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Prevalence of the Metabolic Syndrome Among Employees in Northeast China

Chinese Medical Journal 2015年第15期128卷 1989-1993页

作者： Xin wang Fang Yang Michiel L Bots wei.Ying Guo Bing Zhao arno w hoes Ilonca Vaartjes Department of Epidemiology Julius Center for Health Sciences and Primary Care University Medical Center Utrecht 3508 GA Utrecht The Netherlands International Health Promotion Center First Hospital of Jilin University Changchun Jilin 130000 China Department of Endocrinology First Hospital of Jilin University Changchun Jilin 130000 China Department of Clinical Medicine Changchun Medical College Changchun Jilin 130000 China

Background：The metabolic syndrome is a clustering of metabolic abnormalities and has been associated with increased risk of type 2 diabetes mellitus and cardiovascular *** study aimed to estimate the prevalence of the metabolic syndrome among employees in Northeast ***：Totally,33,149 employees who received health screening in the International Health Promotion Center in the First Hospital of Jilin University were ***,weight,waist circumference,blood pressure,fasting plasma glucose,triglyceride,high-density lipoprotein,and low-density lipoprotein were *** definitions for the metabolic syndrome were applied,revised National Cholesterol Education Program＇s Adult Treatment Panel Ⅲ （NCEP ATP Ⅲ） criteria,the International Diabetes Federation （IDF） criteria,and the Chinese Diabetes Society （CDS） ***：Overall,the age-standardized prevalence of the metabolic syndrome was 22.9%,20.6%,and 15.3% based on dcfinitions of revised NCEP ATP Ⅲ criteria,the IDF criteria,and the CDS criteria,*** had higher age-standardized prevalence than women in all three definitions （P 〈 0.05）.The prevalence was 27.1%,24.5%,and 20.4% for men;17.1%,15.4%,and 8.3% for women,*** most common metabolic component with the metabolic syndrome was overweight （54.7% of men had an elevated body mass index,and 35.9% of women had central obesity）.Conclusions：A large proportion of employees among Northeast China have the metabolic *** findings place emphasis on the need to develop aggressive lifestyle modification for patients with the metabolic syndrome and population level strategies for the prevention,detection,and treatment of cardiovascular risk.

关键词： China Metabolic Syndrome Prevalence

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青霉素治疗儿童急性咽喉痛:随机、双盲临床试验

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英国医学杂志中文版 2004年第3期7卷 148-151页

作者： Sjoerd Zwart Maroeska M Rovers Ruut A de Melker arno w hoes Julius Center for Health Sciences and Primary Care University Medical Center UtrechtStratenum 6.131PO Box 850603508 AB UtrechtNetherlands general practitionerclinical epidemiologistemeritus professor of general practiceprofessor of clinical epidemiology

目的对于小儿咽喉痛患者,应用青霉素治疗3天和7天,并与安慰剂相对照,以评价青霉素的疗效。设计随机、双盲、安慰剂对照试验。设置荷兰的43所全科医疗诊所。对象 156例4～15岁的患儿,具咽喉痛症状<7天;至少符合4项主要诊断标准中的... 详细信息

目的对于小儿咽喉痛患者,应用青霉素治疗3天和7天,并与安慰剂相对照,以评价青霉素的疗效。设计随机、双盲、安慰剂对照试验。设置荷兰的43所全科医疗诊所。对象 156例4～15岁的患儿,具咽喉痛症状<7天;至少符合4项主要诊断标准中的2项(有发热病史;无咳嗽;颈前淋巴结轻度肿大;扁桃体可见分泌物)。干预措施将病人随机分为3组:青霉素治疗7天组、青霉素治疗3天继而服用安慰剂4天组、安慰剂服用7天组。衡量结局的主要指标症状持续的时间;平均使用止痛剂的时间;因病休课的天数;链球菌感染后遗症的发生率;对病原体的根除率及6个月后咽痛的再发率。结果应用青霉素治疗咽喉痛患儿,与安慰剂比较并无明显优势,无论是对参与试验的所有患儿还是对有A组链球菌感染的96名患儿。随机分到青霉素治疗7天组有1名患儿出现了链球菌感染后遗症;青霉素治疗3天后继用安慰剂组有2例,而服用安慰剂7天组有8例患儿出现链球菌感染后遗症。结论在小儿咽喉疼痛平均持续时间方面,青霉素治疗并无明显优势。但是,它可能降低链球菌感染后遗症的发生率。

关键词：青霉素治疗儿童急性咽喉痛临床试验

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可疑肺栓塞的诊断预测模型：基于基层医疗机构的系统性综述和独立外部验证

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英国医学杂志中文版 2016年第6期19卷 304-304页

作者： Janneke M THendriksen Geert-Jan Geersing wwire A M Lucassen Petra M G Erkens Henri E J H Stoffers Henk C P M van weert Harry R Buller arno w hoes Karel G M Moons 龙俐 Departmcnt of Epidemiology Julius Center for HealthSciences and Primary Care University Medical CenterUtrecht 3508GA Utrecht Netherlands Departmenl ofGeneral Practice Academic MedicalCenter AmsterdamNetherlands Department of Family Medicine CAHPRI School forPublic Health and Primary CareMaastricht University MaastrichtNetherlands Department ofVascular Medicine Academic MedicalCenter AmsterdamNetherlands 广州医科大学附属第一医院广州呼吸疾病研究所

目的验证在基层医疗机构易于应用的排除肺栓塞的诊断预测模型。设计在系统性综述后进行独立外部验证，以评估基层医疗机构预测模型的应用价值。背景300家荷兰的全科医疗机构。研究对象基层医疗机构中598例可疑急性肺栓塞患者的个体临床... 详细信息

目的验证在基层医疗机构易于应用的排除肺栓塞的诊断预测模型。设计在系统性综述后进行独立外部验证，以评估基层医疗机构预测模型的应用价值。背景300家荷兰的全科医疗机构。研究对象基层医疗机构中598例可疑急性肺栓塞患者的个体临床数据。主要结局测量指标通过系统性文献检索回顾所有模型的鉴别诊断能力，应用C统计计算和对比数据进行评估。按照前期的特定模型的界值联合定性D，二聚体测定，确定肺栓塞可能性，按肺栓塞的高低可能性分组后计算所有模型的敏感性、特异性、效能（低可能性肺栓塞患者的总体比率）及失效率（低可能性患者中肺栓塞病例的比率）。结果共发现10种已发表的诊断肺栓塞预测模型。其中5种可被基层医疗机构患者数据验证：原版wells量表、改良wells量表、简版weus量表、改良Geneva量表和简版改良Geneva，

关键词：预测模型验证评价系统护理诊断栓塞肺

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Investigating the use cases of a novel heat battery in Dutch residential buildings

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建筑模拟(英文) 2023年第9期16卷 1675-1689页

作者： Shuwei wang Pieter-Jan hoes Jan L.M.Hensen Olaf C.G.Adan Pim A.J.Donkers Department of the Built Environment Eindhoven University of TechnologyEindhovenP.O.Box 5135600 MB Eindhoventhe Netherlands Department of Applied Physics Eindhoven University of TechnologyEindhovenP.O.Box 5135600 MB Eindhoventhe Netherlands TNO Materials Solutions P.O.Box 62355600 HE Eindhoventhe Netherlands Cellcius BV Horsten 15612 AXEindhoventhe Netherlands

Recent advances in thermochemical storage technology have introduced a novel closed-loop thermal energy storage(TES)system,known as the heat battery(HB),which is believed to have great potential for aiding the energy transition in the built environment because of its higher energy density and neglectable storage loss compared to conventional TES *** order to investigate the potential use cases of the HB and provide practical feedback for its further development,this research employs a simulation-based approach to analyze its influence on building performance in various use cases within Dutch residential *** including the homeowner,distribution system operator,and district heating system operator are identified,and a preliminary list of use cases is defined based on relevant literature and input from the HB *** simulation approach is conducted to predict key performance indicators for each *** Kruskal-wallis test was employed to sort and scrutinize the simulation outcomes and discern the significance of each use case *** findings demonstrated that the HB holds the potential to diminish both the operational energy cost by up to 30%for the homeowners and the peak heating load transmitted from the building to the district heating system.

关键词： thermochemical storage building performance simulation use case solar energy demand-side management

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THE STRUCTURE OF A NEw LIGNAN DIOL

引用

Chinese Chemical Letters 1993年第1期4卷 31-32页

作者： hoes Jie wANG, Yan Yong CHEN and Xiao Tian LIANG Institute of Materia Medica, Chinese Academy of Medical Sciences Beljing 100060

A lignan diol (1) was isolated from Schisandra rubriflora Rhed et wils. It is racemic, with RS, RS, RS, SR configurations for the four consecutive asymmetric centers as shown.

关键词： OCH THE STRUCTURE OF A NEw LIGNAN DIOL

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十一个抗病油用向日葵种质品系

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国外农学（向日葵） 1989年第4期 50-51页

作者： hoes,JA 赵侠

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Lymphocyte reduction induced by hindlimb unloading: distinct mechanisms in the spleen and thymus

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Cell Research 2003年第6期13卷 465-471页

作者： ARTHUR I ROBERTS Department of Molecular Genetics Microbiology and Immunology University of Medicine and Dentistry ofNew Jersey-Robert wood Johnson Medical School 661 hoes Lane Piscataway New Jersey 08854 USA

Hindlimb unloading (HU) in rodent is a well-accepted ground-based model used to simulate some of the conditions of space flight and reproduce its deleterious effects on the musculoskeletal, cardiovascular and immune systems. In this study, the effects of HU on lymphocyte homeostasis in the spleen and thymus of mice were examined. HU was found to drastically deplete various cell populations in the spleen and thymus. These changes are likely to be mediated by apoptosis, since DNA strand breaks indicative of apoptosis were detected by terminal deoxynucleotidyl transferase-mediated nick end-labeling in both splenocytes and thymocytes. Surprisingly, administration of opioid antagonists or interference with the Fas-FasL interaction was able to block HU-induced reductions of splenocytes, but not thymocytes. On the other hand, steroid receptor antagonists blocked the reduction of lymphocyte numbers in both spleen and thymus. Therefore, the effects of HU on the homeostasis of splenocytes and thymocytes must be e

关键词： hindlimb unloading apoptosis stress lymphocytes.

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床旁D-二聚体检测在门诊患者排除静脉血栓栓塞的价值：一项诊断性荟萃分析

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英国医学杂志中文版 2009年第6期12卷 342-350页

作者： G J Geersing K J M Janssen R Oudega L Bax A w hoes J B Reitsma K G M Moons 高晓方(译) 陈良安(校) 何耀(校) Julius Centerfor Health Sciencesand Prirrary Care University MedicalCenter UtrechtUtrecht Netherland Kitasato ClinicalResearch Center Kitasato UniversityJapan Department ofClinical Epidemiologyarm Biostatistics Academic MedicalCenter Universityof AmsterdamAmsterdamNetherlands 解放军总医院

目的对目前排除静脉血栓栓塞的床旁D-二聚体检测的诊断准确性的证据进行评价。设计利用双变量回归检验变异来源，系统评价关于床旁D-二聚体检测的准确性的相关研究，并对敏感性和特异性进行评估。数据来源发表于1995年1月至2008年9月，... 详细信息

目的对目前排除静脉血栓栓塞的床旁D-二聚体检测的诊断准确性的证据进行评价。设计利用双变量回归检验变异来源，系统评价关于床旁D-二聚体检测的准确性的相关研究，并对敏感性和特异性进行评估。数据来源发表于1995年1月至2008年9月，并且于Medline和Embase中可检索到的关于床旁D-二聚体检测的诊断准确性的研究报告。评价方法纳入荟萃分析的研究需满足如下条件：对床旁D-二聚体检测与预先定义的静脉血栓栓塞的D-二聚体参考标准进行比较，人选患者为连续门诊病例，并且能够以此构建2×2表格。结果共有23项研究报告（病例总数为13959例，平均年龄为38—65岁，静脉血栓栓塞发病率为4％～51％）纳入荟萃分析。这些研究报告了两种床旁D-二聚体定性检测方法（SimpliREDD-二聚体（n=12）和Clearview Simplify D-二聚体（n=7））和两种床旁D-二聚体定量检测方法（CardiacD-二聚体（n=4）和Triage D-二聚体（n=2））。总体敏感性处于0．85（95％可信区间为0．78～0．90）至0．96（0．91～0．98）之间；总体特异性处于0．48（0．33～0．62）至0．74（0．96～0．78）之间。CardiacD-二聚体和TriageD-二聚体这两种定量检测方法评分最佳。结论在可疑静脉血栓栓塞的门诊患者中，床旁D-二聚体检测能够提供重要信息并指导治疗，在低风险患者（即临床决策规则评分较低的患者）中的价值尤为显著。

关键词： D-二聚体检测静脉血栓栓塞荟萃分析门诊患者床旁诊断性定量检测方法 Medline

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Immunosuppressive properties of cloned bone marrow mesenchymal stem cells

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Cell Research 2007年第3期17卷 240-248页

作者： Robert C Zhao Department of Molecular Genetics Microbiology and Immunology Robert wood Johnson Medical School-University of Medicine and Dentistry of New Jersey 661 hoes Lane Piscataway NJ 08854 USA

Mesenchymal stem cells(MSCs),derived from adult tissues,are multipotent progenitor cells,which hold greatpromise for regenerative *** studies have shown that MSCs are immunosuppressive in vivo and in vitro inboth animals and ***,the mechanisms that govern these immune modulatory functions of MSCs remainlargely *** studies with bulk populations of MSCs indicated that soluble factors such as PGE2 and TGFβ areimportant,while others support a role for cell-cell *** this study,we intended to clarify these issues by examin-ing immunosuppressive effects of cloned *** derived MSC clones from mouse bone marrow and showed thatthe majority of these clones were able to differentiate into adipocytes and osteoblast-like ***,cells fromthese clones exhibited strong inhibitory effects on TCR activation-induced T cell proliferation in vitro,and injection ofa small number of these cells promoted the survival of allogeneic skin grafts in *** medium from MSCcultures showed some inhibitory effect on anti-CD3 induced lymphocyte proliferation independent of PGE2 and TGFβ.In comparison,direct co-culture of MSCs with stimulated lymphocytes resulted in much stronger ***,the suppression was bi-directional,as MSC proliferation was also reduced in the presence of *** together,our findings with cloned MSCs demonstrate that these cells exert their immunosuppressiveeffects through both soluble factor(s)and cell-cell contact,and that lymphocytes and MSCs are mutually inhibitory ontheir respective proliferation.

关键词： suppression T ceils cytokines stem cells transplantation

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Overexpression of Bax sensitizes prostate cancer cells to TGF-β induced apoptosis

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Cell Research 2005年第3期15卷 160-166页

作者： David DANIELPOUR Ireland Cancer Center Case western Reserve University 10900 Euclid Avenue Cleveland OH 44106 USA

NRP-154 is a tumorigenic epithelial cell line derived from the preneoplastic dorsal-lateral prostate of rats. These cells are exquisitely sensitive to TGF-β induced apoptosis. In contrast, we find that NRP-154 cells can sustain overexpression of exogenous Bax protein, which is different from non-tumor cells where Bax functions as a ubiquitous stimulator of apoptosis. NRP-154 cells stably overexpressing Bax show increased sensitivity to TGF-β induced apoptosis. The degree of TGF-β induced apoptosis displays high correlation with cleavage of Bax at the amino-terminus. Our data indicate that prostate cancer cells can host high levels of latent Bax which can be activated through post-translational modification.

关键词： NRP-154 cells prostate cancer Bax TGF-β apoptosis.

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