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Clinical Analysis and Mental Health Survey of Hemophilia Carriers:a Cross-sectional Study

Current Medical Science 2024年第2期44卷 435-440页

作者： Wen WANG Li-juan JIANG Dong-yan CUI ai ZHANG Xiong WANG ai-guo LIU Qun HU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted males,to the upper limit of normal,and may experience mental health *** purpose of this study was to provide genetic information on mothers of hemophilia patients and to understand the clotting factor activity and phenotype of ***,we aimed to investigate the mental health status of HCs in ***:A total of 127 hemophilia mothers,including 93 hemophilia A(HA)mothers and 34 hemophilia B(HB)mothers,were enrolled in this *** distance PCR,multiplex PCR,and Sanger sequencing were used to analyze mutations in F8 or *** factor activity was detected by a one-stage clotting *** Symptom Checklist 90(SCL-90,China/Mandarin version)was given to HCs at the same time to assess their mental ***:A total of 90.6%of hemophilia mothers were diagnosed genetically as carriers,with inversion in intron 22 and missense mutations being the most common mutation types in HA and HB carriers,*** median clotting factor level in carriers was 0.74 IU/mL(ranging from 0.09 to 1.74 IU/mL)compared with 1.49 IU/mL(ranging from 0.93 to 1.89 IU/mL)in noncarriers,of which 14.3%of HCs had clotting factor levels of 0.40 IU/mL or below.A total of 53.8%(7/13)of HA carriers with low clotting factor levels(less than 0.50 IU/mL)had a history of bleeding,while none of the HB carriers displayed a bleeding *** total mean score and the global severity index of the SCL-90 for surveyed HCs were 171.00(±60.37)and 1.78(±0.59),respectively.A total of 67.7%of the respondents had psychological symptoms,with obsessive-compulsive disorder being the most prevalent and *** pooled estimates of all nine factors were significantly higher than those in the general population(P<0.05).Conclusions:The detection rate of gene mutations

关键词： hemophilia A hemophilia B mutation carrier mental health

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Cellular strategies to induce immune tolerance after liver transplantation:Clinical perspectives

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World Journal of Gastroenterology 2024年第13期30卷 1791-1800页

作者： ai-Wei Zhou Jing Jin Yuan Liu Department of Liver Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Nursing Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Liver Transplantation Shanghai Immune Therapy InstituteShanghai 200127China

Liver transplantation(LT)has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative ***,long-term side-effects of immunosuppressants,like infection,metabolic disorders and malignant tumor are gaining more *** tolerance is the status in which LT recipients no longer need to take any immunosuppressants,but the liver function and intrahepatic histology maintain *** approaches to achieve immune tolerance after transplantation include spontaneous,operational and induced *** first two means require no specific intervention but withdrawing immunosuppressant gradually during *** clinical factors or biomarkers so far could accurately predict who are suitable for immunosuppressant withdraw after *** the understanding to the underlying mechanisms of immune tolerance,many strategies have been developed to induce tolerance in LT *** strategy is one of the most promising methods for immune tolerance induction,including chimerism induced by hematopoietic stem cells and adoptive transfer of regulatory immune *** safety and efficacy of various cell products have been evaluated by prospective preclinical and clinical trials,while obstacles still exist before translating into clinical ***,we will summarize the latest perspectives and concerns on the clinical application of cellular strategies in LT recipients.

关键词： Cellular therapy Induced tolerance Liver transplantation Regulatory T cells Regulatory dendritic cells

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Cluster-Based Massive Access for Massive MIMO Systems

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China Communications 2024年第1期21卷 24-33页

作者： Shiyu Liang Wei Chen Zhongwen Sun Ao Chen Bo ai State Key Laboratory of Advanced Rail Autonomous Operation Beijing Jiaotong UniversityBeijing 100091China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100091China Frontiers Science Center for Smart High-speed Railway System Beijing Jiaotong UniversityBeijing 100091China Key Laboratory of Railway Industry of Broadband Mobile Information Communications Beijing Jiaotong UniversityBeijing 100091China Beijing Engineering Research Center of High-speed Railway Broadband Mobile Communications Beijing Jiaotong UniversityBeijing 100091China School of Information Engineering Zhengzhou UniversityZhengzhou 450001China

Massive machine type communication aims to support the connection of massive devices,which is still an important scenario in *** this paper,a novel cluster-based massive access method is proposed for massive multiple input multiple output *** exploiting the angular domain characteristics,devices are separated into multiple clusters with a learned cluster-specific dictionary,which enhances the identification of active *** detected active devices whose data recovery fails,power domain nonorthogonal multiple access with successive interference cancellation is employed to recover their data via *** results show that the proposed scheme and algorithm achieve improved performance on active user detection and data recovery.

关键词： compressive sensing dictionary learning multiuser detection random access

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Distributed Stochastic Scheduling of Massive Backup Batteries in Cellular Networks for Operational Reserve and Frequency Support Ancillary Services

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 393-404页

作者： Kun Li Jiakun Fang Xiaomeng ai Shichang Cui Rongkang Zhao Jinyu Wen State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China IEEE

Base station(BS)backup batteries(BSBBs),with their dispatchable capacity,are potential demand-side resources for future power *** enhance the power supply reliability and post-contingency frequency security of power systems,we propose a two-stage stochastic unit commitment(UC)model incorporating operational reserve and post-contingency frequency support provisions from massive BSBBs in cellular networks,in which the minimum backup energy demand is considered to ensure BS power supply *** energy,operational reserve,and frequency support ancillary services are co-optimized to handle the power balance and post-contingency frequency security in both forecasted and stochastic variable renewable energy(VRE)***,we propose a dedicated and scalable distributed optimization framework to enable autonomous optimizations for both dispatching center(DC)and *** BS model parameters are stored and processed locally,while only the values of BS decision variables are required to upload to DC under the proposed distributed optimization framework,which safeguards BS privacy *** studies on a modified IEEE 14-bus system demonstrate the effectiveness of the proposed method in promoting VRE accommodation,ensuring post-contingency frequency security,enhancing operational economics,and fully utilizing BSBBs'energy and power ***,the proposed distributed optimization framework has been validated to converge to a feasible solution with near-optimal performance within limited ***,numerical results on the Guangdong 500 kV provincial power system in China verify the scalability and practicality of the proposed distributed optimization framework.

关键词： Base station backup battery operational reserve frequency security distributed optimization privacy

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A low-noise,high-gain,and large-dynamic-range photodetector based on a JFET and a charge amplifier

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 316-322页

作者： Jinrong WANG Shuang'e WU Chengdong MI Yaner QIU Xin'ai Bai Department of Physics Lyuliang UniversityLvliang033001China Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques South China University of TechnologyGuangzhou510640China

We demonstrate a low-noise,high-gain,and large-dynamic-range photodetector(PD)based on a junction field-effect transistor(JFET)and a charge amplifier for the measurement of quantum noise in Bell-state detection(BSD).Particular photodiode junction capacitance allows the silicon N-channel JFET 2sk152 to be matched to the noise requirement for charge amplifier *** electronic noise of the PD is effectively suppressed and the signal-to-noise ratio(SNR)is up to 15 dB at the analysis frequency of 2.75 MHz for a coherent laser power of 50.08µ*** combining of the inductor and capacitance,the alternating current(AC)and direct current(DC)branches of the PD can operate linearly in a dynamic range from 25.06µW to 17.50 *** PD can completely meet the requirements of SNR and dynamic range for BSD in quantum optics experiments.

关键词： Quantum noise Bell-state detection(BSD) Photodetector(PD) Junction field-effect transistor(JFET) Charge amplifier

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Numerical analysis of wind effects on aerodynamic characteristics of a ducted fan

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Chinese Journal of Aeronautics 2024年第5期37卷 263-280页

作者： Yiwei LUO Tianfu ai Yuhang HE Bin XU Yuping QIAN Yangjun ZHANG State Key Laboratory of Intelligent Green Vehicle and Mobility School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Key Laboratory of Conveyance and Equipment Ministry of Education East China Jiaotong UniversityNanchang 330013China Vehicle Research Center School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

Ducted fans have been extensively used in Unmanned Aerial Vehicles(UAVs)for a variety of missions because of high efficiency,high safety and low ***,as a kind of typical meteorological condition,brings significant aerodynamic interference to the ducted fan,which seriously threatens flight stability and *** this work,the numerical simulation with the Unsteady Reynolds Averaged Navier-Stokes(URANS)method and the sliding mesh technique is performed to evaluate the steady wind *** results show that the wind will lead to serious unsteady effects in the flow field,and the thrust fluctuates at the blade passing frequency of 200 *** the wind speed increases,the rotor thrust increases,the duct thrust decreases,and the total thrust changes *** instability may occur when the wind speed exceeds 8 m/*** the angle of low-speed wind increases,the rotor thrust changes little,the duct thrust increases,and the total thrust *** addition,we figure out that cases with the same crosswind ratio are similar in results,and increasing the rotating speed or fan radius is beneficial to performance improvement in *** findings are essential to the ducted fan design and UAV flight control design for stable and safe operations in wind conditions.

关键词： Unmanned Aerial Vehicle(UAV) Ducted fan Wind effect Thrust fluctuations Computational Fluid Dynamics(CFD)

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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang ai-ai Gao Cheng Zhu Tao He James G Herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

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Feasible strategy for the nitrogen fixation and humification quality improvement by spent mushroom substrate as conditioning agent

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 235-240页

作者： Shuang ai Yuanbei Zhang Guoxiang Zheng College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Swine Facilities Engineering Ministry of Agriculture and Rural AffairsHarbin 50030China Heilongjiang Key Laboratory of Technology and Equipment for the Utilization of Agricultural Renewable Resources Harbin 150030China

There is an overlooked problem which increasing microbial abundance while reducing nitrogen loss during *** study investigated the viability of spent mushroom substrate(SMS)as conditioners in the aerobic composting of kitchen waste(KW)with cattle manure(CM).The variation of temperature,pH,C/N,organic matter,cellulose,hemicelluloses,germination index(GI),and microflora structure were explored to evaluate the potential in accelerating maturity and nitrogen fixation by SMS *** results showed that the addition of SMS accelerated the heating rate,prolonged the high temperature time,and decreased organic matter,hemicellulose,and cellulose by 17.49%,23.61%,and 18.62%,*** GI reached 105.86%with SMS addition,while 74.17%was found in control treatment after *** changed the microbial community composition and increased the species ***,Clostridium XI and Azomonas were dominant bacteria,which increased the retention of nitrogen,promoted organic matter degradation and reduce compost *** study can provide a feasible strategy for nitrogen fixation in the field of organic waste recycling.

关键词： spent mushroom substrate conditioning agent nitrogen fixation humification quality aerobic composting

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Runout prediction of potential landslides based on the multi-source data collaboration analysis on historical cases

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China Geology 2024年第2期7卷 264-276页

作者： Jun Sun Yu Zhuang ai-guo Xing Guizhou Geology and Mineral Engineering Construction Co. LtdGuiyang 550000China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Long runout landslides involve a massive amount of energy and can be extremely hazardous owing to their long movement distance,high mobility and strong destructive *** methods have been widely used to predict the landslide runout but a fundamental problem remained is how to determine the reliable numerical *** study proposes a framework to predict the runout of potential landslides through multi-source data collaboration and numerical analysis of historical landslide ***,for the historical landslide cases,the landslide-induced seismic signal,geophysical surveys,and possible in-situ drone/phone videos(multi-source data collaboration)can validate the numerical results in terms of landslide dynamics and deposit features and help calibrate the numerical(rheological)***,the calibrated numerical parameters can be used to numerically predict the runout of potential landslides in the region with a similar geological setting to the recorded *** of the runout prediction approach to the 2020 Jiashanying landslide in Guizhou,China gives reasonable results in comparison to the field *** numerical parameters are determined from the multi-source data collaboration analysis of a historical case in the region(2019 Shuicheng landslide).The proposed framework for landslide runout prediction can be of great utility for landslide risk assessment and disaster reduction in mountainous regions worldwide.

关键词： Landslide runout prediction Drone survey Multi-source data collaboration DAN3D numerical modeling Jianshanying landslide Guizhou Province Geological hazards survey engineering

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Constitutive Behavior of the Interface between UHPC and Steel Plate without Shear Connector:From Experimental to Numerical Study

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1863-1888页

作者： Zihan Wang Boshan Zhang Hui Wang Qing ai Xingchun Huang School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Bridge Engineering Tongji UniversityShanghai200092China

The application of ultra-high performance concrete(UHPC)as a covering layer for steel bridge decks has gained widespread *** employing a connection without a shear connector between the steel plate and UHPC,namely,the sandblasted interface and the epoxy adhesive with sprinkled basalt aggregate interface,the installation cannot only be simplified but also the stress concentration resulting from the welded shear connectors can be *** study develops constitutive models for these two interfaces without shear connectors,based on the interfacial pull-off and push-out *** validation,three-point bending tests on the steel-UHPC composite plates are *** results indicated that the proposed bilinear traction-separation model for the sandblasted interface and the trapezoidal traction-separation model for the epoxy adhesive with sprinkled basalt aggregate interface can generally calibrate the interfacial ***,the utilization of the experimentally determined pure shear strength underestimates the load-carrying capacity of the composite plates in the case of three-point bending *** recalling the Mohr-Coulomb criterion,this underestimation is attributed to the enhancement of the interface shear strength by the presence of normal stress.

关键词： Cohesive zone model interfacial behavior finite element simulation UHPC steel plate

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