检索结果-南通市图书馆

缤纷 2008年第10期 142-143页

作者： arnd christian mueller Tina 张密

我相信,平日基本上没人会去注意到这些细节,不管是当地居民还是旅游者。但这并无关紧要,因为这些井盖就是在那里默默地恪守着自己的职责。然而,我却希望能有更多的目光投向这些被忽略的设计,它们通过自身不同的图案和个性,丰富着这座城... 详细信息

我相信,平日基本上没人会去注意到这些细节,不管是当地居民还是旅游者。但这并无关紧要,因为这些井盖就是在那里默默地恪守着自己的职责。然而,我却希望能有更多的目光投向这些被忽略的设计,它们通过自身不同的图案和个性,丰富着这座城市的日常生活。

关键词：立体设计井盖日常生活旅游者当地居民匿名城市图案西班牙细节

Early cisternal fibrinolysis is more effective than rescue spasmolysis for the prevention of delayed infarction after subarachnoid haemorrhage

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Stroke & Vascular Neurology 2022年第2期7卷 108-113页

作者： Roland Roelz christian Scheiwe Jürgen Grauvogel Istvan Csok Volker arnd Coenen Jürgen Beck Peter C Reinacher Department of Neurosurgery Medical Center-University of FreiburgFreiburgGermany Department of Stereotactic and Functional Neurosurgery Medical Center-University of FreiburgFaculty of MedicineFreiburgGermany Fraunhofer Institute for Laser Technology(ILT) AachenGermany

Background To compare the efficacy of two different concepts of cisternal therapy—PREVENTIVE fibrinolysis plus on-demand spasmolysis versus RESCUE spasmolysis—for the prevention of cerebral vasospasm(CVS)and delayed cerebral infarction(DCI)in patients with aneurysmal subarachnoid haemorrhage(aSAH).Methods Retrospective analysis of 84 aSAH patients selected for cisternal therapy for DCI prevention.66 high-risk patients received PREVENTIVE cisternal therapy to enhance blood *** stereotactic catheter ventriculocisternostomy(STX-VCS)or intraoperative placement of a cisterno-ventriculostomy catheter(CVC),followed by fibrinolytic cisternal lavage using urokinase was *** case of vasospasm,nimodipine was applied intrathecally.22 low-risk patients who developed CVS against expectations were selected for STX-VCS as RESCUE intervention for cisternal spasmolysis with *** of DCI and mean flow velocities of daily transcranial Doppler(TCD)ultrasonographies were *** Despite a higher prespecified DCI risk,patients selected for PREVENTIVE intervention primarily aiming at blood clearance had a lower DCI rate compared with patients selected for intrathecal spasmolysis as a RESCUE therapy(11.3%vs 18.2%).After intrathecal treatment onset,CVS(TCD>160 cm/s)occurred in 45%of patients with PREVENTIVE and 77%of patients with RESCUE therapy(p=0.013).A stronger response of CVS to intrathecal nimodipine was observed in patients with PREVENTIVE intervention as the mean CVS duration after start of intrathecal nimodipine was 3.2 days compared with 5.8 days in patients with RESCUE therapy(p=0.026).Conclusions PREVENTIVE cisternal therapy directed at blood clearance is more effective for the prevention of CVS and delayed infarction compared with cisternal RESCUE spasmolysis.

关键词： prevention spasmolysis infarction

Do you want to participate in a clinical study as a healthy control?-Risk or benefit?

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World Journal of Clinical Cases 2017年第12期5卷 437-439页

作者： Hanna Giessen christian A Nebiker Matthias Bruehlmeier Stefan Spreitzer Beat mueller Philipp Schuetz Department of Internal Medicine Kantonsspital Aarau Department of Surgery Kantonsspital Aarau Department of Nuclear Medicine Kan- tonsspital Aarau Department of Pathology Kantonsspital Aarau

A healthy woman volunteered to participate as "healthy control" in a *** increased level of procalcitonin(PCT) was detected and remained elevated on follow-up *** calcitonin levels were elevated as well,thyroid ultrasound was performed which revealed nodes in both thyroid lobes,one of them showing metabolic activity in positron emission tomography-computed tomography *** exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma(MTC) was detected in the right *** is a rare endocrine tumor with a poor prognosis once having spread,therefore early detection remains a priority for the *** parameter is serum calcitonin,in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity.

关键词： Medullary thyroid cancer Procalcitonin Thyroid nodes Endocrinology Public health Healthy control

Evaluation of joint awareness after acetabular fracture:Validation of the Forgotten Joint Score according to the COSMIN checklist protocol

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World Journal of Orthopedics 2021年第2期12卷 69-81页

作者： Viola Freigang Johannes Weber Karolina mueller christian Pfeifer Michael Worlicek Volker Alt Florian Michael Baumann Department of Trauma Surgery Regensburg University Medical CenterRegensburg 93042Germany Center for Clinical Studies Regensburg University Medical CenterRegensburg 93042Germany

BACKGROUND A fracture of the acetabulum is an uncommon,but serious *** outcome tools do not reflect the patient’s perspective after fracture of the hip *** designed for post-arthroplasty patients,the Forgotten Joint Score(FJS)is a patient-reported outcome measurement(PROM)tool evaluating the diseasespecific health-related quality of life(HR-QoL).AIM To validate the FJS in patients after acetabular *** In a prospective mono-centric cohort study,we evaluated 100 patients at mean 5.2±3.6 years after a fracture of the *** validation study followed the complete COSMIN checklist *** calculation of convergent validity,we used the Tegner-Activity Scale,the Western Ontario and McMaster Universities Osteoarthritis Index,the EuroQol-5D,and a subjective rating of change as an anchor *** We confirmed good internal consistency with a Cronbach‘s alpha of *** an intraclass correlation coefficient of 0.99(95%CI:0.97,0.99),test-retest reliability of the FJS was *** coefficients between the questionnaires were moderate to high ranging from|0.56|to|0.83|(absolute value).No relevant floor or ceiling effects *** error of measurement was 3.2 and smallest detectable change(SDC)was ***,changes greater than 8.8 points between two assessments denote a real change in *** The FJS is a valid and reliable tool for evaluation of patient-reported outcome in posttraumatic condition after acetabular *** SDC indicating a real clinical improvement was 8.8 points in the *** could confirm responsiveness of the FJS and found no relevant floor-or ceiling effects.

关键词： Patient reported outcome measurement Validation study Hip joint Forgotten Joint Score Acetabulum fracture COSMIN checklist

光学纯(4S,5R)-4-甲基-5-羟基-3-羰基己酸特丁酯的化学酶促合成

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有机化学 2002年第12期22卷 1009-1012页

作者：吉爱国 Michael mueller Michael Wolberg Werner Hummel christian Wandreyb 山东大学药学院济南250012 德国于利希研究中心生物技术研究所于利希52425 德国于利希研究中心杜塞尔多夫大学酶技术研究所于利希52426

采用化学方法合成了 4 甲基 3,5 二羰基己酸特丁酯 .以Lactobacillusbrevis醇脱氢酶为生物催化剂 ,选择性地将 4 甲基 3,5 二羰基己酸特丁酯还原为 (4S ,5R) 4 甲基 5 羟基 3 羰基己酸特丁酯 (99.2 %ee,syn∶anti=97∶3) .

关键词：光学纯 (4S,5R)-4-甲基-5-羟基-3-羰基己酸特丁酯化学酶促合成 Lactobacillus brevis醇脱氢酶药物中间体

VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab

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World Journal of Gastroenterology 2008年第26期14卷 4156-4167页

作者： Markus Moehler christian Frings Annett mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann 1st Department of Medicine Johannes Gutenberg University Mainz 55101 Germany Department of General and Abdominal Surgery Johannes Gutenberg University Mainz 55101 Germany

AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab.

关键词： Human colorectal cancer Lymphangiogenesis Vascular endothelial growth factor-C Vascular endothelial growth factor-D Epidermal growth factor receptor

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3,5-二羟基-4-甲基己酸叔丁酯的合成

中国医药工业杂志 2003年第2期34卷 57-57,80页

作者：吉爱国 Michael mueller Michael Wolberg christian Wandrey 山东大学药学院山东济南250012 德国于利希研究中心生物技术研究所

以 2 -甲基 - 3-羰基丁酸乙酯为原料 ,经 3-羟基 - 2 -甲基丁酸乙酯和 5 -羟基 - 4-甲基 - 3-羰基己酸叔丁酯合成了3,5 -二羟基 - 4-甲基己酸叔丁酯 ,总收率 38%。

关键词： 3,5-二羟基-4-甲基己酸叔丁酯合成中间体化合物

Limb symmetry index in competitive alpine ski racers:Reference values and injury risk identification according to age-related performance levels

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Journal of Sport and Health Science 2018年第4期7卷 405-415页

作者： Lisa Steidl-Müller Carolin Hildebrandt Erich Müiller christian Fink christian Raschner Department of Sport Science University oflnnsbruekInnsbruck 6020Austria Department of Sport Science and Kinesiology University of SalzburgSalzburg 5400Austria Research Unit for Orthopedic Sports Medicine and Injury Prevention Institute of Psychology（ISAG）The Health ＆ Life Sciences University（UMIT）Innsbruck 6020Austria Gelenkpunkt-Sports and Joint Surgery Innsbruck 6020Austria Corresponding author.E-mail address：lisa.steidl-mueller@uibk.ac.at

Purpose： The aims of this study were to assess differences of limb symmetry index （LSI） in strength- and coordination-related tasks between high-level, competitive, noninjured ski racers of different age-related performance levels and to prospectively assess limb differences as a possible risk factor for traumatic and overuse injury in youth ski racers. Methods： The study （Study 1） included 285 high-level competitive ski racers （125 females, 160 males） of 3 age-related performance levels and based on the school system： 95 youth （10-14 years, secondary modem school）, 107 adolescent （15-19 years, grammar school）, and 83 elite athletes （20-34 years）. To investigate the second aim （Study 2）, 67 of the 95 youth athletes were included and any traumatic or overuse injuries were prospectively recorded over 2 seasons. All athletes performed 4 unilateral tests （strength related： one-leg counter movement jump （OL-CMJ） and one-leg isometric/isokinetic press strength test （OL-ILS）; coordination related： one-leg stability test （OL-ST） and one-leg speedy jump test （OL-SJ））. The LSI was calculated by dividing the dominant leg by the nondominant leg and multiplying by 100. Kruskal-Wallis H tests and binary logistic regression analyses were conducted. Results： There were significant differences between the LSI of the 3 age-related performance-level groups only in the strength-related tests： the OL-CMJ （X^2（2, 285） = 9.09; p = 0.01） and the OL-ILS （X^2（2,285） = 14.79; p 〈 0.01）. The LSI for OL-ILS was found to be a significant risk factor for traumatic injury in youth ski racers （Wald = 7.08; p 〈 0.01）. No significant risk factors were found for overuse injuries. Conclusion： Younger athletes display slightly greater LSI values only in the strength-related tests. The cut-off value of limb differences of 〈 10% for return to sport decisions seems to be appropriate for elite athletes, but for youth and adolescent athletes it has to be critically discussed. It seems to be necessary to defi

关键词： Age-related performance levels Alpine ski racing Injury risk Limb differences Youth athletes

Thermochemical Treatment—Technologies for Recovery and Upvaluating of Materials

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Thermochemical Treatment—Technologies for Recovery and Upva...

7th World Congress on Recovery, Recycling and Re-integration

作者： Gerd arnd Kley Rudolf Simon Brenneis Adamczyk Franz-Georg christian Burkart Adam Peter Kcher Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany BAM LinderhofstraΒe 8 Berlin D-12623 Germany

Raw and waste materials can be converted to more valuable products by biological, mechanical, chemical, thermal and thermochemical treatment technologies. Thermochemical separation is one of the most efficient ways to increase the purity of products or/and decrease the environmental impact of waste materials. The methods of thermochemical substance separation currently used at the Federal Institute for Materials Research and Testing (BAM) were initially developed to convert inferior raw materials (e.g bauxites of different origins) into high-temperature and hard materials by removal of impurities. The principle of the treatment is the chemical conversion of unwanted constituents to volatile compounds or to elements and alloys. While the volatile compounds are removed by the exhausting system, the elemental phase is separated from the mineral fraction due to its higher density. The thermochemical separation was carried out predominantly in molten state, but can also occur below the melting point by physical or chemical processes.

关键词： thermochemical separation, recovery, raw and waste materials, heavy metals, ressources, filter dust, slags, sewage sludge, fertilizer, silicate products

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办公惊喜

缤纷 2012年第7期 52-53页

作者： arnd christian Mller Momentum 赵雨思 Hans Schlupp

"我们希望办公空间能够体现行业特质,但不要‘银行’式的风格;我们希望这个设计能成为经典,而非同行业公司千篇一律的环境;当访客到来时,希望这里能让他们感受到公司的整体素质、企业全球化形象,以及我们对中国市场的重视……"在德国设... 详细信息

"我们希望办公空间能够体现行业特质,但不要‘银行’式的风格;我们希望这个设计能成为经典,而非同行业公司千篇一律的环境;当访客到来时,希望这里能让他们感受到公司的整体素质、企业全球化形象,以及我们对中国市场的重视……"在德国设计师Amd接手这个办公室设计时,客户提出了一系列的个性化需求,主旨只有一个那就是与众不同,摆脱传统金融商贸类公司的冷峻严肃。于是,arnd带领他的设计团队,在深入了解客户需求的基础上。

关键词：设计师设计理念客户需求现代风格团队空间无限公司商贸设计风格区域划分