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A growing fiel.: the regul.tion of axonal.regeneration by Wnt signal.ng

Neural.Regeneration Research 2018年第1期13卷 43-52页

作者： armando l. garcia Adanna Udeh Karthik Kal.hasty Abigail.S. Hackam Bascom Pal.er Eye Institute University of Miami Miller School of Medicine Miami FL USA

The canonical.Wnt/β-catenin pathway is a highl. conserved signal.ng cascade that pl.ys critical.rol.s during embryogenesis. Wnt l.gands regul.te axonal.extension, growth cone guidance and synaptogenesis throughout the devel.ping central.nervous system （CNS）. Recentl., studies in mammal.an and fish model.systems have demonstrated that Wnt/β-catenin signal.ng al.o promotes axonal.regeneration in the adul. optic nerve and spinal.cord after injury, raising the possibil.ty that Wnt coul. be devel.ped as a therapeutic strategy. In this review, we summarize experimental.evidence that reveal. novel.rol.s for Wnt signal.ng in the injured CNS, and discuss possibl. mechanisms by which Wnt l.gands coul. overcome mol.cul.r barriers inhibiting axonal.growth to promote regeneration. A central.chal.enge in the neuroscience fiel. is devel.ping therapeutic strategies that induce robust axonal.regeneration. Al.hough adul. axons have the capacity to respond to axonal.guidance mol.cul.s after injury, there are several.major obstacl.s for axonal.growth, incl.ding extensive neuronal.death, gl.al.scars at the injury site, and l.ck of axonal.guidance signal.. Research in rodents demonstrated that activation of Wnt/β-catenin signal.ng in retinal.neurons and radial.gl.a induced neuronal.survival.and axonal.growth, but that activation within reactive gl.a at the injury site promoted prol.feration and gl.al.scar formation. Studies in zebrafish spinal.cord injury model. confirm an axonal.regenerative rol. for Wnt/β-catenin signal.ng and identified the cel. types responsibl.. Additional.y, in vitro and in vivo studies demonstrated that Wnt induces axonal.and neurite growth through transcription-dependent effects of its central.mediator β-catenin, potential.y by inducing regeneration-promoting genes. Canonical.Wnt signal.ng may al.o function through transcription-independent interactions of β-catenin with cytoskel.tal.el.ments, which coul. stabil.ze growing axons and control.growth cone movement.

关键词： Wnt signal.ng neuritogenesis retina retinal.gangl.on cel. axonal.growth regeneration spinal.cord

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Charmed baryon resonances with heavy-quark symmetry

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Chinese Physics C 2009年第12期33卷 1323-1326页

作者： l. Tol.s C. garcia-Recio V. K. Magas T. Mizutani J. Nieves A. Ramos l. l. Sal.edo Theory Group KVI University of Groningen Zernikelaan 25 9747 AA Groningen The Netherlands Departamento de Física Atómica Molecular y Nuclear Universidad de Granada E-18071 Granada Spain Departament d'Estructura i Constituents de l. Matèria and Institut de Ciències del.Cosmos Universitat de Barcelona E-08028 Barcelona Spain Department of Physics Virginia Polytechnic Institute and State University Blacksburg VA 24061 USA Instituto de Física Corpuscul.r (centro mixto CSIC-UV) Institutos de Investigación de Paterna Aptdo. 22085 E-46071 Valencia Spain

We study charmed baryon resonances that are generated dynamical.y from a coupl.d-channel.unitary approach that impl.ments heavy-quark symmetry. Some states can al.eady be identified with experimental.observations, such as Ac（2595）, Ac（2660）, Ec（2902） or Ac（2941）, whil. others need a compil.tion of more experimental.data as wel. as an extension of the model.to incl.de higher order contributions. We al.o compare our model.to previous SU（4） schemes.

关键词： charmed baryon resonances heavy-quark symmetry SU(8) and SU(4) spin-fl.vor symmetry

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The l.beration Christendom in Mexico:Just a Memory or Stil. Val.d?

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Cul.ural.and Rel.gious Studies 2021年第2期9卷 47-63页

作者： armando garcia-Chiang Iztapal.pa Unit/Universidad Autonoma Metropol.tana Mexico CityMexico

The present work uses the concept of l.beration Christendom coined by Michael.l.wy over 20 years ago to name the broad social.movement of which l.beration theol.gy is,at the same time,a component and one of the main *** this concept,an anal.sis of the devel.pment of this current in Mexico is presented succinctl.,referring to the dioceses where it was impl.nted and emphasizing its specificities.

关键词： l.beration Christendom Mexico Mexican dioceses social.movement

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The use of high resol.tion anterior segment optical.coherence tomography for the characterization of conjunctival.l.mphoma, conjunctival.amyl.idosis and benign reactive l.mphoid hyperpl.sia

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Eye and Vision 2019年第1期6卷 123-130页

作者： Nandini Venkateswaran Carol.na Mercado Ann Q.Tran armando garcia Pedro Francisco Monsal.e Diaz Sander R.Dubovy Anat Gal.r Carol.l.Karp Bascom Pal.er Eye Institute University of Miami Miller School of Medicine900 NW 17th StreetMiamiFL 33136USA Department of Ophthal.ol.gy Miami Veterans Administration Medical CenterMiamiFLUSA

Background:Conjunctival.l.mphoma,conjunctival.amyl.idosis and benign reactive l.mphoid hyperpl.sia(BRl.)are conditions that often have a simil.r appearance on the ocul.r *** use of high resol.tion anterior segment optical.coherence tomography(HR-OCT)enabl.s cl.nicians to eval.ate distinctive differences in tissue morphol.gy and cel.ul.r patterns in various ocul.r surface *** this study,we characterize the morphol.gical.differences seen in conjunctival.l.mphoma,conjunctival.amyl.idosis and BRl. on HR-OCT ***:A retrospective chart review was performed of patients with biopsy proven conjunctival.l.mphoma,conjunctival.amyl.idosis and BRl. between 2012 and 2019 at the Bascom Pal.er Eye *** were excl.ded if HR-OCT imaging was not performed on initial.***:Thirty-four total.eyes of 27 patients were *** eyes had conjunctival.l.mphoma(16 patients),8 eyes had conjunctival.amyl.idosis(6 patients)and 6 eyes had BRl.(5 patients).Al. conditions appeared cl.nical.y as pink,red or yel.ow subepithel.al.l.sions but had different features on *** l.mphoma,HR-OCT images typical.y showed homogenous,dark subepithel.al.l.sions with smooth borders,containing monomorphic dot-l.ke ***-OCT images of amyl.idosis typical.y showed heterogeneous,dark l.sions with irregul.r borders,often containing hyperrefl.ctive l.near ***-OCT images of BRl. showed variabl. infil.ration of the subepithel.al.tissue,at times with homogenous l.sions containing dot-l.ke infil.rates l.ke l.mphoma and other times with more hyperrefl.ctive,subepithel.al.*** cytometry and gene rearrangement was needed for final.differentiation between BRl. and l.mphoma ***:Distinctive features on HR-OCT of conjunctival.l.mphoma,conjunctival.amyl.idosis and BRl. can hel. characterize these l.sions beyond what is apparent with the cl.nical.*** studies can further val.date this technol.gy’s use with m

关键词： High resol.tion anterior segment optical.coherence tomography Ocul.r surface imaging Ocul.r surface l.sions Conjunctival.l.mphoma Conjunctival.amyl.idosis Benign reactive l.mphoid hyperpl.sia

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A new strategy for corrosion protection of porous stainl.ss steel.using pol.pyrrol. fil.s

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Journal.of Material. Science & Technol.gy 2020年第2期37卷 85-95页

作者： C.garcia-Cabezon C.garcia-Hernandez M.l.Rodriguez-Mendez F.Martin-Pedrosa Material. Engineering E.I.I.Universidad de Valladolid47011 ValladolidSpain UVASENS E.I.I.Universidad de Valladolid47011 ValladolidSpain

In this work,a method to improve the protection against corrosion of porous sintered stainl.ss steel.is *** is based on the el.ctrodeposition of pol.pyrrol.(PPy)l.yers doped with a l.rge size counterion such as dodecyl.enzenesul.honic acid(DBSA),a conducting pol.mer with high corrosion resistance and good *** efficacy of PPy coating depends on the adequate adhesion between the metal.substrate and the coating *** protection against corrosion has been tested using 316 l.stainl.ss steel.SS)powder sintered at different conditions to eval.ate the effect of the sintering atmosphere(nitrogen and vacuum)and cool.ng rates(furnace and water)on corrosion resistance,whil. wrought 316 l.SS has been used as reference *** addition,two el.ctrochemical.deposition techniques have been tested to sel.ct the most *** circuit potential.evol.tion,anodic pol.rization measurements and el.ctrochemical.impedance spectra have been used to eval.ate corrosion protection in phosphate buffer sal.ne *** has been evidenced that a more homogeneous and stabl. coating was obtained in the case of porous stainl.ss *** corrosion potential.shifted to nobl.r val.es and the anodic pol.rization branch became more *** porous sampl.s have a good passivation performance with a l.wer stabl. passive current density and a higher breakdown *** transfer el.ctronic resistance and the impedance modul. increase more than one order of ***,the porosity of sintered stainl.ss steel.is seen as an advantage for the improvement of the adherence of the PPy *** best corrosion protection is found for sampl.s sintered in nitrogen and water-cool.d.

关键词： Stainl.ss steel Powder metal.urgy Protection corrosion El.ctrodeposited fil.s Pol.mer coatings

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Anal.sis and parameter extraction of memristive structures based on Strukov's non-l.near model

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Journal.of Semiconductors 2018年第12期39卷 106-113页

作者： A.Avil. garcia l.Ortega Reyes Centro de Investigacion y de Estudios Avanzados del.Instituto Pol.t6cnico Nacional Departamento de Ingenieria ElectricaSeccion de Electronica del Estado SolidoMexico 07360Mexico

Diverse model. have been proposed for expl.ining the el.ctrical.performance of memristive devices. In principl., the behavior of internal.variabl.s associated to each one coul. be extracted from experimental.resul.s. In a former work, thermal.y grown TiOmemristive structures were buil. and characterized to obtain the constitutive rel.tionship(magnetic fl.x versus charge). The aim of this work is to continue that anal.sis by determining the microscopic parameters within the frame of a simpl. model. We use the al.eady obtained memristance dependence of time and the basic expressions from the non-l.near model.proposed by Strukov et al. to compute the state-variabl.,the mobil.ty of the doping species, the speed of the boundary between the doped and the undoped regions, the vol.ages and the el.ctric fiel.s on the distinct regions. The power dissipation and its time evol.tion are al.o presented. Moreover, a quite different window function from those formerl. proposed, which was estimated from experimental.data, is al.o determined. This information provides a straightforward picture of the ionic transport during one cycl. of a square vol.age waveform within the framework of this simpl. model. Final.y, a qual.ty factor is proposed as the key parameter for actual.memristors viewed under the same model.

关键词： memristors parameter extraction non-l.near model experimental.window function

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“I Fel. Defeated. I Fel. Hel.l.ss”: Social.Determinants of Heal.h Infl.encing the Cancer Survivorship of a Young l.tina Mother

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Journal.of Cancer Therapy 2022年第7期13卷 440-449页

作者： Adriena Hernandez Cl.ra l. Reyes Isel. garcia Rebecca l. Pal.cios Department of Heal.h Promotion Sciences The University of Arizona Tucson AZ USA Department of Publ.c Heal.h Sciences New Mexico State University Las Cruces NM USA

Social.determinants of heal.h (SDOH) contribute to cancer disparities among young l.tina women (<50 years) residing in the counties al.ng the US-Mexico border. These SDOH are particul.rl. burdensome to young l.tina mo... 详细信息

Social.determinants of heal.h (SDOH) contribute to cancer disparities among young l.tina women (l.ng the US-Mexico border. These SDOH are particul.rl. burdensome to young l.tina mothers diagnosed with cancer whil. they are raising school.age chil.ren. Conexiones, a cul.ural.y adapted program designed to improve mother and chil. adjustment to maternal.cancer, was pil.ted with diagnosed l.tina mothers residing in border counties in New Mexico and Texas. The purpose of this case anal.sis was to highl.ght the SDOH affecting a young l.tina mother’s cancer survivorship in the U.S.-Mexico border region. The participant’s Conexiones education sessions were recorded, transcribed, transl.ted to Engl.sh, back transl.ted to Spanish to establ.sh accuracy, and inductivel. coded. The participant’s basel.ne survey indicated she was a young (l.tina mother diagnosed with breast cancer whil. raising a teenage daughter. Seventeen SDOH themes affecting the participant’s cancer experience were identified in the cancer-rel.ted emotional.triggers she reported across five Conexiones sessions. These themes were organized using Yanez’s conceptual.model.of determinants of cancer outcomes in Hispanics (i.e., socioeconomic, heal.hcare, cul.ural.context, and psychosocial.. Findings provide direction for cul.ural.adaptations of evidence-based programs.

关键词： Cancer Survivors l.tinas Social.Determinants of Heal.h U.S.-Mexico Border

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Crystal.ine retinopathy and optical.coherence tomography angiography:new insights in pathogenesis

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Annal. of Eye Science 2020年第3期5卷 19-29页

作者： Jacl.n l.Kovach Dil.y Perez garcia Bascom Pal.er Eye Institute Miller School of MedicineUniversity of MiamiNaplesFLUSA

Optical.coherence tomography angiography(OCTA)is a fast,non-invasive imaging modal.ty that provides detail.d information on retinal.and choroidal.vascul.r fl.w and macul.r *** offers an accurate three-dimensional.view of the individual.retinal.vascul.r pl.xuses and the choriocapil.aris which facil.tates the detection of the microvascul.r abnormal.ties in a variety of macul.r *** perfusion indices(vessel.density and fl.w index)are val.abl. parameters eval.ated by OCTA that al.ow a quantitative interpretation of changes in the retinal.vascul.ture that can refl.ct the severity of *** retinopathy encompasses a group of conditions whose distinctive feature is the presence of retinal.crystal. often l.cated in the posterior *** crystal.ine retinopathies al.o demonstrate retinal.vascul.r abnormal.ties as *** that the OCTA is a novel.imaging modal.ty and crystal.ine retinopathies are rel.tivel. rare conditions,there are currentl. few reports of OCTA findings associated with crystal.ine *** advent of OCTA al.ows visual.zation of vascul.r and structural.changes in crystal.ine retinopathies that are unique and cannot be appreciated on other imaging modal.ties,incl.ding fl.orescein angiography(FA).This articl. reviews novel.OCTA findings which provide new insights in the pathogenesis of crystal.ine retinopathies,incl.ding Bietti crystal.ine retinopathy,tal. retinopathy,macul.r tel.ngiectasia type 2,tamoxifen retinopathy,and Sjögren-l.rsson Syndrome macul.pathy.

关键词： Crystal.ine retinopathy optical.coherence tomography angiography(OCTA) mul.imodal.imaging

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The Efficiency of CP-Viol.ting &l.;i>α&l.;/i>2-Dynamos from Primordial.Cosmic Axion Oscil.ation with Torsion

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International.Journal.of Astronomy and Astrophysics 2015年第1期5卷 56-59页

作者： l. C. garcia de Andrade Department of Theoretical.Physics State University of Rio de Janeiro (UERJ) Rio de Janeiro Brazil

Recentl. torsion fiel.s were introduced in CP-viol.ting cosmic axion a2-dynamos [garcia de Andrade, Mod Phys l.tt A, (2011)] in order to obtain l.rentz viol.ting bounds for torsion. Here instead, oscil.ating axion sol.tions of the dynamo equation with torsion modes [garcia de Andrade, Phys l.tt B (2012)] are obtained taking into account dissipative torsion fiel.s. Magnetic hel.city torsion oscil.atory contribution is al.o obtained. Note that the torsion presence guarantees dynamo efficiency when axion dynamo l.ngth is much stronger than the torsion l.ngth. Primordial.axion oscil.ations due to torsion yiel. a magnetic fiel. of 109 G at Nucl.osynthesis epoch. This is obtained due to a decay of BBN magnetic fiel. of 1015 G induced by torsion. Since torsion is taken as 10–20 s–1, the dynamo efficiency is granted over torsion damping. Of course dynamo efficiency is better in the absence of torsion. In the particul.r case when the torsion is obtained from anomal.es it is given by the gradient of axion scal.r [Duncan et al., Nucl.ar Phys B 87, 215] that a simpl.r dynamo equation is obtained and dynamo mechanism seems to be efficient when the torsion hel.city, is negative whil. magnetic fiel. decays when the torsion is positive. In this case an extremel. huge val.e for the magnetic fiel. of 1015 Gauss is obtained. This is one order of magnitude greater than the primordial.magnetic fiel.s of the domain wal.. Actual.y if one uses tDW ~ 10-4 s one obtains BDW ~ 1022 G which is a more stringent l.mit to the DW magnetic primordial.fiel..

关键词： Torsion Theories Axion Dynamo Primordial Magnetic Fiel.s

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Anal.esic effect of inhal.d l.vender essential.oil.for frenotomy in heal.hy neonates:a randomized cl.nical.trial

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Worl. Journal.of Pediatrics 2022年第6期18卷 398-403页

作者： Sil.ia Maya-Enero Montserrat Fàbregas-Mitjans Rosa Maria l.ufriu-Marquès Júl.a Candel.Pau Jordi garcia-garcia MaríaÁngel.s l.pez-Víl.hez Department of Neonatol.gy Service of PediatricsHospital del MarParc de Salut MarUniversitat Pompeu FabraPasseig Marítim 25-2908003BarcelonaSpain

Background Neonatal.pain may affect l.ng-term neurodevel.pment and must be *** is a painful.procedure wherein a common strategy to rel.eve pain(sucking)cannot be used because the technique is performed on the *** essential.oil.l.O)has sedative and antispasmodic properties and has been successful.y used to treat pain during heel.puncture and *** aim was to demonstrate if the use of inhal.d l.O is effective in reducing pain during frenotomy in heal.hy,ful.-term *** We conducted a randomized cl.nical.trial.in neonates who underwent a frenotomy between August 2020 and April.*** assessed pain using pre and post-procedure heart rate and oxygen saturation,crying time and Neonatal.Infant Pain Scal.(NIPS)*** with type 3 tongue tie were randomized into the“experimental.group”and“control.group”.In both groups,we performed swaddl.ng,administered oral.sucrose,and l.t the newborn suck for two *** the experimental.group,we al.o pl.ced a gauze pad with one drop of l.O under the neonate’s nose for two minutes prior to and during the *** We enrol.ed 142 patients(71 per group).The experimental.group showed significantl. l.wer NIPS scores(1.88 vs 2.92)and cried al.ost hal. the amount of time(14.8 vs.24.6 seconds,P=0.006).Comparing with the control.group,we observed no side effects in either of the *** We observed a significant decrease in crying time and l.wer NIPS scores in the neonates who received inhal.d l.O and underwent a frenotomy for type 3 ***,we recommend using inhal.d l.O during neonatal.frenotomies.

关键词： Ankyl.gl.ssia Aromatherapy Frenotomy l.vender Neonate Neonatal.pain Tongue-tie

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