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国外石油地质 1989年第1期11卷 1-11页

作者： aron.,JS 张宏逵

Investigation of the Physico-Chemical Standards of the Ground Waters around Mai-Bella Area in Asmara

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Journal of Geoscience and Environment Protection 2019年第9期7卷 148-161页

作者： Goitom Kfle Mussie Sium Arumugam Manohar Semere Debretsion aron Tesfamariam Nahom Tesfalem Abel Okbaselasie Kibrom Tesfay Department of Chemistry College of Science Eritrea Institute of Technology Asmara Eritrea SGS Mineral Assay Laboratory Bisha Mining Share Company Asmara Eritrea

There are many possible sources of ground water contamination and may include wastes from industrial chemical production, domestic wastewater and pesticide run off from agricultural lands. The groundwater is thus susceptible to chemical, physical and/or microbiological contamination and ultimately becomes a cause for diverse diseases borne from the contaminated water. It has been a common practice to cultivate vegetables, crops and animal feed grasses around Asmara using sewage and industrial effluents and there are likelihoods that contaminants in the wastewater used for irrigation would infiltrate to the nearby wells. It is believed that the groundwater around the wastewater irrigated area is not safe for domestic and agricultural applications. Thus, this study was conducted to evaluate the quality of the groundwater in order to safeguard the public health treats caused by using this water. Samples were collected from five locations around Mai-Bella and thus different physico-chemical parameters were investigated. The pH of the samples was measured by pH metric method;electrical conductivity (EC) and salinity by using conductometric method. Hardness was estimated by EDTA method;total alkalinity (TA) and bicarbonate concentrations by titrimetric methods. Chloride concentration was analyzed by titration against mercurial nitrate. Na and K were determined using flame photometric method. Fe, Mn, nitrate, nitrite, sulphates and ammonia were determined using spectrophotometric method. Chemical Oxygen Demand (COD) was determined using photometric method. Moreover, the concentrations of trace, major and heavy metals were analysed using Inductively Coupled Plasma Optical Emission Spectrophotometer (ICP-OES). The suitability of the groundwater for domestic and irrigation purposes was examined using WHO and FAO standards. Most of the physico-chemical parameters, except the temperature, pH, COD, Al, Cd, Cr, Cu and Zn, of the samples were found above the standard limits given

关键词： Mai-Bella Groundwater Physico-Chemical Heavy Metals

High-Grade Mucoepidermoid Carcinoma Ex-Pleomorphic Adenoma of the Parotid Gland: Case Report and Review of Literature

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第1期3卷 9-13页

作者： aron Z. Pollack Benjamin C. Paul Mike C. Sheu Gady Har-El Department of Otolaryngology-Head and Neck Surgery New York Uni-versity School of Medicine and Lenox Hill Hospital New York USA

Background: Mucoepidermoid carcinoma ex-pleomorphic adenoma (MECxPA) is an extremely rare salivary gland malignancy. With only nine prior reported cases, this entity represents a challenging histopathological diagnosis. Methods: We present a case of a 71-year-old male with an enlarging left neck mass over several months. CT showed both a parapharyngeal space mass and a separate level II neck mass. Results: The patient underwent resection of the left parapharyngeal mass and ipsilateral selective level II-IV lymphadenectomy. The final pathologic diagnosis was metastatic high-grade mucoepidermoid carcinoma ex-pleomorphic adenoma. Conclusions: We describe a novel presentation of high-grade mucoepidermoid carcinoma ex-pleomorphic adenoma as a metastatic parapharyngeal mass.

关键词： Mucoepidermoid Carcinoma Carcinoma ex-Pleomorphic Adenoma Pleomorphic Adenoma Parotid Gland

脂质抗氧化酶Peroxiredoxin 6对急性肺损伤的抗氧化保护作用

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中华儿科杂志 2008年第10期46卷 739-744页

作者：王燕陆权 Feistein S.SHELDON Ye-Shih HO Shelley A.PHELAN Micheal F.BEERSA aron B.FISHER 上海交通大学附属儿童医院呼吸科 200040 Institute of Environmental Medicine the Center of Lung Biology University of Pennsylvania Depart. of pulmonary and Critical Care Medicine Institute of Environmental Health Sciences Wayne State University Depart. of Biology Fairfield University

目的确定脂质抗氧化酶Peroxiredoxin 6（Prdx 6）对急性肺损伤的抗氧化保护作用。方法应用100％O：吸入诱导雄性小鼠，建立急性肺损伤模型，用H2O2干预诱导，建立细胞损伤模型。分别观察Prdx6基因敲除（Prdx6-／-）小鼠、Prdx6基因过... 详细信息

目的确定脂质抗氧化酶Peroxiredoxin 6（Prdx 6）对急性肺损伤的抗氧化保护作用。方法应用100％O：吸入诱导雄性小鼠，建立急性肺损伤模型，用H2O2干预诱导，建立细胞损伤模型。分别观察Prdx6基因敲除（Prdx6-／-）小鼠、Prdx6基因过度表达（TgPrdx6）小鼠、胞浆谷胱甘肽过氧化物酶（Gpxl）基因敲除（Gpxl-／-）小鼠、野生（WT）小鼠及其肺Ⅱ型上皮细胞的生存率，支气管肺泡灌洗液（BALF）中蛋白和细胞总数；WesternBlot法检测Prdx6或Gpxl蛋白表达水平；观察肺Ⅱ型上皮细胞凋亡情况；采用硫代巴比妥酸反应物法和双苯酯-1-磷酸芘荧光测定法分别检测肺组织和肺Ⅱ型上皮细胞膜质脂氧化水平。结果Prdx6-／-小鼠生存时间较WT小鼠缩短约24h，TgPrdx6小鼠的生存时间较其他组延长；在细胞损伤模型中，Prdx6对细胞生存的保护作用与H2O2干预浓度相关；高氧吸入72h后，Prdx6-／-小鼠的肺内Gpxl蛋白表达水平下调7倍；Gpxl-／-小鼠的肺内Prdx6蛋白表达水平则无明显下调。H2O2干预处理后，肺Ⅱ型上皮细胞凋亡细胞数及百分率的增加与H2O2剂量正相关，并在Prdx6-／-小鼠表现最为明显，而TgPrdx6小鼠组则呈现了持续稳定的10％的凋亡细胞数；Prdx6-／-小鼠组的肺Ⅱ型上皮细胞的细胞膜脂质氧化水平升高，约为WT小鼠2倍，为TgPrdx6组4倍；Prdx6-／-小鼠肺组织的脂质氧化水平较其他组明显增高。结论Prdx6具有重要的抗氧化性肺损伤的保护作用，特别是Prdx6抗细胞凋亡和抗细胞膜脂质氧化的功能提示了其以细胞为单位独特的保护机制。

关键词： Peroxiredoxin 6 抗氧化剂小鼠基因敲除细胞凋亡脂质过氧化作用

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两种新型的32位远程控制软件

个人电脑 1996年第7期2卷 34-35页

作者： Ben Z.gottesman 黄国胜

Symantec Corp.和Traveling Software都将它们流行的远程控制程序带进了32位世界。Symantec的Norton pcAnywhere 32 for Windows和Traveling Software的LapLink for Windows 95的报价均为149美元,它们都充分地利用了Windows 95的环境。... 详细信息

关键词：远程控制 pcAnywhere Windows95 多主机系统远程系统文件传输驱动程序估计市价 MODEM Norton

20世纪50年代在华外国公司的间接国有化(英文)

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20世纪50年代在华外国公司的间接国有化(英文)

北京论坛（2004）文明的和谐与共同繁荣

作者： aron Shai East Asian Affairs Tel-Aviv University

This paper will argue that the Chinese, following their successful revolution, introduced an original method of taking over and gaining control over foreign-owned firms. In fact they managed to successfully secure some of the most modern and prosperous business undertakings in China without incurring either the odium or the financial liability of outright confiscation.

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民族国家间的和平与战争

The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers

作者： (法)雷蒙·阿隆(Raymond aron)

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Cancer Drug Resistance 2023年第3期6卷 468-480页

作者： William J.E.Frye Lyn M.Huff JoséM.González Dalmasy Paula Salazar Rachel M.Carter Ryan T.Gensler Dominic Esposito Robert W.Robey Suresh V.Ambudkar Michael M.gottesman Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA Protein Expression Laboratory Frederick National Laboratory for Cancer ResearchLeidos Biomedical ResearchIncFrederickMD 21704USA

Aim:Ferroptosis is a non-apoptotic form of cell death caused by lethal lipid *** small molecule ferroptosis inducers(FINs)have been reported,yet little information is available regarding their interaction with the ATP-binding cassette(ABC)transporters P-glycoprotein(P-gp,ABCB1)and *** thus sought to characterize the interactions of FINs with P-gp and ABCG2,which may provide information regarding oral bioavailability and brain penetration and predict drug-drug ***:Cytotoxicity assays with ferroptosis-sensitive A673 cells transfected to express P-gp or ABCG2 were used to determine the ability of the transporters to confer resistance to FINs;confirmatory studies were performed in OVCAR8 and NCI/ADR-RES *** ability of FINs to inhibit P-gp or ABCG2 was determined using the fluorescent substrates rhodamine 123 or purpuin-18,***:P-gp overexpression conferred resistance to FIN56 and the erastin derivatives imidazole ketone erastin and piperazine erastin.P-gp-mediated resistance to imidazole ketone erastin and piperazine erastin was also reversed in UO-31 renal cancer cells by CRISPR-mediated knockout of *** FINs ML-162,GPX inhibitor 26a,and PACMA31 at 10µM were able to increase intracellular rhodamine 123 fluorescence over 10-fold in P-gp-expressing MDR-19 *** inhibitor 26a was able to increase intracellular purpurin-18 fluorescence over 4-fold in ABCG2-expressing R-5 ***:Expression of P-gp may reduce the efficacy of these FINs in cancers that express the transporter and may prevent access to sanctuary sites such as the *** ability of some FINs to inhibit P-gp and ABCG2 suggests potential drug-drug interactions.

关键词： Ferroptosis drug resistance P-glycoprotein ABCG2

Immune phenotype in children with therapy-nave remitted and relapsed Crohn’s disease

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World Journal of Gastroenterology 2010年第47期16卷 6001-6009页

作者： aron Cseh Barna Vasarhelyi Kriszta Molnar Balazs Szalay Peter Svec Andras Treszl Antal Dezsofi Peter Laszlo Lakatos Andras Arato Tivadar Tulassay Gabor Veres Research Group for Pediatrics and Nephrology Semmelweis University Hungarian Academy of Sciences Department of Laboratory Medicine Semmelweis University First Department of Pediatrics Semmelweis University First Department of Medicine Semmelweis University

AIM: To characterize the prevalence of subpopulations of CD4+ cells along with that of major inhibitor or stimulator cell types in therapy-nave childhood Crohn's disease (CD) and to test whether abnormalities of immune phenotype are normalized with the improvement of clinical signs and symptoms of disease. METHODS: We enrolled 26 pediatric patients with CD. 14 therapy-nave CD children; of those, 10 children remitted on conventional therapy and formed the remission group. We also tested another group of 12 chil-dren who relapsed with conventional therapy and were given infliximab; and 15 healthy children who served as controls. The prevalence of Th1 and Th2, nave and memory, activated and regulatory T cells, along with the members of innate immunity such as natural killer (NK), NK-T, myeloid and plasmocytoid dendritic cells (DCs), monocytes and Toll-like receptor (TLR)-2 and TLR-4 expression were determined in peripheral blood samples. RESULTS: Children with therapy-nave CD and those in relapse showed a decrease in Th1 cell prevalence. Simultaneously, an increased prevalence of memory and activated lymphocytes along with that of DCs and monocytes was observed. In addition, the ratio of myeloid /plasmocytoid DCs and the prevalence of TLR-2 or TLR-4 positive DCs and monocytes were also higher in therapy-nave CD than in controls. The majority of alterations diminished in remitted CD irrespective of whether remission was obtained by conventional or biological therapy. CONCLUSION: The finding that immune phenotype is normalized in remission suggests a link between immune phenotype and disease activity in childhood CD. Our observations support the involvement of members of the adaptive and innate immune systems in childhood CD.

关键词： Crohn’s disease Dendritic cell Infliximab Lymphocyte Monocyte Regulatory T cell Relapse Remission Therapy-nave Toll-like receptor

老年急性心肌梗死的治疗（Ⅱ）：老年急性心肌梗死的治疗

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世界医学杂志 1999年第11期3卷 13-19页

作者： aron.,W Tres.,D

目的：对老年急性心肌梗死（ａｃｕｔｅｍｙｏｃａｒｄｉａｌｉｎｆａｒｃｔｉｏｎ，ＡＭＩ）的早期治疗进行回顾。方法：系统复习近期发天的有关急性心肌梗死早期治疗的文三老龄可能对并发症发生率和临床结果的影响。结果：一般来... 详细信息

目的：对老年急性心肌梗死（ａｃｕｔｅｍｙｏｃａｒｄｉａｌｉｎｆａｒｃｔｉｏｎ，ＡＭＩ）的早期治疗进行回顾。方法：系统复习近期发天的有关急性心肌梗死早期治疗的文三老龄可能对并发症发生率和临床结果的影响。结果：一般来说，对年龄患者有效的Ａ笃老年人也同样有效。但老年人治疗中发生并发症的危险性增加，为了取得最佳疗效和最小的风险，需谨慎挑合适的患者进行治疗。

关键词：老年人心肌梗塞治疗急性