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Genetic diseases conferring resistance to infectious diseases

Genes & Diseases 2015年第3期2卷 247-254页

作者： Isabelle C.Withrock Stephen J.Anderson Matthew A.Jefferson Garrett R.McCormack Gregory S.A.Mlynarczyk aron Nakama Jennifer K.Lange Carrie A.berg Sreemoyee Acharya Matthew L.Stock Melissa S.Lind K.C.Luna Naveen C.Kondru Sireesha Manne bhavika b.Patel bierlein Mde la Rosa Kuei-Pin Huang Shaunik Sharma Hilary Z.Hu Sri Harsha Kanuri Steve A.Carlson Department of biomedical Sciences Iowa State University College of Veterinary MedicineAmesIA 50011USA Department of Psychology Iowa State University College of Liberal Arts and SciencesAmesIA 50011USA Department of Kinesiology Iowa State University College of Liberal Arts and SciencesAmesIA 50011USA Department of Genetics Developmental and Cell BiologyIowa State University College of Liberal Arts and SciencesAmesIA 50011USA Neuroscience Interdepartmental Program Iowa State UniversityAmesIA 50011USA

This review considers available evidence for mechanisms of conferred adaptive advantages in the face of specific infectious *** short,we explore a number of genetic conditions,which carry some benefits in adverse circumstances including exposure to infectious *** examples discussed are conditions known to result in resistance to a specific infectious disease,or have been proposed as being associated with resistance to various infectious *** infectious diseasedgenetic disorder pairings include malaria and hemoglobinopathies,cholera and cystic fibrosis,tuberculosis and Tay-Sachs disease,mycotic abortions and phenylketonuria,infection by enveloped viruses and disorders of glycosylation,infection by filoviruses and NiemannePick C1 disease,as well as rabies and myasthenia *** also discuss two genetic conditions that lead to infectious disease hypersusceptibility,although we did not cover the large number of immunologic defects leading to infectious disease *** of the resistance-associated pairings(malaria/hemogloginopathies,cholera/cystic fibrosis,tuberculosis/Tay-Sachs,and mycotic abortions/phenylketonuria)appear to be a result of selection pressures in geographic regions in which the specific infectious agent is *** other pairings do not appear to be based on selection pressure and instead may be ***,research investigating these relationships may lead to treatment options for the aforementioned diseases by exploiting established mechanisms between genetically affected cells and infectious *** may prove invaluable as a starting point for research in the case of diseases that currently have no reliably curative treatments,e.g.,HIV,rabies,and Ebola.

关键词： Disease Infectious Pathogen Polymorphism Resistance Susceptibility

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Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

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The Journal of biomedical Research 2010年第2期24卷 87-99页

作者： Aarti Ruparelia Frances Wiseman Olivia Sheppard Victor L.J.Tybulewicz Elizabeth M.C.fisher Department of Neurodegenerative Disease UCL Institute of Neurology MRC National Institute for Medical Research

Elizabeth fisher and Victor collaboratively for many years on Tybulewicz have worked the Down syndrome mouse model project. Elizabeth fisher＇s background is in molecular genetics and mouse models, with an interest in anueploidy. Victor Tybulewicz is an immunologist whose primary interest is in signal transduction from the antigen receptors of b and T cells.

关键词： Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

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盔甲骑士

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作者： (美.fisher Robert)费希尔

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Epigenetic Regulation Of Gene Expression In The Protozoan Parasite Entamoeba histolytica.

Epigenetic Regulation Of Gene Expression In The Protozoan Pa...

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12th International Congress of Protozoology

作者： Ankri Serge Ohad fisher Hala Harony Mona Abed Sabina bernes Rama Siman-Tov. Department of Molecular Microbiology The bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel

＜正＞DNA methylation is an epigenetic modification that occurs in a wide range of prokaryotic and eukaryotic organisms. DNA methylation is an important mechanism of regulation of genomic functions such as differential control of gene expression. Our knowledge about the relevance of DNA methylation in the biology of protozoan organisms is scanty. We identified by immunodetection the presence of 5-methylated cytosine （m5C） in the parasite Entamoeba histolytica. The synthesis of m5C is catalyzed by a cytosine-5 DNA methyltransferase （Ehmeth） that belongs to the Dnmt2 proteins family. The biological

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基于大五人格理论应用潜在剖面分析探究2型糖尿病患者的用药依从性

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北京大学学报（医学版） 2021年第3期53卷 530-535页

作者：陈平黎泽明郭怡孙昕霙 Edwinb.fisher 北京大学公共卫生学院社会医学与健康教育系北京100191 Department of Health behavior Gillings School of Global Public Health University of North Carolina-Chapel Hill North Carolina 27599-7440 USA

目的:探究2型糖尿病(type 2 diabetes mellitus,T2DM)患者的人格画像,探讨其与用药依从性的关系及用药依从性的影响因素。方法:选取北京市通州区、顺义区中4个社区卫生服务中心所属的22个社区卫生服务站的T2DM患者作为研究对象,采用自... 详细信息

目的:探究2型糖尿病(type 2 diabetes mellitus,T2DM)患者的人格画像,探讨其与用药依从性的关系及用药依从性的影响因素。方法:选取北京市通州区、顺义区中4个社区卫生服务中心所属的22个社区卫生服务站的T2DM患者作为研究对象,采用自行设计的问卷收集人口学信息,采用大五人格量表简式版收集人格信息,运用潜在剖面分析探究人格画像。采用用药依从性量表评估用药依从性,运用方差分析探究不同人格画像的用药依从性是否有差异,应用有序多分类Logistic回归探究用药依从性的影响因素。结果:751例T2DM患者被纳入研究,潜在剖面分析结果显示,本研究中的T2DM患者可分为4类人格画像,包括内敛稳定型(42.7%)、消极型(12.7%)、焦虑型(15.3%)和活泼负责型(29.3%),其中75例患者表示自己不用药也不打胰岛素,5例患者数据缺失,最终671例患者被纳入用药依从性的相关分析。方差分析结果显示,人格画像为焦虑型的患者其用药依从性得分(5.55±1.65)与消极型患者得分(5.94±1.53)差异无统计学意义(P=0.089),但显著低于内敛稳定型(6.17±1.46,P=0.001)和活泼负责型(6.09±1.65,P=0.004)。将人格画像为焦虑型和消极型的患者合并为焦虑消极型纳入有序多分类Logistic回归,结果显示,相比焦虑消极型患者,人格画像为活泼负责型、内敛稳定型是用药依从性好的保护因素(OR=1.567,95%CI:1.096~2.237;OR=1.774,95%CI:1.214~2.591),且受教育程度也影响患者的用药依从性。结论:基于大五人格理论,T2DM患者可分为4类人格画像,将焦虑型和消极型合并后的焦虑消极型是患者用药依从性差的独立危险因素;此外,受教育程度也是用药依从性的影响因素。

关键词： 2型糖尿病人格画像大五人格用药依从性潜在剖面分析

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Operative complications and economic outcomes of cholecystectomy for acute cholecystitis

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World Journal of Gastroenterology 2019年第48期25卷 6916-6927页

作者： Christopher P Rice Krishnamurthy b Vaishnavi Celia Chao Daniel Jupiter August b Schaeffer Whitney R Jenson Lance W Griffin William J Mileski School of Medicine University of Texas Medical BranchGalvestonTX 77555United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Department of biostatistics University of Texas Medical BranchGalvestonTX 77555United States

bACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost *** adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this *** hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost *** To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute *** Under an IRb-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year *** were identified using the acute care surgery registry and billing *** was retrieved via EMR,operative logs,and Revenue Cycle *** severity of acute cholecystitis was graded according to the Tokyo ***18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,*** were analyzed withχ2,fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<*** Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed *** rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs *** with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=

关键词： Acute cholecystitis Tokyo guidelines Cholecystectomy Complications Delayed cholecystectomy

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第一性

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2001年

作者：海伦·费希尔（Helen E.fisher）王家湘译

本书包括：网式思维、组织中的妇女、妇女的词汇、看透别人的心思、妇女如何领导、明天属于妇女、性文明、合作的社会等内容。

ISBN: (纸本)720505169X

本书包括：网式思维、组织中的妇女、妇女的词汇、看透别人的心思、妇女如何领导、明天属于妇女、性文明、合作的社会等内容。

关键词：哲学、宗教心理学

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A NOTE ON A THEOREM OF TAS, TELCI AND fisher

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Applied Mathematics and Mechanics(English Edition) 1998年第4期19卷 333-334页

作者： A. banerjee b. Singh Thakur (Department of Mathematics, Govt. L. b. Girls P. G. College, Raipur (MP), 492001, India)(Govt. b. H. S. S., Gariaband, Dist. Raipur, 493889, India) Department of Mathematics Govt. L. B. Girls P. G. College Raipur India Govt. b. H. S. S. Gariaband Dist. Raipur India

In this paper ,it has been shown that the condition of continuity in the fixed point theorem of Tas, Telci and Fishe[2] is not necessary. Also the completeness of (X, d)can be replaced by the completeness of T(X).

关键词： fixed point mapping continuity

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基于组织学评估和大宗病例分析的原发性女性尿道癌分期修订建议

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临床与实验病理学杂志 2021年第8期37卷 1008-1008页

作者： aron M Park S Lowenthal b M 方三高(摘译) 魏建国(审校) 不详上海金域医学检验所有限公司病理科上海200120 浙江省绍兴市人民医院病理科绍兴312000

原发性女性尿道癌临床罕见,不足女性恶性肿瘤的1%,预后较差。该病临床病理资料较少,分期及标准制定受限。鉴于明显的解剖学和组织学差异,第八版AJCC女性尿道癌分期系统已不适用当前诊断。作者提供了一种改进的基于组织学的分期系统,反... 详细信息

原发性女性尿道癌临床罕见,不足女性恶性肿瘤的1%,预后较差。该病临床病理资料较少,分期及标准制定受限。鉴于明显的解剖学和组织学差异,第八版AJCC女性尿道癌分期系统已不适用当前诊断。作者提供了一种改进的基于组织学的分期系统,反映了女性尿道解剖特征,可用来预测疾病高、低的不同阶段。

关键词：分期系统女性尿道解剖学和组织学大宗病例修订建议临床病理资料解剖特征女性恶性肿瘤

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fisher and Shannon information entropies for a noncentral inversely quadratic plus exponential Mie-type potential

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Communications in Theoretical Physics 2020年第6期72卷 43-56页

作者： Ituen b Okon Cecilia N Isonguyo Akaninyene D Antia Akpan N Ikot Oyebola O Popoola Theoretical Physics Group Department of PhysicsUniversity of UyoUyoAkwa Ibom StateNigeria Department of Physics University of South AfricaPretoria0002South Africa Theoretical Physics Group Department of PhysicsUniversity of IbadanOyo StateNigeria

In this work,we determine the fisher and Shannon entropies,the expectation values and the squeeze state for a noncentral inversely quadratic plus exponential Mie-type potential *** proposed potential is solved under the Schr?dinger equation using a special Greene Aldrich approximation to the centrifugal term to obtain a normalised wave function within the framework of the Nikiforov–Uvarov *** results are obtained for different screening parameters:α?=?0.1,0.12 and 0.13 for varying real constant parameter(b).The numerical solutions are obtained only for ground *** numerical results of fisher entropy both for position and momentum spaces are in good agreement with existing *** normalisation constant,wave function,and probability density plots are carried out using a well designed Mathematica *** Fourier transform of position space entropy gives the momentum space entropy.

关键词： fisher and Shannon entropies Schr?dinger equation expectation values Nikiforov–Uvarov method

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