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Evaluation of HIV Viral Load Activity at the Bacteriology-Virology Laboratory in the University Hospital Center of Brazzaville

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Open Journal of Medical Microbiology 2019年第4期9卷 178-185页

作者： Esther Nina Ontsira Ngoyi Tanguy Mieret Roland Bienvenu Ossibi Ibara Axel Aloumba Géril Obili Sekangue armel claude itoua Irène Laure Opfou Christian Diamant Mossoro-Kpinde Hervé Léon Iloki Bertrand Dupont Christine Rouzioux Bacteriology-Virology Laboratory of the Teaching Hospital Center (CHU) Brazzaville Congo Health Sciences Faculty of MarienNgouabi University Brazzaville Congo National Laboratory of Clinical Biology and Public Health Ministry of Public Health Central African Republic and University of Bangui Faculty of Health sciences Central African Republic Bangui Central African Republic Infectious Diseases Department of the Teaching Hospital Center (CHU) Brazzaville Congo Gynecology and Obstetrical Department of the Teaching Hospital Center (CHU) Brazzaville Congo Infectious Diseases and Tropical Department Neckerteaching Hospital Center Paris France Virology Laboratory of the Necker Teaching Hospital Center Paris Descartes University Paris France

Introduction: The bacteriology-virology laboratory of the teaching university hospital of Brazzaville, was equipped with a real-time PCR device like Miniopticon (Biorad? , France). The aim of this work was to do an evaluation of the HIV viral load activity, with a view to proposing some recommendations. Material and methods: Retrospective study, January 2013 to March 2015, in patients on first line ARV three-therapy, pre-inclusion therapy checkup in HIV positive patients, but again screening after sexual abuse in women or accident of exposure (AES). A blood sample on EDTA tube was made and RNA extraction with Qiagen kit. Ultrasensitive HIV-RNA quantification was performed using the Generic HIV real-time PCR assay (Biocentric?, Bandol, France). Results: 126 patients were included. The mean age was 37.63 years +/- 10.43 years, sex ratio F/H = 2.3. The HIV viral load was detectable in 94 cases (74.6%). Concerning patients with detectable viral load (copies/ml): 403 to 996 in 35 cases (37.23%), 1411 to 1812 in 41 cases (43.62%) and >1814 in 5 cases (5.32%) (therapeutic failure). Conclusion: This work reports success in the setting up of the molecular biology unit. Procedures that implement information and education actions on the risks associated with AES must be disclosed.

关键词： Viral Load HIV Miniopticon CHU Brazzaville

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A Budd-Chiari Syndrome Due to C Protein Deficiency: A Case Report at YaoundéGeneral Hospital (Cameroon)

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Open Journal of Gastroenterology 2024年第4期14卷 117-124页

作者： Antonin Wilson Ndjitoyap Ndam Gilles Gael Aghoagni Gouajio armel Awana Tenone Danah Larry Tangie Ngek Mathurin Kowo Firmin Andoulo Ankouane Elie claude Ndjitoyap Ndam Department of Internal Medicine Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Came-roon Department of Internal Medicine and Peadiatrics Faculty of Health Sciences University of Buéa Buéa Cameroon Department of Biomedical Sciences Faculty of Sciences University of Ngaoundéré Ngaoundéré Cameroon

Primary Budd-Chiari syndrome (BCS) is a spontaneously fatal disease characterized by an obstruction of the hepatic venous outflow tract due to thrombosis or a primary disease of the venous wall. The primary form of BCS is extremely rare. This is a disease mainly affecting young adults of both sexes. Clinical manifestations are variable;they can be asymptomatic, acute, or subacute but mostly chronic. Several causes have been identified, such as myeloproliferative syndrome, antiphospholipid syndrome, paroxysmal nocturnal hemoglobinuria, and inherited thrombotic disorders. Data on primary BCS in Sub-Saharan Africa is rare as most publications available are case reports. In these reports, the causes are unknown with poor prognosis in most cases often leading to patient death. We herein present a case report of a male patient diagnosed with a primary BCS at Yaoundé General Hospital (Cameroon) caused by a Protein C deficiency who presented with ascites decompensating liver cirrhosis. Treatment was based on anticoagulants, diuretics and laxatives administration. Two years after the diagnosis, the patient is alive with clinical and paraclinical improvement.

关键词： Budd-Chiari Syndrome Hepatic Veins Liver Cirrhosis Protein C Deficiency Cameroon

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Energy Analysis and Exergy Utilization in the Residential Sector of Cameroon

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Energy and Power Engineering 2015年第3期7卷 93-104页

作者： Talla Konchou Franck armel Aloyem Kazé claude Vidal Tchinda René Environmental Energy Technologies Laboratory (EETL) University of Yaounde I Yaounde Cameroon LISIE University Institute of Technology Fotso-Victor University of Dschang Bandjoun Cameroon HTTTC Department of Electrical and Power Engineering/FSC University of Bamenda Bamenda Cameroon

In this paper, we present an analysis of energy and exergy utilization in the residential sector of Cameroon by considering the sectoral energy and exergy flows for the years of 2001-2010. Exergy analysis of Cameroon residential sector utilisation indicates a less efficient picture than that obtained by the energy analysis. Cooking stands out as the most inefficient end use in the Cameroon’s residential sector. In 2010, the energy and exergy efficiency are determined and were respectively 58.74% and 22.63%. Energy and exergy flows diagrams for the overall efficiencies of Cameroon residential sector are illustrated and a comparison with the residential sector of other countries is also done. To carry out this study, a survey of 250 households was conducted and the sharing of the end uses of energy was done and data were gathered.

关键词： Exergy Efficiency Energy Flow Residential Sector

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Burnout among Caregivers in Four Maternities in Brazzaville

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Open Journal of Preventive Medicine 2022年第4期12卷 73-84页

作者： Y. V. Y. Mavoungou A. C. Niama G. M. Voumbo Jean claude Mobousse Levi Mankoussou Arnold Mangani Clautaire itoua Department of Public Health Faculty of Health Sciences Brazzaville Congo Hospital and University Center of Brazzaville Brazzaville Congo Departmental Health Directorate Brazzaville Congo National Institute of Statistics Brazzaville Congo

Introduction: The professional exhaustion syndrome, also referred to as burnout, combines deep fatigue, disinvestment in professional activity, a feeling of failure and incompetence at work resulting from the chronic constraints suffered by the worker. The purpose of this work is to assess its prevalence among caregivers of the maternity wards in the district hospitals of Brazzaville. Methodology: This is a descriptive cross-sectional study carried out in four maternities of respectively Bacongo, Makélékélé, Mfilou and Talangai hospitals in Brazzaville between February 1st and February 28th, 2021. Socio-demographic and professional characteristics were collected from a sample of midwives and nurses. The level of exhaustion was evaluated using the “Maslach Burnout Inventory” scale defined as “high” when the 3 dimensions are reached, “moderate” when only 2 are reached, and low for any other result. Results: Among the 143 caregivers investigated (62.9%) of respondents declared being in burnout. According to the dimensions of the Maslach Burnout Inventory scale, 53.1% are caregivers are in high emotional exhaustion;53.1% have a high level of depersonalization and 75.5% have a low level of personal accomplishment. Workload (OR = 13.69;[4.28 - 61.27];p Conclusion: In our study, all dimensions of burnout were high. It is therefore a real phenomenon among caregivers in the four maternities of the district hospitals of Brazzaville. The associated factors can be avoided through prevention.

关键词： Burnout Caregivers Maternities Brazzaville

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Extraspinal Incidental Findings at Lumbar Spine Magnetic Resonance Imaging in Two Hospitals:Prevalence and Clinical Importance

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Open Journal of Radiology 2017年第4期7卷 241-248页

作者： Odile Fernande Zeh Emilienne Guegang Goujou armel Philippe Awana Julienne Onguene Medza Joshua Tambe claude Sandra Raissa Abomo Ngodo Maxwell Goudjou Sandjong Joseph Gonsu Fotsin Faculty of Medicine and Biomedical Sciences University of Yaounde IYaoundeCameroon Yaounde Gynaecology Obstetrics and Pediatrics Hospital YaoundeCameroon Jordan Medical Center YaoundeCameroon Yaounde General Hospital YaoundeCameroon Yaounde Jamot Hospital YaoundeCameroon Jacques Monod Hospital Le Havre MontivilliersFrance

Objective: To assess the importance of incidental extraspinal findings on Magnetic Resonance Imaging of the lumbar spine in two hospital facilities. Materials and Methods: It was a descriptive and retrospective study from November 2015 to March 2016. The records of patients who had done a Magnetic Resonance Imaging (MRI) scan of the lumbar spine were re-read in search of incidental findings. The incidental findings found were classified using Colonography Reporting and Data System(C-RADS) classification of extracolonic lesions to assess clinical significance. The prevalence of incidental findings was calculated for each facility, as well as the distribution according to age, the organs involved and the clinical importance. A non-detection rate was calculated by confronting the findings of the study with the original reports. Results: The prevalence of incidental findings was respectively 33% (19 out of 36) in Jordan Medical Center (JMC) in Yaounde and 27.74% (106 out of 292) in Jacques Monod Hospital. The extraspinal incidental findings were classified mainly as extracolonic 2 (E2): 58% in each facility. The percentage detection of incidental findings was 5% at JMS and 1.7% at Jacques Monod Hospital. Conclusion: Extraspinal incidental findings are frequent in both hospitals. However, the rate of detection remains very low.

关键词： Incidental Findings Magnetic Resonance Imaging Lumbar Spine Extraspinal Lesions

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Catalytic Performance of Nanoscale-Corrugated Gold and Silver Films for Surface-Enhanced Chemiluminescence

Catalytic Performance of Nanoscale-Corrugated Gold and Silve...

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作者：欧梅贵吕国伟 armel Descamps Christophe Andre Marquette Loc Jacques Blum Gilles Ledoux Stephane Roux Olivier Tillement Pascal Perriat Groupe d'Etude de Metallurgie Physique et de Physique des Materiaux INSA de Lyon 69621 Villeurbanne Cedex(France) Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100080(P.R.China) Laboratoire de Genie Enzymatique et Biomole culaire Universite claude Bernard Lyon I 69622 Villeurbanne Cedex(France) Laboratoire de Physico-Chimie des Materiaux Luminescents Universite claude Bernard Lyon I 69622 Villeurbanne Cedex(France)

Biochips of corrugated gold and silver displaying surface plasmon resonance at different energies are fabricated to determine the nature of the mechanism responsible for the surface-enhanced chemiluminescence (SECL) of *** Full Paper proves that,whereas silver possesses the strongest resonance and the greatest plasmon overlap with luminol emission,silver is also the metal that induces the lowest CL enhancement(two orders of magnitude less than gold).Therefore,the enhancement mechanism is not related to plasmon-assisted processes but rather originates from catalytic properties induced by corrugation of the metal film.

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Electrocardiographic Safety of Daily Hydroxychloroquine 400 mg Plus Azithromycin 250 mg as an Ambulatory Treatment for COVID-19 Patients in Cameroon

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World Journal of Cardiovascular Diseases 2021年第2期11卷 106-112页

作者： Liliane Mfeukeu-Kuate William Djomo Ngatchou Mazou Ngou Temgoua Charles Kouanfack Daniel Lemoungoum Joel Noutakdie Tochie armel Zemsi Lauriane Fomete Skinner Lekelem Sylvain Zemsi Joelle Sobngwi Thierry Ntandzi Christian Ngongang Ouankou Yves Wasnyo Antoinette Tsama Assiga Jan René Nkeck Ahmadou Musa Jingi Magellan Guewo Eric Walter Pefura Yone Charlotte Moussi Omgba Paul Owono Etoundi Jean Cyr Yombi Samuel Kingue Alain Menanga Jacqueline Ze Minkande Pierre Ongolo Zogo Jean claude Mbanya Pierre Joseph Fouda Eugène Sobngwi Central Hospital of Yaoundé Yaoundé Cameroon Department of Internal Medicine and specialities Faculty of Médicine and Biomedical Sciences of the University of Yaounde I Yaoundé Cameroon Department of Surgery University of Douala Hypertension Clinic and Cardiac Surgery Department St Pierre Hospital Université libre de Bruxelles Brussels Belgium Faculty of Medicine and Pharmaceutical Sciences of Dschang University Dschang Cameroon Hypertension Clinic and Cardiology Department Erasme Hospital University of Brussels Brussels Belgium Research-Health and Development Yaoundé Cameroon and London School of Economics and Political Sciences London UK ANRS Cameroon Yaoundé Camerroon Faculty of Health Sciences University of Bamenda Bamenda Cameroon Jamot Hospital of Yaounde Yaounde Cameroon Regional Public Health Delegation for the Centre Ministry of Public Health Cameroon Yaoundé Cameroon Department of Surgery and Specialities Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Centre for the Development of Good Health Practices Yaoundé Cameroon

Objective: To determine the early electrocardiographic changes in a cohort of ambulatory cameroonian COVID-19 patients treated with hydroxychlo- roquine and Azithromycin. Design: Prospective study. Setting: Treatment centres of the city of Yaounde, Cameroon, from May 7th to 24th 2020. Participants: We enrolled 51 consecutive confirmed COVID-19 on RT-PCR who having mild forms of COVID-19 and treated by hydroxychloroquine 200 mg twice daily during seven #days plus Azithromycin 500 mg the first day and 250 mg the remaining 4 days as per national standard. Main Outcomes Measures: The primary end-point was the change in QTc interval between day 0 (D0), day 3 (D3) and day 7 (D7). Secondary endpoints were changes in all other cardiac electrical conductivity patterns and the occurrence of clinical arrhythmic events during the course of treatment. Results: The population (29 men and 22 women) was aged 39 ± 11 years (range 17 to 61 years

关键词： Early Electrocardiographic Changes COVID-19 Hydroxychloroquine Azithromycin Cameroon

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