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CXCR4+ and SDF-1+ Bone Marrow Cells Are Mobilized into the Blood Stream in Acute Myocardial Infarction and Acute Ischemia

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World Journal of Cardiovascular Diseases 2014年第7期4卷 361-367页

作者： Jose Luis Aceves Rafael Vilchis Maria Antonieta Medina Monserrat Borja Silvia Cortes Guillermo Diaz armando Castro Alexis Gomez Jose JParra Martha Alvarado Manuel Lopez Hernandez Virna Poveda Felipe Masso Luis FMontano Division de Cardiocirugia Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Departamento de Hematologia Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Laboratorio de Hormonas Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Departamento de Inmunobiologia Biologia Celular y Tisular Facultad de Medicina UNAMMexico DFMexico

Cell therapy has shown beneficial effects on ventricular function and tissue regeneration in patients with acute and chronic myocardial infarction, although with diverse grades of variability in the results, possibly by proportion, subtype and cell cycle status. Objective: Identify and phenotypically characterize, via CXCR4 and SDF-1 expression, the bone marrow cell subpopulations that are mobilized into the bloodstream in patients with Acute Myocardial Infarction (AMI) and Acute Ischemia (AI) such as acute angina and Chronic Ischemia (CI) such as chronic stable angina, and also determine the cell cycle status of these cells. Method: Patients with AMI and AI were recruited in the ICCU, and patients with CI in the departments of cardiology and cardiovascular surgery. The quantification of cellular subpopulations was made by cytofluorometry with a FACS caliburcyto fluorometry (Becton Dickinson) with specific FITC-labeled anti human monoclonal antibodies against CD34, CD133, CD117, CD48, CXCR4, SDF-1 and Ki67 (Becton Dickinson). Serum concentration of IL-6 and IL-8 were determined by a sequential solid phase chemiluminescent assay performed in a SIEMENS IMMULITE 1000 Analyzer. Statistical analysis was made with the SPSS version 20.0 for Windows. A p value 3/ml) than that in AI (9.2 ± 1.3 × 103/ml) and CI (6.6 ± 1.1 × 103/ml) patients (p p = 0.22 to 0.39), but interestingly in AMI and AI patients, cells were CXCR4+ in almost half of these mobilized cells, although the proportion was significantly higher in AMI patients (46.8% ± 7.1% to 55.7% ± 6.3% vs 23% ± 1.6% to 28.4% ± 2.1%, p = 0.03 to 0.05). A similar behavior was observed with the Ki67 antibody (29.9% ± 2.1% to 36.1% ± 6.3% vs 10% ± 1.2% to 24% ± 1.1%, p = 0.001 to 0.05). Bivariate analysis of the results showed a significant correlation of the cell proportion in AMI but not in AI and CI patients (p = 0.001 to 0.05;0.12 to 0.87 and 0.17 to 0.92 respectively). The amount of myocardial tissue infarcted did not show

关键词： Stem Cells CXCR4:SDF-1 Axis Cardiac Repair Acute and Chronic Ischemia

Effect of Cardioxane and Selenium on Lipoperoxidation and Levels of Dopamine in Rat Brain and Heart

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Neuroscience & Medicine 2019年第4期10卷 354-368页

作者： David Calderón Guzmán Norma Osnaya Brizuela Gerardo Barragán Mejía Hugo Juárez Olguín Lulú Sánchez Reyes armando Valenzuela Pereza Norma Labra Ruiz Daniel Santamaría del Angel Laboratory of Neurosciences Instituto Nacional de Pediatría (INP) Mexico City Mexico Laboratory of Experimental Bacteriology INP Mexico City Mexico Laboratory of Pharmacology INP Mexico City Mexico Faculty of Medicine Universidad Nacional Autónoma de Mexico Mexico City Mexico.

Background: Cardioxane has been probed in patients with advanced malignancies to protect the heart. Selenium, an essential micronutrient exerts varieties of functions such as antioxidant. The aim of this study was to test if cardioxane (CDX) and selenium (Se) have additive antioxidant protective effect on brain and heart, and their relation with dopamine levels. Methods: Thirty-six male Wistar rats divided in groups of 6 animals each, were treated as follows: G1, saline solution 0.9% (control);G2, 100 mg/kg of CDX;G3, 60 μg/kg of Se;G4, 20 mg/kg of 3-nitropropionic acid (3NP);G5, 3NP + CDX and G6, 3NP + Se. 3NP was used as an oxidative stress inducer. Drugs were administered intraperitoneally for 5 days. The animals were sacrificed on the last day of treatment and the brain and heart were extracted and used to measure lipid peroxidation, dopamine, glutathione (GSH), ATPase, calcium, and H2O2. Results: In G2 and G5, dopamine decreased in cortex and striatum while GSH increased in heart, cortex and cerebellum/medulla oblongata. ATPase activity increased in heart and cortex of groups 2, 3, 5 and 6. Lipoperoxidation and H2O2 increased in cortex of animals treated with 3NP. Conclusion: These results suggest that CDX increases antioxidant capacity in the brain and heart while selenium promotes alteration in dopamine metabolism in view of the capacity of 3NP to generate free radicals.

关键词： Brain Dopamine Heart Cardioxane Selenium 3-Nitropropionic Acid

*** the perceptual profiles of children and adolescents with a neurodevelopmental condition

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Annals of Eye Science 2018年第1期 475-475页

作者： Domenico Tullo Margarita Miseros armando Bertone Research Center McGill UniversityMontrealQCCanada

Background:Perceptual profiles,or the performance on visual-perceptual tasks that reflect early visual information processing,have been used to suggest condition-specific visuo-perceptual abilities across neurodevelopmental conditions(NDCs).The complexity-specific hypothesis(Bertone et al.,2010)was based on perceptual profiles defined by a selective decrease in sensitivity to more complex,texture-defined information in adults with autism and fragile-x syndrome,suggesting the atypical development of neural networks underlying early perception in *** aim of this study was to evaluate whether the complexity-specific hypothesis is applicable to children and adolescents with different NDCs by defining and comparing their perceptual ***:A single interval,two alternative forced-choice identification paradigm was used to measure the perceptual profiles of 64 participants with a NDC(MIQ=78)and 43 typically developing(TD)participants(MIQ=103),aged 5 to 17 *** with a NDC were diagnosed with either:autism spectrum disorder(ASD,n=32),attention deficit/hyperactivity disorder(ADHD,n=9),or intellectual disability(ID,n=12).Perceptual profiles were defined by measuring participants’sensitivity to static(orientation identification task)and dynamic(direction identification task)gratings(1 cpd)defined by either luminance(simple)or texture(complex)*** Weschler Abbreviated Scale of Intelligence 2(WASI-2)was used as a measure of cognitive ***:When performance was averaged across NDC and TD participants,no between-group difference in sensitivity was found for any of the conditions ***,when assessed as a function of diagnosis,we found that the ID group was less sensitive to both the luminance(P=0.04)and texture-defined(P=0.01)dynamic information when compared to the TD ***,although the perceptual profile of the ASD group was similar of that of the TD group,a significant positive relationship between mental age an

关键词： Neurodevelopment conditions perception first and second order information processing neural networks

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生命水科技:一种节约用水的建筑

世界建筑导报 2015年第4期30卷 42-44页

作者： armando Bussey Edward Luckman Vichayuth Meenaphant Ana Margarita Wang-Zuniga Robert Stuart-Smith

淡水供应是一个全球关注的问题,而建筑设计可以帮助解决这个问题。＂生命水科技＂是一个计划使建筑中集水、配送和用水一体化的项目。该季节性项目受气候影响较大,该设计策略性地利用了降水和温度的季节性变化,以在多雨季节储存雨水,再... 详细信息

淡水供应是一个全球关注的问题,而建筑设计可以帮助解决这个问题。＂生命水科技＂是一个计划使建筑中集水、配送和用水一体化的项目。该季节性项目受气候影响较大,该设计策略性地利用了降水和温度的季节性变化,以在多雨季节储存雨水,再在夏季用于建筑的无源致冷。这项研究涉及高级水模拟装置以及复合结构材料原型的开发。

关键词：生命水复合结构节约用水淡水供应模拟装置气候影响设计标准多雨季节 seasonal 屋顶结构

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生活,需要“5%的精彩”

现代装饰 2018年第10期 94-101页

作者： Taeg Nishimoto Ohad Benit YOY nortstudio Kamonwan Mungnatee Lalita Kitchachanchaikul armando Bruno Faye Toogood 李薇

记得白岩松曾说过这样的一段话：生活中只有5%的比较精彩,也只有5%的比较痛苦,另外的90%都是在平淡中度过。而人都是被这5%的精彩勾引着,忍受着5%的痛苦,生活在这90%的平淡之中。生活确实如此,我们大多数人、大多时候都生活在波澜不惊... 详细信息

记得白岩松曾说过这样的一段话：生活中只有5%的比较精彩,也只有5%的比较痛苦,另外的90%都是在平淡中度过。而人都是被这5%的精彩勾引着,忍受着5%的痛苦,生活在这90%的平淡之中。生活确实如此,我们大多数人、大多时候都生活在波澜不惊的平平淡淡之中。只是有时候,平淡着平淡着,时间久了,便失去了对生活的感动和生活的幸福感,让人处于一种不明所以的混沌状态。

关键词：生活混沌状态痛苦

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海边公寓

城市环境设计 2010年第Z1期 306-309页

作者： Rok Oman pela Videnik Martina Lipicer Nejc Batisti Neza Oman Florian Frey Marisa baptista Tomaz Gregori Ofis事务所

关键词：斯洛文尼亚阳台

基于PMF模型的湖北随县三里岗地区土壤重金属源解析

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贵州地质 2022年第4期39卷 404-413页

作者：董健彪谢淑云田欢杨文兵李华周徐维 Diego armando Pinzon Nunez 中国地质大学(武汉)地球科学学院湖北武汉430074 中国地质大学(武汉)材料与化学学院湖北武汉430074 湖北省地质局第八地质大队湖北襄阳441002 青海省地质调查局青海西宁810000

随着工矿业、农业的发展,许多国家和地区都已发现重金属污染问题,掌握土壤重金属的来源情况对于维护生态安全十分必要。本文对三里岗镇八种重金属元素进行了含量分析和半变异函数分析,并通过正定矩阵因子分解法结合源贡献率空间分布特... 详细信息

随着工矿业、农业的发展,许多国家和地区都已发现重金属污染问题,掌握土壤重金属的来源情况对于维护生态安全十分必要。本文对三里岗镇八种重金属元素进行了含量分析和半变异函数分析,并通过正定矩阵因子分解法结合源贡献率空间分布特征探究了土壤中8种重金属元素的来源。结果表明:As、Cd、Cr、Cu、Ni和Zn的土壤含量均超出全国背景值,内梅罗综合污染指数均值为0.73,说明研究区整体处于尚清洁水平。半变异函数分析显示8种重金属元素更多受到结构性因素的影响。PMF源解析所得到的4个来源分别解释为震旦系和白垩系地层母岩的影响、元古界地层与乡村道路交通排放的混合源、震旦系和寒武系地层母岩的影响以及奥陶系到志留系地层母岩的影响,说明自然源是研究区重金属的主要来源。此外,本文研究结果表明PMF模型在重金属源解析工作中可以发挥十分重要的作用。

关键词：湖北随县土壤重金属半变异函数正定矩阵因子分解法源解析

陕西紫阳富硒地层硒赋存形式及地球化学意义研究

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贵州地质 2023年第1期40卷 78-87页

作者：周徐维田欢谢淑云 Diego armando Pinzon Nunez 马真真张宏宇中国地质大学(武汉)地球科学学院湖北武汉430074 中国地质大学(武汉)材料与化学学院湖北武汉430074 西北大学大陆动力学国重实验室陕西西安710069

硒是与生物密不可分的微量元素,其含量和赋存形态对人们的生产生活至关重要,本文选择典型富硒地区陕西紫阳,测定该地区地层中29个不同岩性岩石样品的Se含量,探明了该区岩石组合主要以富硒的碳质板岩、硅质岩、黑色页岩和含黄铁矿煤样为... 详细信息

硒是与生物密不可分的微量元素,其含量和赋存形态对人们的生产生活至关重要,本文选择典型富硒地区陕西紫阳,测定该地区地层中29个不同岩性岩石样品的Se含量,探明了该区岩石组合主要以富硒的碳质板岩、硅质岩、黑色页岩和含黄铁矿煤样为主,而在灰岩中硒的富集程度不强。选取14个典型富硒岩石和煤样品,通过四步五态顺序提取法,阐明了硒的五种赋存形态特征及其环境地球化学意义:陕西紫阳地区岩石硒形态以硫/硒化物结合状态为主,残渣态、有机结合状态硒次之,紫阳地区沉积环境偏还原性。本文为深入认识陕西紫阳地区富硒岩石硒含量和硒迁移转化行为及富硒矿产资源综合开发利用提供了数据基础和理论指导。

关键词：陕西紫阳富硒地层硒含量硒形态四步五态顺序提取法

Lot to give,got to live-the restless minds of the“Liver on Tour”project

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World Journal of Hepatology 2016年第19期8卷 825-826页

作者： Guilherme Macedo armando Peixoto Susana Lopes Centro Hospitalar de Sao Joao-Gastroenterology Department Faculty of Medicine University of Porto WGO Training Center

The Liver on Tour was a special project devoted to increase the public awareness on Liver Health and Liver Diseases that the Portuguese Association for the Study of Liver Diseases launched throughout the country in 2010.

关键词： Liver disease Hepatology Hepatitis Public health