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Upper Blepharoplasty Scar and Patient Satisfaction Evaluation in a Plastic Surgery Center in mexico

Journal of Biosciences and medicines 2020年第6期8卷 77-88页

作者： Victor Hugo Avalos Gómez Jaime aron García Espinoza José Carlos martínez López Carlos Illich Navarro Delgadillo Blanca Yadira Arámbula Sánchez Alejandro Costa Dulche Cuahutemoc márquez Espriella Esteban Israel Campos Serna Division of Plastic and Reconstructive Surgery Hospital Central Sur de Alta Especialidad de Petróleos Mexicanos Mexico City Mexico

Background: Eyes are one of the most important facial features, their appearance being associated with state of mind, age and beauty. Therefore, upper blepharoplasty is one of the most common procedures performed in plastic surgery. Standardized tools allow for measurement of outcomes through patient satisfaction and surgeon experience. Objectives: Our objective was to measure the satisfaction index and scar quality of patients who underwent upper blepharoplasty using the Patient-reported Outcome measure Questionnaire (PROm-Q) and Patient and Observer Scar Assessment Scale (POSAS). methods: A retrospective review of patients that underwent upper blepharoplasty in our institution was performed. We included those with a preoperative anthropometric analysis, standardized incision markings (developed in our center), same operative technique and a 3-month postoperative evaluation with PROm-Q and POSAS. The sample for this study consists of 67 patients, all of them operated between January 1 2019 and June 30 2019 at the Department of Plastic Surgery, South Central High Specialty Hospital, Pemex, mexico City, mexico. Results: A total of 67 patients were included, 73% female and 27% male. The most frequent indication for surgery was functional visual symptoms. The index of PROm-Q at 3 months demonstrated an increased satisfaction above 90%, and the evaluation with POSAS reported an almost imperceptible scar. Conclusion: Evaluating outcomes with objective tools provides data useful to improve the surgical protocols of patients subjecting to aesthetic procedures.

关键词： Upper Blepharoplasty Satisfaction Index PROm-Q Quality of Life Scar

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Surgical Complications in Breast Reconstruction: Assessment and Associations

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Journal of Biosciences and medicines 2023年第6期11卷 171-181页

作者： Daniel De-Luna-Gallardo Jaime aron García-Espinoza Cuahútemoc márquez-Espriella Blanca Yadira Arámbula-Sánchez marco Antonio Cuervo-Vergara Rodrigo Dávila-Diaz Ricardo García-Corral Fernando Barbosa-Villarreal Fernando Isaac Recio-España Alberto Ignacio Cahuana-Quispe Plastic and Reconstructive Surgery Department Central South High Specialty Hospital of Petróleos Mexicanos Mexico City Mexico Plastic and Reconstructive Surgery Department Petróleos Mexicanos North Central Hospital Mexico City Mexico

Introduction: Breast cancer represents a pathology that generates catastrophic impact and has recently increased its incidence and survival due to timely diagnosis and treatment. Therefore, improving the quality of life of cancer survivors has become a priority, offering reconstructive procedures that reduce complications, costs, hospital stay, and optimize resources. material and methods: 264 patients reconstructed with autologous tissue (TRAm flap and latissimus dorsi) and alloplastic (breast tissue expander—breast implant and direct breast implant) were included. Variables such as demographic, anthropometric, and histologic type were collected. Results: 62% were reconstructed through the use of alloplastics and 38% with autologous tissue. The risk factors related to a greater probability of immediate postoperative complications (surgical site infection, surgical wound dehiscence and reconstruction failure) were obesity (OR: 2.1, CI: 1.5 - 2.7), preoperative radiation (OR: 1.89, CI: 1.75 - 1.92), arterial hypertension (OR: 1.2), Diabetes mellitus (OR: 1.78) and smoking (OR: 1.31). Conclusions: The reconstructive process is complex and influenced by patient factors, surgeon experience and the hospital center. However, when choosing the reconstructive strategy, risk factors present in each patient must be considered, since radiation and obesity present a greater probability of postoperative complications.

关键词： Breast Cancer Breast Reconstruction Obesity Radiotherapy TRAm

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A short-chain acyl-CoA dehydrogenase is essential for mediating ER-β-oxidation,which is required for conidiogenesis and stress tolerance in the rice blast fungus

A short-chain acyl-CoA dehydrogenase is essential for mediat...

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中国植物病理学会第十一届全国会员代表大会暨2018年学术年会

作者： Sami Rukaiya Aliyu Lin Lili Waheed Abdul Chen Xiaomin Lin Yahong Frankine Jagero Otieno Ammarah Shabbir Wajjiha Batool aron Osakina Tang Wei Wang Zonghua Justice Norvienyeku State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops the School of Life SciencesCollege of Plant ProtectionFujian Agriculture and Forestry University Fujian University Key Laboratory for Plant-microbe Interaction the School of Life SciencesCollege of Plant ProtectionFujian Agriculture and Forestry University Institute of Oceanography Minjiang University

Short-chain acyl-CoA dehydrogenase(Scad) mediated β-oxidation serves as the fastest route for generating essential energies required to support the survival of organisms under stress or *** this study,we identified three putative SCAD genes in the genome of globally destructive rice blast pathogen magnaporthe oryzae,named as moSCAD1,moSCAD1,and *** elucidate their function,we deployed targeted gene deletion strategy to investigate individual and the combined influence of moSCAD genes on growth,stress tolerance,conidiation and pathogenicity of the rice blast ***,localization and co-localization results obtained from this study showed that moScad1 localizes to the peroxisome and endoplasmic reticulum(ER),moScad2 localize exclusively to the mitochondria while moScad3 localize partially to mitochondria and peroxisome during all developmental stages of *** mutants showed they are essential in ER-β-*** observation showed that a minimal but significant growth reduction was caused in the deletion mutants Δmoscad1 andΔmoscad2,while,growth characteristics exhibited by the deletion mutant Δmoscad3 was similar with the wild-type ***,we observed that deletion of moSCAD2 resulted in drastic reduction in conidiation,delayed germination,triggered the development of abnormal appressorium and suppressed host penetration and colonization efficiencies of the Δmoscad1 *** study provides first material evidence confirming the possible existence of ER β-oxidation pathway in *** also infer that mitochondria β-oxidation rather than peroxisomal and ER β-oxidation play an essential role in the vegetative growth,conidiation,appressorial morphogenesis and progression of pathogenesis in ***.

关键词： ER-β-oxidation SCADs lipid peroxidation ROS m.oryzae

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Hereditary Immunity and the Origin of Atherosclerosis

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Open Journal of Immunology 2014年第1期4卷 14-21页

作者： Sergey N. Rumyantsev Vil K. Gerasimov Jergy Grzezczuk Roman A. aron Nataly F. Avrova Irina V. Belyakova Ludmila V. Bobrakova Kirill F. Dubrov Ludmila V. Perkus Vladimir F. Pospelov Nina m. Rogacheva Nikolay P. Shabalov Department of Evolutionary Immunology Andent Inc. Jersey City USA

This paper tries to present new confirmation for the opinion about the infectious origin of atherosclerosis from the viewpoint of the current knowledge of hereditary immunity. The performed integrative investigation included the reinterpretation of known clinical and epidemiological observations, supported by immunological, molecular ecological, genetic, and genomic discoveries. The revealed body of firstly achieved information is compatible with the concept that infectious agents contribute the clue step to the development of atherosclerosis over its initial stage performed during the triggering of the arterial endothelial wall by the molecular agent of proposed infectious origin.

关键词： Epidemic Spread Heterozygosity Homozygosity Immune mosaicism Integrative Approach Plaque Formation

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在mR脑结构成像的时代采用传统方法诊断正常压力脑积水的研究

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国际医学放射学杂志 2017年第6期 725-725页

作者： N.miskin H.Patel A.m.Franceschi B.Ades-aron A.Le B.E.Damadian 汪洋 Department of Radiology New York University School of Medicine

摘要目的评估测量胼胝体夹角和埃文斯指数法诊断正常压力脑积水的准确性,并判定其与自动化测量脑容积法在临床应用中的价值。材料与方法 36例正常压力脑积水病

关键词：正常压力埃文斯胼胝体 mR 脑积水

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后工业社会

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世界社会科学 1990年第7期 34-39页

作者： m.克罗齐埃,王大东 ,马燕法

一个新概念1957年,在巴黎大学的一系列讲座中,雷蒙·阿隆(Raymond aron)第一次在欧洲推广运用了“工业社会”这一新概念。他于翌年发表的那本引人注目的书在法国、在欧洲、甚至在美国都获得了巨大的成功。他阐明了一个总是处于运动状态... 详细信息

一个新概念1957年,在巴黎大学的一系列讲座中,雷蒙·阿隆(Raymond aron)第一次在欧洲推广运用了“工业社会”这一新概念。他于翌年发表的那本引人注目的书在法国、在欧洲、甚至在美国都获得了巨大的成功。他阐明了一个总是处于运动状态的、但已达到某种成熟期的社会所需要的平衡条件。他向人们说明了一种制度的深厚的力量。这个制度可以伴随着它本身的矛盾、——如果不是归功于这些矛盾——生存并繁荣起来。工

关键词：政治逻辑主导地位服务行业服务业欧洲概念思维形式参照系

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帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析

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中国肺癌杂志 2021年第9期24卷 I0007-I0016页

作者： Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit mAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUm Frederick H WILSON Sacit Bulent OmAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOmLO Richa GUPTA Hailey WYATT matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet m KLUGER 董晓荣(翻译/校对) Department of medicine(medical Oncology) Yale School of MedicineNew HavenCTUSA Department of Pathology Yale School of MedicineNew HavenCTUSA Department of Radiology Yale School of MedicineNew HavenCTUSA Department of Neurosurgery Yale School of MedicineNew HavenCTUSA Department of Therapeutic Radiology Yale School of MedicineNew HavenCTUSA Interdepartmental Program in Computational Biology and Bioinformatics Yale School of MedicineNew HavenCTUSA Department of Biostatistics Yale School of Public HealthNew HavenCTUSA 华中科技大学同济医学院附属协和医院胸部肿瘤科

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(ce... 详细信息

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于***登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。

关键词：非小细胞肺癌脑转移免疫治疗帕博利珠单抗

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