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End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899

World Journal of Cardiology 2015年第1期7卷 31-42页

作者： Matthias Lohn Oliver Plettenburg Aimo Kannt Markus Kohlmann armin hofmeister Dieter Kadereit Peter Monecke Alexander Schiffer Anke Schulte Hartmut Ruetten Yuri Ivashchenko Translational Medicine Sanofi-AventisIndustriepark Hoechst65926 Frankfurt am MainGermany

AIM: To compare the therapeutic efficacy of SAR407899 with the current standard treatment for hypertension [an angiotensin converting enzyme(ACE)-inhibitor and a calcium channel blocker] and compare the frequency and severity of the hypertension-related end-organ damage. METHODS: Long-term pharmacological characterization of SAR407899 has been performed in two animal models of hypertension, of which one is sensitive to ACE-inhibition and the other is insensitive [deoxycorticosterone acetate(DOCA)]. SAR407899 efficiently lowered high blood pressure and significantly reduced late-stage end organ damage as indicated by improved heart, kidney and endothelial function and reduced heart and kidney fibrosis in both models of chronic hypertension. RESULTS: Long term treatment with SAR407899 has been well tolerated and dose-dependently reduced elevated blood pressure in both models with no signs of tachyphylaxia. Blood pressure lowering effects and protective effects on hypertension related end organ damage of SAR407899 were superior to ramipril and amlodipine in the DOCA rat. Typical end-organ damage was significantly reduced in the SAR407899-treated animals. Chronic administration of SAR407899 significantly reduced albuminuria in both models. The beneficial effect of SAR407899 was associated with a reduction in leukocyte/macrophage tissue infiltration. The overall protective effect of SAR407899 was superior or comparable to that of ACE-inhibition or calciumchannel blockade. Chronic application of SAR407899 protects against hypertension and hypertension-induced end organ damage, regardless of the pathophysiological mechanism of hypertension. CONCLUSION: Rho-kinases-inhibition by the SAR407899 represents a new therapeutic option for the treatment of hypertension and its complications.

关键词： Hypertension End organ damage Rhokinase Angiotensin converting enzyme-inhibition

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Risk factors for congenital nasolacrimal duct obstruction in children under two years of age

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国际眼科杂志 2025年第1期25卷 17-23页

作者： Rozhin Kasiri Gholamreza Khataminia Ali Kasiri Mohammad Sadegh Mirdehghan Mohammad armin Kasiri Infectious Ophthalmologic Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Islamic Azad University Tehran Medical Sciences Tehran ***Iran

·AIM:To identify various risk factors that may play a significant role in the development of congenital nasolacrimal duct obstruction(CNLDO).·METHODS:This observational case-control study included a case group of 122 children less than two years of age with CNLDO who underwent probing and irrigation treatment at the ophthalmology department of Imam Khomeini Hospital in Ahvaz,Iran,from June 2022 to June2024.A control group of 122 age-matched children without CNLDO was also included for *** was collected from the children's medical records.·RESULTS:The study found a significant correlation between the occurrence of CNLDO and several maternal factors,such as preeclampsia,the use of levothyroxine,hypothyroidism,having more than three pregnancies(gravidity>3),natural pregnancy,and gestational diabetes ***,in children,factors,such as oxygen therapy,anemia,reflux,jaundice,and a family history of CNLDO in first-degree relatives were associated with CNLDO,and maternal preeclampsia and hypothyroidism were found to significantly increase the risk of developing CNLDO in children.·CONCLUSION:Given that CNLDO affects both premature and full-term children,the present findings may potentially facilitate the early identification of children and infants at risk of nasolacrimal duct obstruction,thereby preventing the onset of chronic dacryocystitis.

关键词： risk factors congenital nasolacrimal duct obstruction children

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West Nile virus:North American experience

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Integrative Zoology 2011年第3期6卷 279-289页

作者： Erik K.hofmeister USGS National Wildlife Health Center MadisonWisconsinUSA

West Nile virus,a mosquito-vectored flavivirus of the Japanese encephalitis serogroup,was first detected in North America following an epizootic in the New York City area in *** the intervening 11 years since the arrival of the virus in North America,it has crossed the contiguous USA,entered the Canadian provinces bordering the USA,and has been reported in the Caribbean islands,Mexico,Central America and,more recently,South *** Nile virus has been reported in over 300 species of birds in the USA and has caused the deaths of thousands of birds,local population declines of some avian species,the clinical illness and deaths of thousands of domestic horses,and the clinical disease in over 30000 Americans and the deaths of over *** to the emergence of West Nile virus in North America,*** encephalitis virus and Dengue virus were the only other known mosquito-transmitted flaviviruses in North America capable of causing human *** review will discuss the North American experience with mosquito-borne flavivirus prior to the arrival of West Nile virus,the entry and spread of West Nile virus in North America,effects on wild bird populations,genetic changes in the virus,and the current state of West Nile virus transmission.

关键词： arbovirus emerging infectious disease North America West Nile virus zoonotic disease

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Everything moves:The rapid changes in photogrammetry and remote sensing

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Geo-Spatial Information Science 2021年第1期24卷 33-49,I0007页

作者： armin Gruen Department of Civil Engineering Environmental Engineering and GeomaticsETH ZurichSwitzerland

Changes in technology are coming at an ever increasing *** holds for photogrammetry and remote sensing as well.“Everything moves”-this is why I chose this topic to shed some light on some of the recent ***,this undertaking can never be complete in the sense of covering all developments in Photogrammetry and Remote ***,the impact of Deep Learning in photogrammetry is not mentioned in this *** is a very personal *** may not agree with some of my findings,but this is in the nature of *** any case,this contribution is meant as a tribute to Gottfried’s successful lifelong *** is not a scientific paper in the traditional sense but rather a collection of thoughts that emerged over the 50 years of my professional *** is also meant for an audience who has not necessarily a deep photogrammetric expert know-how.

关键词： History perspective projection photogrammetric pipeline automation 3D modeling

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Anti-(conjugate) linearity

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Science China(Physics,Mechanics & Astronomy) 2016年第3期59卷 1-38页

作者： armin Uhlmann Institute for Theoretical Physics University of Leipzig

This is an introduction to antilinear operators. In following Wigner the terminus antilinear is used as it is standard in *** prefer to say conjugate linear. By restricting to finite-dimensional complex-linear spaces, the exposition becomes elementary in the functional analytic sense. Nevertheless it shows the amazing differences to the linear case. Basics of antilinearity is explained in sects. 2, 3, 4, 7 and in sect. 1.2: Spectrum, canonical Hermitian form, antilinear rank one and two operators,the Hermitian adjoint, classification of antilinear normal operators,(skew) conjugations, involutions, and acq-lines, the antilinear counterparts of 1-parameter operator groups. Applications include the representation of the Lagrangian Grassmannian by conjugations, its covering by acq-lines. As well as results on equivalence relations. After remembering elementary Tomita-Takesaki theory, antilinear maps, associated to a vector of a two-partite quantum system, are defined. By allowing to write modular objects as twisted products of pairs of them, they open some new ways to express EPR and teleportation tasks. The appendix presents a look onto the rich structure of antilinear operator spaces.

关键词： operators canonical form antilinear (skew) hermiticity acq-lines

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How Properties that Distinguish Solids from Fluids and Constraints of Spherical Geometry Suppress Lower Mantle Convection

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Journal of Earth Science 2018年第1期29卷 1-20页

作者： Anne M. hofmeister Everett M. Criss Department of Earth and Planetary Sciences Washington University St. Louis MO 63130 USA Panasonic Avionics Corporation Lake Forest CA 92630 USA

The large magnitude of the dimensionless Rayleigh number （Ra-10^8） for Earth＇s -3 000 km thick mantle is considered evidence of whole mantle convection. However, the current formulation assumes behavior characteristic of gases and liquids and also assumes Cartesian geometry. Issues arising from neglecting physical properties unique to solids and ignoring the spherical shapes for planets include：（1） Planet radius must be incorporated into Ra, in addition to layer thickness, to conserve mass during radial displacements. （2） The vastly different rates for heat and mass diffusion in solids, which result from their decoupled transport mechanisms, promote stability. （3） Unlike liquids, sub- stantial stress is needed to deform solids, which independently promotes stability. （4） High interior compression stabilizes the mantle in additional minor ways. Therefore, representing conditions for convection in solid, self-gravitating spheroids, requires modifying formulae developed for bottom- heated fluids near ambient conditions under an invariant gravitational field. To derive stability criteria appropriate to solid spheres, we use dimensional analysis, and consider the effects of geometry, force competition, and microscopic behavior. We show that internal heating has been improperly ac- counted for in the Ra. We conclude that the lower mantle is stable for two independent reasons： heat diffusion far outpaces mass diffusion （creep） and yield strength of solids at high pressure exceeds the effective deviatoric stress. We discuss the role of partial melt in lubricating plate motion, and explain why the Ra is not applicable to the multi-component upper mantle. When conduction is insufficient to transport heat in the Earth, melt production and ascent are expected, not convection of solid rock.

关键词： plasticity diffusion mantle convection stability criteria dimensional analysis geometry.

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Fluidization behavior of graphitized glassy particles in a fluidized carbon bed cooling process for investment casting

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Particuology 2022年第6期20卷 32-38页

作者： Paul Git Matthias hofmeister Robert F.Singer Carolin Körner Chair of Materials Science and Engineering for Metals(WTM) Friedrich-Alexander UniversitätErlangen-Nürnberg(FAU)Martensstr.591058 ErlangenGermany

Fluidized Carbon Bed Cooling(FCBC)is an innovative investment casting process for directional solidification of superalloy *** takes advantage of a fluidized bed with a base of small glassy carbon beads for cooling and other low-density particles that form an insulating layer by floating to the bed *** so-called“Dynamic Baffle”protects the fluidized bed from the direct heat input from the high-temperature heating zone and provides the basis for an improved bed *** prerequisites for a stable casting process are stable fluidization conditions where neither collapse of the bed nor particle blow out at excessive bubble formation *** work aimed to investigate the fluidization behavior of spherical carbon bed material in argon and air at temperatures between 20 to 350℃.Systematic studies at reduced pressures using the FCBC prototype device were performed to understand the stable fluidization conditions at all stages of the investment casting *** particle shape factor and size distribution characterization and the measurement of the powder’s minimum fluidization velocity and bed voidage show that this material can be fully utilized as a cooling and buoyancy medium during the FCBC process.

关键词： Gas-solid fluidization Glassy carbon Reduced pressure Increased temperature Fluidized carbon bed

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Evaluation of the Heat,Entropy,and Rotational Changes Produced by Gravitational Segregation during Core Formation

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Journal of Earth Science 2015年第1期26卷 124-133页

作者： Anne M.hofmeister Robert E.Criss Department of Earth and Planetary Sciences Washington University

Core formation by gravitational segregation allegedly released sufficient interior heat to melt the Earth. Analysis of the energetics, which compare gravitational potential energy （Ug） of a fictitious, homogeneous reference state to Earth＇s current layered configuration, needs updating to correct errors and omissions, and to accommodate recent findings：（1） An erroneous positive sign was used for Ug while maintaining the reference value of 0 at infinity, which results in an incorrect sign fur AUg, which is crucial in determining whether a process is endothermic or exothermic. （2） The value of Ug for Earth＇s initial state is uncertain. （3） Recent meteorite evidence indicates that core formation began before the Earth was full-sized, which severely limits AUg. （4） Inhomogeneous accretion additionally reduced AUg. （5） The potentially large effect of differential rotation between the core and the mantle was not accounted for. （6） Entropy changes associated with creating order were neglected. Accordingly, we revise values of Ug, evaluate uncertainties, and show that AUg was converted substantially to eonfigurational energy （TAS）. These considerations limit the large sources of primordial heat to impacts and radioactivity. Although these processes may play a role in core formation, their energies are independent of gravitational segregation, which produces order and rotational energy, not internal heat. Instead, gravitational segregation promotes planetary cooling mainly because it segregates lithophilic radioactive elements upward, increasing surface heat flux while shortening the distance over which radiogenic heat diffuses outwards.

关键词： core formation primordial heat configurational energy thermodynamics rotational energy.

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Effect of esketamine on reducing postpartum pain and depression

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World Journal of Clinical Cases 2025年第7期13卷 17-20页

作者： Brandon Lucke-Wold armin Karamian Department of Neurosurgery University of FloridaGainesvilleFL 32608United States School of Medicine Shahid Beheshti University of Medical SciencesTehran 198396-9411TehrānIran

In this editorial,we comment on a recent article by Chen et al,that addressed the effect of intraoperative injection of esketamine on postoperative analgesia and postoperative rehabilitation after cesarean *** management of postcesarean pain is associated with decreased maternal care for the baby,longer hospitalization,and higher risk of developing postpartum *** is a more potent S-enantiomer of ketamine which has shown promising analgesic and antidepressant properties for managing post-cesarean pain and depression in clinical ***,due to its potential adverse effects on the neurological and hemodynamic status of patients,it is recommended that its usage in low doses should be limited to cesarean candidates experiencing unbearable *** any recommendation for routine perioperative use of esketamine,more standardized clinical trials are needed to strengthen our existing knowledge of its effectiveness in reducing postpartum pain and depression.

关键词： Cesarean section Postpartum pain Postpartum depression Postoperative analgesia Esketamine

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Processing of AM60 magnesium alloy by hydrostatic cyclic expansion extrusion at elevated temperature as a new severe plastic deformation method

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International Journal of Minerals,Metallurgy and Materials 2020年第5期27卷 669-677页

作者： Farshad Samadpour Ghader Faraji armin Siahsarani School of Mechanical Engineering College of EngineeringUniversity of TehranTehran11155-4563Iran

Hydrostatic cyclic expansion extrusion(HCEE) process at elevated temperatures is proposed as a method for processing less deformable materials such as magnesium and for producing long ultrafine-grained rods. In the HCEE process at elevated temperatures, high-pressure molten linear low-density polyethylene(LLDPE) was used as a fluid to eliminate frictional forces. To study the capability of the process,AM60 magnesium rods were processed and the properties were investigated. The mechanical properties were found to improve significantly after the HCEE process. The yield and ultimate strengths increased from initial values of 138 and 221 MPa to 212 and 317 MPa, ***, the elongation was enhanced due to the refined grains and the existence of high hydrostatic pressure. Furthermore, the microhardness was increased from HV 55.0 to HV 72.5. The microstructural analysis revealed that ultrafine-grained structure could be produced by the HCEE process. Moreover, the size of the particles decreased, and these particles thoroughly scattered between the grains. Finite element analysis showed that the HCEE was independent of the length of the sample, which makes the process suitable for industrial applications.

关键词： high-pressure fluid elevated temperature severe plastic deformation hydrostatic cyclic expansion extrusion mechanical properties magnesium alloy

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