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Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

Nano-Micro Letters 2024年第6期16卷 127-179页

作者： Amal George kurian Rajendra k.singh Varsha Sagar Jung‑Hwan Lee Hae‑Won kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&Bk21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

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Unleashing the Power of Multi-Agent Reinforcement Learning for Algorithmic Trading in the Digital Financial Frontier and Enterprise Information Systems

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Computers, Materials & Continua 2024年第8期80卷 3123-3138页

作者： Saket Sarin Sunil k.singh Sudhakar kumar Shivam Goyal Brij Bhooshan Gupta Wadee Alhalabi Varsha Arya Chandigarh College of Engineering and Technology Chandigarh160019India Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India Department of Computer Science Immersive Virtual Reality Research GroupKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Business Administration Asia UniversityTaichung413Taiwan Department of Electrical and Computer Engineering Lebanese American UniversityBeirut11022801Lebanon UCRD Chandigarh UniversityChandigarh140413India

In the rapidly evolving landscape of today’s digital economy,Financial Technology(Fintech)emerges as a trans-formative force,propelled by the dynamic synergy between Artificial Intelligence(AI)and Algorithmic *** in-depth investigation delves into the intricacies of merging Multi-Agent Reinforcement Learning(MARL)and Explainable AI(XAI)within Fintech,aiming to refine Algorithmic Trading *** meticulous examination,we uncover the nuanced interactions of AI-driven agents as they collaborate and compete within the financial realm,employing sophisticated deep learning techniques to enhance the clarity and adaptability of trading *** AI-infused Fintech platforms harness collective intelligence to unearth trends,mitigate risks,and provide tailored financial guidance,fostering benefits for individuals and enterprises navigating the digital *** research holds the potential to revolutionize finance,opening doors to fresh avenues for investment and asset management in the digital ***,our statistical evaluation yields encouraging results,with metrics such as Accuracy=0.85,Precision=0.88,and F1 Score=0.86,reaffirming the efficacy of our approach within Fintech and emphasizing its reliability and innovative prowess.

关键词： Neurodynamic Fintech multi-agent reinforcement learning algorithmic trading digital financial frontier

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Numerical modelling of post-failure behaviors of coal specimens

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 514-531页

作者： Ajeet Yadav Bhaskara Behera Gauri Shankar Prasad singh sanjay kumar Sharma Department of Mining Engineering Indian Institute of Technology(Banaras Hindu University)VaranasiUttar Pradesh221005India

A modelling approach consisting of best-fit relations to estimate the post-yield strength parameters is presented for simulating post-peak behavior beyond the point of residual strength of coal pillars having different w/h *** model was developed based on back-analysis of the complete stress-strain behavior of specimens belonging to six different Indian coal seams with different w/h ratios of 0.5 *** was found that the simultaneous degradation of the cohesion and friction angle of the Mohr-Coulomb rock material characterizes the post-peak strength behavior of the *** resulting expressions are simplistic as they require parameters that can be easily determined using uniaxial and triaxial compression ***,the developed model was validated by simulating the triaxial tests of coal specimens with different sizes under varying confining stresses and comparing its findings with the published test *** study showed that its implementation in the numerical model could reproduce laboratory-observed mechanical response,deformation behavior,and failure mechanism very closely.

关键词： Strain softening Dilatancy Interface Shape effect Residual strength

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Recombinant vaccines:Current updates and future prospects

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 338-350页

作者： Vivek kumar Anuj Verma Riddhi singh Priyanshi Garg Santosh kumar Sharma Himanshu Narayan singh Santosh kumar Mishra sanjay kumar Department of Allied Medical Sciences School of Allied Medical SciencesLovely Professional UniversityPhagwaraPunjabIndia Bioengineering Division of Department of Bioscience and Biomedical EngineeringIndian Institute of Technology BhilaiChhattisgarhIndia Department of Biotechnology IMS Engineering CollegeGhaziabadU.P.India Department of Chemistry and Biochemistry University of WindsorOntario N9B3P4Canada Biological and Biocomputational Laboratory Department of Life SciencesSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India Department of System Biology Columbia University Irving Medical CenterNew YorkNY 10032USA Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of *** technology improved vaccine manufacturing,rendering it more efficient and *** vaccines have multiple advantages compared to conventional *** pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing *** work offers an overview of the prospects and advantages associated with recombinant ***,it discusses some of the challenges likely to arise in the *** ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these ***,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many *** review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关键词： Malaria Dengue Emerging diseases Immunoinformatics Virus-like particles CRISPR-Cas9

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Effect of organic component(tartrate) addition on cerium nitrate's ability to inhibit corrosion of mild steel in NaCl solution

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Journal of Rare Earths 2024年第10期42卷 1995-2002页

作者： Minakshi koundal Chhaya Sharma A.k.singh Department of Applied Science and Engineering Indian Institute of Technology RoorkeeSaharanpur CampusSaharanpurU.247001India Department of Pulp and Paper Technology Indian Institute of Technology Roorke Saharanpur CampusSaharanpurU.p247001India

Cerium tartrate(CeTar),produced in this study by precipitating cerium nitrate with potassium sodium tartrate(kNaTar),was examined as a corrosion *** loss tests show inhibition efficiency of 71.7% with Ce(NO_(3))_(3) and 88.7% with CeTar inhibitor for one-month exposure to mild steel in 7 g/L NaCl *** inhibition efficiency drops to 28.6% with the fo rmer and remains around 8 7% with the latter inhibitor after six months of *** results from electrochemical testing indicate that the inhibition efficiency decreases by adding cerium ***,the cerium tartrate inhibitor demonstrates a nearly constant inhibition efficiency for up to 30 d,i.e.,≈90%.Electrochemical impedance spectroscopy(EIS) performed in these cases shows the following results:(ⅰ) with cerium nitrate,a film of iron and cerium oxide,which on prolonged exposure diminishes,and(ⅱ) with cerium tartrate,the formation of a bimetallic film(Fe-tartrate-Ce) and a mixture of cerium hydroxide and iro n oxide that protects steel for a longer *** inferences are based on the analyses of scanning electron microscopy/energydispersive X-ray analysis(SEM/EDAX),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron(XPS),and Raman spectroscopy results.

关键词： Cerium tartrate Cerium nitrate Corrosion inhibition Mild steel Inhibitor film characterization Rare earths

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Evaluation of slope stability through rock mass classification and kinematic analysis of some major slopes along NH-1A from Ramban to Banihal, North Western Himalayas

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 167-182页

作者： Amit Jaiswal A.k.Verma T.N.singh Department of Civil and Environmental Engineering Indian Institute of Technology PatnaPatna801106India

The network of Himalayan roadways and highways connects some remote regions of valleys or hill slopes,which is vital for India’s socio-economic *** to natural and artificial factors,frequency of slope instabilities along the networks has been increasing over last few *** of stability of natural and artificial slopes due to construction of these connecting road networks is significant in safely executing these roads throughout the *** rock mass classification methods are generally used to assess the strength and deformability of rock *** study assesses slope stability along the NH-1A of Ramban district of North Western *** structurally and non-structurally controlled rock mass classification systems have been applied to assess the stability conditions of 14 *** evaluating the stability of these slopes,kinematic analysis was performed along with geological strength index(GSI),rock mass rating(RMR),continuous slope mass rating(CoSMR),slope mass rating(SMR),and Q-slope in the present *** SMR gives three slopes as completely unstable while CoSMR suggests four slopes as completely *** stability of all slopes was also analyzed using a design chart under dynamic and static conditions by slope stability rating(SSR)for the factor of safety(FoS)of 1.2 and 1 respectively.Q-slope with probability of failure(PoF)1%gives two slopes as stable *** slope angle has been determined based on the Q-slope safe angle equation and SSR design chart based on the *** value ranges given by different empirical classifications were RMR(37-74),GSI(27.3-58.5),SMR(11-59),and CoSMR(3.39-74.56).Good relationship was found among RMR&SSR and RMR&GSI with correlation coefficient(R 2)value of 0.815 and 0.6866,***,a comparative stability of all these slopes based on the above classification has been performed to identify the most critical slope along this road.

关键词： Rock mass classification kinematic analysis Slope stability Himalayan road Static and dynamic conditions

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Role of flexible sensors for the electrochemical detection of organophosphate-based chemical warfare agents

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International Journal of Smart and Nano Materials 2024年第3期15卷 502-533页

作者： Aman Dubey Aamir Ahmed Rakesh singh Anoop singh Ashok k.Sundramoorthy Sandeep Arya Department of Physics University of JammuJammuJammu and KashmirIndia Department of Humanities and Sciences Guru Nanak Institutions Technical CampusHyderabadIndia Centre for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia Department of Prosthodontics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia

This review article comprehensively explores the electrochemi-cal detection of organophosphate-based agents,including war-fare agents,pesticides,and *** provides an in-depth analysis of their molecular structures,emphasizing the inherent toxicity and environmental risks posed by these *** review highlights the significant role of flexible sensors in facilitating the electrochemical detection of organophosphate-based agents,offering insights into their design,development,and application in detection ***,the article critically evaluates the challenges encountered in this field,such as sensor sensitivity and sample complexity,and discusses potential solutions to address these ***,it outlines the future scope and opportunities for advancement in electrochemical detection technologies,includ-ing the integration of novel materials and the exploration of innovative detection *** synthesizing current research findings and identifying future research directions,this review contributes to the ongoing discourse on the detection and mitigation of organophosphate-based agents’risks to human health and the environment.

关键词： Chemical warfare agents electrochemical detection flexible nanosensors organophosphates pesticides

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Experimental Investigation of Thermal Performance of Novel Finned Radiators for Automotive Cooling System

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Journal of Thermal Science 2024年第5期33卷 1726-1743页

作者： singh Hardeep TING David S-k READER Graham ESHTIAGHI Nicky ICHIYANAGI Mitsuhisa SUZUkI Takashi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan

This research investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with straight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the design of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins remains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3D printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,Microchannel Water Air Radiator with fin height 10.5 mm(MCWAR10.5)depicted a higher heat transfer rate amongst the *** comparison to Straight Water Air Radiator with fin height 9.5 mm(SWAR9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin surface area analysis,microchannel radiator(MCWAR3.2)illustrates lower heat dissipation than Helical radiator(HWAR138)but higher than HWAR134 and Straight radiator(SWAR6).The examination of pumping loss indicated that the Micro-channel radiator outperformed helical radiators due to its lower pressure *** average pressure loss for Micro-channel radiators was 0.74 kPa,making it 1.2 times higher than that of a straight radiator(0.62 kPa),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3D printing

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Photon orbits and phase transition for Letelier AdS black holes immersed in perfect fluid dark matter

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Chinese Physics C 2024年第6期48卷 247-259页

作者： Ashima Sood Md Sabir Ali J.k.singh Sushant G.Ghosh Department of Mathematics Netaji Subhas University of TechnologyNew Delhi-110078India Centre for Theoretical Physics Jamia Millia IslamiaNew Delhi 110025India Department of Physics Mahishadal Raj CollegePurba MedinipurWest Bengal721628India Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China key Laboratory of Quantum Theory and Applications of MoE Lanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics&key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China Astrophysics and Cosmology Research Unit School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa

We obtain an exact solution for spherically symmetric Letelier AdS black holes immersed in perfect fluid dark matter(PFDM).Considering the cosmological constant as the positive pressure of the system and volume as its conjugate variable,we analyze the thermodynamics of our black holes in the extended phase *** to the background clouds of strings parameter(a)and the parameter endowed with PFDM(β),we analyze the Hawking temperature,entropy,and specific ***,we investigate the relationship between the photon sphere radius and phase transition for the Letelier AdS black holes immersed in *** the analysis,with a particular condition,non-monotonic behaviors are found between the photon sphere radius,impact parameter,PFDM parameter,temperature,and *** can regard the changes in both the photon sphere radius and impact parameter before and after phase transition as the order parameter;their critical exponents near the critical point are equal to the same value,1/2,similar to that in ordinary thermal *** indicates that a universal relation of gravity may exist near the critical point for a black hole thermodynamic system.

关键词： AdS black holes perfect fluid dark matter Letelier spacetime photon orbit extended phase space thermodynamics correlation of photon orbit and thermodynamics

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Prediction of rock fragmentation in a fiery seam of an open-pit coal mine in India

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 2879-2893页

作者： Mukul Sharma Bhanwar singh Choudhary Autar k.Raina Manoj khandelwal Saurav Rukhiyar Department of Mining Engineering Indian Institute of Technology(ISM)Dhanbad826004India CSIR-Central Institute of Mining and Fuel Research Nagpur Research Center(Mining Technology)Nagpur440006India Institute of Innovation Science and SustainabilityFederation University AustraliaBallaratVIC3350Australia

Spontaneous combustion of coal increases the temperature in adjoining overburden strata of coal seams and poses a challenge when loading *** condition,known as hot-hole blasting,is dangerous due to the increased possibility of premature explosions in loaded ***,it is crucial to load the blastholes with an appropriate amount of explosives within a short period to avoid premature detonation caused by high temperatures of ***,it will help achieve the desired fragment *** study tried to ascertain the most influencial variables of mean fragment size and their optimum values adopted for blasting in a fiery *** on blast design,rock mass,and fragmentation of 100 blasts in fiery seams of a coal mine were collected and used to develop mean fragmentation prediction models using soft computational *** coefficient of determination(R^(2)),root mean square error(RMSE),mean absolute error(MAE),mean square error(MSE),variance account for(VAF)and coefficient of efficiency in percentage(CE)were calculated to validate the *** indicates that the random forest algorithm(RFA)outperforms the artificial neural network(ANN),response surface method(RSM),and decision tree(DT).The values of R^(2),RMSE,MAE,MSE,VAF,and CE for RFA are 0.94,0.034,0.027,0.001,93.58,and 93.01,*** parametric sensitivity analyses(MPSAs)of the input variables showed that the Schmidt hammer rebound number and spacing-to-burden ratio are the most influencial variables for the blast fragment *** analysis was finally used to define the best blast design variables to achieve optimum fragment size from *** optimum factor values for RFA of S/B,ld/B and ls/ld are 1.03,1.85 and 0.7,respectively.

关键词： Fiery seam Rock fragmentation Response Surface Method(RSM) Artificial Neural Network(ANN) Random Forest Algorithm(RFA) Multiple Parametric Sensitivity Analysis (MPSA)

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