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Mode of action for inorganic arsenic toxicity and carcinogenesis

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Chinese Science Bulletin 2014年第11期59卷 1078-1082页

作者： Puttappa R.Dodmane Lora L.arnold Samuel M.Cohen Department of Pathology and Microbiology University of Nebraska Medical Center983135 Nebraska Medical Center

Inorganic arsenic(iAs) at high doses is a known human carcinogen, inducing tumors of the skin,urinary bladder, and lung. It is also associated with noncancer toxicities. An understanding of the mode of action(MOA) for arsenic-induced effects is needed to develop a scientifically-based risk assessment. To determine an MOA for iAs induced toxicities, it is necessary to understand the metabolism, kinetics, cell transport, and interaction with specific proteins of iAs. Based on in vitro investigations using animal and human cells, studies from animal models,and clinical and epidemiological studies, we have proposed an MOA involving formation of sufficient levels of reactive trivalent metabolites which interact with critical free sulfhydryl groups, leading to cytotoxicity and regenerative cell proliferation. There is a strong correlation between in vitro cytotoxicity([0.1 lmol/L trivalent arsenicals) and the no effect levels in rodents [approximately 1 ppm(1 ppm = 1 mg/L) of water or diet]. In epithelial target tissues, the cytotoxic effects of iAs result in chronic precursor lesions which have the potential for an increased risk of developing cancer. In non-epithelial tissues, noncancer toxicities such as hypertension and atherosclerosis develop. This MOA implies a non-linear, threshold dose–response relationship for both non-cancer and cancer end points of exposure to iAs.

关键词：体外细胞毒性致癌作用无机砷诱导效应会计准则氧化锌避雷器上皮组织动脉粥样硬化

Cardiac diagnostics before oral propranolol therapy in infantile hemangioma: retrospective evaluation of 234 infants

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World Journal of Pediatrics 2018年第3期14卷 254-258页

作者： Giovanni Frongia Ji-Oun Byeon Raoul arnold Arianeb Mehrabi Patrick Günther Division of Pediatric Surgery Department of GeneralVisceral and Transplantation SurgeryUniversity Hospital of HeidelbergIm Neuenheimer Feld 11069120 HeidelbergGermany Department of Pediatric Cardiology Center for Pediatrics and Adolescent MedicineUniversity Hospital of HeidelbergHeidelbergGermany Department of General Visceral and Transplantation SurgeryUniversity Hospital of HeidelbergHeidelbergGermany

Background The indication and extent of cardiac screening before oral propranolol therapy (OPT) in patients with infantile hemangioma (IH) has been challenged. In this study, we evaluated pre-OPT cardiac diagnostics in a pediatric IH cohort in our department. Methods Retrospective chart review of infants ≤ 12 months old with IH undergoing OPT. The diagnostics prior to OPT, occurrence of complications, and outcome were recorded. Results A total of 234 patients were evaluated. The mean age at the onset of OPT was 4.2 ± 0.3 months, the average dura-tion of OPT was 6.1 ± 0.1 months, and the average follow-up was 12.3 ± 0.7 months. Echocardiograms and electrocardio-grams were performed prior to OPT in all patients. One hundred and three (44.0%) echocardiograms revealed pathological findings, 19 (8.1%) of which were minor (including atrial septal defects, pulmonary stenosis, and patent ductus arteriosus). Pathological findings were observed in 17 (7.3%) of electrocardiograms, only one (0.4%) of which was minor (suspected cardiac arrhythmia, subsequently excluded by long-term electrocardiogram analysis). These findings did not contraindicate OPT and no severe adverse events associated with OPT occurred during the follow-up period. Conclusions Routine cardiac screening by electrocardiogram and echocardiogram before OPT is debatable and not routinely indicated in children with IH. Further studies are necessary to draw definite conclusions on the reasonable indication and extent of this diagnostic approach.

关键词： Cardiac diagnostics Echocardiogram Electrocardiogram Hemangioma Propranolol

Are we really“screening”movement?The role of assessing movement quality in exercise settings

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Journal of Sport and Health Science 2020年第6期9卷 489-492页

作者： Hunter Bennett John arnold Kevin Norton Kade Davison Alliance for Research in Exercise Nutrition and ActivitySansom Institute for Health ResearchUniversity of South AustraliaAdelaideSA 5001 Australia

*** The assessment of movement quality became widespread in exercise settings following the introduction of Gray Cook’s Functional Movement Screen(FMS).1 Assessing muscle and joint function during real-world movement... 详细信息

关键词： movement assessing assessed

Low-Carbon,Mn-Si Cast Steel Structure Modification by Fluidized Bed Heat Treatment

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Journal of Iron and Steel Research International 2011年第S1期18卷 541-545页

作者： Jasiński Józef Podsiad Piotr Jasiński Jaroslaw Bul arnold Kaczmarczyk Andrzej Czestochowa University of Technology Materials Science InstituteArmii Krajowej Av.1942-200 CzestochowaPoland HSW Stalowa Wola E.Kwiatkowskiego St.137-450 Stalowa WolaPoland

The effect of fluidized bed heat treatment (FBHT) on low-carbon Mn-Si cast steel strength properties improvement,strictly ductility is shown in this *** bed heat treatment variants are chosen in order to eliminate the structure defaults after a crystallization *** parameters are set considering an initial state material chemical composition,structure morphology and application criterion after heat *** results are verified according with the standard BS 3100:1991 *** bed heat treatment variants are chosen mainly in order to the Widmanst tten ferrite structures elimination,carbides morphology modification and matrix optimum performance properties *** ZG35SiMn (EN:L30GS) FBHT processes results are verified by the metallographic researches,hardness/microhardness measurements and tensile strength examination.

关键词： cast steel heat treatment modification fluidized bed

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HI! FLY GUY

阅读 2018年第ZB期 22-27页

作者： Tedd arnold

导读一只苍蝇肚子饿了,它出门找吃的。一个男孩也出了门,他要寻找一只宠物。于是,男孩Buzz把苍蝇带回了家,还给苍蝇起了个名字:Fly Guy。Buzz带着Fly Guy去参加宠物大赛,可评委哈哈大笑起来,他们认为苍蝇不是宠物。Fly Guy决定为Buzz争... 详细信息

导读一只苍蝇肚子饿了,它出门找吃的。一个男孩也出了门,他要寻找一只宠物。于是,男孩Buzz把苍蝇带回了家,还给苍蝇起了个名字:Fly Guy。Buzz带着Fly Guy去参加宠物大赛,可评委哈哈大笑起来,他们认为苍蝇不是宠物。Fly Guy决定为Buzz争一口气,他上演了一系列高难度动作,最终获得了"最聪明宠物奖"!于是,一段美好的友谊开始了……

关键词： FLY GUY HI

Preliminary studies on the lichens growing in FEEDS campus and SB garden in Manipur,India

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Studies in Fungi 2020年第1期5卷 392-399页

作者： Nayaka S Joseph S Ngangom R Tilotama K arnold PK Lichenology Laboratory CSIR-National Botanical Research InstituteRana Pratap MargLucknow 226001Uttar PradeshIndia Foundation for Environment and Economic Development Services(FEEDS) HengbungKangpokpi-795129ManipurIndia

In our continuous effort to explore the lichens in new and interesting areas FEEDS campus and SBG garden located in Manipur,a north-eastern state of India are *** study resulted in 47 species in FEEDS campus and 80 species in SB garden respectively,while both areas shared 22 species in *** crustose lichens were more dominant in the area represented by Graphidaceae(16 spp.)and Pyrenulaceae(15 spp.).The species composition in both the sites represented photophilic communities such as graphidaceous,physcioid and parmelioid *** campus had open areas with cultivated plants where as SBG garden had semi-evergreen forest at its initial stage of *** study also added 55 lichen species as new distributional records to Manipur.

关键词： Biodiversity Lichenized fungi Mycobiota North east India Taxonomy

Myocardial Oxygenation Response to Stress Performing a Single-set Compared to Volume-Matched Multiple-Set of Leg Press in Untrained Young Adults

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Journal of Science in Sport and Exercise 2023年第2期5卷 174-181页

作者： Junhai Xu arnold G.Nelson James J.Tufano Juntao Wang School of Kinesiology Louisiana State UniversityBaton RougeLouisianaUSA Faculty of Physical Education and Sport Charles UniversityPragueCzech Republic School of Sport Economic and Management Central University of Finance&EconomicsBeijingP.R.China

Background Debates exist about the preference for single-or multiple-set resistance exercise(RE)on achieving similar training outcome,however,no study examined their effects on the heart,thus,this study was to examine the effect of volume-matched single-and multiple-set RE on the myocardial response through examining rate pressure product(RPP).Methods Fourteen healthy untrained college students performed two leg press exercises(4×10 and 1×40 at 150%body mass)on different days,and each was performed twice in a counterbalanced crossover ***-and post-exercise SBP and HR were measured by auscultatory method,RPP was calculated as SBP×HR×10^(-3),RPP difference(RPPdiff)was calcu-lated by post-exercise RPP subtracting pre-exercise *** Single-set post-exercise RPP(17.48±3.16 mmHg·beats/min),HR(123.86±20.25 beats/min)was significantly greater than multiple-set post-exercise RPP(13.66±3.04 mmHg·beats/min),HR(101.61±19.14 beats/min),*** was no significant difference of SBP(141.07±9.37 vs.134.29±15.16 mmHg)between exercise protocols(P=0.13).The RPPdiff of single-set(6.74±2.86 mmHg·beats/min)was significantly greater than that of multiple-set(3.62±2.90 mmHg·beats/min)(P<0.001).Conclusions Single-set RE exerts a greater myocardial oxygenation response as compared to multiple-set,HR contributed more than SBP to the increase of RPP in *** results indicate that single-set RE can be warranted when wanting to train the heart,while multiple-set RE would appear best for those who should avoid heart stress.

关键词： Myocardial oxygen consumption Rate pressure product Heart rate Systolic blood pressure Resistance exercise

Defensive pressure affects basketball technical actions but not the time-motion variables

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Journal of Sport and Health Science 2016年第3期5卷 375-380页

作者： Jaime Sampaio Roland Leser arnold Baca Julio Calleja-Gonzalez Diogo Coutinho Bruno Goncalves Nuno Leite Research Centre in Sports Sciences Health Sciences and Human Development CIDESD Creative Lab Research Community Sport Sciences Department University of Trás-Os-Montes e Alto Douro Centre for Sport Science and University Sports University of Vienna Faculty of Sport Sciences University of the Basque Country

Background: Novel player tracking technologies can change the understanding of performance determinants in team sports by allowing to accurately measuring the activity demands. The aim of this study was to identify how the defensive pressure affects the time-motion variables and the technical actions in ***: Twenty international male players(age: 16.05 ± 2.09 years, weight: 73.13 ± 8.10 kg, height: 183.10 ± 5.88 cm) played two 10 min basketball quarters, where they used a man-to-man 1/4-court defense until the 4th min(F1/4), changed to man-to-man full court(FULL) for 3 min and, from the 7th to the 10 th min returned to 1/4-court defense(S1/4). A computerized notational analysis was performed using Simi Scout and positional data were captured with the Ubisense Real Time Location System(mean sampling rate 3.74 ± 0.45 Hz per transmitter/player).Results: The time-motion variables presented similar results between defensive conditions, showing a total distance covered around 90 m/***, results suggested possible vertical jump impairments in S1/4 periods. There was more distance covered while jogging in the offensive court(38.15 ± 12.17 m/min offensive court vs. 32.94 ± 10.84 m/min defensive court, p < 0.05) and more distance covered while running in the defensive court(16.41 ± 10.27 m/min offensive court vs. 19.56 ± 10.29 m/min defensive court, p < 0.05).Conclusion: These results suggest how to improve task representativeness during specific conditioning or game-based training situations and also to help coaches' strategic decisions during the games.

关键词： Activity demands Performance analysis Performance indicators Team sports

THE STRUCTURE OF SACRED OMEISHAN, SZECHUAN (Preliminary Notes)

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地质学报 1930年第1期 65-87页

作者： arnold HEIM Professor at the Chungshan University and Geologist to the Geological Survey of Kwangtung and Kwangsi Camon

The following notes are rapidly written as part of the result of a five days excursion. It has been made on a geological expedition to Szechuan during the summer of 1929, executed under the auspices of the Sunyatsen U... 详细信息

关键词： SZECHUAN THE STRUCTURE OF SACRED OMEISHAN Preliminary Notes