimal solution to parent and embryo survival under hypoxia in brooding fishes [Current Zoology 58 （3）： 401-412, 2012].

关键词： African cichlid lake Victoria life-history Parental care Dissolved oxygen

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EFFECT OF SIlICON ADDITION ON RECRYSTAllIZATION AND PHASE TRANSFORMATION BEHAVIOR OF HIGH-STRENGTH HOT-ROllED TRIP STEEl

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Acta Metallurgica Sinica(English letters) 2008年第3期21卷 163-168页

作者： l.j. Zhu D. Wu X.M. Zhao College of Materials Science and Engineering Jilin University Changchun 130025 China The State Key laboratory of Rolling Technology and Automation Northeastern University Shenyang110004 China

Because Si is a noncarbide forming element, a multiphase microstructure consisting of ferrite, bainite, and retained austenite, at room temperature, can be formed by controlling the thermomechanical process strictly. The cooling schedules must be restricted by the formation of pearlite and cementite. In the present article, a new integrated mathematical model for prediction of microstructure evolution during controlled rolling and controlled cooling is developed for a typical kind of low carbon Si-Mn TRIP steel, which consists of temperature simulation, recrystallization, and transformation models. The influence of Si contents has been thoroughly investigated. The calculated results indicate that Si retards recrystallization, restrains austenite grain growth as well as accelerates polygonal ferrite transformation.

关键词： TRIP steel Recrystallization Ferrite transformation Bainite transformation Silicon

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EFFECT OF Si CONTENT ON ORDERING DEGREE AND ElECTROMAGNETIC CHARACTERISTICS IN FeSiAl AllOYS

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Acta Metallurgica Sinica(English letters) 2008年第3期21卷 191-196页

作者： T.D. Zhou l.j. Deng D.F. liang School of Microelectronics and Solid-state Electronics University of Electronic Science and Technology of China Chengdu 610054 China School of Materials Science and Engineering Xihua University Chengdu 610039 China

FeSiAl alloys ribbons synthesized by melt-quench were annealed in vacuum at 873 K for 60 rain. The flaky powders were prepared by milling the annealed ribbons for 70 h. After milling, the powders were heat treated at 573 K for 90 rain. The ordering degree of the powders lattice structure was analyzed by X-ray diffraction （XRD）. The measurement of specific saturation magnetization was carried out by vibrating samples magnetometer （VSM）. Complex permittivity and complex permeability in the frequency band of 0.5-18 GHz were measured with the vector network analyzer. The ordering degree of the superlattice structure increased from 0.2＇7 to 0.49. Complex permittivity and complex permeability decreased with increasing Si content. After ordering, the specific saturation magnetization decreased from 134.2 to 85.0 ***-1. For use in anti-EMI material, the total contents of Si and Al in FeSiAl alloys should be controlled at a low level.

关键词： Flaky powder Ordering degree Specific saturation magnetization Complex permittivity Complex permeability

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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ElECTROCHEMICAl STUDY ON THE lOCAlIZED CORROSION OF TWO DIFFERENT TEMPER lY12 AllOYS

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Acta Metallurgica Sinica(English letters) 2005年第5期18卷 609-619页

作者： F.H. Cao l. Guo l.j. Zhang Z. Zhang j. Q. Zhang Department of Chemistry Yuquan Campus Zhejiang University Hangzhou 310027 China State Key laboratory for Corrosion and Protection of Metals Institute of Metal Research The Chinese Academy of Sciences Shenyang 110016 China

The corrosion behavior of two different aged lY12 alloys in EXCO （234g/l NaCl, 50g/l KNO3 0.1M HNO3） and MIl-H-600 （35g/l NaCl, 5g/l （NH4）2SO4） solutions were studied using electrochemical impedance spectroscopy （EIS） in conjunction with SEM technique respectively, and the pH variation of the above accelerated corrosion solution during materials corroding was also measured to characterize the corrosion processes. At the beginning of corrosion, EIS plots exhibited two capacitive arcs in the high frequency range （Cd） and mediate frequency range （ Cf） originating from the original corroded surface and the newly formed interface respectively, and a low frequency inductive loop due to the relaxation phenomenon of reaction intermediates. In the EXCO,solution, the EIS results showed that once the exfoliation corrosion occurred, the inductive loop disappeared. The results also showed that the exfoliation corrosion susceptibility of state T6 is much higher than that of state T3, but the intergranular corrosion susceptibility has a reverse order. Based on the relationship of EIS results with SEM and metalloscopy morphologies of the corroding substrates and physic-chemical meaning of EIS parameters, an index （Cf/Cd） has been proposed to characterize the extent of the localized corrosion, which variation tallies with the real corrosion extent correctly. Meanwhile, good agreement was found between the experimental results and the electrochemical model proposed and, good coherence between the electrochemical features and the distribution type of constituent particles of corroding material was observed.

关键词： electrochemical impedance spectroscope lY12 alloy exfoliation corrosion intergranular corrosion

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A Theoretical Approach for Estimating Fracture Toughness of Ductile Metals

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上海交通大学学报 2004年第z2期38卷 114-119页

作者： Y.T. He F. li G.Q. Zhang l.j. Ernst X.j. FU College of Aeronautics University of Air Force Engineering Xi''an 710038 China College of Aeronautics Northwestern Polytechnical University Xi''an710072 China College of Aeronautics University of Air Force Engineering Xi''an 710038 China Philips Centre for Industrial Technology P.O.Box 218 5600 MD Eindhoven The Netherlands Delft University of Technology 2628 CD Delft The Netherlands College of Aeronautics Northwestern Polytechnical University Xi''an 710072 China

Fracture toughness is very important when applying Damage Tolerance Design and Assessment Techniques. The traditional testing approach for obtaining fracture toughness values is costly and time consuming. In order to estimate the fracture toughness of ductile metals, the fracture mechanics theory, materials plastic deformation theory and materials constructive relationships are employed here. A series of formulae and a theoretical approach are presented to calculate fracture toughness values of different materials in the plane stress and plane strain conditions. Compared with test results, evaluated values have a good agreement.

关键词： fracture toughness testing approach evaluated method fracture mechanics theory plastic deformation theory materials constructive relationship theoretical approach

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HIGH-TEMPERATURE lOW-CYClE FATIGUE BEHAVIOR OF NICKEl-BASED SUPERAllOY GH4049

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Acta Metallurgica Sinica(English letters) 1999年第1期12卷 12-15页

作者： Chen, l.j. Yao, G. Wang, Z.G. Tian, j.F. Inst of Metal Research The Chinese Acad of Sciences Shenyang China

The cyclic stress response and lowcycle fatigue life for wrought nickelbased superalloy GH4049 were investigated in the temperature range from 500 to 800 The relationship between the strain amplitude and the number of stress reversals was given. The behavior of cyclic hardening was observed for higher strain amplitudes at all testing temperatures and the lowcycle fatigue life generally decreased with increasing testing temperature for the same strain range. In addition, fracture surfaces of the fatigued samples were examined by using a scanning electron microscope.

关键词： superalloy low cycle fatigue fatigue life

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