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Mesenchymal stem cell enhances chondral defects healing in horses

Stem Cell Discovery 2013年第4期3卷 218-225页

作者： Ana Lucia Miluzzi Yamada armando de mattos carvalho Andrei Moroz Elenice deffune Marcos Jun Watanabe Carlos Alberto Hussni Celso Antonio Rodrigues Ana Liz Garcia Alves department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science(FMVZ)UNESPUniversidade Estadual PaulistaBotucatuBrazil Faculty of Veterinary Medicine Cuiaba UniversityCuiabaBrazil department of Morphology Institute of BiosciencesUNESPBotucatuBrazil Blood Center School of MedicineUNESPBotucatuBrazil

The purpose of this study was to evaluate the effect of intralesional Mesenchymal Stem Cells (MSC) on the treatment of experimentally induced articular chondral defects in horses, emphasizing the benefits of this application in veterinary medicine. Chondral defects were induced in the medial femoral trochlea of both hind limbs of four horses. Thirty days post induction;the horses were divided into two groups. The G1 was submitted to treatment with MSC and the G2 was the control group. Clinical evaluations, synovial fluid analysis and synovial Prostaglandin E2 (PGE2) assessment were performed prior to defects and fortnightly up to 120 and 150 days. Macroscopic, histopathological and histochemical evaluations were performed at the end of the experiment. The treatment with MSC reduced the intraarticular inflammatory process. The G1 showed lower PGE2 concentrations in the synovial fluid and greater percentage of mononuclear cells and lower percentages of lymphocytes and neutrophils. The treatment improved the macro and microscopic aspects of repair tissue. No difference was observed in the scores of lameness between the G1 and G2. The use of MSC in the treatment of chondral defects minimized joint inflammation, as confirmed by synovial fluid analysis. The treatment resulted in an improved repair tissue, verified by macroscopic examination, histochemical and histopathological analysis.

关键词： Arthroscopy Cartilage Equine Lameness Mesenchymal Stem Cells

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Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics

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Animal Diseases 2022年第1期2卷 16-26页

作者： Luciano Rodrigo Lopes Giancarlo de mattos Cardillo Natalia carvalho de Lucca Pina Antonio Carlos da Silva Junior Silvana Kertzer Kasinski Paulo Bandiera-Paiva SPBrasil SPBrasil

Severe acute respiratory syndrome coronavirus(SARS-CoV)and SARS-CoV-2 are thought to transmit to humans via wild mammals,especially bats.However,evidence for direct bat-to-human transmission is lacking.Involvement of intermediate hosts is considered a reason for SARS-CoV-2 transmission to humans and emergence of outbreak.Large biodiversity is found in tropical territories,such as Brazil.On the similar line,this study aimed to predict potential coronavirus hosts among Brazilian wild mammals based on angiotensin-converting enzyme 2(ACE2)sequences using evolutionary bioinformatics.Cougar,maned wolf,and bush dogs were predicted as potential hosts for coronavirus.These indigenous carnivores are philogenetically closer to the known SARS-CoV/SARS-CoV-2 hosts and presented low ACE2 divergence.A new coronavirus transmission chain was developed in which white-tailed deer,a susceptible SARS-CoV-2 host,have the central position.Cougar play an important role because of its low divergent ACE2 level in deer and humans.The discovery of these potential coronavirus hosts will be useful for epidemiological surveillance and discovery of interventions that can contribute to break the transmission chain.

关键词： SARS-CoV-2 Angiotensin-converting enzyme 2 Coronavirus Brazilian mammals White-tailed deer

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Fraud investigation in commercial coffee by chromatography

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Food Quality and Safety 2018年第3期2卷 121-133页

作者： Víctor de carvalho Martins Ronoel Luiz de Oliveira Godoy Ana Cristina Miranda Senna Gouvêa Manuela Cristina Pessanha de Araujo Santiago Renata Galhardo Borguini Elaine Cristina de Oliveira Braga Sidney Pacheco Luzimar da Silva de mattos do Nascimento departamento de Tecnologia de Alimentos Instituto de TecnologiaUniversidade Federal Rural do Rio de JaneiroCEP 23890-000Seropédica-RJBrazil Laboratório de Cromatografia Líquida Embrapa Agroindústria de AlimentosCEP 23020-470Rio de Janeiro-RJBrazil Centro de Tecnologia Instituto de QuímicaUniversidade Federal do Rio de JaneiroCEP 22290-180Rio de Janeiro-RJBrazil

Coffee is currently the second largest commodity on the world market today,and there is great concern about the quality of the beans exported from producer countries to Europe and USA.Practices such as using blends of different species and adding low-cost raw materials,such as chicory,corn,and soybean,impair the sensory and functional characteristics of the drink made from roasted and ground coffee beans.There is a need to adopt more efficient analytical methods than the microscopy technique currently used.The first chromatographic method used to determine fraud was reported in 1958.This method used paper chromatography to differentiate between coffee and chicory based on the free reducing sugars.As of the 1980s,different methods involving high-performance liquid chromatography and gas chromatography were developed in order to demonstrate geographic authenticity,distinction between species,occurrence of adulteration,and the presence of defective beans by determining the monosaccharides,oligosaccharides,tocopherols,fatty acids,volatiles,diterpenes,sterols,and phenolic substances,among others.As far as the authors know,there are no papers published in the literature that have compiled such an extensive set of information about these chromatographic methods as here.Over the last 2 years,there has been a trend to develop analytical methods for ultra-performance liquid chromatography coupled with tandem mass spectrometry to confirm fraud in coffee,due to high sensitivity and selectivity.

关键词： adulteration coffee chromatographic methods carbohydrates volatile substances

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Effects of Sky Conditions Measured by the Clearness Index on the Estimation of Solar Radiation Using a Digital Elevation Model

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Atmospheric and Climate Sciences 2013年第4期3卷 618-626页

作者： Marcelo de carvalho Alves Luciana Sanches José de Souza Nogueira Vanessa Augusto mattos Silva department of Physics Federal University of Mato Grosso Mato Grosso Brazil department of Sanitary and Environmental Engineering Federal University of Mato Grosso Cuiabá Brazil Soil and Rural Engineering department Federal University of Mato Grosso Mato Grosso Brazil

This study evaluated the effects of sky conditions (measured by the clearness index, KT) on the estimation of solar radiation and its components. Solar radiation was calculated by a digital elevation model derived from the Shuttle Radar Topography Mission (SRTM). The calculated radiation was parameterized and validated with measured solar radiation from two stations inside the urban perimeter of the city of Cuiabá, Brazil, during 2006 to 2008. The measured solar radiation varied seasonally, with the highest values in december-March and the lowest in June-September. Comparisons between calculated and measured values for two sites in Cuiabá demonstrate that the model is accurate for daily Rg estimates under clear sky conditions based on Root Mean Square Error, Mean Bias Error and Willmott’s index. However, under partially cloudy and cloudy sky conditions the model was not able to provide robust estimates. Spatially, the highest values of incident Rg occurred on strands with North, Northeast and Northwest orientations and were lowest on those oriented to the South, Southeast and Southwest.

关键词： Sky Cover Spatial Radiation Mapping Solar Geographic Information Systems

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Use of Extra-Narrow-Diameter Implants in Reduced Alveolar Ridge:A Case Report

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Journal of Biomaterials and Nanobiotechnology 2020年第2期11卷 101-109页

作者： Camila Ferreira mattos Marco Antonio Alencar de carvalho Jorge Jose de carvalho Paulo Goncalo Pinto Dos Santos Jorge Luis Da Silva Pires Igor Da Silva Brum department of Implantology Faculty of DentistryState University of Rio de JaneiroRio de JaneiroBrazil department of Biology Faculty of DentistryState University of Rio de JaneiroRio de JaneiroBrazil

Background: Narrow-diameter implants (3.0 - 3.5 mm range) have been introduced for the replacement of teeth with insufficient bone structure and/or limited mesiodistal or interimplant spaces, and appear to offer clinical results similar to those obtained with implants of greater diameter. Studies using extra-narrow-diameter implants (2.8 mm) are scarce. Case Presentation: A 59-year-old male patient received two extra-narrow-diameter implants, 2.8 × 11 mm in the region between elements 11 and 14. Together, two 3.5 × 8.5 mm SYSTHEX®platform 4.1 implants were installed in the region of elements 15 and 16 to provide greater stability in the occlusion. Of four previous implants on the maxillary left side, one in the region between the elements 23 and 24 that was located in a very apical position and vestibularized was removed. The provisional was already installed on the elements 11, 21, and 22 with the metal cores already prepared and with the Globteck®implants in the region of the elements 23, 24, and 27. The functional and esthetic results were satisfactory. Conclusions: Insertion of extra-narrow-diameter implants of 2.8 mm in the maxillary anterior region is a reliable option in a patient with absence of elements 12 and 13, restoring masticatory function and aesthetics in the upper arch.

关键词： dental Implants Narrow-Diameter Maxilla Bone density

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Environmental Exposure Associated with Oxidative Stress Biomarkers in Children and Adolescents Residents in Brazilian Western Amazon

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Journal of Environmental Protection 2018年第4期9卷 347-367页

作者： Beatriz Fatima Alves de Oliveira Leandro Vargas Barreto de carvalho dennys de Souza Mourao Rita de Cassia Oliveira da Costa mattos Hermano Albuquerque de Castro Paulo Artaxo Washington Leite Junger Sandra Hacon National School of Public Health Oswaldo Cruz FoundationRio de JaneiroBrazil Center for Studies of Worker’s Health and Human Ecology Oswaldo Cruz FoundationRio de JaneiroBrazil Institute of Physics University of Sao PauloSao PauloBrazil departament of Epidemiology/Social Medicine Institute State University of Rio de JaneiroRio de JaneiroBrazil

Oxidative stress is a biological process that occurs in response to an imbalance between prooxidant and antioxidant substances and has been described in the pathophysiology of more than 200 clinical disorders. In this study, we evaluate the relationship between genetic, demographic, social, environmental, and health factors and redox imbalance biomarkers in a group of children and adolescents environmentally exposed to atmospheric pollutants and mercury in the Brazilian Western Amazon. This is a cross-sectional study of the relationship between demographic, genetic, and socioenvironmental factors and serum concentrations of redox imbalance biomarkers (thiol groups, malondialdehyde, and glutathione S-transferase [GST]) in children and adolescents living in the municipality of Porto Velho, Rond?nia. The investigated factors were hierarchically organized into groups of variables and their relationship with redox imbalance biomarkers was estimated by a multiple linear regression model. Children and adolescents with asthma, with C-reactive protein values, with the polymorphic variant GSTP1, and exposed to indoor air pollution presented lower thiol serum concentrations when compared to those categorized in their respective reference groups. GST activity and malondialdehyde serum concentrations were positively related to weekly fish consumption and exposure to PM2.5. This study showed that enzymatic GST activity and malondialdehyde serum concentrations are positively associated with environmental factors, especially air pollution (β = 8.64 U/L for GST and β = 0.244 μmol/L for MDA in high exposure group;p-value < 0.01);while serum thiol concentrations presented an inversely proportional relationship with markers of general health status, such asthma (median: 0.45 mmol/L vs. 0.48 mmol/L;p-value < 0.05), acute inflammation (β = -0.25 mmol/L;p-value < 0.01), and positively with genetic factor (β = 0.12 mmol/L for Val/Val;p-value < 0.05).

关键词： Redox Imbalance Glutathione S-Transferase Thiol Groups Malondialdehyde Brazilian Amazon

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