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International Journal of Smart and Nano Materials 2022年第3期13卷 504-528页

作者： Mohammad Aghvami-Panah Ao Wang Mahyar Panahi-Sarmad Seyed armin Seyed Esfahani Amir Abbas Seraji Mehrnaz Shahbazi Reza Ghaffarian Seifollah Jamalpour Xueliang Xiao Key Laboratory of Eco-Textiles Ministry of EducationJiangnan UniversityWuxiJiangsuChina Department of Polymer Engineering AmirKabir University of TechnologyTehranIran Department of Chemical Engineering Auburn UniversityAuburnALUSA Department of Chemical Engineering Faculty of EngineeringShahid Chamran University of AhvazAhvazIran

The effect of carbon black(CB),carbon nanotube(CNT),and graphene(G)on foaming,electrical conductivity(EC),and electromagnetic interference(EMI)shielding of polystyrene(PS)foam that has been produced via microwave heating operation and supercritical carbon dioxide(CO_(2))was *** containing 1 wt%,CNT,and G reached over 90%porosity after 30 s and 3 min radiation time,respectively;however,PS/CB foam did not expand properly even after 3.5 *** addition,the expansion ratio of PS/CB and PS/G was one-sixth and one-half of PS/CNT,respectively-due to the great CNT’s ability to convert microwave radiation to *** of solid and porous nanocomposites has been increased via raising filler content;however,PS/CNT displayed the highest value at the same volume *** ascending trend could not endure during foaming,so a remarkable optimum-point has been observed for nanocomposite ***,EMI-shielding properties of solid and foam nanocomposites were discussed.

关键词： Microcellular foams Polymer-matrix composites EMI shielding carbonic particles microwave

The Compound Spectral Indices of Human Stress

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Applied Mathematics 2018年第12期9卷 1378-1394页

作者： Petr Kloucek armin Von Gunten CAMPsyN SUPPA H&ocirc pital de Cery Lausanne Switzerland

Temporally fine-grained and objective measures of mental states or their surrogate states are desperately needed in clinical psychiatry. Stress, both acute and especially chronic stress, is an important mental and physiological state observed in many mental disorders. It is a potential precipitant of acute psychiatric decompensations, be they anxious, affective, psychotic, or behavioural. Thus, being able to objectively follow stress or its surrogate parameters over time in a clinician-friendly way would help predict and prevent decompensations and monitor subsequent treatment success. Thus, we introduce the Compound Spectral Stress Indices (CSSI) that are derived from sensing data of various physiological and physiological and behavioural parameters we use as surrogate stress measures. To obtain the CSSI we use a hierarchical approach provided by adaptability, congruency and derived stress coefficient matrices. Adaptability is defined as a macroscopic characterisation of physiological and physiological and behavioural performance constructed as a product of the total variation of time-segmented complexity indices multiplied by the frequency of the time-varying distribution of complexity indices of the measured physiological or physiological and behavioural parameters, where complexity is expressed in terms of the Hurst exponent. Congruency is expressed by a constant characterising a demand-resource balance and it is then expressed in the form of a stress coefficient matrix. The CSSI is given by the spectral distance of the stress coefficient matrices from the ideal demand-resource matrix.

关键词： Stress Physiological and Behavioural Complexity Surrogate Data Self-Similar Normally Distributed Processes Hurst Exponent

FORSAT:a 3D forest monitoring system for cover mapping and volumetric 3D change detection

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International Journal of Digital Earth 2020年第8期13卷 854-885页

作者： Efstratios Stylianidis Devrim Akca Daniela Poli Martin Hofer armin Gruen Victor Sanchez Martin Konstantinos Smagas Andreas Walli Orhan Altan Elisa Jimeno Alejandro Garcia School of Spatial Planning and Development Aristotle University of ThessalonikiThessalonikiGreece Department of Civil Engineering Isik UniversitySileIstanbulTurkey DiXplorer AG ZurichSwitzerland GeoVille Information Systems GmbH InnsbruckAustria Chair of Information Architecture ETH ZurichSwitzerland Ingeniería Y Soluciones Informáticas S.L. SevillaSpain GeoImaging Ltd NicosiaCyprus Ekinoks Surveying Software Engineering Ltd IstanbulTurkey

A 3D forest monitoring system,called FORSAT(a satellite very high resolution image processing platform for forest assessment),was developed for the extraction of 3D geometric forest information from very high resolution(VHR)satellite imagery and the automatic 3D change *** is composed of two complementary tasks:(1)the geometric and radiometric processing of satellite optical imagery and digital surface model(DSM)reconstruction by using a precise and robust image matching approach specially designed for VHR satellite imagery,(2)3D surface comparison for change *** allows the users to import DSMs,align them using an advanced 3D surface matching approach and calculate the 3D differences and volume changes(together with precision values)between *** is a single source and flexible forest information solution,allowing expert and non-expert remote sensing users to monitor forests in three and four(time)*** geometric resolution and thematic content of VHR optical imagery are sufficient for many forest information needs such as deforestation,clear-cut and fire severity *** capacity and benefits of FORSAT,as a forest information system contributing to the sustainable forest management,have been tested and validated in case studies located in Austria,Switzerland and Spain.

关键词： Deforestation 3D VHR satellite imagery orientation image matching DSM generation co-registration volumetric change detection volume precision

PCOS模型小鼠与NK细胞CD2表达减少有关，但不被二甲双胍所逆转

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PCOS模型小鼠与NK细胞CD2表达减少有关，但不被二甲双胍所逆转

作者： Czika armin 重庆医科大学

学位级别：硕士

背景来自外周血和脾脏组织的自然杀伤（Natural killer,NK）细胞是各种组织补充其免疫细胞群的来源,其异常可能与多囊卵巢综合征（polycystic ovarian syndrome,PCOS）发生相关。PCOS病人大多表现为高雄激素血症和白介素2（interleukin-... 详细信息

背景来自外周血和脾脏组织的自然杀伤（Natural killer,NK）细胞是各种组织补充其免疫细胞群的来源,其异常可能与多囊卵巢综合征（polycystic ovarian syndrome,PCOS）发生相关。PCOS病人大多表现为高雄激素血症和白介素2（interleukin-2,IL-2）水平增高,它们可能是加剧PCOS症状的不利因素。但是,这些因素对NK细胞的分布和功能产生影响,以及用于治疗PCOS的最常用药物之一——二甲双胍能否对其逆转,目前尚不清楚。本研究的目的是评估NK细胞在PCOS模型小鼠外周血和脾脏组织中的分布及其CD2和CD94的表达模式,并检测二甲双胍是否可以逆转PCOS对NK细胞分布和功能所产生的影响。材料和方法雌性C57BL/6小鼠随机分为四组,每组各15只:采用脱氢表雄酮（dehydroepiandrosterone,DHEA）皮下注射联合高脂饮食（high-fat diet,HFD）建立PCOS模型小鼠（PCOS组）,以芝麻油注射联合普通喂养小鼠作为正常对照（Control组）,PCOS小鼠建模的同时,给予二甲双胍（PCOS+Metformin组）,以相应溶剂处理模型鼠作为实验对照（PCOS+Vehicle组）,检测小鼠体重、卵巢质量、空腹血糖及动情周期变化;HE染色评估卵巢形态;ELISA法检测血清T、FSH及LH水平。在确定PCOS模型小鼠的生殖和代谢特性以及二甲双胍对PCOS模型小鼠生殖和代谢方面的影响后,进一步采用流式细胞术分析外周血和脾脏组织NK、NKT、T细胞的分布,以及外周血、脾脏组织NK、NKT、T细胞CD2和CD94的百分比和平均荧光强度（mean fluorescence intensity,MFI）。通过酶联免疫吸附法分析了四组小鼠血清IL-2水平。结果与正常对照组相比,PCOS模型小鼠外周血和脾脏组织组织NK、NKT和T细胞的分布均无明显差异。给予二甲双胍后并没有对其分布产生显著影响。通过分析这些免疫细胞中CD2和CD94受体的百分比和MFI,结果显示,PCOS模型小鼠外周血NK细胞CD2受体MFI降低,脾脏组织NK细胞CD2+受体百分比降低。并且,脾脏组织NKT细胞CD94+细胞百分比升高,而外周血T细胞CD2-MFI升高。二甲双胍能显著降低PCOS模型小鼠的LH水平,但不能影响其FSH、LH/FSH比值和睾酮水平,这可能是为什么给予二甲双胍后不能对防止多囊卵巢诱导的多囊卵巢形态和动情周期紊乱提供保护的原因。二甲双胍对PCOS模型小鼠外周血和脾脏组织NK、NKT及T细胞的分布及CD2、CD94受体表达均无明显影响。尽管如此,IL-2水平在PCOS模型小鼠中显著升高,并在服用二甲双胍后显著降低。结论我们的研究表明,诱发PCOS的条件改变了外周血和脾脏组织NK细胞、NKT细胞和T细胞的功能。这些发现可以帮助我们进一步研究PCOS病理生理学中所涉及的免疫机制。

关键词：多囊卵巢综合征 NK细胞 CD2 CD94 二甲双胍 IL-2

Retroperitoneal High Grade Undifferentiated Pleomorphic Sarcoma as a Second Metachronous Neoplasm Following Intracranial Meningioma

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Journal of Cancer Therapy 2011年第4期2卷 515-517页

作者： armin Kamyab Michael John Jacobs 不详

Introduction: Meningiomas and retroperitoneal sarcomas are two distinct rare tumors, with an incidence of 2 and 0.4 cases per 100,000 respectively. Case Report: We report the case of a 39 year old woman with a history of intracranial meningioma who was found two months later to have a large retroperitoneal sarcoma on CT scan after presenting to the emergency department complaining of abdominal pain. Pathologic evaluation was consistent with a high grade undifferentiated sarcoma. Discussion: It is highly unusual for a 39 year old otherwise healthy patient to present with two rare, seemingly unrelated tumors. It is our suspicion that there is a genetic component involved, however to date no association has been described in the literature between intracranial meningiomas and extracranial sarcomas. Conclusion: Besides being the first report of a retroperitoneal sarcoma occurring as a second metachronous neoplasm following an intracranial meningioma, we suspect that there is a genetic component involved. Further studies may indicate a genetic mutational link.

关键词： Meningioma Sarcoma Genetic

Powering Axons: Novel Functions of Oligodendrocytes in Energy Metabolism

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Pharmacological drug screening to inhibit uveal melanoma metastatic cells either via EGF-R, MAPK, mTOR or PI3K

中国神经科学学会第十二届全国学术会议

作者： Klaus-armin Nave Max Planck Institute of Experimental Medicine

Myelin is the multilayered membrane ensheathment of axons, made by oligodendrocytes and Schwann cells, which enables rapid saltatory impulse propagation. However, myelin also deprives the insulated axonal compartment from the outside milieu and thus from rapid access to essentual metabolites, such as glucose. Thus for fastspiking axons with elevated energy consumption the myelin architecture poses a potential metabolic problem. In different mouse mutants with oligodendrocyte defects, we found that oligodendrocytes are required for both myelination and the survival of axons. In fact, two cellular functions in myelination and in axon support can be genetically uncoupled in different mutant mice. Recently, we discovered an underlying mechanism, by which oligodendroytes provide lactate to the axonal compartment for the generation of ATP. Trying to understand how lactate supply is matched to the real axonal energy needs, which can differ widely, we noticed that activation of oligodendroglial NMDA receptors（as a proxy for axonal spiking activity） causes the rapid redistribution of the glucose transporter GLUT1 and enhanced glucose import. In mice lacking oligodendroglial NMDA receptors, functional GLUT1 expression in the myelin compartment is reduced, which perturbs axon conduction, most visibly under metabolic stress and at higher spiking frequency. Reduced axonal ATP levels can be measured real time when using transgenic mice with neuronally expressed metabolic sensors. Loss of metabolic support by oligodendrocytes is likely a contributing factor for a range of myelin diseases, and is also relevant for neurodegenerative diseases, since long axons are a bottle neck of neuronal integrity.

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1569-1576页

作者： Stefan Kassumeh Sebastian Arrow AndréKafka Nikolaus Luft Siegfried G.Priglinger armin Wolf Kirsten Eibl-Lindner Christian M.Wertheimer Department of Ophthalmology University HospitalLMU MunichMunich 80336Germany Department of Ophthalmology University HospitalUniversity UlmUlm 89075Germany

AIM: To screen five potential pharmacological substances specifically targeting EGF-R, MAPK, mTOR, or PI3K for their antiproliferative effects, possible impact on cell viability, as well as cell death rates on three different uveal melanoma metastasis cell lines in vitro. METHODS: Three different uveal melanoma metastasis cell lines(OMM2.5, OMM2.3, and OMM1), that originated from human hepatic and subcutaneous metastasis, were exposed to inhibitors of different targets: erlotinib(EGF-R), everolimus(mTOR), selumetinib(MAPK), trametinib(MAPK) or the alkylphosphocholine erufosine(PI3K). Cell viability was assessed with a 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide(XTT) dye reduction assay after 24 h of treatment. Antiproliferative effects were evaluated separately after a 72-hour incubation of the cells with the pharmacological substance. Subsequently, the IC_(50) was calculated. Tumor cell death was investigated using a double stain apoptosis detection assay. RESULTS: Selumetinib, trametinib, and erufosine significantly decreased cell viability of all OMM cell lines(P<0.04). In addition, selumetinib and trametinib showed a significant inhibition of cell proliferation(P<0.05). Everolimus and erlotinib solely inhibited cell proliferation at the used concentrations(P<0.05). Besides an increase of necrotic cells after erufosine treatment(P<0.001), no changes in the number of dead cells for the other substances were ***: The preliminary drug screening demonstrates five new candidates, successfully targeting the canonical MAPK/ERK and PI3K/AKT/m TOR pathways in uveal melanoma metastasis cells in vitro. Hence, these findings provide an experimental basis to explore future single or combined therapy strategies for metastatic uveal melanoma.

关键词： uveal melanoma selumetinib trametinib erufosine erlotinib

The Compound Indexing of Human Self-Similar Behavioural Patterns

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Applied Mathematics 2016年第17期7卷 2212-2228页

作者： Petr Kloucek Pavel Zakharov armin von Gunten CAMPsyN Old Age Psychiatry Service Lausanne University Hospital Lausanne Switzerland Biovotion AG Zurich Switzerland

Applications of a constitutive framework providing compound complexity analysis and indexing of coarse-grained self-similar time series representing behavioural data are presented. A notion of behavioural entropy and hysteresis is introduced as two different forms of compound measures. These measures provide clinically applicable complexity analysis of behavioural patterns yielding scalar characterisation of time-varying behaviours registered over an extended period of time. The behavioural data are obtained using body attached sensors providing non-invasive readings of heart rate, skin blood perfusion, blood oxygenation, skin temperature, movement and steps frequency. The results using compound measures of behavioural patterns of fifteen healthy individuals are presented. The application of the compound measures is shown to correlate with complexity analysis. The correlation is demonstrated using two healthy subjects compared against a control group. This indicates a possibility to use these measures in place of fractional dimensions to provide a finer characterisation of behavioural patterns observed using sensory data acquired over a long period of time.

关键词： Behavioural Complexity Physiological and Behavioural Surrogate Data Behavioural Entropy Behavioural Hysteresis Seld-Similar Normally Distributed Precesses Non-Integer Hausdorff-Besicovitch Dimension Hurst Exponent

Exploring Greenhouse Gases Water and Climate Changes:Scientific Opportunities for the Climate and Atmospheric Composition Exploring Satellites Mission

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空间科学学报 2020年第2期40卷 151-168页

作者： LIU Congliang KIRCHENGAST Gottfried SUN Yueqiang WANG Xin LU Daren BAI Weihua DU Qifei LOSCHER armin SYNDERGAARD Stig TIAN Longfei ZHANG Zhihua Beijing Key Laboratory of Space Environment Exploration National Space Science CenterChinese Academy of SciencesBeijing 100190 Wegener Center for Climate and Global Change and Institute for Geophysics Astrophysicsand Meteorology/Institute of PhysicsUniversity of GrazGraz A-8010 Joint Laboratory on Occultations for Atmosphere and Climate Beijing 100190 Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029 Future Missions and Instrument Division European Space AgencyNoordwijkNL-2200 Danish Meteorological Institute CopenhagenDK-2100 Innovation Academy for Microsatellite of Chinese Academy of Sciences Shanghai 201210 University of Chinese Academy of Sciences Beijing 100049

The Essential Climate Variables(ECVs),such as the atmospheric thermodynamic state variables and greenhouse gases,play an important role in the atmosphere physical processes and global climate *** the need of improvements in existing ground-based and satellite observations to successfully deliver atmosphere and climate benchmark data and reduce data ambiguity,the Climate and Atmospheric Composition Exploring Satellites mission(CACES)was proposed and selected as a candidate mission of the Strategic Priority Research Program of Chinese Academy Science(SPRPCAS).This paper presents an overview of the key scientific questions and responses of EC Vs in relation to global change;the principles,algorithms,and payloads of microwave occultation using centimeter and millimeter wave signals between low Earth orbit satellites(LEO-LEO microwave occultation,LMO)as well as of the LEO-LEO infrared-laser occultation(LIO);the CACES mission with its scientific objectives,mission concept,spacecraft and instrumentation.

关键词： Climate Greenhouse gases Water Microwave occultation Infrared-laser occultation

应用T1 mapping技术评价肝硬化病人的Child-Pugh分级

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应用T1 mapping技术评价肝硬化病人的Child-Pugh分级

作者： armin Ghavamian（爱民）山东大学

学位级别：硕士

目的:应用T1 mapping技术测量肝硬化病人的肝脏T1值,并评价肝硬化病人的Child-Pugh分级。方法:本研究为前瞻性研究,纳入了从2019年8月至2020年3月接受腹部MRI（3T）检查的81例患者,其中包括57位肝硬化患者和24名无慢性肝脏疾病的健康人... 详细信息

目的:应用T1 mapping技术测量肝硬化病人的肝脏T1值,并评价肝硬化病人的Child-Pugh分级。方法:本研究为前瞻性研究,纳入了从2019年8月至2020年3月接受腹部MRI（3T）检查的81例患者,其中包括57位肝硬化患者和24名无慢性肝脏疾病的健康人。应用T1 mapping技术,对病人进行肝脏MRI扫描,扫描方法采用改良的的Look-Locker序列。由一位阅片者在肝脏的T1 mapping上进行3个圆形感兴趣区ROI的测量。使用统计学分析方法,比较各个组之间T1的差别。结果:健康人及Child-PughA、B、C组肝硬化病人的T1值结果分别为:885.88±41.52 ms 957.64±64.38 ms、987.03±73.95 ms、1114.79±249.18 ms;健康人与肝硬化组病人之间的T1值存在显著差异;从Child-Pugh A级到C级不断增加（Child-Pugh A级:957.64±64.38 ms;Child-Pugh B 级:987.03±73.95 ms;Child-Pugh C 级:1114.79±249.18 ms）。Child-Pugh A 与 Child-Pugh C 及 Child-Pugh B 与 Child-Pugh C 之间具有显著差异差别（Child-Pugh A:C,p=0.003;Child-Pugh B:C,p=0.026）.而 Child-Pugh A 与Child-PughB之间无显著性差异（p=0.64）。结论:肝硬化病人的各Child-Pugh分级组之间T1弛豫时间存在差别,因此,应用T1 mapping技术可以定量评价肝硬化病人的肝功能。

关键词：肝硬化 Child-Pugh肝功能分级核磁共振定量检测 T1弛豫时间